WO2003023375A3 - Toxicity monitoring - Google Patents

Toxicity monitoring Download PDF

Info

Publication number
WO2003023375A3
WO2003023375A3 PCT/GB2002/003964 GB0203964W WO03023375A3 WO 2003023375 A3 WO2003023375 A3 WO 2003023375A3 GB 0203964 W GB0203964 W GB 0203964W WO 03023375 A3 WO03023375 A3 WO 03023375A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
toxicity monitoring
detector
toxicity
normalisation
Prior art date
Application number
PCT/GB2002/003964
Other languages
French (fr)
Other versions
WO2003023375A2 (en
Inventor
Peter Robert Fielden
Nicholas John Goddard
Andrew William Knight
Richard Maurice Walmsley
Original Assignee
Gentronix Ltd
Peter Robert Fielden
Nicholas John Goddard
Andrew William Knight
Richard Maurice Walmsley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentronix Ltd, Peter Robert Fielden, Nicholas John Goddard, Andrew William Knight, Richard Maurice Walmsley filed Critical Gentronix Ltd
Priority to AU2002321564A priority Critical patent/AU2002321564A1/en
Publication of WO2003023375A2 publication Critical patent/WO2003023375A2/en
Publication of WO2003023375A3 publication Critical patent/WO2003023375A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G01N21/532—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke with measurement of scattering and transmission
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

A toxicity monitoring apparatus comprising a light emitting diode (7) for illuminating a sample, a first detector (13) arranged to defect fluorescent light emitted by the sample, and a second detector (19) arranged to detect light scattered by the sample, thereby allowing determination of the cell density of the sample and normalisation of the measured fluorescence.
PCT/GB2002/003964 2001-09-13 2002-08-30 Toxicity monitoring WO2003023375A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002321564A AU2002321564A1 (en) 2001-09-13 2002-08-30 Toxicity monitoring

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0122219.9 2001-09-13
GB0122219A GB0122219D0 (en) 2001-09-13 2001-09-13 Toxicity monitoring

Publications (2)

Publication Number Publication Date
WO2003023375A2 WO2003023375A2 (en) 2003-03-20
WO2003023375A3 true WO2003023375A3 (en) 2003-10-30

Family

ID=9922083

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/003964 WO2003023375A2 (en) 2001-09-13 2002-08-30 Toxicity monitoring

Country Status (3)

Country Link
AU (1) AU2002321564A1 (en)
GB (1) GB0122219D0 (en)
WO (1) WO2003023375A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11002655B2 (en) 2015-09-23 2021-05-11 Malvern Panalytical Limited Cuvette carrier
JP6936229B2 (en) 2015-09-23 2021-09-15 マルバーン パナリティカル リミテッド Particle characterization
GB201516851D0 (en) 2015-09-23 2015-11-04 Malvern Instr Ltd Cuvette carrier
GB201604460D0 (en) 2016-03-16 2016-04-27 Malvern Instr Ltd Dynamic light scattering
EP3379232A1 (en) 2017-03-23 2018-09-26 Malvern Panalytical Limited Particle characterisation
CN109781569B (en) * 2019-03-15 2024-01-16 云南大学 Reservoir hydro-fluctuation belt wave erosion monitoring device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044194A1 (en) * 1997-03-31 1998-10-08 Fort James Corporation Soft bulky single-ply tissue paper
US6509161B1 (en) * 2000-02-29 2003-01-21 Gentronix Limited Green fluorescent protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044194A1 (en) * 1997-03-31 1998-10-08 Fort James Corporation Soft bulky single-ply tissue paper
US6509161B1 (en) * 2000-02-29 2003-01-21 Gentronix Limited Green fluorescent protein

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KNIGHT A W ET AL: "THE APPLICATION OF FLUORESCENCE POLARISATION FOR THE ENHANCED DETECTION OF GREEN FLUORESCENT PROTEIN (GFP) IN THE PRESENCE OF CELLULAR AUTO-FLUORESCENCE AND OTHER GREEN FLUORESCENT COMPOUNDS", ANALYST, LONDON, GB, vol. 125, 2000, pages 499 - 506, XP008010463 *
KOSTOV Y ET AL: "ALL SOLID-STATE GFP SENSOR", BIOTECHNOLOGY AND BIOENGINEERING. INCLUDING: SYMPOSIUM BIOTECHNOLOGY IN ENERGY PRODUCTION AND CONSERVATION, JOHN WILEY & SONS. NEW YORK, US, vol. 70, no. 4, 20 November 2000 (2000-11-20), pages 473 - 477, XP001126300, ISSN: 0006-3592 *
RANDERS-EICHHORN L ET AL: "ON-LINE GREEN FLUORESCENT PROTEIN SENSOR WITH LED EXCITATION", BIOTECHNOLOGY AND BIOENGINEERING. INCLUDING: SYMPOSIUM BIOTECHNOLOGY IN ENERGY PRODUCTION AND CONSERVATION, JOHN WILEY & SONS. NEW YORK, US, vol. 55, no. 6, 20 September 1997 (1997-09-20), pages 921 - 926, XP001109244, ISSN: 0006-3592 *

Also Published As

Publication number Publication date
AU2002321564A1 (en) 2003-03-24
WO2003023375A2 (en) 2003-03-20
GB0122219D0 (en) 2001-11-07

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