ES2185627T3 - Complejos metalicos de texafirinas solubles en agua. - Google Patents
Complejos metalicos de texafirinas solubles en agua.Info
- Publication number
- ES2185627T3 ES2185627T3 ES93902982T ES93902982T ES2185627T3 ES 2185627 T3 ES2185627 T3 ES 2185627T3 ES 93902982 T ES93902982 T ES 93902982T ES 93902982 T ES93902982 T ES 93902982T ES 2185627 T3 ES2185627 T3 ES 2185627T3
- Authority
- ES
- Spain
- Prior art keywords
- metal complexes
- texaffirins
- water soluble
- soluble
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002184 metal Substances 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 239000003504 photosensitizing agent Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
- A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0036—Porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Laminated Bodies (AREA)
- Conductive Materials (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Paints Or Removers (AREA)
Abstract
EL PRESENTE INVENTO ATAÑE A TEXAPIRINAS HIDROXISUSTITUIDAS SOLUBLES EN AGUA QUE RETIENEN LA LIPOFILICIDAD, DE FORMULA (I) EN DONDE: M ES H, UN CATION DE METAL DIVALENTE O TRIVALENTE; R1,R2,R3,R4 Y R5 SON INDEPENDIENTEMENTE H,OH,CNH(2N+1)OY O OCNH(2N+1)OY DONDE AL MENOS UNO DE R1,R2,R3,R4 Y R5 TIENE AL MENOS UN SUSTITUYENTE HIDROXI; EL PESO MOLECULAR DE CUALQUIERA DE R1,R2,R3,R4 Y R5 ES MENOR O IGUAL QUE 1000 DALTONS; N ES UN ENTERO POSITIVO O CERO; Y ES CERO O UN ENTERO POSITIVO MENOR O IGUAL QUE (2N+1); Y N UN ENTERO ENTRE -20 Y +2. ESOS MACROCICLOS DE PORFIRINIDOS EXPANDIDOS SON QUELATORES EFICIENTES DE IONES DE METAL DIVALENTE Y TRIVALENTE. VARIOS COMPLEJOS DE METAL (POR EJEMPLO, TRANSICION, GRUPO PRINCIPAL Y LANTANIDO) DE LOS DERIVADOS TEXAFIRIN SUSTITUIDO DE HIDROXI DEL PRESENTE INVENTO TIENEN ESTABILIDAD Y SOLUBILIDAD EN AGUA INUSUALES. ABSORBE LUZ FUERTEMENTE EN UNA REGION IMPORTANTE FISIOLOGICAMENTE (POR EJEMPLO 690-880 NM). TIENEN RELAJAMIENTO INCREMENTADO Y POR ELLO SON UTILES ENREPRESENTACION DE IMAGENES DE RESONANCIA MAGNETICA. FORMA TRIOS DE ESTADOS DE LARGA VIDA EN PRODUCCION ALTA Y ACTUA COMO FOTOSENSIBILIZADORES PARA LA GENERACION DE OXIGENO SIMPLE. ASI, SON UTILES PARA LA INACTIVACION O DESTRUCCION DEL VIRUS DE INMUNODEFICIENCIA HUMANO (HIV-1), MONONUCLEAR U OTRAS CELULAS INFECTADAS CON DICHO VIRUS COMO TAMBIEN CELULAS DE TUMOR. SON SOLUBLES EN AGUA, ADEMAS RETIENEN SUFICIENTE LIPOFILICIDAD PARA TENER AFINIDAD MAS GRANDE PARA AREAS RICAS EN LIPIDOS TALES COMO ATEROMAS Y TUMORES. DEBEN SER USADOS PARA REPRESENTAR IMAGENES DE RESONANCIAS MAGNETICAS SEGUIDAS POR LA TERAPIA DE TUMOR FOTODINAMICA EN EL TRATAMIENTO DEL ATEROMA Y TUMORES. ESAS PROPIEDADES, ACOPLADAS CON SU ALTA ESTABILIDAD QUIMICA Y APRECIABLE SOLUBILIDAD EN AGUA, LAS AÑADE A SU UTILIDAD.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/822,964 US5252720A (en) | 1989-03-06 | 1992-01-21 | Metal complexes of water soluble texaphyrins |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2185627T3 true ES2185627T3 (es) | 2003-05-01 |
Family
ID=25237423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93902982T Expired - Lifetime ES2185627T3 (es) | 1992-01-21 | 1993-01-07 | Complejos metalicos de texafirinas solubles en agua. |
Country Status (15)
Country | Link |
---|---|
US (9) | US5252720A (es) |
EP (1) | EP0623134B1 (es) |
JP (1) | JP3530529B2 (es) |
KR (1) | KR100286963B1 (es) |
AT (1) | ATE227291T1 (es) |
AU (1) | AU664877B2 (es) |
CA (1) | CA2127530C (es) |
DE (1) | DE69332469T2 (es) |
DK (1) | DK0623134T3 (es) |
ES (1) | ES2185627T3 (es) |
FI (1) | FI107157B (es) |
NO (1) | NO301828B1 (es) |
NZ (1) | NZ246795A (es) |
PT (1) | PT623134E (es) |
WO (1) | WO1993014093A1 (es) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5457183A (en) * | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
US5252720A (en) * | 1989-03-06 | 1993-10-12 | Board Of Regents, The University Of Texas System | Metal complexes of water soluble texaphyrins |
US5162509A (en) * | 1989-03-06 | 1992-11-10 | Board Of Regents, The University Of Texas System | Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
US5567687A (en) * | 1989-03-06 | 1996-10-22 | University Of Texas | Texaphyrins and uses thereof |
US5599923A (en) * | 1989-03-06 | 1997-02-04 | Board Of Regents, University Of Tx | Texaphyrin metal complexes having improved functionalization |
US4935498A (en) * | 1989-03-06 | 1990-06-19 | Board Of Regents, The University Of Texas System | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
US5559207A (en) * | 1989-03-06 | 1996-09-24 | Board Of Regents, University Of Texas | Texaphyrin metal complex mediated ester hydrolysis |
US5457195A (en) * | 1989-12-21 | 1995-10-10 | Board Of Regents, The University Of Texas System | Sapphyrin derivatives and conjugates |
US5543514A (en) * | 1989-12-21 | 1996-08-06 | Board Of Regents, The University Of Texas System | Water-soluble sapphyrins |
US5594136A (en) * | 1989-12-21 | 1997-01-14 | Pharmacyclics, Inc. | Texaphyrin solid supports and devices |
US5595726A (en) * | 1992-01-21 | 1997-01-21 | Pharmacyclics, Inc. | Chromophore probe for detection of nucleic acid |
US5607924A (en) * | 1992-01-21 | 1997-03-04 | Pharmacyclics, Inc. | DNA photocleavage using texaphyrins |
US5763172A (en) * | 1992-01-21 | 1998-06-09 | Board Of Regents, The University Of Texas System | Method of phosphate ester hydrolysis |
US5888997A (en) * | 1994-04-14 | 1999-03-30 | Pharmacyclics, Inc. | Radiation sensitization using texaphyrins |
US5565552A (en) * | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
US5798491A (en) * | 1993-06-09 | 1998-08-25 | Board Of Regents, The University Of Texas System | Multi-mechanistic chemical cleavage using certain metal complexes |
KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
ATE215839T1 (de) * | 1994-03-21 | 2002-04-15 | Dusa Pharmaceuticals Inc | Pflaster und steuereinrichtung für photodynamische therapie von dermalen verletzungen |
US5969111A (en) * | 1994-04-14 | 1999-10-19 | Board Of Regents, The University Of Texas System | Texaphyrins substituted with imidazole are provided |
AU733805C (en) * | 1994-06-13 | 2001-12-13 | Unilever Plc | Bleach activation |
AU2614895A (en) * | 1994-06-13 | 1996-01-05 | Unilever N.V. | Bleach activation |
US5530122A (en) * | 1994-08-23 | 1996-06-25 | Pharmacyclics, Inc. | Method of isolating texaphyrins |
US5633354A (en) * | 1994-09-21 | 1997-05-27 | Pharmacyclics, Inc. | Phosphoramidite derivatives of texaphyrins |
US5837866A (en) * | 1994-09-21 | 1998-11-17 | Board Of Regents, The University Of Texas | Phosphoramidite derivatives of macrocycles |
US6095147A (en) * | 1994-12-01 | 2000-08-01 | The Regents Of The University Of California | Method for photo-altering a biological system to improve biological effect |
US5703230A (en) * | 1994-12-02 | 1997-12-30 | University Of British Columbia | Meso-monoiodo-substituted tetramacrocyclic compounds and methods for making and using the same |
US6329139B1 (en) | 1995-04-25 | 2001-12-11 | Discovery Partners International | Automated sorting system for matrices with memory |
US5591422A (en) * | 1995-06-02 | 1997-01-07 | Pharmacyclics, Inc. | Texaphyrin complexes having improved functionalization |
US5714328A (en) * | 1995-06-07 | 1998-02-03 | Board Of Regents, The University Of Texas System | RNA photocleavage using texaphyrins |
AU6722496A (en) * | 1995-08-17 | 1997-03-12 | Monsanto Company | Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands |
BR9610241A (pt) | 1995-08-17 | 1999-06-29 | Monsanto Co | Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio |
WO1997009043A1 (en) | 1995-09-06 | 1997-03-13 | The Research Foundation Of State University Of New York | Two-photon upconverting dyes and applications |
US5776925A (en) * | 1996-01-25 | 1998-07-07 | Pharmacyclics, Inc. | Methods for cancer chemosensitization |
US5883246A (en) * | 1996-03-07 | 1999-03-16 | Qlt Phototherapeutics, Inc. | Synthesis of polypyrrolic macrocycles from meso-substituted tripyrrane compounds |
US5955586A (en) * | 1996-03-22 | 1999-09-21 | Sessler; Jonathan L. | Highly boronated derivatives of texaphyrins |
AU717193B2 (en) * | 1996-03-26 | 2000-03-23 | Pharmacyclics, Inc. | Use of a texaphyrin in photodynamic therapy of pigment-related lesions |
US6375930B2 (en) | 1996-06-04 | 2002-04-23 | Board Of Regents, The University Of Texas System | Membrane incorporation of texaphyrins |
US6022959A (en) * | 1996-08-20 | 2000-02-08 | Pharmacyclics, Inc. | Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof |
US6270749B1 (en) | 1996-12-11 | 2001-08-07 | Pharmacyclics, Inc. | Use of Texaphyrin in ocular diagnosis and therapy |
US6444194B1 (en) | 1997-02-14 | 2002-09-03 | Miravant Pharmaceuticals, Inc. | Indium photosensitizers for PDT |
US6214817B1 (en) | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
US6022526A (en) * | 1997-07-30 | 2000-02-08 | Pharmacyclics, Inc. | Use of texaphyrins in detection of melanin and melanin metabolites diagnostic of melanotic melanoma |
US5886173A (en) * | 1997-07-30 | 1999-03-23 | Pharmacyclics, Inc. | Metallation of macrocycles with 2,4-dicarbonyl-metal complexes |
US20020155999A1 (en) * | 1998-04-30 | 2002-10-24 | Han In Suk | Method of using a porphyrin-like molecule conjugated with an anti-cancer drug for the treatment of cancer |
DE19831217A1 (de) * | 1998-07-03 | 2000-01-05 | Schering Ag | Neue Porphyrinderivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik |
US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
US7157418B1 (en) | 1998-07-22 | 2007-01-02 | Osprey Pharmaceuticals, Ltd. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
ATE291446T1 (de) | 1999-05-27 | 2005-04-15 | Monsanto Co | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
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AU2001227837A1 (en) * | 2000-01-12 | 2001-07-24 | Light Sciences Corporation | Novel treatment for eye disease |
DE60109745T2 (de) * | 2000-01-26 | 2006-02-23 | Japan Science And Technology Agency, Kawaguchi | Polymere micellenartige struktur |
WO2001093914A2 (en) * | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
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WO2002017925A1 (en) * | 2000-08-30 | 2002-03-07 | Pharmacyclics, Inc. | Non-symmetric tripyrrannes in the synthesis of novel macrocycles |
US7449454B2 (en) * | 2000-08-30 | 2008-11-11 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
AU2002310351A1 (en) * | 2001-06-11 | 2002-12-23 | Cavalier Discovery | Accelerators for increasing the rate of formation of free radicals and reactive oxygen species |
WO2002101847A2 (en) * | 2001-06-12 | 2002-12-19 | University Of Florida | Method and device for producing near-infrared radiation |
IL162469A0 (en) * | 2001-12-13 | 2005-11-20 | Pharmacyclics Inc | Process for affecting neurologic progression pharmacyclics, inc. |
WO2003072581A1 (en) | 2002-02-26 | 2003-09-04 | Board Of Regents, The University Of Texas System | Cyclo[n]pyrroles and methods thereto |
US6723750B2 (en) | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
AU2003298725A1 (en) * | 2002-12-04 | 2004-06-23 | Pharmacyclics, Inc. | Preparation of metallotexaphyrins |
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-
1992
- 1992-01-21 US US07/822,964 patent/US5252720A/en not_active Expired - Lifetime
-
1993
- 1993-01-07 JP JP51256293A patent/JP3530529B2/ja not_active Expired - Fee Related
- 1993-01-07 AU AU34367/93A patent/AU664877B2/en not_active Ceased
- 1993-01-07 AT AT93902982T patent/ATE227291T1/de not_active IP Right Cessation
- 1993-01-07 NZ NZ246795A patent/NZ246795A/en not_active IP Right Cessation
- 1993-01-07 WO PCT/US1993/000107 patent/WO1993014093A1/en active IP Right Grant
- 1993-01-07 ES ES93902982T patent/ES2185627T3/es not_active Expired - Lifetime
- 1993-01-07 DK DK93902982T patent/DK0623134T3/da active
- 1993-01-07 EP EP93902982A patent/EP0623134B1/en not_active Expired - Lifetime
- 1993-01-07 PT PT93902982T patent/PT623134E/pt unknown
- 1993-01-07 KR KR1019940702497A patent/KR100286963B1/ko not_active IP Right Cessation
- 1993-01-07 CA CA002127530A patent/CA2127530C/en not_active Expired - Fee Related
- 1993-01-07 DE DE69332469T patent/DE69332469T2/de not_active Expired - Fee Related
- 1993-07-28 US US08/100,093 patent/US5432171A/en not_active Expired - Lifetime
- 1993-07-28 US US08/098,514 patent/US5569759A/en not_active Expired - Lifetime
- 1993-08-25 US US08/112,871 patent/US5439570A/en not_active Expired - Lifetime
- 1993-08-25 US US08/112,786 patent/US5475104A/en not_active Expired - Lifetime
- 1993-08-25 US US08/112,872 patent/US5451576A/en not_active Expired - Lifetime
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1994
- 1994-07-20 FI FI943445A patent/FI107157B/fi active
- 1994-07-20 NO NO942719A patent/NO301828B1/no unknown
- 1994-07-26 US US08/280,351 patent/US5504205A/en not_active Expired - Lifetime
-
1996
- 1996-07-10 US US08/679,162 patent/US5733903A/en not_active Expired - Lifetime
-
1998
- 1998-02-26 US US09/031,239 patent/US5994535A/en not_active Expired - Lifetime
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DK0623134T3 (da) | 2003-03-17 |
NO942719D0 (no) | 1994-07-20 |
EP0623134A1 (en) | 1994-11-09 |
US5569759A (en) | 1996-10-29 |
FI943445A (fi) | 1994-07-20 |
US5504205A (en) | 1996-04-02 |
ATE227291T1 (de) | 2002-11-15 |
CA2127530C (en) | 2001-05-29 |
KR100286963B1 (ko) | 2001-04-16 |
US5994535A (en) | 1999-11-30 |
CA2127530A1 (en) | 1993-07-22 |
NO942719L (no) | 1994-09-19 |
JPH07503009A (ja) | 1995-03-30 |
EP0623134B1 (en) | 2002-11-06 |
NO301828B1 (no) | 1997-12-15 |
JP3530529B2 (ja) | 2004-05-24 |
FI107157B (fi) | 2001-06-15 |
US5451576A (en) | 1995-09-19 |
DE69332469T2 (de) | 2003-07-10 |
FI943445A0 (fi) | 1994-07-20 |
NZ246795A (en) | 1996-02-27 |
DE69332469D1 (de) | 2002-12-12 |
US5475104A (en) | 1995-12-12 |
US5432171A (en) | 1995-07-11 |
US5733903A (en) | 1998-03-31 |
PT623134E (pt) | 2003-03-31 |
AU664877B2 (en) | 1995-12-07 |
WO1993014093A1 (en) | 1993-07-22 |
US5252720A (en) | 1993-10-12 |
US5439570A (en) | 1995-08-08 |
AU3436793A (en) | 1993-08-03 |
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