ATE366121T1 - Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie - Google Patents

Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie

Info

Publication number
ATE366121T1
ATE366121T1 AT99903557T AT99903557T ATE366121T1 AT E366121 T1 ATE366121 T1 AT E366121T1 AT 99903557 T AT99903557 T AT 99903557T AT 99903557 T AT99903557 T AT 99903557T AT E366121 T1 ATE366121 T1 AT E366121T1
Authority
AT
Austria
Prior art keywords
serum
cancer therapy
systemic administration
lipid particles
stable plasmid
Prior art date
Application number
AT99903557T
Other languages
English (en)
Inventor
Ian Maclachlan
Roger Graham
Original Assignee
Protiva Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27535971&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE366121(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Protiva Biotherapeutics Inc filed Critical Protiva Biotherapeutics Inc
Application granted granted Critical
Publication of ATE366121T1 publication Critical patent/ATE366121T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT99903557T 1998-02-03 1999-02-03 Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie ATE366121T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7359898P 1998-02-03 1998-02-03
US8691798P 1998-05-27 1998-05-27
US10142998P 1998-09-22 1998-09-22
US11238498P 1998-12-14 1998-12-14
US24310299A 1999-02-02 1999-02-02

Publications (1)

Publication Number Publication Date
ATE366121T1 true ATE366121T1 (de) 2007-07-15

Family

ID=27535971

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99903557T ATE366121T1 (de) 1998-02-03 1999-02-03 Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie

Country Status (7)

Country Link
EP (1) EP1053023B2 (de)
JP (1) JP2002502831A (de)
AT (1) ATE366121T1 (de)
AU (1) AU749881B2 (de)
CA (2) CA2321837C (de)
DE (1) DE69936444T3 (de)
WO (2) WO1999039740A2 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1044021B1 (de) 1998-01-05 2009-09-23 The University of Washington Erhöhter transport unter benutzung membranzerstörender stoffe
EP1459761A4 (de) * 2001-06-08 2005-04-13 Fourth Military Medical Univ Pharmazeutisches set mit anti-human sperma-plasmaprotein einzelketten-antikörper/human-carboxypeptidase fusionsprotein und prodrug
WO2003049764A1 (en) 2001-12-12 2003-06-19 Fh Faulding & Co Limited Composition for viral preservation
AU2003239368A1 (en) 2002-05-06 2003-11-17 Board Of Regents, The University Of Texas System Targeting proteins to deliver therapeutic or diagnostic reagents
CA3033577A1 (en) 2008-11-10 2010-05-14 Arbutus Biopharma Corporation Novel lipids and compositions for the delivery of therapeutics
WO2018081480A1 (en) 2016-10-26 2018-05-03 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
EP3596112A2 (de) 2017-03-17 2020-01-22 Newcastle University Freisetzung eines adeno-assoziierten virusvektors eines fragments von mikrodystrophin zur behandlung von muskeldystrophie
WO2018191719A1 (en) 2017-04-13 2018-10-18 Acuitas Therapeutics, Inc. Lipid delivery of therapeutic agents to adipose tissue
WO2019089828A1 (en) 2017-10-31 2019-05-09 Acuitas Therapeutics, Inc. Lamellar lipid nanoparticles
JP7646362B2 (ja) 2018-06-18 2025-03-17 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル 筋ジストロフィーを治療するための筋肉特異的マイクロジストロフィンのアデノ随伴ウイルスベクターデリバリー
EP3852911B1 (de) 2018-09-21 2025-01-22 Acuitas Therapeutics, Inc. Systeme und verfahren zur herstellung von lipidnanopartikeln und liposomen
PH12022550363A1 (en) 2019-08-14 2023-02-27 Acuitas Therapeutics Inc Improved lipid nanoparticles for delivery of nucleic acids
WO2021198157A1 (en) 2020-03-30 2021-10-07 BioNTech SE Rna compositions targeting claudin-18.2
US20210393801A1 (en) 2020-06-15 2021-12-23 Research Institute At Nationwide Children's Hospital Adeno-Associated Virus Vector Delivery for Muscular Dystrophies
WO2025056938A1 (en) 2023-09-11 2025-03-20 BioNTech SE Rna compositions for delivery of incretin agents
EP4319803B1 (de) 2021-04-08 2025-11-26 Vaxthera SAS Mosaikproteinhaltige coronavirus-impstoff
WO2023023055A1 (en) 2021-08-16 2023-02-23 Renagade Therapeutics Management Inc. Compositions and methods for optimizing tropism of delivery systems for rna
EP4402123A1 (de) 2021-09-14 2024-07-24 Renagade Therapeutics Management Inc. Cyclische lipide und verfahren zur verwendung davon
WO2023044343A1 (en) 2021-09-14 2023-03-23 Renagade Therapeutics Management Inc. Acyclic lipids and methods of use thereof
WO2023081756A1 (en) 2021-11-03 2023-05-11 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Precise genome editing using retrons
EP4433450A1 (de) 2021-11-16 2024-09-25 Sail Biomedicines, Inc. Neue ionisierbare lipide und lipidnanopartikel und verfahren zur verwendung davon
WO2023091787A1 (en) 2021-11-22 2023-05-25 Senda Biosciences, Inc. Novel ionizable lipids and lipid nanoparticles and methods of using the same
EP4452928A1 (de) 2021-12-23 2024-10-30 Renagade Therapeutics Management Inc. Eingeschränkte lipide und verfahren zur verwendung davon
WO2023141602A2 (en) 2022-01-21 2023-07-27 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
EP4469063A1 (de) 2022-01-27 2024-12-04 BioNTech SE Pharmazeutische zusammensetzungen zur abgabe von herpes-simplex-virus-antigenen und zugehörige verfahren
JP2025510229A (ja) 2022-03-25 2025-04-14 セイル バイオメディシンズ インコーポレイテッド 新規のイオン化脂質および脂質ナノ粒子ならびにそれらを使用する方法
AU2023251104A1 (en) 2022-04-07 2024-10-17 Renagade Therapeutics Management Inc. Cyclic lipids and lipid nanoparticles (lnp) for the delivery of nucleic acids or peptides for use in vaccinating against infectious agents
CN119562966A (zh) 2022-05-13 2025-03-04 生物技术公司 靶向hiv的rna组合物
EP4531905A1 (de) 2022-05-25 2025-04-09 BioNTech SE Rna-zusammensetzungen zur abgabe von afepox-antigenen und zugehörige verfahren
CN119562807A (zh) 2022-05-30 2025-03-04 生物技术公司 用于递送核酸的复合物
WO2024049979A2 (en) 2022-08-31 2024-03-07 Senda Biosciences, Inc. Novel ionizable lipids and lipid nanoparticles and methods of using the same
WO2024063788A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of malaria antigens and related methods
AU2023347387A1 (en) 2022-09-23 2025-04-10 BioNTech SE Compositions for delivery of liver stage antigens and related methods
AU2023347390A1 (en) 2022-09-23 2025-04-10 BioNTech SE Compositions for delivery of plasmodium csp antigens and related methods
WO2024063789A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of malaria antigens and related methods
WO2024074211A1 (en) 2022-10-06 2024-04-11 BioNTech SE Rna compositions targeting claudin-18.2
AU2023357320A1 (en) 2022-10-06 2025-04-17 BioNTech SE Rna compositions targeting claudin-18.2
WO2024141955A1 (en) 2022-12-28 2024-07-04 BioNTech SE Rna compositions targeting hiv
WO2024228044A1 (en) 2023-05-03 2024-11-07 BioNTech SE Optimized csp variants and related methods
AU2024266138A1 (en) 2023-05-03 2025-11-13 Manifold Biotechnologies, Inc. Methods and compositions for high-throughput protein delivery, screening, and detection
AU2024265158A1 (en) 2023-05-03 2025-11-06 BioNTech SE Optimized csp variants and related methods
AU2024301077A1 (en) 2023-07-21 2026-01-08 BioNTech SE Compositions for delivery of plasmodium antigens and related methods
WO2025024324A1 (en) 2023-07-21 2025-01-30 BioNTech SE Compositions for delivery of plasmodium antigens and related methods
AU2024299365A1 (en) 2023-07-24 2026-01-08 BioNTech SE Compositions for delivery of plasmodium antigens and related methods
WO2025026545A1 (en) 2023-08-01 2025-02-06 BioNTech SE Ionizable thioplipids and uses thereof
AU2024315222A1 (en) 2023-08-01 2026-02-05 BioNTech SE Ionizable thiolipids and uses thereof
WO2025027576A2 (en) 2023-08-03 2025-02-06 BioNTech SE Rna compositions targeting hiv
WO2025027579A2 (en) 2023-08-03 2025-02-06 BioNTech SE Rna compositions targeting hiv
WO2025030154A1 (en) 2023-08-03 2025-02-06 The Trustees Of The University Of Pennsylvania Pharmaceutical compositions for delivery of herpes simplex virus glycoprotein b antigens and related methods
WO2025030097A2 (en) 2023-08-03 2025-02-06 BioNTech SE Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods
WO2025054556A1 (en) 2023-09-07 2025-03-13 BioNTech SE Rna compositions for delivery of mpox antigens and related methods
WO2025057088A1 (en) 2023-09-11 2025-03-20 BioNTech SE Rna compositions for delivery of incretin agents
WO2025064850A1 (en) 2023-09-22 2025-03-27 BioNTech SE Rna constructs with n-terminal degrons to enhance an immune response
WO2025081042A1 (en) 2023-10-12 2025-04-17 Renagade Therapeutics Management Inc. Nickase-retron template-based precision editing system and methods of use
TW202539697A (zh) 2023-11-15 2025-10-16 德商拜恩技術股份公司 冠狀病毒疫苗
GB202416789D0 (en) 2023-11-15 2025-01-01 BioNTech SE SARS-COV-2 immunogenic compositions
WO2025124711A1 (en) 2023-12-13 2025-06-19 BioNTech SE Glycolipid compositions
WO2025134062A2 (en) 2023-12-21 2025-06-26 Biontech Delivery Technologies Gmbh Ionizable lipids
WO2025133105A1 (en) 2023-12-21 2025-06-26 Biontech Delivery Technologies Gmbh Compositions and methods
WO2025134066A1 (en) 2023-12-21 2025-06-26 Biontech Delivery Technologies Gmbh Ionizable lipids
WO2025149492A1 (en) 2024-01-08 2025-07-17 BioNTech SE Rna encoding an immune inhibitory il-1 family member
WO2025155753A2 (en) 2024-01-17 2025-07-24 Renagade Therapeutics Management Inc. Improved gene editing system, guides, and methods
WO2025184508A1 (en) 2024-03-01 2025-09-04 Acuitas Therapeutics, Inc. Materials and methods for encapsulating therapeutics in lipid nanoparticles
WO2025202937A1 (en) 2024-03-26 2025-10-02 BioNTech SE Cancer vaccines
WO2025213131A1 (en) 2024-04-05 2025-10-09 BioNTech SE Rna compositions for delivery of orthopox antigens and related methods
WO2025262460A1 (en) 2024-06-21 2025-12-26 BioNTech SE Lipid compositions for nucleic acid delivery
WO2026015882A1 (en) 2024-07-12 2026-01-15 BioNTech SE Hsv antigen fragments and related methods
WO2026018213A1 (en) 2024-07-18 2026-01-22 Vaxthera Sas A broadly protective mosaic vaccine against highly pathogenic avian influenza viruses
WO2026020171A2 (en) 2024-07-19 2026-01-22 Aera Therapeutics, Inc. Chimeric antigen receptor constructs

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5676954A (en) 1989-11-03 1997-10-14 Vanderbilt University Method of in vivo delivery of functioning foreign genes
AU625013B2 (en) * 1989-11-03 1992-06-25 Vanderbilt University Method of in vivo delivery of functioning foreign genes
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
JPH07502510A (ja) 1991-12-17 1995-03-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 嚢胞性繊維症膜貫通型コンダクタンス調節活性（ｃｆｔｒ）のための遺伝子治療
JP3285355B2 (ja) 1992-06-04 2002-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ｉｎｖｉｖｏ遺伝子治療のための方法及び組成物
US5631236A (en) * 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
CA2169635C (en) * 1993-08-26 2002-11-12 Dennis A. Carson Method, compositions and devices for administration of naked polynucleotides which encode biologically active peptides
US5885795A (en) 1994-04-26 1999-03-23 The Children's Medical Center Corporation Methods of expressing angiostatic protein
GB9415167D0 (en) 1994-07-27 1994-09-14 Springer Caroline J Improvements relating to cancer therapy
GB9501052D0 (en) 1995-01-19 1995-03-08 Cancer Res Campaign Tech Improvements relating to prodrugs
US5705385A (en) 1995-06-07 1998-01-06 Inex Pharmaceuticals Corporation Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US7517858B1 (en) * 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
JP4335310B2 (ja) 1995-06-07 2009-09-30 ザ ユニバーシティ オブ ブリティッシュ コロンビア 疎水性脂質−核酸複合中間体を通して調製される脂質−核酸粒子、及び遺伝子移送のための使用
GB9517001D0 (en) 1995-08-18 1995-10-18 Denny William Enediyne compounds
ES2206602T3 (es) 1995-10-23 2004-05-16 The Children's Medical Center Corporation Compuestos y metodos terapeuticos inhibidores de angiogenesis.
GB9523703D0 (en) 1995-11-20 1996-01-24 Wellcome Found Enzyme prodrug thearapy
US6347397B1 (en) 1999-03-29 2002-02-12 International Business Machines Corporation System, method, and program for providing an object-oriented install architecture
US8266598B2 (en) 2008-05-05 2012-09-11 Microsoft Corporation Bounding resource consumption using abstract interpretation

Also Published As

Publication number Publication date
JP2002502831A (ja) 2002-01-29
AU2405799A (en) 1999-08-23
WO1999039740A3 (en) 1999-10-28
EP1053023A2 (de) 2000-11-22
WO1999039741A3 (en) 1999-09-30
WO1999039740A2 (en) 1999-08-12
EP1053023B2 (de) 2011-03-30
WO1999039740A8 (en) 1999-09-23
CA2321837C (en) 2011-08-16
WO1999039740A9 (en) 1999-11-25
AU749881B2 (en) 2002-07-04
CA2319468A1 (en) 1999-08-12
CA2321837A1 (en) 1999-08-12
EP1053023B1 (de) 2007-07-04
DE69936444T3 (de) 2012-05-10
DE69936444T2 (de) 2008-03-20
DE69936444D1 (de) 2007-08-16
WO1999039741A2 (en) 1999-08-12

Similar Documents

Publication Publication Date Title
DE69936444D1 (de) Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie
ATE196844T1 (de) Zusammensetzungen die konjugate von cis- docosahexaenoic-säure und taxotere enthalten
DE69708100D1 (de) Konjugate von cis-docosahexaensäure und paclitaxel
AU2592600A (en) Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
MX9709915A (es) Heterociclos de peptidilo y composiciones que los contienen, utiles en el tratamiento de trastornos relacionados con trombina, y uso de los mismos.
TR199902956T2 (xx) Pozisyonlar 5 ve 6 i�inde de�i�tirilmi� olan GnRH antagonistleri.
NO985574L (no) FremgangsmÕter og preparater anvendelige for inhibering av angiogenese
BG104599A (en) Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas
ATE233735T1 (de) Neue phenanthridine
IL134445A0 (en) A method of preventing or treating estrogen-dependent diseases and disorders
ID21529A (id) Metode dan komposisi untuk pengobatan dan pencegahan tumor, gangguan yang berhubungan dengan tumor dan kakeksia
SI0889886T1 (en) Novel phenanthridines substituted in the 6 position
TW362971B (en) Pharmaceutical composition and kit for treating cancer by conjunctive therapy with 2'-halomethylidene derivatives and a S-phase or M-phase specific anti
IL141686A0 (en) Methods of treating hypertension and compositions for use therein
ATE239509T1 (de) Konjugate zur behandlung von prostatakrebs
MXPA04003674A (es) Uso mejorado de compuesto antitumoral en terapia de cancer.
ATE241993T1 (de) Zubereitungen zur tumorbehandlung enthaltend hai- knorpelextrakte und antineoplastische mittel
IL146125A0 (en) Novel quinones as disease therapies
HUP0004326A3 (en) Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
CA2259960A1 (en) Down-regulation of dna repair to enhance sensitivity to p53-mediated suppression
BG103832A (en) Leptin as tumour cells proliferation inhibitor
EP0944389A4 (de) Gereinigte zubereitungen von 10-propargyl-10-deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung
IL141550A0 (en) Methods and compositions for the prevention or treatment of cancer
HUP0302913A3 (en) Methods of inducing cancer cell death and tumor regression and preparation of pharmaceutical compositions suitable for treating the same
DE69633178D1 (de) Eisenverbindungen, zusammensetzungen, herstellungsverfahren und verwendungen davon

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties