ES2246177B1 - Uso de anticuerpos para el tratamiento de enfermedades amiloideas. - Google Patents

Uso de anticuerpos para el tratamiento de enfermedades amiloideas. Download PDF

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Publication number
ES2246177B1
ES2246177B1 ES200403158A ES200403158A ES2246177B1 ES 2246177 B1 ES2246177 B1 ES 2246177B1 ES 200403158 A ES200403158 A ES 200403158A ES 200403158 A ES200403158 A ES 200403158A ES 2246177 B1 ES2246177 B1 ES 2246177B1
Authority
ES
Spain
Prior art keywords
peptide
amyloid
disease
treatment
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200403158A
Other languages
English (en)
Spanish (es)
Other versions
ES2246177A1 (es
Inventor
Jose Manuel Sarasa Barrio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Zaragoza
Original Assignee
University of Zaragoza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Zaragoza filed Critical University of Zaragoza
Publication of ES2246177A1 publication Critical patent/ES2246177A1/es
Application granted granted Critical
Publication of ES2246177B1 publication Critical patent/ES2246177B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES200403158A 2003-05-08 2003-05-08 Uso de anticuerpos para el tratamiento de enfermedades amiloideas. Expired - Fee Related ES2246177B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200301054A ES2246105B1 (es) 2003-05-08 2003-05-08 Uso de anticuerpos para el tratamiento de enfermedades amiloideas.

Publications (2)

Publication Number Publication Date
ES2246177A1 ES2246177A1 (es) 2006-02-01
ES2246177B1 true ES2246177B1 (es) 2007-03-01

Family

ID=32982086

Family Applications (6)

Application Number Title Priority Date Filing Date
ES200403158A Expired - Fee Related ES2246177B1 (es) 2003-05-08 2003-05-08 Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
ES200301054A Expired - Fee Related ES2246105B1 (es) 2003-05-08 2003-05-08 Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
ES200403159A Expired - Fee Related ES2246178B1 (es) 2003-05-08 2003-05-08 Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
ES04730882T Expired - Lifetime ES2329369T3 (es) 2003-05-08 2004-05-03 Tratamiento de la enfermedad de alzheimer y la angiopatia amiloide cerebral.
ES08170222T Expired - Lifetime ES2423281T3 (es) 2003-05-08 2004-05-03 Tratamiento de la enfermedad de Alzheimer
ES10012342T Expired - Lifetime ES2423590T3 (es) 2003-05-08 2004-05-03 Tratamiento de la enfermedad de Alzheimer

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES200301054A Expired - Fee Related ES2246105B1 (es) 2003-05-08 2003-05-08 Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
ES200403159A Expired - Fee Related ES2246178B1 (es) 2003-05-08 2003-05-08 Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
ES04730882T Expired - Lifetime ES2329369T3 (es) 2003-05-08 2004-05-03 Tratamiento de la enfermedad de alzheimer y la angiopatia amiloide cerebral.
ES08170222T Expired - Lifetime ES2423281T3 (es) 2003-05-08 2004-05-03 Tratamiento de la enfermedad de Alzheimer
ES10012342T Expired - Lifetime ES2423590T3 (es) 2003-05-08 2004-05-03 Tratamiento de la enfermedad de Alzheimer

Country Status (19)

Country Link
US (6) US20090162362A1 (enExample)
EP (5) EP2082747A3 (enExample)
JP (5) JP2006525288A (enExample)
CN (2) CN101264326A (enExample)
AT (1) ATE435024T1 (enExample)
AU (2) AU2004237373A1 (enExample)
BR (1) BRPI0410684A (enExample)
CA (1) CA2524571C (enExample)
CY (1) CY1109454T1 (enExample)
DE (1) DE602004021797D1 (enExample)
DK (3) DK2075007T3 (enExample)
ES (6) ES2246177B1 (enExample)
IL (8) IL171651A (enExample)
MX (1) MXPA05010914A (enExample)
PL (3) PL2075007T3 (enExample)
PT (3) PT2075007E (enExample)
RU (2) RU2385161C2 (enExample)
SI (1) SI1623719T1 (enExample)
WO (1) WO2004098631A1 (enExample)

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DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
ES2246177B1 (es) * 2003-05-08 2007-03-01 Universidad De Zaragoza. Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
AU2005290250A1 (en) 2004-07-30 2006-04-06 Rinat Neuroscience Corp. Antibodies directed against amyloid-beta peptide and methods using same
PE20061323A1 (es) 2005-04-29 2007-02-09 Rinat Neuroscience Corp Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
RU2442793C2 (ru) 2005-11-30 2012-02-20 Эбботт Лэборетриз АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ
NZ568012A (en) * 2005-12-12 2012-07-27 Ac Immune Sa A beta 1-42 specific monoclonal antibodies with therapeutic properties
RU2498999C2 (ru) * 2006-07-14 2013-11-20 Ац Иммуне Са Гуманизированное антитело к амилоиду бета
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
US8048420B2 (en) * 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
AU2008311366B2 (en) * 2007-10-05 2015-03-12 Ac Immune S.A. Use of anti-amyloid beta antibody in ocular diseases
PL2238166T3 (pl) * 2007-10-05 2014-07-31 Genentech Inc Zastosowanie przeciwciała anty-Beta amyloidowego w chorobach oczu
EP2149380A1 (en) * 2008-07-29 2010-02-03 Medivet Pharma, S.L. Veterinary immunotherapy compositions for the Aged Related Cognitive Dysfunction.
EP2258398A1 (en) * 2009-05-26 2010-12-08 Araclón Biotech, S. L. Albumin-amyloid peptide conjugates and uses thereof
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
EP2510359B1 (en) 2009-12-11 2015-09-02 Araclón Biotech, S. L. Methods and reagents for improved detection of amyloid beta peptides
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
WO2011130377A2 (en) 2010-04-15 2011-10-20 Abbott Laboratories Amyloid-beta binding proteins
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
US20130115227A1 (en) * 2010-07-14 2013-05-09 Renee C. Gaspar Anti-addl monoclonal antibody and uses thereof
US9221900B2 (en) * 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies
US9062101B2 (en) 2010-08-14 2015-06-23 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
EP3027205A4 (en) 2013-07-28 2017-07-19 Qantu Therapeutics, Inc. Vaccine formulations that induce a th2 immune response
ES2571055B1 (es) * 2016-02-15 2016-12-28 Araclon Biotech, S.L. Conjugado amiloide y usos y procedimientos del mismo
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
PL237739B1 (pl) 2018-06-06 2021-05-17 Univ Gdanski Genisteina do zastosowania do leczenia choroby Alzheimera
KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
MX2022014786A (es) 2020-05-26 2023-01-16 Truebinding Inc Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3.

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WO1999027944A1 (en) * 1997-12-02 1999-06-10 Neuralab Limited Prevention and treatment of amyloidogenic disease

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AU2003279216A1 (en) * 2002-10-09 2004-05-04 Rinat Neuroscience Corp. Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof
KR20050118669A (ko) * 2003-02-01 2005-12-19 뉴랄랩 리미티드 가용성 ａ-베타에 대한 항체를 생성하기 위한 능동 면역화
ES2246177B1 (es) * 2003-05-08 2007-03-01 Universidad De Zaragoza. Uso de anticuerpos para el tratamiento de enfermedades amiloideas.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996015452A1 (en) * 1994-11-14 1996-05-23 Athena Neurosciences, Inc. METHODS FOR AIDING IN THE DIAGNOSIS OF ALZHEIMER'S DISEASE BY MEASURING AMYLOID-β PEPTIDE (X- ≥41) AND TAU
WO1999027944A1 (en) * 1997-12-02 1999-06-10 Neuralab Limited Prevention and treatment of amyloidogenic disease

Also Published As

Publication number Publication date
IL207881A0 (en) 2011-07-31
MXPA05010914A (es) 2006-03-21
AU2011200170C1 (en) 2012-03-22
ES2246105A1 (es) 2006-02-01
JP2016065100A (ja) 2016-04-28
EP1623719B1 (en) 2009-07-01
EP2305286A3 (en) 2011-11-09
IL207881A (en) 2013-02-28
IL207879A0 (en) 2011-07-31
SI1623719T1 (sl) 2009-12-31
ES2246105B1 (es) 2007-03-01
BRPI0410684A (pt) 2006-06-20
CN1784240A (zh) 2006-06-07
JP2006525288A (ja) 2006-11-09
CA2524571C (en) 2017-01-10
IL207876A (en) 2013-03-24
ES2246177A1 (es) 2006-02-01
ES2246178A1 (es) 2006-02-01
US20200140488A1 (en) 2020-05-07
CY1109454T1 (el) 2014-08-13
DK2356996T5 (da) 2013-08-26
ES2423590T3 (es) 2013-09-23
JP2012006967A (ja) 2012-01-12
EP2305286A2 (en) 2011-04-06
ES2246178B1 (es) 2007-03-01
EP2075007B9 (en) 2013-09-04
DK2356996T3 (da) 2013-07-22
AU2011200170B2 (en) 2011-09-01
CA2524571A1 (en) 2004-11-18
IL207879A (en) 2013-02-28
IL207876A0 (en) 2011-07-31
EP1623719A1 (en) 2006-02-08
JP2014129389A (ja) 2014-07-10
IL207877A (en) 2013-03-24
US20110262458A1 (en) 2011-10-27
AU2004237373A1 (en) 2004-11-18
IL207877A0 (en) 2011-07-31
JP2018119011A (ja) 2018-08-02
PL1623719T3 (pl) 2010-11-30
IL207880A (en) 2013-02-28
EP2075007A3 (en) 2009-11-11
DK2075007T3 (da) 2013-07-29
ATE435024T1 (de) 2009-07-15
PT2075007E (pt) 2013-08-23
EP2075007B1 (en) 2013-05-22
RU2005134351A (ru) 2006-04-27
IL207878A0 (en) 2011-07-31
EP2356996A1 (en) 2011-08-17
US20090162362A1 (en) 2009-06-25
WO2004098631A1 (es) 2004-11-18
US20140044725A1 (en) 2014-02-13
PL2075007T3 (pl) 2013-09-30
ES2329369T3 (es) 2009-11-25
PT2356996E (pt) 2013-08-23
DE602004021797D1 (de) 2009-08-13
EP2075007A2 (en) 2009-07-01
RU2009148539A (ru) 2011-06-27
ES2423281T3 (es) 2013-09-19
CN101264326A (zh) 2008-09-17
US20210214394A1 (en) 2021-07-15
IL207875A (en) 2013-02-28
RU2385161C2 (ru) 2010-03-27
EP2082747A2 (en) 2009-07-29
IL207875A0 (en) 2011-07-31
IL171651A (en) 2011-11-30
DK1623719T3 (da) 2009-11-09
AU2011200170A1 (en) 2011-02-03
RU2526155C2 (ru) 2014-08-20
PL2356996T3 (pl) 2013-09-30
PT1623719E (pt) 2009-10-08
US20170260234A1 (en) 2017-09-14
EP2356996B9 (en) 2013-08-28
EP2356996B1 (en) 2013-06-26
IL207878A (en) 2013-02-28
IL207880A0 (en) 2011-07-31
EP2082747A3 (en) 2010-01-13

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