ES2215305T3 - Metodos analgesicos usando los catalizadores sinteticos para la dismutacion de los radicales superoxido. - Google Patents
Metodos analgesicos usando los catalizadores sinteticos para la dismutacion de los radicales superoxido.Info
- Publication number
- ES2215305T3 ES2215305T3 ES98929022T ES98929022T ES2215305T3 ES 2215305 T3 ES2215305 T3 ES 2215305T3 ES 98929022 T ES98929022 T ES 98929022T ES 98929022 T ES98929022 T ES 98929022T ES 2215305 T3 ES2215305 T3 ES 2215305T3
- Authority
- ES
- Spain
- Prior art keywords
- heterocycle
- cycloalkyl
- attached
- independently
- carbon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5040297P | 1997-06-20 | 1997-06-20 | |
| US50402P | 1997-06-20 |
Publications (1)
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|---|---|
| ES2215305T3 true ES2215305T3 (es) | 2004-10-01 |
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| JP (1) | JP2002506445A (enExample) |
| AT (1) | ATE256467T1 (enExample) |
| AU (1) | AU733415B2 (enExample) |
| CA (1) | CA2294155A1 (enExample) |
| DE (1) | DE69820633T2 (enExample) |
| DK (1) | DK1001752T3 (enExample) |
| ES (1) | ES2215305T3 (enExample) |
| PT (1) | PT1001752E (enExample) |
| WO (1) | WO1998058636A1 (enExample) |
| ZA (1) | ZA985376B (enExample) |
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| US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| US20050171198A1 (en) * | 1997-06-20 | 2005-08-04 | Metaphore Pharmaceuticals, Inc. | SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease |
| US20060270639A1 (en) * | 1997-06-20 | 2006-11-30 | Daniela Salvemini | Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs |
| US6214817B1 (en) | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| DE69813898T2 (de) | 1997-11-03 | 2004-03-11 | Duke University | Substituierte porphyrinen |
| ATE312103T1 (de) * | 1999-01-25 | 2005-12-15 | Nat Jewish Med & Res Center | Substituierte porphyrine und deren therapeutische verwendungen |
| ES2240101T3 (es) | 1999-05-27 | 2005-10-16 | Monsanto Company | Biomateriales modificados con mimeticos de superoxido dismutasa. |
| US20030069281A1 (en) * | 2000-06-14 | 2003-04-10 | Irwin Fridovich | Tetrapyrroles |
| US20020072512A1 (en) * | 2000-12-08 | 2002-06-13 | Metaphore Pharmaceuticals, Inc | Method of preventing and treating HIV-mediated central nervous system damage |
| DE60235955D1 (de) * | 2001-01-05 | 2010-05-27 | Metaphore Pharmaceuticals Inc | Zusammensetzungen und verfahren zur erhöhung der zytokin-aktivität und zur behandlung der hypotension assoziiert mit der verabreichung von zytokinen |
| DK1392328T3 (da) | 2001-01-19 | 2009-11-09 | Nat Jewish Health | Medikament til beskyttelse i radioterapi |
| AU2002236861A1 (en) * | 2001-01-26 | 2002-08-06 | Metaphore Pharmaceuticals, Inc. | Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes |
| JP4369124B2 (ja) * | 2001-03-02 | 2009-11-18 | メタファー・ファーマシューティカルズ・インコーポレイテッド | 金属錯体のクロマトグラフィー |
| US20040137638A1 (en) | 2002-03-04 | 2004-07-15 | Slomczynska Urszula J. | Chromatography of metal complexes |
| EP1439842A4 (en) * | 2001-06-01 | 2009-09-02 | Nat Jewish Med & Res Center | OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE |
| US20040236519A1 (en) * | 2001-06-08 | 2004-11-25 | Marshall Garland R. | Libraries of confomationally constrained peptides, chiral azacrowns, and peptidomimetics and methods of making the same |
| CA2451602A1 (en) * | 2001-06-26 | 2003-01-03 | Metaphore Pharmaceuticals, Inc. | Combination therapy of an sodm and a corticosteroid for prevention and/or treatment of inflammatory disease |
| WO2003039561A1 (en) * | 2001-11-02 | 2003-05-15 | Elan Corporation, Plc | Pharmaceutical composition |
| DE60231246D1 (de) * | 2001-12-14 | 2009-04-02 | Alcon Inc | Superoxiddismutas-mimetika zur behandlung von augenerkrankungen |
| US6933275B2 (en) * | 2002-05-01 | 2005-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase C peptides for use in withdrawal |
| WO2003103680A1 (en) * | 2002-06-07 | 2003-12-18 | Duke University | Substituted porphyrins |
| US20030232784A1 (en) * | 2002-06-14 | 2003-12-18 | Benedict James J. | Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain |
| CA2397684A1 (en) * | 2002-08-12 | 2004-02-12 | Michael P. Murphy | Mitochondrially targeted antioxidants |
| JP5189242B2 (ja) * | 2002-09-23 | 2013-04-24 | アルケルメス ファーマ アイルランド リミテッド | 乱用抵抗性の医薬組成物 |
| MXPA05005240A (es) * | 2002-12-06 | 2005-07-25 | Alcon Inc | Imitadores de la superoxido - dismutasa para el tratamiento de desordenes y enfermedades oculares. |
| MXPA05005937A (es) * | 2002-12-06 | 2005-08-18 | Alcon Inc | Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares. |
| KR100648618B1 (ko) * | 2003-11-19 | 2006-11-23 | 주식회사 웰스킨 | 활성 산소 억제제 |
| CN1889961A (zh) * | 2003-12-11 | 2007-01-03 | 爱尔康公司 | 用于治疗视神经和视网膜损伤的超氧化物歧化酶拟似物 |
| US8217166B2 (en) * | 2005-05-05 | 2012-07-10 | Galera Therapeutics, Llc | Polyethylene glycolated superoxide dismutase mimetics |
| US20120301403A1 (en) | 2007-06-21 | 2012-11-29 | Galera Therapeutics, Llc | Polyethylene glycolated superoxide dismutase mimetics |
| WO2006069326A2 (en) * | 2004-12-21 | 2006-06-29 | Metaphore Pharmaceuticals, Inc. | Polyethylene glycolated superoxide dismutase mimetics |
| KR100724586B1 (ko) | 2005-12-09 | 2007-06-04 | 세종대학교산학협력단 | 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물 |
| LT2056675T (lt) | 2006-10-12 | 2019-05-27 | Galera Labs, Llc | Burnos gleivinės mukozito gydymo būdai |
| WO2009065059A2 (en) | 2007-11-14 | 2009-05-22 | Kereos, Inc. | Super-oxide dismutase mimetics |
| EP2859916B1 (en) | 2008-05-22 | 2017-11-29 | Galera Labs, LLC | Combination of an antimitotic agent and a selective superoxide dismutase mimetic in antitumor therapy |
| DK2300003T3 (da) | 2008-05-23 | 2014-05-26 | Nat Jewish Health | Forbindelser til anvendelse i behandling af skade forbundet med eksponering for en alkylerende art |
| CA3120505C (en) | 2011-09-26 | 2024-11-12 | Galera Labs, Llc | METHODS OF TREATING DISEASES |
| UA126788C2 (uk) | 2015-08-11 | 2023-02-08 | Ґалера Лебз, Елелсі | Комплексні сполуки, що містять макроциклічне кільце пентаази, які мають пероральну біодоступність |
| MX393974B (es) | 2016-05-03 | 2025-03-24 | Galera Labs Llc | Terapia de combinacion para tratamiento de cancer. |
| JP7166634B2 (ja) | 2016-09-01 | 2022-11-08 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー | ペンタアザ大環状環複合体およびアスコルビン酸化合物による組み合わせ癌療法 |
| JP2020507598A (ja) | 2017-02-15 | 2020-03-12 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーＧａｌｅｒａ Ｌａｂｓ， Ｌｌｃ | 局所腸送達のためのペンタアザマクロ環錯体 |
| EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| EA201992431A1 (ru) | 2017-10-13 | 2020-03-13 | ГАЛЕРА ЛЭБЗ, ЭлЭлСи | Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса |
| AU2019215032A1 (en) | 2018-01-31 | 2020-09-10 | Board Of Regents Of The University Of Texas System | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent |
| CA3167087A1 (en) * | 2020-02-13 | 2021-08-19 | Anantha Rajmohan MUTHUSAMY | Solid state forms of avasopasem manganese and process for preparation thereof |
| WO2025024390A2 (en) * | 2023-07-21 | 2025-01-30 | Galera Labs, Llc | Carcinogenesis reduction with pentaaza macrocyclic ring complex |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0751496B2 (ja) | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| US5216021A (en) | 1986-08-28 | 1993-06-01 | Sorenson John R J | Analgesic method |
| US4999347A (en) | 1986-08-28 | 1991-03-12 | Sorenson John R J | Analgesic method |
| JPS63313581A (ja) * | 1987-06-16 | 1988-12-21 | Ube Ind Ltd | 修飾ス−パ−オキシドジスムタ−ゼ |
| DE69224839T2 (de) | 1991-07-19 | 1998-10-08 | Monsanto Co | Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren. |
| CA2072934C (en) | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| CN1088086A (zh) * | 1992-12-14 | 1994-06-22 | 西北大学 | 一种新型的护肤保健品 |
| US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| WO1997033877A1 (en) | 1996-03-13 | 1997-09-18 | Monsanto Company | Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
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1998
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- 1998-06-15 DK DK98929022T patent/DK1001752T3/da active
- 1998-06-15 EP EP98929022A patent/EP1001752B1/en not_active Expired - Lifetime
- 1998-06-15 PT PT98929022T patent/PT1001752E/pt unknown
- 1998-06-15 DE DE69820633T patent/DE69820633T2/de not_active Expired - Fee Related
- 1998-06-15 ES ES98929022T patent/ES2215305T3/es not_active Expired - Lifetime
- 1998-06-15 AU AU80685/98A patent/AU733415B2/en not_active Ceased
- 1998-06-15 CA CA002294155A patent/CA2294155A1/en not_active Abandoned
- 1998-06-15 AT AT98929022T patent/ATE256467T1/de not_active IP Right Cessation
- 1998-06-15 JP JP50459399A patent/JP2002506445A/ja not_active Ceased
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- 1998-06-19 ZA ZA985376A patent/ZA985376B/xx unknown
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2000
- 2000-08-09 US US09/634,152 patent/US6395725B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002506445A (ja) | 2002-02-26 |
| PT1001752E (pt) | 2004-05-31 |
| AU733415B2 (en) | 2001-05-17 |
| US6180620B1 (en) | 2001-01-30 |
| EP1001752B1 (en) | 2003-12-17 |
| DE69820633D1 (de) | 2004-01-29 |
| DE69820633T2 (de) | 2004-09-23 |
| WO1998058636A1 (en) | 1998-12-30 |
| EP1001752A1 (en) | 2000-05-24 |
| DK1001752T3 (da) | 2004-04-19 |
| AU8068598A (en) | 1999-01-04 |
| US6395725B1 (en) | 2002-05-28 |
| CA2294155A1 (en) | 1998-12-30 |
| ATE256467T1 (de) | 2004-01-15 |
| ZA985376B (en) | 1999-06-21 |
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