ATE227291T1 - Metallkomplexe von wasserlöslichen texaphyrinen - Google Patents
Metallkomplexe von wasserlöslichen texaphyrinenInfo
- Publication number
- ATE227291T1 ATE227291T1 AT93902982T AT93902982T ATE227291T1 AT E227291 T1 ATE227291 T1 AT E227291T1 AT 93902982 T AT93902982 T AT 93902982T AT 93902982 T AT93902982 T AT 93902982T AT E227291 T1 ATE227291 T1 AT E227291T1
- Authority
- AT
- Austria
- Prior art keywords
- water
- metal complexes
- soluble
- soluble texaphyrins
- texaphyrins
- Prior art date
Links
- 239000002184 metal Substances 0.000 title abstract 2
- 230000003211 malignant effect Effects 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 239000003504 photosensitizing agent Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
- A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0036—Porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Laminated Bodies (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Conductive Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/822,964 US5252720A (en) | 1989-03-06 | 1992-01-21 | Metal complexes of water soluble texaphyrins |
PCT/US1993/000107 WO1993014093A1 (en) | 1992-01-21 | 1993-01-07 | Metal complexes of water soluble texaphyrins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE227291T1 true ATE227291T1 (de) | 2002-11-15 |
Family
ID=25237423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93902982T ATE227291T1 (de) | 1992-01-21 | 1993-01-07 | Metallkomplexe von wasserlöslichen texaphyrinen |
Country Status (15)
Country | Link |
---|---|
US (9) | US5252720A (de) |
EP (1) | EP0623134B1 (de) |
JP (1) | JP3530529B2 (de) |
KR (1) | KR100286963B1 (de) |
AT (1) | ATE227291T1 (de) |
AU (1) | AU664877B2 (de) |
CA (1) | CA2127530C (de) |
DE (1) | DE69332469T2 (de) |
DK (1) | DK0623134T3 (de) |
ES (1) | ES2185627T3 (de) |
FI (1) | FI107157B (de) |
NO (1) | NO301828B1 (de) |
NZ (1) | NZ246795A (de) |
PT (1) | PT623134E (de) |
WO (1) | WO1993014093A1 (de) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5457183A (en) * | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
US5599923A (en) * | 1989-03-06 | 1997-02-04 | Board Of Regents, University Of Tx | Texaphyrin metal complexes having improved functionalization |
US5567687A (en) * | 1989-03-06 | 1996-10-22 | University Of Texas | Texaphyrins and uses thereof |
US4935498A (en) * | 1989-03-06 | 1990-06-19 | Board Of Regents, The University Of Texas System | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
US5559207A (en) * | 1989-03-06 | 1996-09-24 | Board Of Regents, University Of Texas | Texaphyrin metal complex mediated ester hydrolysis |
US5162509A (en) * | 1989-03-06 | 1992-11-10 | Board Of Regents, The University Of Texas System | Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
US5252720A (en) * | 1989-03-06 | 1993-10-12 | Board Of Regents, The University Of Texas System | Metal complexes of water soluble texaphyrins |
US5457195A (en) * | 1989-12-21 | 1995-10-10 | Board Of Regents, The University Of Texas System | Sapphyrin derivatives and conjugates |
US5594136A (en) * | 1989-12-21 | 1997-01-14 | Pharmacyclics, Inc. | Texaphyrin solid supports and devices |
US5543514A (en) * | 1989-12-21 | 1996-08-06 | Board Of Regents, The University Of Texas System | Water-soluble sapphyrins |
US5763172A (en) * | 1992-01-21 | 1998-06-09 | Board Of Regents, The University Of Texas System | Method of phosphate ester hydrolysis |
US5607924A (en) * | 1992-01-21 | 1997-03-04 | Pharmacyclics, Inc. | DNA photocleavage using texaphyrins |
US5888997A (en) * | 1994-04-14 | 1999-03-30 | Pharmacyclics, Inc. | Radiation sensitization using texaphyrins |
US5565552A (en) * | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
US5595726A (en) * | 1992-01-21 | 1997-01-21 | Pharmacyclics, Inc. | Chromophore probe for detection of nucleic acid |
US5798491A (en) * | 1993-06-09 | 1998-08-25 | Board Of Regents, The University Of Texas System | Multi-mechanistic chemical cleavage using certain metal complexes |
KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
ATE215839T1 (de) * | 1994-03-21 | 2002-04-15 | Dusa Pharmaceuticals Inc | Pflaster und steuereinrichtung für photodynamische therapie von dermalen verletzungen |
US5969111A (en) * | 1994-04-14 | 1999-10-19 | Board Of Regents, The University Of Texas System | Texaphyrins substituted with imidazole are provided |
WO1995034628A1 (en) * | 1994-06-13 | 1995-12-21 | Unilever N.V. | Bleach activation |
AU733805C (en) * | 1994-06-13 | 2001-12-13 | Unilever Plc | Bleach activation |
US5530122A (en) * | 1994-08-23 | 1996-06-25 | Pharmacyclics, Inc. | Method of isolating texaphyrins |
US5837866A (en) * | 1994-09-21 | 1998-11-17 | Board Of Regents, The University Of Texas | Phosphoramidite derivatives of macrocycles |
US5633354A (en) * | 1994-09-21 | 1997-05-27 | Pharmacyclics, Inc. | Phosphoramidite derivatives of texaphyrins |
US6095147A (en) * | 1994-12-01 | 2000-08-01 | The Regents Of The University Of California | Method for photo-altering a biological system to improve biological effect |
US5703230A (en) * | 1994-12-02 | 1997-12-30 | University Of British Columbia | Meso-monoiodo-substituted tetramacrocyclic compounds and methods for making and using the same |
US6329139B1 (en) | 1995-04-25 | 2001-12-11 | Discovery Partners International | Automated sorting system for matrices with memory |
US5591422A (en) * | 1995-06-02 | 1997-01-07 | Pharmacyclics, Inc. | Texaphyrin complexes having improved functionalization |
US5714328A (en) * | 1995-06-07 | 1998-02-03 | Board Of Regents, The University Of Texas System | RNA photocleavage using texaphyrins |
BR9610241A (pt) | 1995-08-17 | 1999-06-29 | Monsanto Co | Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio |
EP0844889A1 (de) * | 1995-08-17 | 1998-06-03 | Monsanto Company | Diagnostische bildanalyseverfahrenunter verwendung von metallkomplexen von stickstoff-enthaltenden makrozyklischen liganden |
JP2001520637A (ja) * | 1995-09-06 | 2001-10-30 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 二光子アップコンバーティング色素および応用 |
US5776925A (en) * | 1996-01-25 | 1998-07-07 | Pharmacyclics, Inc. | Methods for cancer chemosensitization |
US5883246A (en) * | 1996-03-07 | 1999-03-16 | Qlt Phototherapeutics, Inc. | Synthesis of polypyrrolic macrocycles from meso-substituted tripyrrane compounds |
US5955586A (en) * | 1996-03-22 | 1999-09-21 | Sessler; Jonathan L. | Highly boronated derivatives of texaphyrins |
WO1997035617A1 (en) * | 1996-03-26 | 1997-10-02 | Pharmacyclics, Inc. | Use of a texaphyrin in photodynamic therapy of pigment-related lesions |
US6375930B2 (en) | 1996-06-04 | 2002-04-23 | Board Of Regents, The University Of Texas System | Membrane incorporation of texaphyrins |
US6022959A (en) * | 1996-08-20 | 2000-02-08 | Pharmacyclics, Inc. | Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof |
US6270749B1 (en) | 1996-12-11 | 2001-08-07 | Pharmacyclics, Inc. | Use of Texaphyrin in ocular diagnosis and therapy |
EP1091742A4 (de) | 1997-02-14 | 2007-05-30 | Miravant Pharm Inc | Indium photosensibilisatoren zur pdt |
US6214817B1 (en) | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
US6022526A (en) * | 1997-07-30 | 2000-02-08 | Pharmacyclics, Inc. | Use of texaphyrins in detection of melanin and melanin metabolites diagnostic of melanotic melanoma |
US5886173A (en) * | 1997-07-30 | 1999-03-23 | Pharmacyclics, Inc. | Metallation of macrocycles with 2,4-dicarbonyl-metal complexes |
US20020155999A1 (en) * | 1998-04-30 | 2002-10-24 | Han In Suk | Method of using a porphyrin-like molecule conjugated with an anti-cancer drug for the treatment of cancer |
DE19831217A1 (de) * | 1998-07-03 | 2000-01-05 | Schering Ag | Neue Porphyrinderivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik |
US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
US7157418B1 (en) | 1998-07-22 | 2007-01-02 | Osprey Pharmaceuticals, Ltd. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
DE60018925T2 (de) | 1999-05-27 | 2006-04-13 | Pharmacia Corp.(N.D.Ges.D.Staates Delaware) | Biomaterialien, modifiziert mit superoxid-dismutase imitatoren |
CN1762990A (zh) * | 1999-06-08 | 2006-04-26 | 拉卓拉药物公司 | 包含氨基氧基的化合价平台分子 |
EP1267935A2 (de) * | 2000-01-12 | 2003-01-02 | Light Sciences Corporation | Behandlung von augenerkrankungen |
DE60109745T2 (de) * | 2000-01-26 | 2006-02-23 | Japan Science And Technology Agency, Kawaguchi | Polymere micellenartige struktur |
EP1292337A2 (de) * | 2000-06-08 | 2003-03-19 | La Jolla Pharmaceutical | Polyethylenoxid mit hohem molekulargewicht enthaltende multivalenz-plattformmoleküle |
US6638924B2 (en) | 2000-08-30 | 2003-10-28 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
WO2002017925A1 (en) * | 2000-08-30 | 2002-03-07 | Pharmacyclics, Inc. | Non-symmetric tripyrrannes in the synthesis of novel macrocycles |
US7449454B2 (en) * | 2000-08-30 | 2008-11-11 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
CA2450370A1 (en) * | 2001-06-11 | 2002-12-19 | Jody Mesaros | Accelerators for increasing the rate of formation of free radicals and reactive oxygen species |
AU2002315208A1 (en) * | 2001-06-12 | 2002-12-23 | University Of Florida | Method and device for producing near-infrared radiation |
CN1615129A (zh) * | 2001-12-13 | 2005-05-11 | 环状药物公司 | 影响神经病学进展的方法 |
WO2003072581A1 (en) | 2002-02-26 | 2003-09-04 | Board Of Regents, The University Of Texas System | Cyclo[n]pyrroles and methods thereto |
US6723750B2 (en) | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
US20070287829A1 (en) * | 2002-12-04 | 2007-12-13 | Pharmacyclics, Inc. | Preparation of metallotexaphyrins |
CA2505608A1 (en) * | 2002-12-06 | 2004-06-24 | Alcon, Inc. | Superoxide dismutase mimics for the treatment of ocular disorders and diseases |
US7220778B2 (en) * | 2003-04-15 | 2007-05-22 | The General Hospital Corporation | Methods and devices for epithelial protection during photodynamic therapy |
US7659301B2 (en) * | 2003-04-15 | 2010-02-09 | The General Hospital Corporation | Methods and devices for epithelial protection during photodynamic therapy |
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EP1848466A4 (de) * | 2005-01-31 | 2012-11-21 | Yeda Res & Dev | Mri-kontrastmittel zur diagnose und prognose von tumoren |
JP2006224318A (ja) * | 2005-02-15 | 2006-08-31 | Brother Ind Ltd | インクジェット記録装置 |
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US20070072838A1 (en) | 2005-09-26 | 2007-03-29 | Pharmacyclics, Inc. | High-purity texaphyrin metal complexes |
US20070078119A1 (en) * | 2005-09-30 | 2007-04-05 | Pharmacyclics, Inc. | Storage system for texaphyrin pharmaceutical formulations |
WO2007059329A2 (en) * | 2005-11-16 | 2007-05-24 | Pharmacyclics, Inc. | Methods and compositions for treating cancer |
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US8216856B2 (en) * | 2006-08-18 | 2012-07-10 | Abacus Diagnostica Oy | Luminescent lanthanide labelling reagents and their use |
US8133474B2 (en) * | 2006-09-15 | 2012-03-13 | Massachusetts Institute Of Technology | Sensors for fluorescence and magnetic resonance imaging |
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US8580845B2 (en) * | 2007-06-29 | 2013-11-12 | Board Of Regents, The University Of Texas System | Functionalized expanded porphyrins |
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1992
- 1992-01-21 US US07/822,964 patent/US5252720A/en not_active Expired - Lifetime
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- 1993-01-07 KR KR1019940702497A patent/KR100286963B1/ko not_active IP Right Cessation
- 1993-01-07 EP EP93902982A patent/EP0623134B1/de not_active Expired - Lifetime
- 1993-01-07 WO PCT/US1993/000107 patent/WO1993014093A1/en active IP Right Grant
- 1993-01-07 DK DK93902982T patent/DK0623134T3/da active
- 1993-01-07 CA CA002127530A patent/CA2127530C/en not_active Expired - Fee Related
- 1993-01-07 DE DE69332469T patent/DE69332469T2/de not_active Expired - Fee Related
- 1993-01-07 AT AT93902982T patent/ATE227291T1/de not_active IP Right Cessation
- 1993-01-07 ES ES93902982T patent/ES2185627T3/es not_active Expired - Lifetime
- 1993-01-07 NZ NZ246795A patent/NZ246795A/en not_active IP Right Cessation
- 1993-01-07 AU AU34367/93A patent/AU664877B2/en not_active Ceased
- 1993-01-07 PT PT93902982T patent/PT623134E/pt unknown
- 1993-01-07 JP JP51256293A patent/JP3530529B2/ja not_active Expired - Fee Related
- 1993-07-28 US US08/098,514 patent/US5569759A/en not_active Expired - Lifetime
- 1993-07-28 US US08/100,093 patent/US5432171A/en not_active Expired - Lifetime
- 1993-08-25 US US08/112,871 patent/US5439570A/en not_active Expired - Lifetime
- 1993-08-25 US US08/112,872 patent/US5451576A/en not_active Expired - Lifetime
- 1993-08-25 US US08/112,786 patent/US5475104A/en not_active Expired - Lifetime
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1994
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- 1994-07-20 FI FI943445A patent/FI107157B/fi active
- 1994-07-26 US US08/280,351 patent/US5504205A/en not_active Expired - Lifetime
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NO942719L (no) | 1994-09-19 |
FI107157B (fi) | 2001-06-15 |
US5439570A (en) | 1995-08-08 |
NZ246795A (en) | 1996-02-27 |
US5994535A (en) | 1999-11-30 |
CA2127530A1 (en) | 1993-07-22 |
NO301828B1 (no) | 1997-12-15 |
DE69332469T2 (de) | 2003-07-10 |
EP0623134A1 (de) | 1994-11-09 |
DE69332469D1 (de) | 2002-12-12 |
US5504205A (en) | 1996-04-02 |
WO1993014093A1 (en) | 1993-07-22 |
PT623134E (pt) | 2003-03-31 |
AU3436793A (en) | 1993-08-03 |
US5733903A (en) | 1998-03-31 |
US5569759A (en) | 1996-10-29 |
FI943445A (fi) | 1994-07-20 |
KR100286963B1 (ko) | 2001-04-16 |
DK0623134T3 (da) | 2003-03-17 |
JP3530529B2 (ja) | 2004-05-24 |
NO942719D0 (no) | 1994-07-20 |
US5451576A (en) | 1995-09-19 |
FI943445A0 (fi) | 1994-07-20 |
US5475104A (en) | 1995-12-12 |
EP0623134B1 (de) | 2002-11-06 |
US5252720A (en) | 1993-10-12 |
JPH07503009A (ja) | 1995-03-30 |
AU664877B2 (en) | 1995-12-07 |
ES2185627T3 (es) | 2003-05-01 |
CA2127530C (en) | 2001-05-29 |
US5432171A (en) | 1995-07-11 |
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