ES2190727B1 - Dispositivo para formar y/o aumentar el numero relativo de celulas indiferenciadas en una poblacion celular y procedimientos correspondientes. - Google Patents
Dispositivo para formar y/o aumentar el numero relativo de celulas indiferenciadas en una poblacion celular y procedimientos correspondientes.Info
- Publication number
- ES2190727B1 ES2190727B1 ES200101054A ES200101054A ES2190727B1 ES 2190727 B1 ES2190727 B1 ES 2190727B1 ES 200101054 A ES200101054 A ES 200101054A ES 200101054 A ES200101054 A ES 200101054A ES 2190727 B1 ES2190727 B1 ES 2190727B1
- Authority
- ES
- Spain
- Prior art keywords
- cells
- cell
- increasing
- relative number
- forming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000001413 cellular effect Effects 0.000 title 1
- 230000001010 compromised effect Effects 0.000 abstract 3
- 230000004069 differentiation Effects 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/14—Incubators; Climatic chambers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/04—Flat or tray type, drawers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/26—Constructional details, e.g. recesses, hinges flexible
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/14—Erythropoietin [EPO]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Thermal Sciences (AREA)
- Physics & Mathematics (AREA)
- Computer Hardware Design (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Dispositivo para formar y/o aumentar el número relativo de células indiferenciadas en una población celular, así como a un procedimiento para preparar una célula indiferenciada y a un procedimiento para aumentar el número relativo de dichas células. El cual dispositivo comprende medios para poner en contacto una célula más comprometida con un agente que provoca que la célula más comprometida se retrodiferencie a una célula indiferenciada. El procedimiento para preparar una célula indiferenciada comprende retrodiferenciar una célula más comprometida a una célula indiferenciada. La invención también comprende la utilización de los medios de retrodiferenciación para desplazar la proporción de células diferenciadas normales en una población celular, para llevar a cabo la retrodiferenciación de una o más de dichas células diferenciadas a una célula o células indiferenciadas.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/568254 | 2000-05-10 | ||
US09/568,254 US9068164B1 (en) | 1995-02-02 | 2000-05-10 | Method of preparing an undifferentiated cell |
GB0101315A GB0101315D0 (en) | 2001-01-18 | 2001-01-18 | A device |
GB0101315 | 2001-01-18 | ||
US27149701P | 2001-02-26 | 2001-02-26 | |
US60/271497 | 2001-02-26 | ||
GB0107093A GB0107093D0 (en) | 2001-03-21 | 2001-03-21 | A device |
GB0107093 | 2001-03-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2190727A1 ES2190727A1 (es) | 2003-08-01 |
ES2190727B1 true ES2190727B1 (es) | 2004-09-01 |
Family
ID=27447916
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200101054A Expired - Fee Related ES2190727B1 (es) | 2000-05-10 | 2001-05-09 | Dispositivo para formar y/o aumentar el numero relativo de celulas indiferenciadas en una poblacion celular y procedimientos correspondientes. |
ES01929796T Expired - Lifetime ES2330190T3 (es) | 2000-05-10 | 2001-05-10 | Dispositivo para la preparacion de celulas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01929796T Expired - Lifetime ES2330190T3 (es) | 2000-05-10 | 2001-05-10 | Dispositivo para la preparacion de celulas. |
Country Status (27)
Country | Link |
---|---|
US (1) | US8163536B2 (es) |
EP (1) | EP1366144B1 (es) |
JP (2) | JP4860883B2 (es) |
KR (2) | KR100875089B1 (es) |
AR (1) | AR030280A1 (es) |
AT (1) | ATE440944T1 (es) |
AU (1) | AU5647701A (es) |
BE (1) | BE1014172A3 (es) |
BR (2) | BR0110751A (es) |
CA (2) | CA2446955C (es) |
CH (1) | CH696146B9 (es) |
CY (1) | CY1109515T1 (es) |
DE (1) | DE60139716D1 (es) |
DK (1) | DK1366144T3 (es) |
ES (2) | ES2190727B1 (es) |
FR (1) | FR2808800B1 (es) |
GB (2) | GB2366295B (es) |
HK (2) | HK1044172A1 (es) |
IL (2) | IL152737A0 (es) |
IT (1) | ITMI20010952A1 (es) |
JO (1) | JO2295B1 (es) |
MA (1) | MA25677A1 (es) |
MX (1) | MXPA02012295A (es) |
NL (1) | NL1017973C2 (es) |
NZ (2) | NZ556592A (es) |
SA (1) | SA01220163B1 (es) |
WO (1) | WO2001085917A2 (es) |
Families Citing this family (27)
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US6946246B1 (en) * | 1997-04-08 | 2005-09-20 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Production of functional proteins: balance of shear stress and gravity |
US7565647B2 (en) * | 2002-03-22 | 2009-07-21 | Sun Microsystems, Inc. | Markup compiler that outputs MIDlets |
TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
DE10231655A1 (de) * | 2002-07-12 | 2004-02-26 | Blasticon Biotechnologische Forschung Gmbh | Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
WO2004011049A1 (ja) * | 2002-07-25 | 2004-02-05 | Japan Science And Technology Agency | 生体組織材料を処理する交互浸漬装置および交互浸漬方法 |
PL379549A1 (pl) * | 2003-07-11 | 2006-10-16 | Blasticon Biotechnologische Forschung Gmbh | Autologiczne, indukujące tolerancję na antygeny własne komórki pochodzenia monocytarnego oraz ich zastosowanie w preparatach farmaceutycznych |
GB0410130D0 (en) * | 2004-05-06 | 2004-06-09 | Molmed Spa | Cell preparation |
WO2005113754A1 (en) * | 2004-05-20 | 2005-12-01 | New York Medical College | Pluripotent adult stem cells |
US7147626B2 (en) * | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
US7909806B2 (en) * | 2004-09-23 | 2011-03-22 | Anthrogenesis Corporation | Cord blood and placenta collection kit |
AU2006286149B2 (en) | 2005-08-29 | 2012-09-13 | Technion Research And Development Foundation Ltd. | Media for culturing stem cells |
CA2644922C (en) | 2006-03-07 | 2019-07-23 | Geeta Shroff | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation |
US9040297B2 (en) | 2006-08-02 | 2015-05-26 | Technion Research & Development Foundation Limited | Methods of expanding embryonic stem cells in a suspension culture |
AR065584A1 (es) * | 2007-03-01 | 2009-06-17 | Cryo Cell Internat Inc | Obtencion aislamiento y crioconservacion de celulas endometriales / menstruales |
GB0917565D0 (en) * | 2009-10-08 | 2009-11-25 | Univ Nottingham | An observation cell arrangement |
GB2474492B (en) * | 2009-10-19 | 2014-05-21 | Tristem Trading Cyprus Ltd | Treatment using reprogrammed mature adult cells |
ES2932664T3 (es) | 2009-11-12 | 2023-01-23 | Technion Res & Dev Foundation | Medios de cultivo, cultivos celulares y métodos de cultivo de células madre pluripotentes en estado no diferenciado |
EP2639294A1 (fr) * | 2012-03-15 | 2013-09-18 | CellProthera | Automate et procédé automatisé de culture cellulaire |
CA2927712A1 (en) | 2013-10-24 | 2015-04-30 | Ospedale San Raffaele S.R.L. | Method for the genetic modification of haematopoietic stem and progenitor cells (hspcs) and the use of genetically modified hspcs in gene therapy |
WO2016183231A1 (en) | 2015-05-12 | 2016-11-17 | Baker Group, LLP | Method and system for a bioartificial organ |
WO2017202949A1 (en) | 2016-05-25 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers |
US10711237B2 (en) * | 2017-08-22 | 2020-07-14 | Idex Health & Science Llc | Apparatus and methods for bioprocesses and other processes |
CA3083158A1 (en) | 2017-11-24 | 2019-05-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods and compositions for treating cancers |
CN108889357A (zh) * | 2018-05-10 | 2018-11-27 | 刘英文 | 一种检验科样品临时存储装置 |
EP3833383A1 (en) | 2018-08-06 | 2021-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers |
CN111560345A (zh) * | 2019-05-10 | 2020-08-21 | 华中科技大学同济医学院附属协和医院 | 一种猪原代瓣膜内皮细胞分离纯化方法 |
WO2022207889A1 (en) | 2021-04-01 | 2022-10-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Liver organoid manufacturing methods, liver organoids obtained with the same, and uses thereof |
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