ES2253839T3 - Supresion de cambios relacionados con amiloide beta en la enfermedad de alzheimer. - Google Patents
Supresion de cambios relacionados con amiloide beta en la enfermedad de alzheimer.Info
- Publication number
- ES2253839T3 ES2253839T3 ES98961894T ES98961894T ES2253839T3 ES 2253839 T3 ES2253839 T3 ES 2253839T3 ES 98961894 T ES98961894 T ES 98961894T ES 98961894 T ES98961894 T ES 98961894T ES 2253839 T3 ES2253839 T3 ES 2253839T3
- Authority
- ES
- Spain
- Prior art keywords
- amyloid
- peptide
- disease
- mice
- alzheimer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US6923964B1 (en) | 1997-12-02 | 2005-08-02 | Neuralab Limited | Active immunization of AScr for prion disorders |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| AU742970C (en) * | 1997-12-03 | 2003-03-20 | Janssen Alzheimer Immunotherapy | Method of suppressing beta-amyloid-related changes in Alzheimer's disease |
| US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
| US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| ATE286072T1 (de) | 2000-05-22 | 2005-01-15 | Univ New York | Synthetische immunogene jedoch nicht amyloidogene peptide, die homolog zu amyloid beta sind und deren verwendung zur induktion einer immunantwort gegen amyloid beta und amyloidaggregate |
| WO2002003911A2 (en) | 2000-07-07 | 2002-01-17 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| US7320793B2 (en) | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| EP1572894B1 (en) | 2001-11-21 | 2016-04-13 | New York University | Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha synuclein, or polyglutamine repeats for induction of an immune response thereto |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| CA2492930C (en) | 2002-07-19 | 2013-01-08 | Cytos Biotechnology Ag | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| WO2004056318A2 (en) | 2002-12-19 | 2004-07-08 | New York University | Method for treating amyloid disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| TWI374893B (en) | 2003-05-30 | 2012-10-21 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| TW200635607A (en) | 2004-12-15 | 2006-10-16 | Elan Pharm Inc | Humanized Aβ antibodies for use in improving cognition |
| WO2006066049A2 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| GT200600031A (es) | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| PT1976877E (pt) | 2005-11-30 | 2014-04-29 | Abbvie Inc | Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações |
| CN117903302A (zh) | 2005-11-30 | 2024-04-19 | Abbvie 公司 | 抗-Aβ球聚体抗体，其相关产品，生产所述抗体的方法，所述抗体的应用以及使用方法 |
| RU2429244C2 (ru) | 2006-03-23 | 2011-09-20 | Байоарктик Ньюросайенс Аб | Улучшенные селективные в отношении протофибрилл антитела и их применение |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| DK2182983T3 (da) | 2007-07-27 | 2014-07-14 | Janssen Alzheimer Immunotherap | Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| CN104744591B (zh) | 2010-04-15 | 2022-09-27 | Abbvie德国有限责任两合公司 | β淀粉样蛋白结合蛋白 |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| US8906382B2 (en) | 2011-07-19 | 2014-12-09 | New York University | Method for treating amyloid disease |
| US9926353B2 (en) | 2011-07-19 | 2018-03-27 | New York University | Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides |
| WO2014074744A1 (en) * | 2012-11-09 | 2014-05-15 | Lasser Elliott C | X-ray contrast media compositions and methods of using the same to treat inflammation associated conditions |
| RS61717B1 (sr) | 2014-07-10 | 2021-05-31 | Bioarctic Ab | Poboljšana antitela koja vezuju a-beta protofibril |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223482A (en) * | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
| DE69126304T2 (de) * | 1990-04-27 | 1997-09-04 | Mcmichael, John, Delanson, N.Y. | Verfahren und zusammensetzung zur behandlung von erkrankungen des zns hervorgerufen durch abnormales beta-amyloid-protein |
| EP0760676B1 (en) * | 1994-05-25 | 2001-07-11 | McMICHAEL, John | Materials and methods for treatment of plaquing diseases |
| WO1996039176A1 (en) * | 1995-06-05 | 1996-12-12 | Brigham & Women's Hospital | USE OF ORAL TOLERANCE TO SUPPRESS BOTH Th1 AND Th2 IMMUNE RESPONSES AND TO SUPPRESS ANTIBODY PRODUCTION |
| WO1997018855A1 (en) * | 1995-11-21 | 1997-05-29 | Eduard Naumovich Lerner | Device for enhanced delivery of biologically active substances and compounds in an organism |
| ZA97452B (en) * | 1996-01-25 | 1997-08-15 | Trinity College Dublin | Streptococcus equi vaccine. |
| JPH09208485A (ja) * | 1996-01-31 | 1997-08-12 | Teijin Ltd | ペプチド・蛋白質性薬物の水難溶性組成物 |
| AU742970C (en) * | 1997-12-03 | 2003-03-20 | Janssen Alzheimer Immunotherapy | Method of suppressing beta-amyloid-related changes in Alzheimer's disease |
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1998
- 1998-12-03 AU AU17099/99A patent/AU742970C/en not_active Expired
- 1998-12-03 CA CA2312475A patent/CA2312475C/en not_active Expired - Lifetime
- 1998-12-03 ES ES98961894T patent/ES2253839T3/es not_active Expired - Lifetime
- 1998-12-03 DE DE69831971T patent/DE69831971T2/de not_active Expired - Lifetime
- 1998-12-03 WO PCT/US1998/025694 patent/WO1999027949A1/en not_active Ceased
- 1998-12-03 JP JP2000522934A patent/JP2002511385A/ja active Pending
- 1998-12-03 EP EP98961894A patent/EP1033998B1/en not_active Expired - Lifetime
- 1998-12-03 DE DE1033998T patent/DE1033998T1/de active Pending
- 1998-12-03 AT AT98961894T patent/ATE306931T1/de not_active IP Right Cessation
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2010
- 2010-04-02 JP JP2010086400A patent/JP2010215627A/ja active Pending
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| DE69831971D1 (de) | 2006-03-02 |
| EP1033998A4 (en) | 2003-06-04 |
| AU1709999A (en) | 1999-06-16 |
| EP1033998B1 (en) | 2005-10-19 |
| DE1033998T1 (de) | 2001-05-23 |
| JP2010215627A (ja) | 2010-09-30 |
| EP1033998A1 (en) | 2000-09-13 |
| ATE306931T1 (de) | 2005-11-15 |
| CA2312475C (en) | 2010-08-03 |
| WO1999027949A1 (en) | 1999-06-10 |
| DE69831971T2 (de) | 2006-07-06 |
| WO1999027949A9 (en) | 1999-09-10 |
| JP2002511385A (ja) | 2002-04-16 |
| AU742970C (en) | 2003-03-20 |
| CA2312475A1 (en) | 1999-06-10 |
| AU742970B2 (en) | 2002-01-17 |
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