ES2187968T3 - Dispositivo detector de fluorescencia mejorado. - Google Patents

Dispositivo detector de fluorescencia mejorado.

Info

Publication number
ES2187968T3
ES2187968T3 ES98922204T ES98922204T ES2187968T3 ES 2187968 T3 ES2187968 T3 ES 2187968T3 ES 98922204 T ES98922204 T ES 98922204T ES 98922204 T ES98922204 T ES 98922204T ES 2187968 T3 ES2187968 T3 ES 2187968T3
Authority
ES
Spain
Prior art keywords
analyte
hole
fluorescent
light
detector device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98922204T
Other languages
English (en)
Inventor
Arthur E Colvin Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2187968T3 publication Critical patent/ES2187968T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence

Abstract

Se presenta un dispositivo detector de la fluorescencia para determinar la presencia o la concentración de un analito en un medio líquido o gaseoso. El dispositivo consta de un diodo emisor de luz que tiene un orificio (29) generalmente perpendicular a la unión P-N, de manera que la luz se emita desde la unión al interior del orificio (29). El orificio se llena de una matriz fluorescente (32) que es permeable al analito y que contiene moléculas indicadoras fluorescentes cuya fluorescencia se atenúa o se mejora por la presencia del analito. Se sitúa un fotodetector (23) en un extremo del orificio, de manera que la luz fluorescente recibida desde las moléculas indicadoras de la fluorescencia se convierta en una señal eléctrica que pueda correlacionarse con la presencia o concentración del analito en el medio gaseoso o líquido en contacto con la matriz fluorescente.
ES98922204T 1997-05-13 1998-05-12 Dispositivo detector de fluorescencia mejorado. Expired - Lifetime ES2187968T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/855,234 US5894351A (en) 1997-05-13 1997-05-13 Fluorescence sensing device

Publications (1)

Publication Number Publication Date
ES2187968T3 true ES2187968T3 (es) 2003-06-16

Family

ID=25320700

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98922204T Expired - Lifetime ES2187968T3 (es) 1997-05-13 1998-05-12 Dispositivo detector de fluorescencia mejorado.

Country Status (16)

Country Link
US (1) US5894351A (es)
EP (1) EP0981736B1 (es)
JP (1) JP4088352B2 (es)
KR (1) KR100508666B1 (es)
CN (1) CN1146726C (es)
AT (1) ATE229178T1 (es)
AU (1) AU723849B2 (es)
CA (1) CA2287307C (es)
DE (1) DE69809902T2 (es)
DK (1) DK0981736T3 (es)
ES (1) ES2187968T3 (es)
HK (1) HK1023401A1 (es)
NO (1) NO328830B1 (es)
PT (1) PT981736E (es)
TW (1) TW385365B (es)
WO (1) WO1998052024A1 (es)

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US6572561B2 (en) 1998-01-16 2003-06-03 Healthetech, Inc. Respiratory calorimeter
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US6922576B2 (en) * 1998-06-19 2005-07-26 Becton, Dickinson And Company Micro optical sensor device
US6535753B1 (en) * 1998-08-20 2003-03-18 Microsense International, Llc Micro-invasive method for painless detection of analytes in extra-cellular space
US20090011945A1 (en) * 1999-07-28 2009-01-08 Bright Frank V Method For Making Microsensor Arrays For Detecting Analytes
US6492182B1 (en) * 1999-07-28 2002-12-10 The Research Foundation Of State University Of New York Microsensor arrays and method of using same for detecting analytes
US6612306B1 (en) 1999-10-13 2003-09-02 Healthetech, Inc. Respiratory nitric oxide meter
EP1228357B1 (en) * 1999-11-12 2008-05-28 E. I. du Pont de Nemours and Company Fluorometer with low heat-generating light source
JP2004506069A (ja) 2000-08-04 2004-02-26 センサーズ・フォー・メデセン・アンド・サイエンス・インコーポレーテッド 水性環境中での検体検出
AU2001296456A1 (en) 2000-09-29 2002-04-08 Healthetech, Inc. Indirect calorimetry system
US6653141B2 (en) 2000-12-05 2003-11-25 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing method and device
US7470420B2 (en) 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US6627177B2 (en) * 2000-12-05 2003-09-30 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
US20020119581A1 (en) * 2001-01-05 2002-08-29 Daniloff George Y. Detection of analytes
US6844563B2 (en) * 2001-05-22 2005-01-18 Matsushita Electric Industrial Co., Ltd. Fluorescence detecting device with integrated circuit and photodiode, and detection method
TWI293363B (en) 2001-12-11 2008-02-11 Sensors For Med & Science Inc High performance fluorescent optical sensor
US20030153026A1 (en) * 2002-01-04 2003-08-14 Javier Alarcon Entrapped binding protein as biosensors
US6855556B2 (en) 2002-01-04 2005-02-15 Becton, Dickinson And Company Binding protein as biosensors
US6867420B2 (en) * 2002-06-03 2005-03-15 The Regents Of The University Of California Solid-state detector and optical system for microchip analyzers
US7108659B2 (en) * 2002-08-01 2006-09-19 Healthetech, Inc. Respiratory analyzer for exercise use
US20040161853A1 (en) 2003-02-13 2004-08-19 Zhongping Yang Implantable chemical sensor with rugged optical coupler
US20040175821A1 (en) * 2003-03-07 2004-09-09 Ehman Michael F. Integrated photodetector for heavy metals and biological activity analysis
EP1618768B1 (en) * 2003-04-15 2013-06-12 Senseonics, Incorporated Implantable sensor processing system with integrated printed circuit board antenna
US20040234962A1 (en) * 2003-05-02 2004-11-25 Javier Alarcon Multicoated or multilayer entrapment matrix for protein biosensor
US7713745B2 (en) * 2004-04-13 2010-05-11 Sensors For Medicine And Science, Inc. Non-covalent immobilization of indicator molecules
US20050234316A1 (en) 2004-04-16 2005-10-20 Sensors For Medicine And Science, Inc. Housing for a circuit that is to be implanted in-vivo and process of making the same
WO2005124348A1 (en) * 2004-06-09 2005-12-29 Becton, Dickinson And Company Multianalyte sensor
JP5011650B2 (ja) * 2005-04-01 2012-08-29 パナソニック株式会社 光検知方法
JP5041714B2 (ja) * 2006-03-13 2012-10-03 信越化学工業株式会社 マイクロチップ及びマイクロチップ製造用ｓｏｉ基板
AU2007240316A1 (en) 2006-04-20 2007-11-01 Becton, Dickinson And Company Thermostable proteins and methods of making and using thereof
JP5638343B2 (ja) 2010-10-25 2014-12-10 テルモ株式会社 蛍光センサ
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Also Published As

Publication number Publication date
US5894351A (en) 1999-04-13
HK1023401A1 (en) 2000-09-08
TW385365B (en) 2000-03-21
AU7480398A (en) 1998-12-08
NO328830B1 (no) 2010-05-25
ATE229178T1 (de) 2002-12-15
AU723849B2 (en) 2000-09-07
NO995282D0 (no) 1999-10-28
EP0981736B1 (en) 2002-12-04
EP0981736A1 (en) 2000-03-01
CA2287307C (en) 2007-07-10
WO1998052024A1 (en) 1998-11-19
KR20010012545A (ko) 2001-02-15
CN1146726C (zh) 2004-04-21
KR100508666B1 (ko) 2005-08-17
DE69809902T2 (de) 2003-05-28
DE69809902D1 (de) 2003-01-16
JP2001525930A (ja) 2001-12-11
NO995282L (no) 2000-01-10
DK0981736T3 (da) 2003-03-31
CA2287307A1 (en) 1998-11-19
PT981736E (pt) 2003-04-30
CN1255973A (zh) 2000-06-07
JP4088352B2 (ja) 2008-05-21

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