ES2190727A1 - Dispositivo para formar y/o aumentar el numero relativo de celulas indiferenciadas en una poblacion celular y procedimientos correspondientes. - Google Patents

Dispositivo para formar y/o aumentar el numero relativo de celulas indiferenciadas en una poblacion celular y procedimientos correspondientes.

Info

Publication number
ES2190727A1
ES2190727A1 ES200101054A ES200101054A ES2190727A1 ES 2190727 A1 ES2190727 A1 ES 2190727A1 ES 200101054 A ES200101054 A ES 200101054A ES 200101054 A ES200101054 A ES 200101054A ES 2190727 A1 ES2190727 A1 ES 2190727A1
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Spain
Prior art keywords
cell
undifferentiated
cells
procedure
increasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200101054A
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English (en)
Other versions
ES2190727B1 (es
Inventor
Abuljadayel Ilham Mohame Saeed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tristem Trading Cyprus Ltd
Original Assignee
Tristem Trading Cyprus Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447916&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2190727(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/568,254 external-priority patent/US9068164B1/en
Priority claimed from GB0101315A external-priority patent/GB0101315D0/en
Priority claimed from GB0107093A external-priority patent/GB0107093D0/en
Application filed by Tristem Trading Cyprus Ltd filed Critical Tristem Trading Cyprus Ltd
Publication of ES2190727A1 publication Critical patent/ES2190727A1/es
Application granted granted Critical
Publication of ES2190727B1 publication Critical patent/ES2190727B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14—Incubators; Climatic chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/04—Flat or tray type, drawers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/14—Erythropoietin [EPO]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
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    • C12N2510/00—Genetically modified cells

Abstract

Dispositivo para formar y/o aumentar el número relativo de células indiferenciadas en una población celular, así como a un procedimiento para preparar una célula indiferenciada y a un procedimiento para aumentar el número relativo de dichas células. El cual dispositivo comprende medios para poner en contacto una célula más comprometida con un agente que provoca que la célula más comprometida se retrodiferencie a una célula indiferenciada. El procedimiento para preparar una célula indiferenciada comprende retrodiferenciar una célula más comprometida a una célula indiferenciada. La invención también comprende la utilización de los medios de retrodiferenciación para desplazar la proporción de células diferenciadas normales en una población celular, para llevar a cabo la retrodiferenciación de una o más de dichas células diferenciadas a una célula o células indiferenciadas.
ES200101054A 2000-05-10 2001-05-09 Dispositivo para formar y/o aumentar el numero relativo de celulas indiferenciadas en una poblacion celular y procedimientos correspondientes. Expired - Fee Related ES2190727B1 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US09/568,254 US9068164B1 (en) 1995-02-02 2000-05-10 Method of preparing an undifferentiated cell
US09/568254 2000-05-10
GB0101315 2001-01-18
GB0101315A GB0101315D0 (en) 2001-01-18 2001-01-18 A device
US27149701P 2001-02-26 2001-02-26
US60/271497 2001-02-26
GB0107093 2001-03-21
GB0107093A GB0107093D0 (en) 2001-03-21 2001-03-21 A device

Publications (2)

Publication Number Publication Date
ES2190727A1 true ES2190727A1 (es) 2003-08-01
ES2190727B1 ES2190727B1 (es) 2004-09-01

Family

ID=27447916

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200101054A Expired - Fee Related ES2190727B1 (es) 2000-05-10 2001-05-09 Dispositivo para formar y/o aumentar el numero relativo de celulas indiferenciadas en una poblacion celular y procedimientos correspondientes.
ES01929796T Expired - Lifetime ES2330190T3 (es) 2000-05-10 2001-05-10 Dispositivo para la preparacion de celulas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01929796T Expired - Lifetime ES2330190T3 (es) 2000-05-10 2001-05-10 Dispositivo para la preparacion de celulas.

Country Status (27)

Country Link
US (1) US8163536B2 (es)
EP (1) EP1366144B1 (es)
JP (2) JP4860883B2 (es)
KR (2) KR100875089B1 (es)
AR (1) AR030280A1 (es)
AT (1) ATE440944T1 (es)
AU (1) AU5647701A (es)
BE (1) BE1014172A3 (es)
BR (2) BRPI0110751B1 (es)
CA (2) CA2776904A1 (es)
CH (1) CH696146B9 (es)
CY (1) CY1109515T1 (es)
DE (1) DE60139716D1 (es)
DK (1) DK1366144T3 (es)
ES (2) ES2190727B1 (es)
FR (1) FR2808800B1 (es)
GB (2) GB2366295B (es)
HK (2) HK1044172A1 (es)
IL (2) IL152737A0 (es)
IT (1) ITMI20010952A1 (es)
JO (1) JO2295B1 (es)
MA (1) MA25677A1 (es)
MX (1) MXPA02012295A (es)
NL (1) NL1017973C2 (es)
NZ (2) NZ556592A (es)
SA (1) SA01220163B1 (es)
WO (1) WO2001085917A2 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946246B1 (en) * 1997-04-08 2005-09-20 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Production of functional proteins: balance of shear stress and gravity
US7565647B2 (en) * 2002-03-22 2009-07-21 Sun Microsystems, Inc. Markup compiler that outputs MIDlets
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
DE10231655A1 (de) * 2002-07-12 2004-02-26 Blasticon Biotechnologische Forschung Gmbh Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
WO2004011049A1 (ja) * 2002-07-25 2004-02-05 Japan Science And Technology Agency 生体組織材料を処理する交互浸漬装置および交互浸漬方法
KR20060040671A (ko) * 2003-07-11 2006-05-10 블라스티콘 바이오테크놀로지셰 포르슝 게엠베하 단구성 기원의 자기 유래 자가 관용성 유도 세포 및약제학적 제제에 있어서의 이의 용도
GB0410130D0 (en) * 2004-05-06 2004-06-09 Molmed Spa Cell preparation
US7259011B2 (en) * 2004-05-20 2007-08-21 Paul Lucas Pluripotent adult stem cells
US7909806B2 (en) * 2004-09-23 2011-03-22 Anthrogenesis Corporation Cord blood and placenta collection kit
US7147626B2 (en) * 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
EP3354723B1 (en) 2005-08-29 2023-12-13 Technion Research & Development Foundation Ltd. Media for culturing stem cells
DK1993575T3 (da) 2006-03-07 2019-10-14 Geeta Shroff Sammensætninger omfattende humane embryostamceller og derivater deraf, fremgangsmåder til anvendelse og fremgangsmåder til fremstilling
DK3441459T3 (da) 2006-08-02 2021-06-07 Technion Res & Dev Foundation Fremgangsmåder til ekspansion af embryonale stamceller i en suspensionskultur
AR065584A1 (es) * 2007-03-01 2009-06-17 Cryo Cell Internat Inc Obtencion aislamiento y crioconservacion de celulas endometriales / menstruales
GB0917565D0 (en) * 2009-10-08 2009-11-25 Univ Nottingham An observation cell arrangement
GB2474492B (en) * 2009-10-19 2014-05-21 Tristem Trading Cyprus Ltd Treatment using reprogrammed mature adult cells
EP4166652A1 (en) 2009-11-12 2023-04-19 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
EP2639294A1 (fr) * 2012-03-15 2013-09-18 CellProthera Automate et procédé automatisé de culture cellulaire
SG11201603166UA (en) 2013-10-24 2016-05-30 Ospedale San Raffaele Srl Method
WO2016183231A1 (en) 2015-05-12 2016-11-17 Baker Group, LLP Method and system for a bioartificial organ
CA3025057A1 (en) 2016-05-25 2017-11-30 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for treating cancers
US10711237B2 (en) * 2017-08-22 2020-07-14 Idex Health & Science Llc Apparatus and methods for bioprocesses and other processes
US11679148B2 (en) 2017-11-24 2023-06-20 Institut National De La Santé Et De La Recherche Médicale (Inserm) Methods and compositions for treating cancers
CN108889357A (zh) * 2018-05-10 2018-11-27 刘英文 一种检验科样品临时存储装置
US20210236633A1 (en) 2018-08-06 2021-08-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cancers
CN111560345A (zh) * 2019-05-10 2020-08-21 华中科技大学同济医学院附属协和医院 一种猪原代瓣膜内皮细胞分离纯化方法
WO2022207889A1 (en) 2021-04-01 2022-10-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Liver organoid manufacturing methods, liver organoids obtained with the same, and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2297558A (en) * 1995-02-02 1996-08-07 Ilham Mohamed Sale Abuljadayel Conversion of a more committed cell into an undifferentiated cell
FR2771421A1 (fr) * 1997-11-27 1999-05-28 Bertin & Cie Dispositif d'amplification de cellules hematopoietiques et ses applications
FR2794130A1 (fr) * 1999-05-26 2000-12-01 Bertin Technologies Sa Procede et dispositif de culture de cellules a applications multiples

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4058367A (en) * 1976-05-19 1977-11-15 Gilford Instrument Laboratories Inc. Automatic asynchronous fluid processing apparatus
US4563907A (en) * 1983-10-31 1986-01-14 Micromedic Systems Inc. Direct reading automatic pipette
US4812314A (en) * 1986-02-24 1989-03-14 Yissum Research & Dev. Co. Of The Hebrew Univ. Of Jerusalem And Hadassah Medical Organization Lipid replacement therapy
JPS63196854A (ja) * 1987-02-10 1988-08-15 Toa Medical Electronics Co Ltd リンパ球亜群の測定方法およびその装置
US5004681B1 (en) 1987-11-12 2000-04-11 Biocyte Corp Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
US5399493A (en) * 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5763266A (en) * 1989-06-15 1998-06-09 The Regents Of The University Of Michigan Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells
US5635387A (en) * 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
WO1993016384A1 (en) * 1992-02-07 1993-08-19 Abbott Laboratories Method for accurately enumerating and sensitively qualifying heterogeneous cell populations in cytolytic processing conditions
AU685743B2 (en) * 1992-03-04 1998-01-29 Regents Of The University Of Michigan, The Methods, compositions and devices for maintaining and growing human stem and/or hematopoietic cells
WO1996002255A1 (fr) * 1994-07-15 1996-02-01 Taiyo Kagaku Co., Ltd. Composition medicamenteuse contenant un derive d'acide sialique
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
AU704236B2 (en) * 1995-02-02 1999-04-15 Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Enrichment of hematopoietic stem cells from blood or bone marrow
GB9502022D0 (en) * 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US5627070A (en) * 1995-07-26 1997-05-06 Celltherapy, Inc. Cell growing device for in vitro cell population expansion
US5902732A (en) * 1995-10-04 1999-05-11 Cytoscan Sciences Llc Drug screening process measuring changes in cell volume
US6227202B1 (en) * 1996-09-03 2001-05-08 Maulana Azad Medical College Method of organogenesis and tissue regeneration/repair using surgical techniques
EA001551B1 (ru) * 1996-11-11 2001-04-23 Бык Гюльден Ломберг Хемише Фабрик Гмбх Бензонафтиридины в качестве бронхиальных терапевтических средств
AU6691798A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
AU770896C (en) * 1998-09-29 2006-09-07 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
IL137757A0 (en) * 1998-02-17 2001-10-31 Gamida Cell Ltd Method of controlling proliferation and differentiation of stem and progenitor cells
ES2338405T3 (es) * 1999-02-04 2010-05-07 Pluristem Ltd. Metodo y aparato para mantenimiento y expasion de celulas madre hemopoyeticas y/o celulas progenitoras.
JP2002537851A (ja) * 1999-03-09 2002-11-12 アコルディス インダストリアル ファイバース ゲゼルシャフト ミット ベシュレンクテル ハフツング 作用物質のインビトロテスト法、その装置および使用
IL147669A0 (en) * 1999-07-29 2002-08-14 Baranowitz Steven Method for transdifferentiation of body tissues
US6624621B2 (en) * 2000-04-03 2003-09-23 Howard L. North, Jr. Particle counter volume sensor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2297558A (en) * 1995-02-02 1996-08-07 Ilham Mohamed Sale Abuljadayel Conversion of a more committed cell into an undifferentiated cell
FR2771421A1 (fr) * 1997-11-27 1999-05-28 Bertin & Cie Dispositif d'amplification de cellules hematopoietiques et ses applications
FR2794130A1 (fr) * 1999-05-26 2000-12-01 Bertin Technologies Sa Procede et dispositif de culture de cellules a applications multiples

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KR100875089B1 (ko) 2008-12-22
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CA2446955C (en) 2012-07-17
IL152737A (en) 2010-11-30
CA2446955A1 (en) 2001-11-15
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CH696146A5 (fr) 2007-01-15
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KR100967071B1 (ko) 2010-07-01
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