ATE366121T1 - Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie - Google Patents
Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapieInfo
- Publication number
- ATE366121T1 ATE366121T1 AT99903557T AT99903557T ATE366121T1 AT E366121 T1 ATE366121 T1 AT E366121T1 AT 99903557 T AT99903557 T AT 99903557T AT 99903557 T AT99903557 T AT 99903557T AT E366121 T1 ATE366121 T1 AT E366121T1
- Authority
- AT
- Austria
- Prior art keywords
- serum
- cancer therapy
- systemic administration
- lipid particles
- stable plasmid
- Prior art date
Links
- 238000011275 oncology therapy Methods 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 238000007910 systemic administration Methods 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7359898P | 1998-02-03 | 1998-02-03 | |
| US8691798P | 1998-05-27 | 1998-05-27 | |
| US10142998P | 1998-09-22 | 1998-09-22 | |
| US11238498P | 1998-12-14 | 1998-12-14 | |
| US24310299A | 1999-02-02 | 1999-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE366121T1 true ATE366121T1 (de) | 2007-07-15 |
Family
ID=27535971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99903557T ATE366121T1 (de) | 1998-02-03 | 1999-02-03 | Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1053023B2 (de) |
| JP (1) | JP2002502831A (de) |
| AT (1) | ATE366121T1 (de) |
| AU (1) | AU749881B2 (de) |
| CA (2) | CA2321837C (de) |
| DE (1) | DE69936444T3 (de) |
| WO (2) | WO1999039741A2 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1044021B1 (de) | 1998-01-05 | 2009-09-23 | The University of Washington | Erhöhter transport unter benutzung membranzerstörender stoffe |
| CN1278739C (zh) * | 2001-06-08 | 2006-10-11 | 中国人民解放军第四军医大学 | 包含抗人精浆蛋白单链抗体/人羧肽酶a融合蛋白及前体药物的药盒 |
| JP4550421B2 (ja) | 2001-12-12 | 2010-09-22 | メイン・ファ−マ・インタ−ナショナル・プロプライエタリ−・リミテッド | ウイルスの保存のための組成物 |
| EP1501861A4 (de) | 2002-05-06 | 2007-06-20 | Univ Texas | Gezielt bindende proteine zur verabreichung therapeutischer oder diagnostischer reagentien |
| WO2010054406A1 (en) | 2008-11-10 | 2010-05-14 | Alnylam Pharmaceuticals, Inc. | Novel lipids and compositions for the delivery of therapeutics |
| EP3532103B1 (de) | 2016-10-26 | 2025-12-03 | Acuitas Therapeutics, Inc. | Lipidnanopartikelformulierung |
| US11338045B2 (en) | 2017-03-17 | 2022-05-24 | Newcastle University | Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy |
| WO2018191719A1 (en) | 2017-04-13 | 2018-10-18 | Acuitas Therapeutics, Inc. | Lipid delivery of therapeutic agents to adipose tissue |
| WO2019089828A1 (en) | 2017-10-31 | 2019-05-09 | Acuitas Therapeutics, Inc. | Lamellar lipid nanoparticles |
| US12491265B2 (en) | 2018-06-18 | 2025-12-09 | Research Institute At Nationwide Children's Hospital | Adeno-associated virus vector delivery of muscle specific micro-dystrophin to treat muscular dystrophy |
| IL281615B1 (en) | 2018-09-21 | 2025-09-01 | Acuitas Therapeutics Inc | Systems and methods for producing lipid nanoparticles and liposomes |
| JOP20220037A1 (ar) | 2019-08-14 | 2023-01-30 | Acuitas Therapeutics Inc | جسيمات نانوية دهنية محسنة لتوصيل الأحماض النووية |
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| KR20230035043A (ko) | 2020-06-15 | 2023-03-10 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 근이영양증을 위한 아데노-연관 바이러스 벡터 전달 |
| WO2025056938A1 (en) | 2023-09-11 | 2025-03-20 | BioNTech SE | Rna compositions for delivery of incretin agents |
| WO2022215036A1 (en) | 2021-04-08 | 2022-10-13 | Vaxthera Sas | Coronavirus vaccine comprising a mosaic protein |
| WO2023023055A1 (en) | 2021-08-16 | 2023-02-23 | Renagade Therapeutics Management Inc. | Compositions and methods for optimizing tropism of delivery systems for rna |
| EP4402121A1 (de) | 2021-09-14 | 2024-07-24 | Renagade Therapeutics Management Inc. | Acyclische lipide und verfahren zur verwendung davon |
| TW202328067A (zh) | 2021-09-14 | 2023-07-16 | 美商雷納嘉德醫療管理公司 | 環狀脂質及其使用方法 |
| CA3237482A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
| CA3238292A1 (en) | 2021-11-16 | 2023-05-25 | Alessandra Bartolozzi | Novel ionizable lipids and lipid nanoparticles and methods of using the same |
| KR20240128683A (ko) | 2021-11-22 | 2024-08-26 | 세일 바이오메디슨스, 인크. | 신규한 이온화 가능 지질 및 지질 나노입자, 및 이를 사용하는 방법 |
| CA3243054A1 (en) | 2021-12-23 | 2025-04-08 | Renagade Therapeutics Management Inc. | Constrained Lipids and Associated Utilization Processes |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| AU2023212857A1 (en) | 2022-01-27 | 2024-07-04 | BioNTech SE | Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods |
| JP2025510229A (ja) | 2022-03-25 | 2025-04-14 | セイル バイオメディシンズ インコーポレイテッド | 新規のイオン化脂質および脂質ナノ粒子ならびにそれらを使用する方法 |
| AU2023251104A1 (en) | 2022-04-07 | 2024-10-17 | Renagade Therapeutics Management Inc. | Cyclic lipids and lipid nanoparticles (lnp) for the delivery of nucleic acids or peptides for use in vaccinating against infectious agents |
| CN119562966A (zh) | 2022-05-13 | 2025-03-04 | 生物技术公司 | 靶向hiv的rna组合物 |
| JP2025522297A (ja) | 2022-05-25 | 2025-07-15 | ビオンテック エスエー | サルポックス抗原の送達のためのrna組成物及び関連する方法 |
| US20250375534A1 (en) | 2022-05-30 | 2025-12-11 | BioNTech SE | Complexes for delivery of nucleic acids |
| CN120239693A (zh) | 2022-08-31 | 2025-07-01 | 赛欧生物医药股份有限公司 | 新型可电离脂质和脂质纳米颗粒以及其使用方法 |
| IL319414A (en) | 2022-09-23 | 2025-05-01 | BioNTech SE | Compositions for delivering antigens at the liver level and related methods |
| WO2024063789A1 (en) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions for delivery of malaria antigens and related methods |
| WO2024064934A1 (en) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions for delivery of plasmodium csp antigens and related methods |
| WO2024063788A1 (en) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions for delivery of malaria antigens and related methods |
| EP4598954A1 (de) | 2022-10-06 | 2025-08-13 | BioNTech SE | Gegen claudin-18 gerichtete rna-zusammensetzungen.2 |
| WO2024074211A1 (en) | 2022-10-06 | 2024-04-11 | BioNTech SE | Rna compositions targeting claudin-18.2 |
| WO2024141955A1 (en) | 2022-12-28 | 2024-07-04 | BioNTech SE | Rna compositions targeting hiv |
| WO2024228044A1 (en) | 2023-05-03 | 2024-11-07 | BioNTech SE | Optimized csp variants and related methods |
| CN121038807A (zh) | 2023-05-03 | 2025-11-28 | 生物技术欧洲股份公司 | 优化的csp变体及相关方法 |
| WO2024229309A2 (en) | 2023-05-03 | 2024-11-07 | Manifold Biotechnologies, Inc. | Methodsand compositions for high-throughput protein delivery, screening, and detection |
| WO2025024324A1 (en) | 2023-07-21 | 2025-01-30 | BioNTech SE | Compositions for delivery of plasmodium antigens and related methods |
| WO2025024335A2 (en) | 2023-07-21 | 2025-01-30 | BioNTech SE | Compositions for delivery of plasmodium antigens and related methods |
| WO2025024337A1 (en) | 2023-07-24 | 2025-01-30 | BioNTech SE | Compositions for delivery of plasmodium antigens and related methods |
| WO2025027089A1 (en) | 2023-08-01 | 2025-02-06 | BioNTech SE | Ionizable thiolipids and uses thereof |
| WO2025026545A1 (en) | 2023-08-01 | 2025-02-06 | BioNTech SE | Ionizable thioplipids and uses thereof |
| WO2025027576A2 (en) | 2023-08-03 | 2025-02-06 | BioNTech SE | Rna compositions targeting hiv |
| WO2025030097A2 (en) | 2023-08-03 | 2025-02-06 | BioNTech SE | Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods |
| WO2025030154A1 (en) | 2023-08-03 | 2025-02-06 | The Trustees Of The University Of Pennsylvania | Pharmaceutical compositions for delivery of herpes simplex virus glycoprotein b antigens and related methods |
| WO2025027579A2 (en) | 2023-08-03 | 2025-02-06 | BioNTech SE | Rna compositions targeting hiv |
| WO2025054556A1 (en) | 2023-09-07 | 2025-03-13 | BioNTech SE | Rna compositions for delivery of mpox antigens and related methods |
| WO2025057088A1 (en) | 2023-09-11 | 2025-03-20 | BioNTech SE | Rna compositions for delivery of incretin agents |
| WO2025064850A1 (en) | 2023-09-22 | 2025-03-27 | BioNTech SE | Rna constructs with n-terminal degrons to enhance an immune response |
| WO2025081042A1 (en) | 2023-10-12 | 2025-04-17 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| KR20250071877A (ko) | 2023-11-15 | 2025-05-22 | 바이오엔테크 에스이 | Sars-cov-2 면역원성 조성물 |
| WO2025106754A1 (en) | 2023-11-15 | 2025-05-22 | BioNTech SE | Coronavirus vaccine |
| WO2025124711A1 (en) | 2023-12-13 | 2025-06-19 | BioNTech SE | Glycolipid compositions |
| WO2025133105A1 (en) | 2023-12-21 | 2025-06-26 | Biontech Delivery Technologies Gmbh | Compositions and methods |
| WO2025134066A1 (en) | 2023-12-21 | 2025-06-26 | Biontech Delivery Technologies Gmbh | Ionizable lipids |
| WO2025134062A2 (en) | 2023-12-21 | 2025-06-26 | Biontech Delivery Technologies Gmbh | Ionizable lipids |
| WO2025149492A1 (en) | 2024-01-08 | 2025-07-17 | BioNTech SE | Rna encoding an immune inhibitory il-1 family member |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| WO2025184508A1 (en) | 2024-03-01 | 2025-09-04 | Acuitas Therapeutics, Inc. | Materials and methods for encapsulating therapeutics in lipid nanoparticles |
| WO2025202937A1 (en) | 2024-03-26 | 2025-10-02 | BioNTech SE | Cancer vaccines |
| WO2025213131A1 (en) | 2024-04-05 | 2025-10-09 | BioNTech SE | Rna compositions for delivery of orthopox antigens and related methods |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| DK0452457T3 (da) | 1989-11-03 | 1998-03-02 | Univ Vanderbilt | Fremgangsmåde til in vivo fjernelse af funktionelle fremmede gener |
| US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| WO1993012240A1 (en) | 1991-12-17 | 1993-06-24 | The Regents Of The University Of California | Gene therapy for cystic fibrosis transmembrane conductance regulator activity (cftr) |
| EP0646178A1 (de) | 1992-06-04 | 1995-04-05 | The Regents Of The University Of California | Expression kassette mit im säugetier wirt funktionnellen regulator sequenzen |
| JPH09501936A (ja) * | 1993-08-26 | 1997-02-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物活性ペプチドをコードする裸のポリヌクレオチドを投与するための方法、組成物および装置 |
| US5631236A (en) * | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| CN1636594B (zh) | 1994-04-26 | 2012-08-29 | 儿童医学中心公司 | 血管生成抑制素和用于抑制血管生成的方法 |
| GB9415167D0 (en) | 1994-07-27 | 1994-09-14 | Springer Caroline J | Improvements relating to cancer therapy |
| GB9501052D0 (en) | 1995-01-19 | 1995-03-08 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US7517858B1 (en) * | 1995-06-07 | 2009-04-14 | The Regents Of The University Of California | Prodrugs of pharmaceuticals with improved bioavailability |
| US5705385A (en) | 1995-06-07 | 1998-01-06 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| CA2222328C (en) * | 1995-06-07 | 2012-01-10 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| GB9517001D0 (en) | 1995-08-18 | 1995-10-18 | Denny William | Enediyne compounds |
| CN1202932A (zh) | 1995-10-23 | 1998-12-23 | 儿童医学中心公司 | 治疗用抗血管生成的组合物和方法 |
| GB9523703D0 (en) | 1995-11-20 | 1996-01-24 | Wellcome Found | Enzyme prodrug thearapy |
| US6347397B1 (en) | 1999-03-29 | 2002-02-12 | International Business Machines Corporation | System, method, and program for providing an object-oriented install architecture |
| US8266598B2 (en) | 2008-05-05 | 2012-09-11 | Microsoft Corporation | Bounding resource consumption using abstract interpretation |
-
1999
- 1999-02-03 CA CA2321837A patent/CA2321837C/en not_active Expired - Lifetime
- 1999-02-03 WO PCT/CA1999/000090 patent/WO1999039741A2/en not_active Ceased
- 1999-02-03 WO PCT/CA1999/000089 patent/WO1999039740A2/en not_active Ceased
- 1999-02-03 AU AU24057/99A patent/AU749881B2/en not_active Expired
- 1999-02-03 JP JP2000530238A patent/JP2002502831A/ja active Pending
- 1999-02-03 EP EP99903557A patent/EP1053023B2/de not_active Expired - Lifetime
- 1999-02-03 AT AT99903557T patent/ATE366121T1/de not_active IP Right Cessation
- 1999-02-03 CA CA002319468A patent/CA2319468A1/en not_active Abandoned
- 1999-02-03 DE DE69936444T patent/DE69936444T3/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69936444D1 (de) | 2007-08-16 |
| AU749881B2 (en) | 2002-07-04 |
| EP1053023A2 (de) | 2000-11-22 |
| AU2405799A (en) | 1999-08-23 |
| CA2321837C (en) | 2011-08-16 |
| WO1999039741A2 (en) | 1999-08-12 |
| EP1053023B1 (de) | 2007-07-04 |
| WO1999039740A3 (en) | 1999-10-28 |
| WO1999039740A2 (en) | 1999-08-12 |
| WO1999039740A8 (en) | 1999-09-23 |
| DE69936444T2 (de) | 2008-03-20 |
| WO1999039740A9 (en) | 1999-11-25 |
| CA2319468A1 (en) | 1999-08-12 |
| WO1999039741A3 (en) | 1999-09-30 |
| JP2002502831A (ja) | 2002-01-29 |
| CA2321837A1 (en) | 1999-08-12 |
| EP1053023B2 (de) | 2011-03-30 |
| DE69936444T3 (de) | 2012-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |