ES2206955T3 - Inhibidores de metaloproteinasas, su empleo terapeutico y procedimiento para la produccion del compuesto de partida en su sintesis. - Google Patents
Inhibidores de metaloproteinasas, su empleo terapeutico y procedimiento para la produccion del compuesto de partida en su sintesis.Info
- Publication number
- ES2206955T3 ES2206955T3 ES98932516T ES98932516T ES2206955T3 ES 2206955 T3 ES2206955 T3 ES 2206955T3 ES 98932516 T ES98932516 T ES 98932516T ES 98932516 T ES98932516 T ES 98932516T ES 2206955 T3 ES2206955 T3 ES 2206955T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- compounds
- mmol
- zinc
- metalloproteinases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97RM000441A IT1296305B1 (it) | 1997-07-17 | 1997-07-17 | Inibitori di metalloproteinasi loro uso terapeutico e procedimento per la produzione del composto di partenza nella loro |
| ITRM970441 | 1997-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2206955T3 true ES2206955T3 (es) | 2004-05-16 |
Family
ID=11405183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98932516T Expired - Lifetime ES2206955T3 (es) | 1997-07-17 | 1998-07-17 | Inhibidores de metaloproteinasas, su empleo terapeutico y procedimiento para la produccion del compuesto de partida en su sintesis. |
Country Status (8)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
| US6683165B1 (en) | 1999-04-13 | 2004-01-27 | Genome Therapeutics Corporation | Human gene relating to respiratory diseases and obesity |
| GB9922577D0 (en) * | 1999-09-23 | 1999-11-24 | Center For Clinical & Basic Re | Substituted phosphinate based peptide derivatives |
| AU2001253512A1 (en) * | 2000-04-13 | 2001-10-30 | Genome Therapeutics Corporation | Novel human gene relating to respiratory diseases, obesity, and inflammatory bowel disease |
| WO2004032708A2 (en) * | 2002-10-04 | 2004-04-22 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Vasoregulating compounds and methods of their use |
| JP5068428B2 (ja) * | 2002-11-07 | 2012-11-07 | アメリカ合衆国 | 血管新生および抗血管新生療法のための標的 |
| BRPI0400284A (pt) * | 2004-03-18 | 2005-11-01 | Fundacao Oswaldo Cruz | Uso de dm 43 e seus fragmentos como inibidor de metaloproteases de matriz |
| WO2007141029A1 (en) * | 2006-06-08 | 2007-12-13 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Specific protease inhibitors and their use in cancer therapy |
| GB0708507D0 (en) | 2007-05-02 | 2007-06-13 | Queen Mary & Westfield College | Substituted phosphonates and their use |
| WO2017117130A1 (en) | 2015-12-28 | 2017-07-06 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for inhibiting human immunodeficiency virus (hiv) release from infected cells |
| AU2019352741A1 (en) | 2018-10-04 | 2021-05-06 | Assistance Publique-Hôpitaux De Paris (Aphp) | EGFR inhibitors for treating keratodermas |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0401963A1 (en) | 1989-04-13 | 1990-12-12 | Beecham Group p.l.c. | Phosphonopeptides with collagenase inhibiting activity |
| IT1242002B (it) * | 1990-10-03 | 1994-02-02 | Polifarma Spa | Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centrale |
| IT1277904B1 (it) * | 1995-08-07 | 1997-11-12 | Polifarma Spa | Metodo per determinare l'attivita' terapeutica di composti inibitori di metalloproteinasi, nuovi composti inibitori, e loro impiego |
-
1997
- 1997-07-17 IT IT97RM000441A patent/IT1296305B1/it active IP Right Grant
-
1998
- 1998-07-17 AU AU82418/98A patent/AU8241898A/en not_active Abandoned
- 1998-07-17 ES ES98932516T patent/ES2206955T3/es not_active Expired - Lifetime
- 1998-07-17 DE DE69818698T patent/DE69818698T2/de not_active Expired - Fee Related
- 1998-07-17 JP JP2000503100A patent/JP3325017B2/ja not_active Expired - Fee Related
- 1998-07-17 US US09/462,932 patent/US6339160B1/en not_active Expired - Fee Related
- 1998-07-17 EP EP98932516A patent/EP1019434B1/en not_active Expired - Lifetime
- 1998-07-17 WO PCT/IT1998/000202 patent/WO1999003878A2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE69818698T2 (de) | 2004-08-19 |
| EP1019434A2 (en) | 2000-07-19 |
| US6339160B1 (en) | 2002-01-15 |
| ITRM970441A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-07-17 |
| ITRM970441A1 (it) | 1999-01-17 |
| DE69818698D1 (de) | 2003-11-06 |
| WO1999003878A2 (en) | 1999-01-28 |
| IT1296305B1 (it) | 1999-06-25 |
| JP3325017B2 (ja) | 2002-09-17 |
| EP1019434B1 (en) | 2003-10-01 |
| AU8241898A (en) | 1999-02-10 |
| JP2001525315A (ja) | 2001-12-11 |
| WO1999003878A3 (en) | 1999-04-01 |
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