ES2214129B1 - 3-fenilfuran-2-onas. - Google Patents
3-fenilfuran-2-onas.Info
- Publication number
- ES2214129B1 ES2214129B1 ES200300353A ES200300353A ES2214129B1 ES 2214129 B1 ES2214129 B1 ES 2214129B1 ES 200300353 A ES200300353 A ES 200300353A ES 200300353 A ES200300353 A ES 200300353A ES 2214129 B1 ES2214129 B1 ES 2214129B1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- cox
- phenylfuran
- treatment
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
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- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
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- 201000005671 spondyloarthropathy Diseases 0.000 description 1
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- 150000003431 steroids Chemical class 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200300353A ES2214129B1 (es) | 2003-02-13 | 2003-02-13 | 3-fenilfuran-2-onas. |
| US10/544,359 US20060189684A1 (en) | 2003-02-13 | 2004-02-12 | 3-Phenylfuran-2-one derivatives as cox-2 inhibitor |
| PCT/EP2004/001296 WO2004072057A1 (en) | 2003-02-13 | 2004-02-12 | 3-phenylfuran-2-one derivatives as cox-2 inhibitor |
| CNB2004800096102A CN100349884C (zh) | 2003-02-13 | 2004-02-12 | 3－苯基呋喃－2－酮衍生物作为环加氧酶的抑制剂 |
| EP04710354A EP1592678A1 (en) | 2003-02-13 | 2004-02-12 | 3-phenylfuran-2-one derivatives as cox-2 inhibitor |
| JP2006501816A JP2006517561A (ja) | 2003-02-13 | 2004-02-12 | Ｃｏｘ−２阻害剤としての３−フェニルフラン−２−オン誘導体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200300353A ES2214129B1 (es) | 2003-02-13 | 2003-02-13 | 3-fenilfuran-2-onas. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2214129A1 ES2214129A1 (es) | 2004-09-01 |
| ES2214129B1 true ES2214129B1 (es) | 2005-12-01 |
Family
ID=32865134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200300353A Expired - Fee Related ES2214129B1 (es) | 2003-02-13 | 2003-02-13 | 3-fenilfuran-2-onas. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060189684A1 (enExample) |
| EP (1) | EP1592678A1 (enExample) |
| JP (1) | JP2006517561A (enExample) |
| CN (1) | CN100349884C (enExample) |
| ES (1) | ES2214129B1 (enExample) |
| WO (1) | WO2004072057A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2213485B1 (es) * | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| ES2214130B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
| AU2006244297A1 (en) * | 2005-04-06 | 2006-11-16 | Adamas Pharmaceuticals, Inc. | Methods and compositions for treatment of CNS disorders |
| JP2015522528A (ja) | 2012-05-09 | 2015-08-06 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 慢性閉塞性肺疾患の予防または治療方法および医薬組成物 |
| JP7291220B2 (ja) * | 2018-11-21 | 2023-06-14 | トレモ― ファーマシューティカルズ，インコーポレーテッド | ロフェコキシブの精製形態、製造方法および使用 |
| US10945992B1 (en) | 2019-11-13 | 2021-03-16 | Tremeau Pharmaceuticals, Inc. | Dosage forms of rofecoxib and related methods |
| US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020032230A1 (en) * | 2000-05-22 | 2002-03-14 | Dr. Reddy's Laboratories Ltd. | Novel compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them |
| US6492416B1 (en) * | 1999-04-14 | 2002-12-10 | Pacific Corporation | 4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486194B2 (en) * | 1993-06-24 | 2002-11-26 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
| US6231888B1 (en) * | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
| CA2250350A1 (en) * | 1996-03-29 | 1997-10-09 | Merck Frosst Canada Inc. | Bisarylcyclobutene derivates as cyclooxygenase inhibitors |
| EE03746B1 (et) * | 1996-05-17 | 2002-06-17 | Merck & Co., Inc. | Farmatseutiline kompositsioon tsüklooksügenaas-2 vahendatud haiguste raviks, 3-fenüül-4-(4-(metüülsulfonüül) fenüül)-2-(5H)-furanooni kasutamine ja ühikuline oraalne doseerimisvorm |
| US6307047B1 (en) * | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| ATE281458T1 (de) * | 1997-09-05 | 2004-11-15 | Glaxo Group Ltd | Pharmazeutische zusammensetzung, enthaltend 2,3- diaryl-pyrazolo(1,5-b)pyridazin derivate |
| US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
| CA2320290A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding inhibitors of cyclooxygenase-2 |
| KR100295206B1 (ko) * | 1998-08-22 | 2001-07-12 | 서경배 | 디아릴벤조피란유도체및이를함유하는시클로옥시게네이즈-2저해제조성물 |
| TW587079B (en) * | 1998-09-25 | 2004-05-11 | Almirall Prodesfarma Ag | 2-phenylpyran-4-one derivatives |
| ES2208227T3 (es) * | 1999-12-03 | 2004-06-16 | Pfizer Products Inc. | Compuestos de heteroarilfenilpirazol como agentes antiinflamatorios/analgesicos. |
| ES2214130B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
| ES2213485B1 (es) * | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
-
2003
- 2003-02-13 ES ES200300353A patent/ES2214129B1/es not_active Expired - Fee Related
-
2004
- 2004-02-12 CN CNB2004800096102A patent/CN100349884C/zh not_active Expired - Fee Related
- 2004-02-12 US US10/544,359 patent/US20060189684A1/en not_active Abandoned
- 2004-02-12 WO PCT/EP2004/001296 patent/WO2004072057A1/en not_active Ceased
- 2004-02-12 EP EP04710354A patent/EP1592678A1/en not_active Withdrawn
- 2004-02-12 JP JP2006501816A patent/JP2006517561A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492416B1 (en) * | 1999-04-14 | 2002-12-10 | Pacific Corporation | 4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors |
| US20020032230A1 (en) * | 2000-05-22 | 2002-03-14 | Dr. Reddy's Laboratories Ltd. | Novel compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| US20060189684A1 (en) | 2006-08-24 |
| JP2006517561A (ja) | 2006-07-27 |
| CN100349884C (zh) | 2007-11-21 |
| EP1592678A1 (en) | 2005-11-09 |
| WO2004072057A1 (en) | 2004-08-26 |
| ES2214129A1 (es) | 2004-09-01 |
| CN1771240A (zh) | 2006-05-10 |
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