CA2335254A1 - Bis-indole derivatives and their use as antiinflammatory agents - Google Patents
Bis-indole derivatives and their use as antiinflammatory agents Download PDFInfo
- Publication number
- CA2335254A1 CA2335254A1 CA002335254A CA2335254A CA2335254A1 CA 2335254 A1 CA2335254 A1 CA 2335254A1 CA 002335254 A CA002335254 A CA 002335254A CA 2335254 A CA2335254 A CA 2335254A CA 2335254 A1 CA2335254 A1 CA 2335254A1
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- alkyl
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- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 230000001962 neuropharmacologic effect Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 238000005897 peptide coupling reaction Methods 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000008299 semisolid dosage form Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9199198P | 1998-07-08 | 1998-07-08 | |
| US60/091,991 | 1998-07-08 | ||
| PCT/US1999/015376 WO2000002857A1 (en) | 1998-07-08 | 1999-07-08 | Bis-indole derivatives and their use as antiinflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2335254A1 true CA2335254A1 (en) | 2000-01-20 |
Family
ID=22230663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002335254A Abandoned CA2335254A1 (en) | 1998-07-08 | 1999-07-08 | Bis-indole derivatives and their use as antiinflammatory agents |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6323233B1 (https=) |
| EP (1) | EP1093455B1 (https=) |
| JP (1) | JP2002520315A (https=) |
| AT (1) | ATE277010T1 (https=) |
| CA (1) | CA2335254A1 (https=) |
| DE (1) | DE69920455T2 (https=) |
| ES (1) | ES2229736T3 (https=) |
| WO (1) | WO2000002857A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589975B2 (en) | 1998-07-08 | 2003-07-08 | The Regents Of The University Of California | Synthetic compounds for treatment of inflammation |
| WO2000002857A1 (en) * | 1998-07-08 | 2000-01-20 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole derivatives and their use as antiinflammatory agents |
| WO2003022274A2 (en) | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 2-aroylimidazole compounds for treating cancer |
| US6800655B2 (en) * | 2002-08-20 | 2004-10-05 | Sri International | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents |
| US7074938B2 (en) * | 2002-11-19 | 2006-07-11 | The Regents Of The University Of California | Method for the synthesis of soritin compounds |
| US7232771B2 (en) * | 2003-11-04 | 2007-06-19 | Regents Of The University Of Minnesota | Method and apparatus for depositing charge and/or nanoparticles |
| US7592269B2 (en) * | 2003-11-04 | 2009-09-22 | Regents Of The University Of Minnesota | Method and apparatus for depositing charge and/or nanoparticles |
| CA2593084C (en) | 2004-12-30 | 2014-03-18 | Bioresponse, Llc | Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions |
| EP1893576A4 (en) * | 2005-05-27 | 2010-03-17 | Univ Kingston | TREATMENT OF PROTEIN DISORDERING |
| UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
| BRPI0717753B1 (pt) | 2006-10-27 | 2022-04-12 | Bioresponse, Llc | Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição |
| US20080220175A1 (en) * | 2007-01-22 | 2008-09-11 | Lorenzo Mangolini | Nanoparticles wtih grafted organic molecules |
| CA2982162C (en) | 2015-04-10 | 2023-10-10 | Bioresponse, L.L.C. | Self-emulsifying formulations of dim-related indoles |
| CN108822116A (zh) * | 2018-06-04 | 2018-11-16 | 南京中医药大学 | 具有抗肿瘤活性的吲哚生物碱及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1403617A (fr) | 1962-04-02 | 1965-06-25 | Rhone Poulenc Sa | Nouveaux dérivés de l'indole et leur préparation |
| US4866084A (en) * | 1987-07-17 | 1989-09-12 | Harbor Branch Oceanographic Institution, Inc. | Topsentin compounds effective against viruses and certain tumors |
| CA2015996C (en) * | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| US4970226A (en) | 1989-10-03 | 1990-11-13 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents |
| CA2046801C (en) | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
| US5290777A (en) | 1993-02-24 | 1994-03-01 | Regents Of The Univ. Of California | Use for topsentin compounds and pharmaceutical compositions containing same |
| US5955462A (en) * | 1996-10-31 | 1999-09-21 | Harbor Branch Oceanographic Institution, Inc. | Anti-neurogenic inflammatory compounds and compositions and methods of use thereof |
| EP0887348A1 (en) * | 1997-06-25 | 1998-12-30 | Boehringer Mannheim Italia S.p.A. | Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them |
| WO2000002857A1 (en) * | 1998-07-08 | 2000-01-20 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole derivatives and their use as antiinflammatory agents |
-
1999
- 1999-07-08 WO PCT/US1999/015376 patent/WO2000002857A1/en not_active Ceased
- 1999-07-08 US US09/349,316 patent/US6323233B1/en not_active Expired - Lifetime
- 1999-07-08 ES ES99933759T patent/ES2229736T3/es not_active Expired - Lifetime
- 1999-07-08 JP JP2000559088A patent/JP2002520315A/ja active Pending
- 1999-07-08 DE DE69920455T patent/DE69920455T2/de not_active Expired - Fee Related
- 1999-07-08 CA CA002335254A patent/CA2335254A1/en not_active Abandoned
- 1999-07-08 AT AT99933759T patent/ATE277010T1/de not_active IP Right Cessation
- 1999-07-08 EP EP99933759A patent/EP1093455B1/en not_active Expired - Lifetime
-
2001
- 2001-07-27 US US09/916,470 patent/US6444697B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6323233B1 (en) | 2001-11-27 |
| ES2229736T3 (es) | 2005-04-16 |
| EP1093455B1 (en) | 2004-09-22 |
| WO2000002857A1 (en) | 2000-01-20 |
| WO2000002857A9 (en) | 2000-07-20 |
| DE69920455T2 (de) | 2005-01-20 |
| US6444697B2 (en) | 2002-09-03 |
| DE69920455D1 (de) | 2004-10-28 |
| EP1093455A1 (en) | 2001-04-25 |
| JP2002520315A (ja) | 2002-07-09 |
| US20010056112A1 (en) | 2001-12-27 |
| ATE277010T1 (de) | 2004-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |