ES2241264T3 - Metodo para el analisis de una muestra por medio de una prueba de la reaccion de enlace por electroquimiluminiscencia. - Google Patents
Metodo para el analisis de una muestra por medio de una prueba de la reaccion de enlace por electroquimiluminiscencia.Info
- Publication number
- ES2241264T3 ES2241264T3 ES99907282T ES99907282T ES2241264T3 ES 2241264 T3 ES2241264 T3 ES 2241264T3 ES 99907282 T ES99907282 T ES 99907282T ES 99907282 T ES99907282 T ES 99907282T ES 2241264 T3 ES2241264 T3 ES 2241264T3
- Authority
- ES
- Spain
- Prior art keywords
- potential
- pulse
- working electrode
- oxidizing
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 29
- 238000004458 analytical method Methods 0.000 title claims description 27
- 238000006243 chemical reaction Methods 0.000 title claims description 21
- 238000012360 testing method Methods 0.000 title abstract description 24
- 230000001590 oxidative effect Effects 0.000 claims abstract description 33
- 238000001514 detection method Methods 0.000 claims abstract description 31
- 230000003750 conditioning effect Effects 0.000 claims abstract description 25
- 230000001603 reducing effect Effects 0.000 claims abstract description 23
- 238000009739 binding Methods 0.000 claims abstract description 14
- 239000011859 microparticle Substances 0.000 claims abstract description 14
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 5
- 239000003550 marker Substances 0.000 claims abstract description 5
- 238000004140 cleaning Methods 0.000 claims description 19
- 238000005259 measurement Methods 0.000 claims description 19
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 14
- 239000003638 chemical reducing agent Substances 0.000 claims description 9
- 230000008021 deposition Effects 0.000 claims description 9
- 230000007935 neutral effect Effects 0.000 claims description 9
- 229910052697 platinum Inorganic materials 0.000 claims description 9
- 230000006872 improvement Effects 0.000 claims description 7
- 239000007800 oxidant agent Substances 0.000 claims description 6
- 239000000700 radioactive tracer Substances 0.000 claims description 6
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 5
- 230000002829 reductive effect Effects 0.000 claims description 5
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 5
- 230000009471 action Effects 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- 239000010839 body fluid Substances 0.000 claims description 2
- 239000013049 sediment Substances 0.000 claims 2
- 230000005518 electrochemistry Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 29
- 238000011084 recovery Methods 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 1
- 239000011324 bead Substances 0.000 description 18
- 239000000523 sample Substances 0.000 description 12
- 230000036961 partial effect Effects 0.000 description 6
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- 239000003153 chemical reaction reagent Substances 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 239000012491 analyte Substances 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 4
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 3
- 102100038358 Prostate-specific antigen Human genes 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
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- 229910052751 metal Inorganic materials 0.000 description 3
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- 230000008569 process Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000012327 Ruthenium complex Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
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- 239000002243 precursor Substances 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 1
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
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- 238000000354 decomposition reaction Methods 0.000 description 1
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- 239000003599 detergent Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
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- 239000008188 pellet Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 108091008695 photoreceptors Proteins 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 210000002966 serum Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Plasma & Fusion (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803528A DE19803528A1 (de) | 1998-01-30 | 1998-01-30 | Verfahren zur Analyse einer Probe mittels eines Elektrochemolumineszenz-Bindungsreaktion-Tests |
| DE19803528 | 1998-01-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2241264T3 true ES2241264T3 (es) | 2005-10-16 |
Family
ID=7856088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99907282T Expired - Lifetime ES2241264T3 (es) | 1998-01-30 | 1999-01-23 | Metodo para el analisis de una muestra por medio de una prueba de la reaccion de enlace por electroquimiluminiscencia. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6599473B1 (enExample) |
| EP (1) | EP1051621B1 (enExample) |
| JP (1) | JP4388693B2 (enExample) |
| AT (1) | ATE293791T1 (enExample) |
| DE (2) | DE19803528A1 (enExample) |
| ES (1) | ES2241264T3 (enExample) |
| WO (1) | WO1999039206A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6614987B1 (en) * | 1998-06-12 | 2003-09-02 | Metabyte, Inc. | Television program recording with user preference determination |
| US8352984B2 (en) | 1998-06-12 | 2013-01-08 | Thomson Licensing | System and method for generating and managing user preference information for scheduled and stored television programs |
| US8087051B2 (en) * | 2000-06-30 | 2011-12-27 | Thomson Licensing | Database management system and method for electronic program guide and television channel lineup organization |
| US8302127B2 (en) * | 2000-09-25 | 2012-10-30 | Thomson Licensing | System and method for personalized TV |
| US8818871B2 (en) | 2001-06-21 | 2014-08-26 | Thomson Licensing | Method and system for electronic purchases using an intelligent data carrier medium, electronic coupon system, and interactive TV infrastructure |
| US7641784B2 (en) * | 2003-01-30 | 2010-01-05 | Tanita Corporation | Method for measuring by means of chemical sensor, and chemical sensor type measuring apparatus |
| US20100126858A1 (en) * | 2003-01-30 | 2010-05-27 | Tanita Corporation | Chemical sensor type measuring apparatus |
| WO2005088291A1 (en) * | 2004-03-15 | 2005-09-22 | University Of Saskatchewan | Small volume electrochemical analysis system |
| KR100605536B1 (ko) | 2005-02-18 | 2006-07-28 | 주식회사 셀텍 | 광 다이오드 어레이 표면에 전극을 형성하여 이를 이용한전기화학발광반응이 도입된 광 검출 셀 회로를 이용한 유전자 및 단백질 검색장치 |
| US8021529B2 (en) * | 2005-04-20 | 2011-09-20 | Thermo Orion, Inc. | Ion measurement/calibration cell |
| CA2609379C (en) * | 2005-06-03 | 2016-11-29 | Allen J. Bard | Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode |
| EP2035831B1 (en) * | 2006-06-30 | 2013-08-14 | Applied Biosystems, LLC | Methods of analyzing binding interactions |
| EP1892524B1 (en) | 2006-08-25 | 2011-10-26 | F. Hoffmann-La Roche AG | Cell for conducting electrochemiluminescence measurements |
| EP3096147B1 (en) | 2009-07-29 | 2023-12-20 | Hitachi High-Tech Corporation | Automatic analyzer |
| WO2012055815A1 (en) | 2010-10-25 | 2012-05-03 | Roche Diagnostics Gmbh | Use of signal enhancing compounds in electrochemiluminescence detection |
| EP2620764B1 (en) | 2012-01-25 | 2015-11-04 | Roche Diagniostics GmbH | A luminescence method of detecting an analyte in a liquid sample and analysis system |
| EP2816345A1 (en) | 2013-06-19 | 2014-12-24 | Roche Diagniostics GmbH | Electrochemiluminescence method of detecting an analyte in a liquid sample and analysis system |
| WO2017129803A1 (en) | 2016-01-29 | 2017-08-03 | Roche Diagnostics Gmbh | Electrochemiluminescence method and apparatus for detecting an analyte in a liquid sample |
| CN108698047B (zh) | 2016-03-11 | 2022-04-01 | 豪夫迈·罗氏有限公司 | 电化学发光检测中的支链胺 |
| EP3662268B1 (en) | 2017-08-01 | 2021-03-24 | Roche Diagnostics GmbH | Method of monitoring an operation of detection of an analyte in a liquid sample |
| CN108037285A (zh) * | 2017-11-29 | 2018-05-15 | 北京美联泰科生物技术有限公司 | 一种磁微粒化学发光定量检测uchl-1的试剂盒及其制备方法 |
| CN108051586A (zh) * | 2017-11-29 | 2018-05-18 | 北京美联泰科生物技术有限公司 | 一种磁微粒化学发光定量检测gfap的试剂盒及其制备方法 |
| AU2021327754A1 (en) * | 2020-08-21 | 2023-03-30 | Meso Scale Technologies, Llc. | Electrochemical cells with auxiliary electrodes having a defined interface potential and methods of using them |
| CN115480055B (zh) * | 2021-09-07 | 2025-11-18 | 长沙安赛诊断生物技术有限公司 | 电化学发光免疫分析试剂盒及其使用方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4917777A (en) * | 1986-04-24 | 1990-04-17 | Shipley Company Inc. | Method for analyzing additive concentration |
| CA1339465C (en) * | 1986-04-30 | 1997-09-16 | Richard J. Massey | Electrochemiluminescent assays |
| IL90105A (en) * | 1988-04-29 | 1993-05-13 | Igen Inc | Method and apparatus for conducting electro- chemiluminescence measurements |
| US5779976A (en) * | 1988-11-03 | 1998-07-14 | Igen International, Inc. | Apparatus for improved luminescence assays |
| US5746974A (en) * | 1988-11-03 | 1998-05-05 | Igen International, Inc. | Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence and chemiluminescence detection |
| US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| IL100866A (en) * | 1991-02-06 | 1995-10-31 | Igen Inc | Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets |
-
1998
- 1998-01-30 DE DE19803528A patent/DE19803528A1/de not_active Withdrawn
-
1999
- 1999-01-23 US US09/600,663 patent/US6599473B1/en not_active Expired - Lifetime
- 1999-01-23 ES ES99907282T patent/ES2241264T3/es not_active Expired - Lifetime
- 1999-01-23 AT AT99907282T patent/ATE293791T1/de active
- 1999-01-23 DE DE59911941T patent/DE59911941D1/de not_active Expired - Lifetime
- 1999-01-23 EP EP99907282A patent/EP1051621B1/de not_active Expired - Lifetime
- 1999-01-23 JP JP2000529609A patent/JP4388693B2/ja not_active Expired - Fee Related
- 1999-01-23 WO PCT/DE1999/000197 patent/WO1999039206A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE19803528A1 (de) | 1999-08-05 |
| ATE293791T1 (de) | 2005-05-15 |
| US6599473B1 (en) | 2003-07-29 |
| EP1051621A1 (de) | 2000-11-15 |
| JP4388693B2 (ja) | 2009-12-24 |
| EP1051621B1 (de) | 2005-04-20 |
| WO1999039206A1 (de) | 1999-08-05 |
| JP2002502035A (ja) | 2002-01-22 |
| DE59911941D1 (de) | 2005-05-25 |
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