ES2157221T3 - Composiciones metaloporfirinicas. - Google Patents
Composiciones metaloporfirinicas.Info
- Publication number
- ES2157221T3 ES2157221T3 ES93921333T ES93921333T ES2157221T3 ES 2157221 T3 ES2157221 T3 ES 2157221T3 ES 93921333 T ES93921333 T ES 93921333T ES 93921333 T ES93921333 T ES 93921333T ES 2157221 T3 ES2157221 T3 ES 2157221T3
- Authority
- ES
- Spain
- Prior art keywords
- well
- metaloporphirinic
- compositions
- metal
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title 1
- VAJVGAQAYOAJQI-UHFFFAOYSA-N 3-[18-(2-carboxylatoethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphyrin-21,24-diium-2-yl]propanoate Chemical compound N1C(C=C2C(C)=CC(N2)=CC=2C(=C(CCC(O)=O)C(=C3)N=2)C)=CC(C)=C1C=C1C(C)=C(CCC(O)=O)C3=N1 VAJVGAQAYOAJQI-UHFFFAOYSA-N 0.000 abstract 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 102000004580 Aspartic Acid Proteases Human genes 0.000 abstract 1
- 108010017640 Aspartic Acid Proteases Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical class [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- -1 porphyrin compounds Chemical class 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
COMPUESTOS DE PORFIRINA SUSTITUIDOS DE CARBORANO SELECTIVAMENTE INHIBEN PROTEASAS ASPARTILO VIRALES, Y SON UTILES EN EL TRATAMIENTO DE INFECCIONES TALES COMO AIDS (ENFERMEDAD DE SISTEMA INUNE), ASI COMO USOS EN EL TRATAMIENTO DE TUMORES SOLIDOS. TRATAMIENTOS PARTICULARMENTE PREFERENTES DE CONFORMIDAD CON LA INVENCION USAN LA SAL DIPOTASICA DE 2''4 - BIS [ ,(BETA) - (1''2 - DICARBACLOSODODECABORANO CARBOXI) ETIL] DEUTEROPORFIRINA COMPLEJO CON UN METAL O UN METAL DE TRANSICION, QUE SE SOLUBILIZA BIEN EN AGUA, Y ES ADECUADO PARA ADMINISTRACION ORAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94009592A | 1992-09-03 | 1992-09-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2157221T3 true ES2157221T3 (es) | 2001-08-16 |
Family
ID=25474216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93921333T Expired - Lifetime ES2157221T3 (es) | 1992-09-03 | 1993-09-03 | Composiciones metaloporfirinicas. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0658109B1 (es) |
JP (1) | JPH08501103A (es) |
AT (1) | ATE201595T1 (es) |
AU (1) | AU4846193A (es) |
DE (1) | DE69330275T2 (es) |
ES (1) | ES2157221T3 (es) |
WO (1) | WO1994005285A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0626178A1 (de) * | 1993-05-17 | 1994-11-30 | Ciba-Geigy Ag | Verwendung von Hemmstoffen von HIV-Aspartatproteasen zur Bekämpfung von Tumorerkrankungen |
DE69425666T2 (de) * | 1993-10-01 | 2001-04-12 | Univ California | Borierte metalloporphyrine und diagnostische verfahren |
DE19708461A1 (de) * | 1997-02-18 | 1998-08-27 | Meulen Volker Prof Dr Ter | Verwendung aminerg wirkender Substanzen zur Herstellung eines Arzneimittels für die Behandlung viraler Infektionen des zentralen Nervensystems |
IL135949A0 (en) | 1997-11-03 | 2001-05-20 | Univ Duke | Substituted porphyrins |
WO1999055388A1 (en) * | 1998-04-24 | 1999-11-04 | Duke University | Substituted porphyrins |
JP4501128B2 (ja) | 1999-01-25 | 2010-07-14 | ナショナル ジュウィッシュ ヘルス | 置換ポルフィリン |
WO2002098431A1 (en) | 2001-06-01 | 2002-12-12 | National Jewish Medical And Research Center | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
EP1513537A4 (en) | 2002-06-07 | 2006-09-06 | Univ Duke | SUBSTITUTED PORPHYRINS |
CZ303046B6 (cs) * | 2005-01-14 | 2012-03-14 | Vysoká Škola Chemicko-Technologická | II. Inhibitory HIV proteasy |
CN102105146A (zh) | 2008-05-23 | 2011-06-22 | 国立犹太保健医院 | 用于治疗与暴露于烷化物质有关的损伤的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5128319A (en) * | 1987-08-28 | 1992-07-07 | Board Of Regents, The University Of Texas System | Prophylaxis and therapy of acquired immunodeficiency syndrome |
EP0337598A3 (en) * | 1988-02-26 | 1991-07-03 | Georgia State University Foundation, Inc. | Use of porphyrins and metalloporphyrins in the treatment of diseases caused by human immunodeficiency viruses |
US5109016A (en) * | 1988-05-23 | 1992-04-28 | Georgia State University Foundation, Inc. | Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions |
US4959356A (en) * | 1989-05-26 | 1990-09-25 | The United States Of America As Represented By The United States Department Of Energy | Porphyrins for boron neutron capture therapy |
CA2088593A1 (en) * | 1990-07-31 | 1992-02-01 | Attallah Kappas | Use of metalloporphyrins to potentiate aids therapy |
US5149801A (en) * | 1990-11-21 | 1992-09-22 | The Regents Of The University Of California | Boronated porphyrin compounds |
-
1993
- 1993-09-03 EP EP93921333A patent/EP0658109B1/en not_active Expired - Lifetime
- 1993-09-03 JP JP6507464A patent/JPH08501103A/ja active Pending
- 1993-09-03 WO PCT/US1993/008317 patent/WO1994005285A1/en active IP Right Grant
- 1993-09-03 AT AT93921333T patent/ATE201595T1/de not_active IP Right Cessation
- 1993-09-03 DE DE69330275T patent/DE69330275T2/de not_active Expired - Fee Related
- 1993-09-03 AU AU48461/93A patent/AU4846193A/en not_active Abandoned
- 1993-09-03 ES ES93921333T patent/ES2157221T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0658109B1 (en) | 2001-05-30 |
EP0658109A4 (en) | 1997-04-09 |
WO1994005285A1 (en) | 1994-03-17 |
ATE201595T1 (de) | 2001-06-15 |
EP0658109A1 (en) | 1995-06-21 |
AU4846193A (en) | 1994-03-29 |
DE69330275D1 (de) | 2001-07-05 |
DE69330275T2 (de) | 2001-10-31 |
JPH08501103A (ja) | 1996-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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