MX9303594A - Oximas piridino, pirrolidino y azepino substituidas utiles como agentes antiateroscleroticos y antihipercolesterolemicos. - Google Patents

Oximas piridino, pirrolidino y azepino substituidas utiles como agentes antiateroscleroticos y antihipercolesterolemicos.

Info

Publication number
MX9303594A
MX9303594A MX9303594A MX9303594A MX9303594A MX 9303594 A MX9303594 A MX 9303594A MX 9303594 A MX9303594 A MX 9303594A MX 9303594 A MX9303594 A MX 9303594A MX 9303594 A MX9303594 A MX 9303594A
Authority
MX
Mexico
Prior art keywords
oximas
pirrolidino
piridino
azepino
atherosclerotic
Prior art date
Application number
MX9303594A
Other languages
English (en)
Inventor
Scott D Larsen
Charles H Spilman
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX9303594A publication Critical patent/MX9303594A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Abstract

Está invención se relaciona con oximas imidazopiridino, pirazolpiridino, pirazolpirrolidino y pirazolazepino sustituidas que son útiles para el tratamiento de la aterosclerosis e hipercolesterolemia.
MX9303594A 1992-06-17 1993-06-16 Oximas piridino, pirrolidino y azepino substituidas utiles como agentes antiateroscleroticos y antihipercolesterolemicos. MX9303594A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90022992A 1992-06-17 1992-06-17

Publications (1)

Publication Number Publication Date
MX9303594A true MX9303594A (es) 1994-01-31

Family

ID=25412199

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9303594A MX9303594A (es) 1992-06-17 1993-06-16 Oximas piridino, pirrolidino y azepino substituidas utiles como agentes antiateroscleroticos y antihipercolesterolemicos.

Country Status (13)

Country Link
US (3) US5565468A (es)
EP (1) EP0649425B1 (es)
JP (1) JPH07507796A (es)
CN (1) CN1081678A (es)
AT (1) ATE177426T1 (es)
AU (1) AU4293393A (es)
DE (1) DE69323883T2 (es)
DK (1) DK0649425T3 (es)
ES (1) ES2130269T3 (es)
GR (1) GR3029946T3 (es)
IL (1) IL105693A0 (es)
MX (1) MX9303594A (es)
WO (1) WO1993025553A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
KR100876622B1 (ko) * 2001-04-27 2008-12-31 에자이 알앤드디 매니지먼트 가부시키가이샤 피라졸로[1,5-ａ]피리딘 화합물 및 그 의약
CN1951939A (zh) * 2001-05-24 2007-04-25 伊莱利利公司 作为药物的新的吡唑衍生物
US7176216B2 (en) * 2002-10-22 2007-02-13 Eisai Co., Ltd. 7-phenylpyrazolopyridine compounds
ATE426600T1 (de) * 2002-10-22 2009-04-15 Eisai R&D Man Co Ltd 7-phenylpyrazolopyridinverbindungen
WO2007008529A2 (en) * 2005-07-08 2007-01-18 Kalypsys, Inc Celullar cholesterol absorption modifiers
US7501438B2 (en) 2006-07-07 2009-03-10 Forest Laboratories Holdings Limited Pyridoimidazole derivatives
EP2176260A1 (en) * 2007-07-11 2010-04-21 Auckland Uniservices Limited Pyrazolo[1,5-a]pyridines and their use in cancer therapy
ES2396126T3 (es) * 2008-04-15 2013-02-19 Eisai R&D Management Co., Ltd. Compuesto de 3-fenilpirazol[5,1-b]tiazol
WO2011043387A1 (ja) * 2009-10-08 2011-04-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロオキサゾール化合物
AR078521A1 (es) * 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
CA2939082C (en) 2014-02-13 2022-06-07 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
ES2672797T3 (es) 2014-02-13 2018-06-18 Incyte Corporation Ciclopropilaminas como inhibidores de LSD1
ME03580B (me) 2014-02-13 2020-07-20 Incyte Corp Ciklopropilamini kao lsd1 inhibitori
CN103980281B (zh) * 2014-05-27 2016-06-08 天津市斯芬克司药物研发有限公司 一种咪唑吡嗪化合物及其制备方法
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TWI714567B (zh) 2015-04-03 2021-01-01 美商英塞特公司 作為lsd1抑制劑之雜環化合物
CR20180152A (es) 2015-08-12 2018-08-09 Incyte Corp Sales de un inhibidor de lsd1
MX2018012901A (es) 2016-04-22 2019-06-06 Incyte Corp Formulaciones de inhibidor de demetilasa 1 especifica para lisina (lsd1).
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1600969A (en) * 1977-01-07 1981-10-21 Acf Chemiefarma Nv Heterocyclic compounds
US4352804A (en) * 1978-07-25 1982-10-05 Acf Chemiefarma Nv Oxime ethers, their preparation and pharmaceutical compositions containing them
US4925849A (en) * 1987-06-15 1990-05-15 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutically useful pyrazolopyridines

Also Published As

Publication number Publication date
US5565468A (en) 1996-10-15
CN1081678A (zh) 1994-02-09
JPH07507796A (ja) 1995-08-31
WO1993025553A1 (en) 1993-12-23
ATE177426T1 (de) 1999-03-15
DE69323883D1 (de) 1999-04-15
IL105693A0 (en) 1993-09-22
US5523318A (en) 1996-06-04
EP0649425B1 (en) 1999-03-10
US5597816A (en) 1997-01-28
DE69323883T2 (de) 1999-07-22
EP0649425A1 (en) 1995-04-26
DK0649425T3 (da) 1999-09-27
GR3029946T3 (en) 1999-07-30
ES2130269T3 (es) 1999-07-01
AU4293393A (en) 1994-01-04

Similar Documents

Publication Publication Date Title
MX9303594A (es) Oximas piridino, pirrolidino y azepino substituidas utiles como agentes antiateroscleroticos y antihipercolesterolemicos.
BG101748A (en) Heterocyclic condensated pyridines
NO930615D0 (no) Hypoglykemiske hydroksyurinstoffderivater
BG99261A (en) Steroid glycosides for the treatment of hyperchlesterolemia
CA2245142A1 (en) New phenanthridines
MX9700557A (es) Dihidrobenzofuranos.
FR2694497B1 (fr) Desodorisant de table.
AU2291097A (en) Novel phenanthridines substituted in the 6 position
ATE126215T1 (de) Anti-entzündende 4-aminophenol-derivate.
IT1285770B1 (it) Composti corticoidei
YU194691A (sh) Benzodiazepinoni
DE69528983T2 (de) Indolalkaloide als antientzündliche wirkstoffe
DK0464845T3 (da) Pyrrolderivater
DK0696278T3 (da) Herbicidtvirkende substituerede 1-phenyl- eller 1-pyridinylbenzotriazoler
DE59700064D1 (de) Homogenisierung von Dispersionen
SE9402241L (sv) Inhibitor
DE69111851T2 (de) Stabile Dispersionen von Benzotriazol-Ultraviolett-absorbierenden Agenzien.
FI961339A (fi) Triaryylieteenijohdannaiset käytettäväksi hoidossa
TR199700435A2 (xx) Pestisit florolefin bile�imlerinin haz�rlanmas� i�in i�lem ve ara bile�imler.
MY106167A (en) 6-substituted purinyl piperazine derivatives.
MX9800053A (es) Herbicidas de cis-2,3-expoxicicloalcanol bencilado.
DE69425061D1 (de) Verwendung von einer suspension auf der basis von sucralfatgel als antazidum
RU1809521C (ru) Генератор плазмы
ATA81694A (de) Ortsveränderbare von wasser getragene veranstaltungseinrichtung
FI904885A (fi) Registreringsanordning foer idrottsprestationer, speciellt foer haendelsefoerloppet i lagspel.