ES2257858T3 - Porfirinas sustituidas. - Google Patents

Porfirinas sustituidas.

Info

Publication number
ES2257858T3
ES2257858T3 ES99919995T ES99919995T ES2257858T3 ES 2257858 T3 ES2257858 T3 ES 2257858T3 ES 99919995 T ES99919995 T ES 99919995T ES 99919995 T ES99919995 T ES 99919995T ES 2257858 T3 ES2257858 T3 ES 2257858T3
Authority
ES
Spain
Prior art keywords
mmol
compound according
alkyl
manganese
porphyrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99919995T
Other languages
English (en)
Spanish (es)
Inventor
James D. National Jewish Med. And Res. Cen. Crapo
Brian National Jewish Med. And Res. Cen. Day
Polivina Jolicia F. Albany Molecular Gauuan
Anthony D. Jr. Albany Molec. Res. Inc. Pechulis
Michael P. Albany Molec. Res. Inc. Trova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeolus Sciences Inc
Duke University
Original Assignee
Aeolus Sciences Inc
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeolus Sciences Inc, Duke University filed Critical Aeolus Sciences Inc
Application granted granted Critical
Publication of ES2257858T3 publication Critical patent/ES2257858T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES99919995T 1998-04-24 1999-04-23 Porfirinas sustituidas. Expired - Lifetime ES2257858T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8288198P 1998-04-24 1998-04-24
US82881P 1998-04-24

Publications (1)

Publication Number Publication Date
ES2257858T3 true ES2257858T3 (es) 2006-08-01

Family

ID=22174053

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99919995T Expired - Lifetime ES2257858T3 (es) 1998-04-24 1999-04-23 Porfirinas sustituidas.

Country Status (10)

Country Link
US (1) US6479477B1 (enExample)
EP (1) EP1071474B1 (enExample)
JP (1) JP4648542B2 (enExample)
AT (1) ATE311206T1 (enExample)
AU (1) AU771259B2 (enExample)
CA (1) CA2329751C (enExample)
DE (1) DE69928655T2 (enExample)
DK (1) DK1071474T3 (enExample)
ES (1) ES2257858T3 (enExample)
WO (1) WO1999055388A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
ES2198767T3 (es) 1997-11-03 2004-02-01 Duke University Porfirinas sustituidas.
AU771259B2 (en) 1998-04-24 2004-03-18 Aeolus Sciences, Inc. Substituted porphyrins
US6632808B1 (en) 1998-08-11 2003-10-14 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of amyloid formation
JP4501128B2 (ja) * 1999-01-25 2010-07-14 ナショナル ジュウィッシュ ヘルス 置換ポルフィリン
US6403788B1 (en) 2000-07-11 2002-06-11 Eukarion, Inc. Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
WO2002098431A1 (en) * 2001-06-01 2002-12-12 National Jewish Medical And Research Center Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
JP2003012547A (ja) * 2001-06-27 2003-01-15 Meiji Seika Kaisha Ltd インスリン依存性糖尿病の診断剤および治療剤
US20040132706A1 (en) * 2001-10-05 2004-07-08 Daniela Salvemini Composition comprising a catalyst for the dismutation of superoxide and use of the composition for preventing and treating hypotension
AU2003237500A1 (en) 2002-06-07 2003-12-22 Duke University Substituted porphyrins
US6861525B2 (en) * 2002-07-15 2005-03-01 Scinopharm Taiwan, Ltd. Process for the preparation imidazo[1,2-A]pyridine-3-acetamides
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
US7649091B2 (en) * 2003-06-06 2010-01-19 Eukarion, Inc. Orally bioavailable low molecular weight metalloporphyrins as antioxidants
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
EP1718201B1 (en) * 2004-02-09 2016-09-14 Duke University Substituted porphyrins
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
KR20060135922A (ko) 2004-03-29 2006-12-29 이노텍 파마슈티컬스 코포레이션 피리딜 치환된 포르피린 화합물 및 이의 사용 방법
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US20080289053A1 (en) * 2007-05-15 2008-11-20 The Regents Of The University Of California Methods and systems for identifying modulators of longevity
US20110098262A1 (en) * 2008-01-31 2011-04-28 Yondim Moussa B H Corroles for neuroprotection and neurorescue
WO2010016965A2 (en) 2008-05-23 2010-02-11 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
RS54911B1 (sr) * 2010-10-06 2016-10-31 Aeolus Sciences Inc Lečenje neurodegenerativnih oboljenja porfirinom
MX2014006255A (es) 2011-12-02 2015-04-10 Univ Colorado Regents Tratamientos neurologiocos con metaloporfirina.
US10646595B2 (en) * 2013-02-12 2020-05-12 The Governing Council Of The University Of Toronto Porphyrin compounds and their use as MRI contrast agents
WO2015034778A1 (en) 2013-09-03 2015-03-12 Biomimetix J.V., Llc Methods of treating erectile dysfunction
EP3089666B1 (en) 2013-12-31 2020-08-19 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
WO2015112588A1 (en) 2014-01-22 2015-07-30 Biomimetix Jv, Llc Methods of treating skin disorders
US10080759B2 (en) 2014-01-22 2018-09-25 Duke University Methods of treating pruritus
KR101894575B1 (ko) * 2017-01-03 2018-09-04 주식회사 인트론바이오테크놀로지 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 화학적 방법
WO2022074014A1 (en) * 2020-10-05 2022-04-14 Biolitec Unternehmensbeteiligungs Ii Ag Tetrapyrrole-based compounds and their formulations for anti-microbial therapy

Family Cites Families (58)

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Publication number Priority date Publication date Assignee Title
US465902A (en) * 1891-12-29 Cultivator
US2951799A (en) 1957-11-13 1960-09-06 Monsanto Chemicals Photoxidation processes using heterocyclic photosensitizers
EP0127797B1 (de) 1983-06-03 1987-06-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
GB8429845D0 (en) 1984-11-26 1985-01-03 Efamol Ltd Porphyrins & cancer treatment
US4758422A (en) 1985-01-04 1988-07-19 Salutar Inc. Ferrioxamine paramagnetic contrast agents for MR imaging
ATE78158T1 (de) 1985-05-22 1992-08-15 Liposome Technology Inc Verfahren und system zum einatmen von liposomen.
DK402785D0 (da) 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
US5248603A (en) 1985-09-03 1993-09-28 Symbicom Aktiebolag Superoxide dismutase
US4746735A (en) 1986-11-21 1988-05-24 The Dow Chemical Company Regiospecific aryl nitration of meso-substituted tetraarylporphyrins
DE3854872D1 (de) 1987-03-14 1996-02-22 Boehringer Ingelheim Int Humane Mangan-Superoxiddismutase (hMn-SOD)
US5227405A (en) 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
US5223538A (en) 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
US4892941A (en) 1987-04-17 1990-01-09 Dolphin David H Porphyrins
US4851403A (en) 1987-04-21 1989-07-25 Johnson Matthey, Inc. Radiation sensitizers
US4885114A (en) 1987-04-22 1989-12-05 Barnes Engineering Co. Metallized tetra((meso)-5-methyl-2-thiophene)porphines, platinum (5-bromo octaethylporphine) and optical filters containing same
US5051337A (en) 1987-06-10 1991-09-24 Director-General Of Agency Of Industrial Science And Technology Optical recording material
US5162519A (en) 1988-03-11 1992-11-10 Efamol Holdings Plc Porphyrins and cancer treatment
GB8805849D0 (en) 1988-03-11 1988-04-13 Efamol Holdings Porphyrins & cancer treatment
US5284647A (en) 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
DE3809671A1 (de) 1988-03-18 1989-09-28 Schering Ag Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5109016A (en) 1988-05-23 1992-04-28 Georgia State University Foundation, Inc. Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions
FR2632187B1 (fr) 1988-06-02 1990-09-14 Centre Nat Rech Scient Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides
US5171680A (en) 1988-06-14 1992-12-15 Chiron Corporation Superoxide dismutase analogs having novel binding properties
EP0414915B1 (en) 1989-03-06 1996-06-12 Suntory Limited New superoxide dismutase
DK455789D0 (da) 1989-09-15 1989-09-15 Symbicom Ab Polypeptid
EP0424033A3 (en) 1989-10-19 1991-07-31 Pola Chemical Industries Inc External skin preparation
US5236915A (en) 1990-05-31 1993-08-17 Health Research, Inc. Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing agents
EP0462836A3 (en) 1990-06-20 1992-08-26 Mitsui Toatsu Chemicals, Inc. Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme
US5217966A (en) 1990-09-13 1993-06-08 The Regents Of The University Of California Synthetic drug molecules that mimic metalloenzymes
US5202317A (en) 1990-09-13 1993-04-13 The Regents Of The University Of California Synthetic drug molecules that mimic metalloenzymes
AU8947791A (en) 1990-11-01 1992-05-26 Scripps Research Institute, The Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions
US5192757A (en) * 1990-12-20 1993-03-09 Glaxo Inc. Cobalt porphyrins
GB9103991D0 (en) 1991-02-26 1991-04-10 Nat Res Dev Molecular electronic devices
FR2676738B1 (fr) 1991-05-22 1995-05-05 Ir2M Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante.
DE69224839T2 (de) 1991-07-19 1998-10-08 Monsanto Co Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren.
CA2072934C (en) 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5262532A (en) 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
US5212300A (en) 1991-09-12 1993-05-18 Sun Company, Inc. (R&M) Cyano- and polycyanometallo-porphyrins as catalysts for alkane oxidation
US5599924A (en) * 1992-08-14 1997-02-04 Trustees Of The University Of Pennsylvania Electron-deficient porphyrins and processes and intermediates for preparing same
US5371199B1 (en) 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5493017A (en) 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
ES2157221T3 (es) * 1992-09-03 2001-08-16 Univ California Composiciones metaloporfirinicas.
US5696109A (en) 1992-12-07 1997-12-09 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
DE4305523A1 (de) 1993-02-17 1994-08-18 Diagnostikforschung Inst Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US5994339A (en) 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
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AU3758695A (en) 1994-09-20 1996-04-09 Duke University Oxidoreductase activity of manganic porphyrins
CA2132690A1 (en) 1994-09-22 1996-03-23 Dean Willis Control and modulation of inflammatory response in humans in need of such control and modulation
ES2249784T3 (es) 1995-06-07 2006-04-01 Duke University Antioxidantges de oxidantes.
AU6650198A (en) 1997-02-05 1998-08-25 Board Of Regents, The University Of Texas System Porphyrin compounds as telomerase inhibitors
ES2198767T3 (es) 1997-11-03 2004-02-01 Duke University Porfirinas sustituidas.
AU771259B2 (en) 1998-04-24 2004-03-18 Aeolus Sciences, Inc. Substituted porphyrins
JP4501128B2 (ja) 1999-01-25 2010-07-14 ナショナル ジュウィッシュ ヘルス 置換ポルフィリン
US6372727B1 (en) 1999-10-13 2002-04-16 Uab Research Foundation Metalloporphyrin treatment of neurologic disease
CA2412623A1 (en) 2000-06-14 2001-12-20 Brian J. Day Tetrapyrroles

Also Published As

Publication number Publication date
CA2329751C (en) 2010-10-12
AU3758899A (en) 1999-11-16
EP1071474A1 (en) 2001-01-31
WO1999055388A1 (en) 1999-11-04
US6479477B1 (en) 2002-11-12
JP2002512989A (ja) 2002-05-08
WO1999055388A9 (en) 2000-01-27
DK1071474T3 (da) 2006-04-10
AU771259B2 (en) 2004-03-18
DE69928655T2 (de) 2006-08-24
DE69928655D1 (de) 2006-01-05
EP1071474B1 (en) 2005-11-30
EP1071474A4 (en) 2002-10-24
ATE311206T1 (de) 2005-12-15
JP4648542B2 (ja) 2011-03-09
CA2329751A1 (en) 1999-11-04

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