ES2229736T3 - Derivados de bis-indol y su uso como agentes antiinflamatorios. - Google Patents
Derivados de bis-indol y su uso como agentes antiinflamatorios.Info
- Publication number
- ES2229736T3 ES2229736T3 ES99933759T ES99933759T ES2229736T3 ES 2229736 T3 ES2229736 T3 ES 2229736T3 ES 99933759 T ES99933759 T ES 99933759T ES 99933759 T ES99933759 T ES 99933759T ES 2229736 T3 ES2229736 T3 ES 2229736T3
- Authority
- ES
- Spain
- Prior art keywords
- inflammatory
- bis
- compounds
- inflammation
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9199198P | 1998-07-08 | 1998-07-08 | |
| US91991P | 1998-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2229736T3 true ES2229736T3 (es) | 2005-04-16 |
Family
ID=22230663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99933759T Expired - Lifetime ES2229736T3 (es) | 1998-07-08 | 1999-07-08 | Derivados de bis-indol y su uso como agentes antiinflamatorios. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6323233B1 (https=) |
| EP (1) | EP1093455B1 (https=) |
| JP (1) | JP2002520315A (https=) |
| AT (1) | ATE277010T1 (https=) |
| CA (1) | CA2335254A1 (https=) |
| DE (1) | DE69920455T2 (https=) |
| ES (1) | ES2229736T3 (https=) |
| WO (1) | WO2000002857A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589975B2 (en) | 1998-07-08 | 2003-07-08 | The Regents Of The University Of California | Synthetic compounds for treatment of inflammation |
| WO2000002857A1 (en) * | 1998-07-08 | 2000-01-20 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole derivatives and their use as antiinflammatory agents |
| WO2003022274A2 (en) | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 2-aroylimidazole compounds for treating cancer |
| US6800655B2 (en) * | 2002-08-20 | 2004-10-05 | Sri International | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents |
| US7074938B2 (en) * | 2002-11-19 | 2006-07-11 | The Regents Of The University Of California | Method for the synthesis of soritin compounds |
| US7232771B2 (en) * | 2003-11-04 | 2007-06-19 | Regents Of The University Of Minnesota | Method and apparatus for depositing charge and/or nanoparticles |
| US7592269B2 (en) * | 2003-11-04 | 2009-09-22 | Regents Of The University Of Minnesota | Method and apparatus for depositing charge and/or nanoparticles |
| CA2593084C (en) | 2004-12-30 | 2014-03-18 | Bioresponse, Llc | Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions |
| EP1893576A4 (en) * | 2005-05-27 | 2010-03-17 | Univ Kingston | TREATMENT OF PROTEIN DISORDERING |
| UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
| BRPI0717753B1 (pt) | 2006-10-27 | 2022-04-12 | Bioresponse, Llc | Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição |
| US20080220175A1 (en) * | 2007-01-22 | 2008-09-11 | Lorenzo Mangolini | Nanoparticles wtih grafted organic molecules |
| CA2982162C (en) | 2015-04-10 | 2023-10-10 | Bioresponse, L.L.C. | Self-emulsifying formulations of dim-related indoles |
| CN108822116A (zh) * | 2018-06-04 | 2018-11-16 | 南京中医药大学 | 具有抗肿瘤活性的吲哚生物碱及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1403617A (fr) | 1962-04-02 | 1965-06-25 | Rhone Poulenc Sa | Nouveaux dérivés de l'indole et leur préparation |
| US4866084A (en) * | 1987-07-17 | 1989-09-12 | Harbor Branch Oceanographic Institution, Inc. | Topsentin compounds effective against viruses and certain tumors |
| CA2015996C (en) * | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| US4970226A (en) | 1989-10-03 | 1990-11-13 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents |
| CA2046801C (en) | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
| US5290777A (en) | 1993-02-24 | 1994-03-01 | Regents Of The Univ. Of California | Use for topsentin compounds and pharmaceutical compositions containing same |
| US5955462A (en) * | 1996-10-31 | 1999-09-21 | Harbor Branch Oceanographic Institution, Inc. | Anti-neurogenic inflammatory compounds and compositions and methods of use thereof |
| EP0887348A1 (en) * | 1997-06-25 | 1998-12-30 | Boehringer Mannheim Italia S.p.A. | Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them |
| WO2000002857A1 (en) * | 1998-07-08 | 2000-01-20 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole derivatives and their use as antiinflammatory agents |
-
1999
- 1999-07-08 WO PCT/US1999/015376 patent/WO2000002857A1/en not_active Ceased
- 1999-07-08 US US09/349,316 patent/US6323233B1/en not_active Expired - Lifetime
- 1999-07-08 ES ES99933759T patent/ES2229736T3/es not_active Expired - Lifetime
- 1999-07-08 JP JP2000559088A patent/JP2002520315A/ja active Pending
- 1999-07-08 DE DE69920455T patent/DE69920455T2/de not_active Expired - Fee Related
- 1999-07-08 CA CA002335254A patent/CA2335254A1/en not_active Abandoned
- 1999-07-08 AT AT99933759T patent/ATE277010T1/de not_active IP Right Cessation
- 1999-07-08 EP EP99933759A patent/EP1093455B1/en not_active Expired - Lifetime
-
2001
- 2001-07-27 US US09/916,470 patent/US6444697B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6323233B1 (en) | 2001-11-27 |
| CA2335254A1 (en) | 2000-01-20 |
| EP1093455B1 (en) | 2004-09-22 |
| WO2000002857A1 (en) | 2000-01-20 |
| WO2000002857A9 (en) | 2000-07-20 |
| DE69920455T2 (de) | 2005-01-20 |
| US6444697B2 (en) | 2002-09-03 |
| DE69920455D1 (de) | 2004-10-28 |
| EP1093455A1 (en) | 2001-04-25 |
| JP2002520315A (ja) | 2002-07-09 |
| US20010056112A1 (en) | 2001-12-27 |
| ATE277010T1 (de) | 2004-10-15 |
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