ES2216544T3 - Procedimiento de inyeccion de muestras liquidas para separaciones de radioisotopos. - Google Patents
Procedimiento de inyeccion de muestras liquidas para separaciones de radioisotopos.Info
- Publication number
- ES2216544T3 ES2216544T3 ES99935287T ES99935287T ES2216544T3 ES 2216544 T3 ES2216544 T3 ES 2216544T3 ES 99935287 T ES99935287 T ES 99935287T ES 99935287 T ES99935287 T ES 99935287T ES 2216544 T3 ES2216544 T3 ES 2216544T3
- Authority
- ES
- Spain
- Prior art keywords
- valve
- separator
- isotope
- port
- air
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 50
- 239000007788 liquid Substances 0.000 title claims description 40
- 238000002347 injection Methods 0.000 title description 2
- 239000007924 injection Substances 0.000 title description 2
- 238000000926 separation method Methods 0.000 claims abstract description 51
- 238000005406 washing Methods 0.000 claims abstract description 17
- 230000008569 process Effects 0.000 claims abstract description 10
- 238000010828 elution Methods 0.000 claims description 29
- 239000012528 membrane Substances 0.000 claims description 29
- 230000008859 change Effects 0.000 claims description 22
- 239000002699 waste material Substances 0.000 claims description 20
- 230000003750 conditioning effect Effects 0.000 claims description 19
- 230000001105 regulatory effect Effects 0.000 claims description 19
- 239000003480 eluent Substances 0.000 claims description 18
- 239000003153 chemical reaction reagent Substances 0.000 claims description 16
- 238000011068 loading method Methods 0.000 claims description 12
- 238000003860 storage Methods 0.000 claims description 10
- 230000002457 bidirectional effect Effects 0.000 claims description 9
- 238000005349 anion exchange Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 239000003011 anion exchange membrane Substances 0.000 claims description 5
- 238000011049 filling Methods 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims description 2
- 238000011084 recovery Methods 0.000 abstract description 8
- 238000011109 contamination Methods 0.000 abstract description 7
- 238000013459 approach Methods 0.000 abstract description 6
- 238000005202 decontamination Methods 0.000 abstract description 2
- 230000003588 decontaminative effect Effects 0.000 abstract description 2
- 239000012530 fluid Substances 0.000 abstract description 2
- 239000011159 matrix material Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 58
- 239000000047 product Substances 0.000 description 22
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 15
- 238000002474 experimental method Methods 0.000 description 14
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 11
- 239000011347 resin Substances 0.000 description 11
- 229920005989 resin Polymers 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000005342 ion exchange Methods 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 238000009739 binding Methods 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 4
- 241000282465 Canis Species 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229910052767 actinium Inorganic materials 0.000 description 3
- QQINRWTZWGJFDB-UHFFFAOYSA-N actinium atom Chemical compound [Ac] QQINRWTZWGJFDB-UHFFFAOYSA-N 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 229910052797 bismuth Inorganic materials 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 238000005341 cation exchange Methods 0.000 description 3
- 239000013522 chelant Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 150000002892 organic cations Chemical group 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229920009441 perflouroethylene propylene Polymers 0.000 description 3
- 238000000163 radioactive labelling Methods 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000003957 anion exchange resin Substances 0.000 description 2
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 2
- 239000003729 cation exchange resin Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910017604 nitric acid Inorganic materials 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 238000011027 product recovery Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 239000012217 radiopharmaceutical Substances 0.000 description 2
- 229940121896 radiopharmaceutical Drugs 0.000 description 2
- 230000002799 radiopharmaceutical effect Effects 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 239000002594 sorbent Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 1
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- FVIVKIGLBDRWNR-UHFFFAOYSA-N 4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine Chemical compound N1=C2SC(C)=CC2=C(C=2C(=CC=CC=2)F)N=C1N1CCNCC1 FVIVKIGLBDRWNR-UHFFFAOYSA-N 0.000 description 1
- 206010000830 Acute leukaemia Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 101100421536 Danio rerio sim1a gene Proteins 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 102000012214 Immunoproteins Human genes 0.000 description 1
- 108010036650 Immunoproteins Proteins 0.000 description 1
- 229920006370 Kynar Polymers 0.000 description 1
- 108010013709 Leukocyte Common Antigens Proteins 0.000 description 1
- 102000017095 Leukocyte Common Antigens Human genes 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 229920006356 Teflon™ FEP Polymers 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- JCXGWMGPZLAOME-RNFDNDRNSA-N bismuth-213 Chemical compound [213Bi] JCXGWMGPZLAOME-RNFDNDRNSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 238000004858 feed analysis Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000001730 gamma-ray spectroscopy Methods 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 238000013101 initial test Methods 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000003014 ion exchange membrane Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000011049 pearl Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- -1 polytrifluoroethylene Polymers 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000033772 system development Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940127044 therapeutic radiopharmaceutical Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Measurement Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86623 | 1998-05-27 | ||
| US09/086,623 US6153154A (en) | 1998-05-27 | 1998-05-27 | Method for sequential injection of liquid samples for radioisotope separations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2216544T3 true ES2216544T3 (es) | 2004-10-16 |
Family
ID=22199806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99935287T Expired - Lifetime ES2216544T3 (es) | 1998-05-27 | 1999-05-26 | Procedimiento de inyeccion de muestras liquidas para separaciones de radioisotopos. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6153154A (https=) |
| EP (1) | EP1090396B1 (https=) |
| JP (1) | JP4486252B2 (https=) |
| AT (1) | ATE266894T1 (https=) |
| AU (1) | AU5079799A (https=) |
| CA (1) | CA2333356C (https=) |
| DE (1) | DE69917265T2 (https=) |
| ES (1) | ES2216544T3 (https=) |
| WO (1) | WO1999062073A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0967618B1 (en) * | 1998-06-22 | 2003-07-30 | European Community | Method and apparatus for preparing Bi-213 for human therapeutic use |
| US6852296B2 (en) * | 2001-06-22 | 2005-02-08 | Pg Research Foundation | Production of ultrapure bismuth-213 for use in therapeutic nuclear medicine |
| WO2003000376A1 (en) * | 2001-06-22 | 2003-01-03 | Pg Research Foundation, Inc. | Automated radionuclide separation system and method |
| CN1306981C (zh) * | 2001-06-22 | 2007-03-28 | Pg研究基金会公司 | 小型放射性核素自动分离器 |
| WO2003018852A1 (en) * | 2001-08-24 | 2003-03-06 | Actinium Pharmaceuticals Ltd. | Method for rapid elution of bismuth-213 and uses thereof |
| EA007452B1 (ru) * | 2002-04-12 | 2006-10-27 | Пи Джи Рисерч Фаундейшн, Инк. | Многоколоночный генератор с инверсией избирательности для производства сверхчистых радионуклидов |
| AU2003228206A1 (en) * | 2002-06-21 | 2004-01-06 | Lynntech, Inc. | Ion exchange materials for use in a bi-213 generator |
| US6951634B2 (en) * | 2002-09-18 | 2005-10-04 | Battelle Energy Alliance, Llc | Process for recovery of daughter isotopes from a source material |
| US6972414B2 (en) * | 2003-03-24 | 2005-12-06 | Battelle Memorial Institute | Method and apparatus for production of 213Bi from a high activity 225Ac source |
| DE102004022200B4 (de) | 2004-05-05 | 2006-07-20 | Actinium Pharmaceuticals, Inc. | Radium-Target sowie Verfahren zu seiner Herstellung |
| ATE517418T1 (de) * | 2005-04-27 | 2011-08-15 | Comecer Spa | System zur automatischen gewinnung von radioisotopen |
| CA2612461C (en) * | 2005-07-27 | 2013-11-19 | Mallinckrodt Inc. | Radiation-shielding assemblies and methods of using the same |
| EP1772157A1 (de) * | 2005-10-06 | 2007-04-11 | Karl-Heinz Jansen | Modul-Bausatz und Syntheseverfahren zum Herstellen von Radiopharmaka und Radionukliden |
| DE102006008023B4 (de) * | 2006-02-21 | 2008-05-29 | Actinium Pharmaceuticals, Inc. | Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets |
| CA2662932C (en) | 2006-09-08 | 2017-06-06 | Actinium Pharmaceuticals, Inc. | Method for the purification of radium from different sources |
| DE102009049108B4 (de) * | 2009-10-12 | 2016-12-08 | Johannes Gutenberg-Universität Mainz | Verfahren und Vorrichtung zur Gewinnung eines Radionuklids |
| AU2023403061A1 (en) * | 2022-11-30 | 2025-06-19 | Jubilant Draximage Inc. | Improved and safe techniques for use of radioactive generator |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3576998A (en) * | 1966-11-16 | 1971-05-04 | Nen Picker Radiopharmaceutical | Self-contained, closed system and method for generating and collecting a short-lived daughter radionuclide from a long-lived parent radionuclide |
| US3740558A (en) * | 1971-02-17 | 1973-06-19 | Dainabot Radioisotope Labor Lt | Radioactive isotope generator of short-lived nuclides |
| US3902849A (en) * | 1971-08-19 | 1975-09-02 | Medi Physics Inc | Radioisotope and radiopharmaceutical generators |
| US3774036A (en) * | 1972-02-23 | 1973-11-20 | Searle & Co | Generation of a supply of radionuclide |
| NL7411605A (nl) * | 1974-09-02 | 1976-03-04 | Philips Nv | Werkwijze voor het automatisch transporteren en injekteren van een vloeistofmonster. |
| DK150802C (da) * | 1974-09-16 | 1988-02-01 | Bifok Ab | Fremgangsmaade og apparat til kontinuerlig hoejhastighedsanalyse af en vaeskeproeve i en baererstroem |
| SE414228B (sv) * | 1976-09-13 | 1980-07-14 | Bifok Ab | Sett att tillsetta prov till en kontinuerligt strommande berarlosning for automatisk analys samt anordning for genomforande av settet |
| SE414554B (sv) * | 1977-02-16 | 1980-08-04 | Bifok Ab | Sett vid kontinuerlig genomstromningsanalys, der en oavbruten, laminer berarstromning, icke segmenterad av luftblasor, genom en huvudledning transporterar en provplugg till en genomstromningsdetektor samt anordning ... |
| US4314824A (en) * | 1977-02-16 | 1982-02-09 | Bifok Ab | Programmable, continuous flow analyzer |
| SE418017B (sv) * | 1978-06-14 | 1981-04-27 | Bifok Ab | Sett att kontinuerligt bestemma olika langsamt reagerande substanser kvantitativt med anvendning av en enda metcell |
| US4315754A (en) * | 1979-08-28 | 1982-02-16 | Bifok Ab | Flow injection analysis with intermittent flow |
| US4663129A (en) * | 1985-01-30 | 1987-05-05 | The United States Of America As Represented By The United States Department Of Energy | Isotopic generator for bismuth-212 and lead-212 from radium |
| SE455537B (sv) * | 1985-01-31 | 1988-07-18 | Bifok Ab | Sett for kemisk analys vid vilken provet och/eller dess reaktionsprodukter bringas att passera en genomstromningscell, samt en apparatur for utovande av settet |
| US4683123A (en) * | 1985-08-26 | 1987-07-28 | The United States Of America As Represented By The United States Department Of Energy | Osmium-191/iridium-191m radionuclide |
| US5154897A (en) * | 1991-03-06 | 1992-10-13 | University Of Missouri | Method and apparatus for the generation of radioisotopes |
| US5186913A (en) * | 1991-04-26 | 1993-02-16 | Martin Marietta Energy Systems, Inc. | Tungsten-188/carrier-free rhenium-188 perrhenic acid generator system |
| US5749042A (en) * | 1997-01-28 | 1998-05-05 | Battelle Memorial Institute | Bismuth generator method |
| US5854968A (en) * | 1997-06-09 | 1998-12-29 | Arch Development Corporation | Process and apparatus for the production of BI-213 cations |
-
1998
- 1998-05-27 US US09/086,623 patent/US6153154A/en not_active Expired - Fee Related
-
1999
- 1999-05-26 WO PCT/US1999/011830 patent/WO1999062073A1/en not_active Ceased
- 1999-05-26 ES ES99935287T patent/ES2216544T3/es not_active Expired - Lifetime
- 1999-05-26 DE DE69917265T patent/DE69917265T2/de not_active Expired - Lifetime
- 1999-05-26 JP JP2000551396A patent/JP4486252B2/ja not_active Expired - Fee Related
- 1999-05-26 EP EP99935287A patent/EP1090396B1/en not_active Expired - Lifetime
- 1999-05-26 AU AU50797/99A patent/AU5079799A/en not_active Abandoned
- 1999-05-26 CA CA002333356A patent/CA2333356C/en not_active Expired - Fee Related
- 1999-05-26 AT AT99935287T patent/ATE266894T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2333356C (en) | 2009-08-25 |
| US6153154A (en) | 2000-11-28 |
| EP1090396A1 (en) | 2001-04-11 |
| DE69917265T2 (de) | 2005-05-19 |
| EP1090396B1 (en) | 2004-05-12 |
| JP4486252B2 (ja) | 2010-06-23 |
| ATE266894T1 (de) | 2004-05-15 |
| CA2333356A1 (en) | 1999-12-02 |
| JP2002517005A (ja) | 2002-06-11 |
| WO1999062073A1 (en) | 1999-12-02 |
| DE69917265D1 (de) | 2004-06-17 |
| AU5079799A (en) | 1999-12-13 |
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