ES2183883T3 - Compuestos de imidazolilo sustituidos en 1,2 para el tratamiento de la inflamacion. - Google Patents
Compuestos de imidazolilo sustituidos en 1,2 para el tratamiento de la inflamacion.Info
- Publication number
- ES2183883T3 ES2183883T3 ES95928164T ES95928164T ES2183883T3 ES 2183883 T3 ES2183883 T3 ES 2183883T3 ES 95928164 T ES95928164 T ES 95928164T ES 95928164 T ES95928164 T ES 95928164T ES 2183883 T3 ES2183883 T3 ES 2183883T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- sup
- halo
- radicals
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010061218 Inflammation Diseases 0.000 title abstract 2
- 230000004054 inflammatory process Effects 0.000 title abstract 2
- -1 cycloalkylthioalkyl Chemical group 0.000 abstract 4
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 241000243320 Hydrozoa Species 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004689 alkyl amino carbonyl alkyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000005164 aryl thioalkyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 abstract 1
- 125000005366 cycloalkylthio group Chemical group 0.000 abstract 1
- 125000004692 haloalkylcarbonyl group Chemical group 0.000 abstract 1
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000005368 heteroarylthio group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCRIBE UNA CLASE DE COMPUESTOS DE IMIDAZOLILO PARA USO EN EL TRATAMIENTO DE INFLAMACION. SE DEFINEN COMPUESTOS DE PARTICULAR INTERES POR LA FORMULA (II), EN DONDE R{SUP,3} ES UN RADICAL SELECCIONADO DE HIBRIDO, ALQUILO, HALOALQUILO, ARALQUILO, HETEROCICLOALQUILO, ACILO, CIANO, ALCOXI, ALQUILTIO, ALQUILTIOALQUILTIO, ALQUILSULFONILO, CICLOALQUILOXIDO, CICLALQUILOXIALQUILO, CICLOALQUILTIO, CICLOALQUILTIOALQUILO, CICLOALQUILSULFONILO, CIANOALQUILO, CICLOALQUILSULFONILALQUILO, HALOALQUILSULFONILO, ACIDOALQUILO, ARILSUFONILO, HALO, HIDROXIALQUILO, ALCOXIALQUILO, ARILTIO, ALQUILCARBONILO, ARILCARBONILO, ARALQUILCARBONILO, ARILOXI, HETEROCICLOALQUILCARBONILO, ALQUILAMINOALQUILO, NARILAMINOALQUILO, N-ALQUILO-N-ARILAMINOALQUILO, CARBOXIALQUILO, ALCOXICARBONILALQUILO, ALCOXICARBONILO, HALOALQUILCARBONILO, AMINOCARBONILO, ALQUILAMINOCARBONILALQUILO, ARALQUILTIO, HETEROARILALCOXIALQUILO, HETEROARILOXIALQUILO, ARALCOXI, HETEROARILTIOALQUILO, HETEROARALCOXI, HETEROARALQUILTIO, HETEROARILALQUILTIOALQUILO, HETEROARILOXI, HETEROARILTIO, ARILTIOALQUILO, ARILOXIALQUILO, ARALQUILTIOALQUILO, ARALCOXIALQUILO, ARILO Y HETEROARILO, EN DONDE LOS RADICALES DE ARILO Y HETEROARILO SON OPCIONALMENTE SUSTITUIDOS EN UNA POSICION SUSTITUIBLE CON UNO O MAS RADICALES SELECCIONADOS DE HALO, ALQUILTIO, ALQUILSULFINILO, ALQUILO, CIANO, HALOALQUILO, HIDROXILO, ALCOXI, HIDROXIALQUILO Y HALOALCOXI; EN DONDE R{SUP,7} ES UN RADICAL SELECCIONADO DE ALQUILO Y AMINO; Y EN DONDE R{SUP,8} ES UNO O MAS RADICALES SELECCIONADOS DE HIDRIDO, HALO, ALQUILO, HALOALQUILO, ALCOXI, AMINO, HALOALCOXI, CIANO, CARBOXILO, HIDROXILO, HIDROXIALQUILO, ALCOXIALQUILO, ALQUILAMINA, NITRO Y ALQUILTIO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28239594A | 1994-07-28 | 1994-07-28 | |
US08/464,154 US5616601A (en) | 1994-07-28 | 1995-06-05 | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2183883T3 true ES2183883T3 (es) | 2003-04-01 |
Family
ID=26961423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95928164T Expired - Lifetime ES2183883T3 (es) | 1994-07-28 | 1995-07-27 | Compuestos de imidazolilo sustituidos en 1,2 para el tratamiento de la inflamacion. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5616601A (es) |
EP (1) | EP0772600B1 (es) |
JP (1) | JP3930560B2 (es) |
AT (1) | ATE224374T1 (es) |
AU (1) | AU3202595A (es) |
CA (1) | CA2195845A1 (es) |
DE (1) | DE69528273T2 (es) |
DK (1) | DK0772600T3 (es) |
ES (1) | ES2183883T3 (es) |
PT (1) | PT772600E (es) |
WO (1) | WO1996003388A1 (es) |
Families Citing this family (148)
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DE69635048T2 (de) * | 1995-06-12 | 2006-02-16 | G.D. Searle & Co. | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
US5700816A (en) * | 1995-06-12 | 1997-12-23 | Isakson; Peter C. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor |
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AU767993C (en) * | 1996-01-26 | 2004-08-05 | G.D. Searle & Co. | Heterocyclo-substituted imidazoles for the treatment of inflammation |
DK0880504T3 (da) * | 1996-01-26 | 2003-07-21 | Searle & Co | Heterocyclosubstituerede imidazoler til behandling af inflammation |
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- 1995-07-27 CA CA002195845A patent/CA2195845A1/en not_active Abandoned
- 1995-07-27 DE DE69528273T patent/DE69528273T2/de not_active Expired - Fee Related
- 1995-07-27 WO PCT/US1995/009506 patent/WO1996003388A1/en active IP Right Grant
- 1995-07-27 EP EP95928164A patent/EP0772600B1/en not_active Expired - Lifetime
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- 1995-07-27 AT AT95928164T patent/ATE224374T1/de not_active IP Right Cessation
- 1995-07-27 PT PT95928164T patent/PT772600E/pt unknown
- 1995-07-27 DK DK95928164T patent/DK0772600T3/da active
- 1995-07-27 JP JP50597296A patent/JP3930560B2/ja not_active Expired - Fee Related
- 1995-07-27 AU AU32025/95A patent/AU3202595A/en not_active Abandoned
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EP0772600B1 (en) | 2002-09-18 |
EP0772600A1 (en) | 1997-05-14 |
DE69528273T2 (de) | 2004-02-26 |
JP3930560B2 (ja) | 2007-06-13 |
ATE224374T1 (de) | 2002-10-15 |
CA2195845A1 (en) | 1996-02-08 |
PT772600E (pt) | 2003-01-31 |
US5616601A (en) | 1997-04-01 |
AU3202595A (en) | 1996-02-22 |
WO1996003388A1 (en) | 1996-02-08 |
DE69528273D1 (de) | 2002-10-24 |
JPH10503211A (ja) | 1998-03-24 |
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