HUP0001960A2 - Metotrexát kombináció autoimmun tünetek befolyásolására - Google Patents
Metotrexát kombináció autoimmun tünetek befolyásolásáraInfo
- Publication number
- HUP0001960A2 HUP0001960A2 HU0001960A HUP0001960A HUP0001960A2 HU P0001960 A2 HUP0001960 A2 HU P0001960A2 HU 0001960 A HU0001960 A HU 0001960A HU P0001960 A HUP0001960 A HU P0001960A HU P0001960 A2 HUP0001960 A2 HU P0001960A2
- Authority
- HU
- Hungary
- Prior art keywords
- methotrexate
- administered
- autoimmune disease
- tolerization
- treatment
- Prior art date
Links
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 title abstract 4
- 229960000485 methotrexate Drugs 0.000 title abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 230000000981 bystander Effects 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
- B41J2/00—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed
- B41J2/005—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
- B41J2/01—Ink jet
- B41J2/21—Ink jet for multi-colour printing
- B41J2/2107—Ink jet for multi-colour printing characterised by the ink properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K2215/00—Arrangements for producing a permanent visual presentation of the output data
- G06K2215/0082—Architecture adapted for a particular function
- G06K2215/0094—Colour printing
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K2215/00—Arrangements for producing a permanent visual presentation of the output data
- G06K2215/0082—Architecture adapted for a particular function
- G06K2215/0097—Printing on special media, e.g. labels, envelopes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány bystander antigén és metotrexát autoimmun betegség ellenható gyógyászati készítmény előállítására történő alkalmazásáravonatkozik, ahol a komponensek külön-külön vagy egymást követőadagolása esetében a bystander antigént gyógyászatilag elfogadhatóformában orálisan, enterálisan vagy inhalálás útján és a metotrexátotgyógyászatilag elfogadható formában orálisan vagy parenterálisanadagolják, és a két komponens ugyanazon készítményben valóadagolásakor mindkettőt enterálisan vagy orálisan adagolják. Atalálmány tárgyát képezi a metotrexátot és a bystander antigént vagyautoantigént tartalmazó gyógyászati készítmény és kit előállításieljárása is. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3672297P | 1997-01-24 | 1997-01-24 | |
PCT/US1998/001648 WO1998032451A1 (en) | 1997-01-24 | 1998-01-26 | Treatment of autoimmune disease using tolerization in combination with methotrexate |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0001960A2 true HUP0001960A2 (hu) | 2000-10-28 |
Family
ID=21890248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001960A HUP0001960A2 (hu) | 1997-01-24 | 1998-01-26 | Metotrexát kombináció autoimmun tünetek befolyásolására |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0994717A4 (hu) |
JP (1) | JP2001511134A (hu) |
KR (1) | KR20000070460A (hu) |
AU (1) | AU6648898A (hu) |
BR (1) | BR9807112A (hu) |
CA (1) | CA2278152A1 (hu) |
HU (1) | HUP0001960A2 (hu) |
IL (1) | IL131025A0 (hu) |
NO (1) | NO993600L (hu) |
WO (1) | WO1998032451A1 (hu) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040103930A (ko) | 2002-02-11 | 2004-12-09 | 앤태어스 파머, 인코퍼레이티드 | 피내 주사기 |
BRPI0614025A2 (pt) | 2005-01-24 | 2012-12-25 | Antares Pharma Inc | injetores de jato |
GB0523576D0 (en) * | 2005-11-18 | 2005-12-28 | Theradeas Ltd | Drug composition and its use in therapy |
US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
EP2268342B1 (en) | 2008-03-10 | 2015-09-16 | Antares Pharma, Inc. | Injector safety device |
JP5611208B2 (ja) | 2008-08-05 | 2014-10-22 | アンタレス・ファーマ・インコーポレーテッド | 多数回服用量の注射装置 |
AU2010226442A1 (en) | 2009-03-20 | 2011-10-13 | Antares Pharma, Inc. | Hazardous agent injection system |
EP2582373A4 (en) | 2010-06-16 | 2013-10-30 | Bruce Chandler May | USE OF LEVOCETIRIZIN AND MONTELUKAST IN THE TREATMENT OF INFLUENZA, COLLECTIONS AND INFLAMMATION |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
JP6165786B2 (ja) | 2012-03-06 | 2017-07-19 | アンタレス・ファーマ・インコーポレーテッド | 離脱力特徴を備える充填シリンジ |
CN104487114A (zh) | 2012-04-06 | 2015-04-01 | 安塔雷斯药品公司 | 针头辅助喷射注射给予睾酮组合物 |
WO2013169800A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
EP2953667B1 (en) | 2013-02-11 | 2019-10-23 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
WO2014164786A1 (en) | 2013-03-11 | 2014-10-09 | Madsen Patrick | Dosage injector with pinion system |
WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
CA2901413A1 (en) | 2013-03-13 | 2014-10-09 | Bruce Chandler May | Use of levocetirizine and montelukast in the treatment of vasculitis |
RU2672871C2 (ru) | 2013-03-13 | 2018-11-20 | Инфламматори Респонс Ресёрч, Инк. | Применение левоцетиризина и монтелукаста при лечении травматических повреждений |
RU2015134423A (ru) * | 2013-03-13 | 2017-04-26 | Инфламматори Респонс Ресёрч, Инк. | Применение левоцитиризина и монтелукаста при лечении аутоиммуных расстройств |
EP3193875B1 (en) | 2014-09-15 | 2022-02-16 | Inflammatory Response Research, Inc. | Levocetirizine and montelukast in the treatment of inflammation mediated conditions |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE258065T1 (de) * | 1987-06-24 | 2004-02-15 | Brigham & Womens Hospital | Behandlung von autoimmun-erkrankungen durch orale verabreichung von autoantigenen |
US5571500A (en) * | 1987-06-24 | 1996-11-05 | Autoimmune, Inc. | Treatment of autoimmune diseases through administration by inhalation of autoantigens |
US5571499A (en) * | 1987-06-24 | 1996-11-05 | Autoimmune, Inc. | Treatment of autoimmune diseases by aerosol administration of autoantigens |
WO1992004049A1 (en) * | 1990-09-06 | 1992-03-19 | Rijksuniversiteit Te Utrecht | Inhibitor of lymphocyte response and immune-related disease |
BR9306042A (pt) * | 1992-02-28 | 1997-11-18 | Autoimmune Inc | Método para tratar uma doença auto-immune em um mamifero e formas de dosagens farmacêuticas oral e inalável |
WO1996040235A1 (en) * | 1995-06-07 | 1996-12-19 | Nexstar Pharmaceuticals, Inc. | Method to use superantigens to target subpopulations of t cells |
EP0834321B1 (en) * | 1995-06-13 | 2003-05-02 | Nippon Meat Packers, Inc. | Oral remedy for rheumatoid arthritis and functional food |
-
1998
- 1998-01-26 BR BR9807112-2A patent/BR9807112A/pt not_active Application Discontinuation
- 1998-01-26 IL IL13102598A patent/IL131025A0/xx unknown
- 1998-01-26 EP EP98908452A patent/EP0994717A4/en not_active Withdrawn
- 1998-01-26 CA CA002278152A patent/CA2278152A1/en not_active Abandoned
- 1998-01-26 JP JP53225298A patent/JP2001511134A/ja active Pending
- 1998-01-26 WO PCT/US1998/001648 patent/WO1998032451A1/en not_active Application Discontinuation
- 1998-01-26 KR KR1019997006698A patent/KR20000070460A/ko not_active Application Discontinuation
- 1998-01-26 AU AU66488/98A patent/AU6648898A/en not_active Abandoned
- 1998-01-26 HU HU0001960A patent/HUP0001960A2/hu unknown
-
1999
- 1999-07-23 NO NO993600A patent/NO993600L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO993600L (no) | 1999-09-23 |
IL131025A0 (en) | 2001-01-28 |
NO993600D0 (no) | 1999-07-23 |
AU6648898A (en) | 1998-08-18 |
EP0994717A1 (en) | 2000-04-26 |
CA2278152A1 (en) | 1998-07-30 |
BR9807112A (pt) | 2001-09-18 |
EP0994717A4 (en) | 2000-07-26 |
JP2001511134A (ja) | 2001-08-07 |
KR20000070460A (ko) | 2000-11-25 |
WO1998032451A1 (en) | 1998-07-30 |
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