ES2187752T3 - Procedimiento para la preparacion de derivados de ganciclovir. - Google Patents

Procedimiento para la preparacion de derivados de ganciclovir.

Info

Publication number
ES2187752T3
ES2187752T3 ES97902187T ES97902187T ES2187752T3 ES 2187752 T3 ES2187752 T3 ES 2187752T3 ES 97902187 T ES97902187 T ES 97902187T ES 97902187 T ES97902187 T ES 97902187T ES 2187752 T3 ES2187752 T3 ES 2187752T3
Authority
ES
Spain
Prior art keywords
procedure
ganciclovir
preparation
ester
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97902187T
Other languages
English (en)
Spanish (es)
Inventor
Humberto B Arzeno
Eric R Humphreys
Jim-Wah Wong
Christopher R Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2187752T3 publication Critical patent/ES2187752T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
ES97902187T 1996-01-26 1997-01-20 Procedimiento para la preparacion de derivados de ganciclovir. Expired - Lifetime ES2187752T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59228296A 1996-01-26 1996-01-26

Publications (1)

Publication Number Publication Date
ES2187752T3 true ES2187752T3 (es) 2003-06-16

Family

ID=24370063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97902187T Expired - Lifetime ES2187752T3 (es) 1996-01-26 1997-01-20 Procedimiento para la preparacion de derivados de ganciclovir.

Country Status (7)

Country Link
US (2) US5840890A (2)
EP (1) EP0885224B1 (2)
JP (1) JP4094666B2 (2)
AU (1) AU1593197A (2)
DE (1) DE69717974T2 (2)
ES (1) ES2187752T3 (2)
WO (1) WO1997027197A1 (2)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
JP2001503767A (ja) * 1996-11-12 2001-03-21 メディヴィル・アクチボラグ ヌクレオシド
CZ2004446A3 (cs) * 2001-09-07 2005-01-12 Teva Pharmaceutical Industries Ltd. Krystalické formy valaciklovir hydrochloridu
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
BRPI0413331A (pt) * 2003-08-28 2006-10-10 Ranbaxy Lab Ltd cloridrato de valganciclovir amorfo, composição farmacêutica contendo o mesmo e processo para sua preparação
JP2007513074A (ja) * 2004-09-04 2007-05-24 テバ ファーマシューティカル インダストリーズ リミティド 単離されたバラシクロビル不純物、バラシクロビル不純物の調製方法および参照標準としての使用
HRP20110603T1 (hr) * 2005-01-25 2011-09-30 Sigma Coatings B.V. Sastav veziva
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
EP1870411B1 (en) * 2006-06-21 2016-03-16 Fidia Farmaceutici S.p.A. Process for the preparation and purification of valgancyclovir
MX2009005921A (es) 2006-12-13 2009-06-17 Hoffmann La Roche Formulacion en polvo del valganciclovir.
US20090076040A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched valganciclovir
WO2010036904A2 (en) * 2008-09-26 2010-04-01 Dr. Reddy's Laboratories Ltd. Preparation of valganciclovir and its salts
IT1397233B1 (it) * 2010-01-08 2013-01-04 Fidia Farmaceutici Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir.
CN101955481B (zh) * 2010-10-09 2016-04-20 广东肇庆星湖生物科技股份有限公司 一种盐酸缬更昔洛韦的制备方法
EP2714691B1 (en) 2011-05-31 2016-09-07 Pharmathen S.A. Process for the preparation of 2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1h-purin-6(9h)-one compound useful in the preparation of valganciclovir
CN105693722B (zh) * 2016-04-20 2018-07-20 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN105732630B (zh) * 2016-04-20 2018-11-30 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN105693724B (zh) * 2016-04-20 2017-08-11 安徽海康药业有限责任公司 一种cbz‑缬更昔洛韦的制备方法
CN112409359A (zh) * 2020-11-30 2021-02-26 沃德药业(安徽)股份有限公司 一种盐酸缬更昔洛韦制备方法
CN113880838B (zh) * 2021-11-15 2024-03-19 仁合益康集团有限公司 一种微通道反应器合成盐酸缬更昔洛韦的方法
CN115286632B (zh) * 2022-09-16 2023-05-09 河北医科大学 一种盐酸缬更昔洛韦的制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
DD202717A5 (de) * 1981-08-11 1983-09-28 Wellcome Found Antivirale purinderivate und verfahren zu ihrer herstellung
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
EP0108285B1 (en) * 1982-10-14 1988-04-20 The Wellcome Foundation Limited Antiviral purine derivatives
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
GB8829571D0 (en) 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
DE69426880T2 (de) * 1993-06-10 2001-10-31 Rolabo S.L., Zaragoza Verfahren zur herstellung von aminosäureester von nukleosid analogen
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives

Also Published As

Publication number Publication date
US6103901A (en) 2000-08-15
WO1997027197A1 (en) 1997-07-31
JP4094666B2 (ja) 2008-06-04
US5840890A (en) 1998-11-24
JP2000505080A (ja) 2000-04-25
EP0885224A1 (en) 1998-12-23
AU1593197A (en) 1997-08-20
DE69717974D1 (de) 2003-01-30
DE69717974T2 (de) 2003-10-02
EP0885224B1 (en) 2002-12-18

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