DK0649425T3 - Pyridino-, pyrrolidino- og azepino-substituerede oximer, som er anvendelige som anti-atherosklerose- og anti-hypercholester - Google Patents

Pyridino-, pyrrolidino- og azepino-substituerede oximer, som er anvendelige som anti-atherosklerose- og anti-hypercholester

Info

Publication number
DK0649425T3
DK0649425T3 DK93912362T DK93912362T DK0649425T3 DK 0649425 T3 DK0649425 T3 DK 0649425T3 DK 93912362 T DK93912362 T DK 93912362T DK 93912362 T DK93912362 T DK 93912362T DK 0649425 T3 DK0649425 T3 DK 0649425T3
Authority
DK
Denmark
Prior art keywords
atherosclerosis
substituted
oxymers
hypercholester
azepino
Prior art date
Application number
DK93912362T
Other languages
English (en)
Inventor
Charles H Spilman
Scott D Larsen
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0649425T3 publication Critical patent/DK0649425T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK93912362T 1992-06-17 1993-05-05 Pyridino-, pyrrolidino- og azepino-substituerede oximer, som er anvendelige som anti-atherosklerose- og anti-hypercholester DK0649425T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90022992A 1992-06-17 1992-06-17
PCT/US1993/004059 WO1993025553A1 (en) 1992-06-17 1993-05-05 Pyridino-, pyrrolidino- and azepino-substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents

Publications (1)

Publication Number Publication Date
DK0649425T3 true DK0649425T3 (da) 1999-09-27

Family

ID=25412199

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912362T DK0649425T3 (da) 1992-06-17 1993-05-05 Pyridino-, pyrrolidino- og azepino-substituerede oximer, som er anvendelige som anti-atherosklerose- og anti-hypercholester

Country Status (13)

Country Link
US (3) US5565468A (da)
EP (1) EP0649425B1 (da)
JP (1) JPH07507796A (da)
CN (1) CN1081678A (da)
AT (1) ATE177426T1 (da)
AU (1) AU4293393A (da)
DE (1) DE69323883T2 (da)
DK (1) DK0649425T3 (da)
ES (1) ES2130269T3 (da)
GR (1) GR3029946T3 (da)
IL (1) IL105693A0 (da)
MX (1) MX9303594A (da)
WO (1) WO1993025553A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
CZ301491B6 (cs) * 2001-04-27 2010-03-24 Eisai R&D Management Co., Ltd. Pyrazolo[1,5-a]pyridiny a léciva s jejich obsahem
SI1397364T1 (sl) * 2001-05-24 2007-12-31 Lilly Co Eli Novi pirolni derivati kot farmacevtske uäśinkovine
NZ538860A (en) * 2002-10-22 2006-07-28 Eisai Co Ltd 7-Phenyl pyrazolopyridine compounds
US7176216B2 (en) * 2002-10-22 2007-02-13 Eisai Co., Ltd. 7-phenylpyrazolopyridine compounds
WO2007008529A2 (en) * 2005-07-08 2007-01-18 Kalypsys, Inc Celullar cholesterol absorption modifiers
US7501438B2 (en) 2006-07-07 2009-03-10 Forest Laboratories Holdings Limited Pyridoimidazole derivatives
AU2008273050A1 (en) * 2007-07-11 2009-01-15 Auckland Uniservices Limited Pyrazolo[1,5-a]pyridines and their use in cancer therapy
SI2266990T1 (sl) * 2008-04-15 2013-01-31 Eisai R&D Management Co. Ltd. Spojina 3-fenilpirazolo(5,1-b)tiazola
AR078521A1 (es) * 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
EP2487177A1 (en) * 2009-10-08 2012-08-15 Eisai R&D Management Co., Ltd. Pyrazoloxazole compound
WO2015123408A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
TWI720451B (zh) 2014-02-13 2021-03-01 美商英塞特控股公司 作為lsd1抑制劑之環丙胺
ES2760261T3 (es) 2014-02-13 2020-05-13 Incyte Corp Ciclopropilaminas como inhibidores de LSD1
CN103980281B (zh) * 2014-05-27 2016-06-08 天津市斯芬克司药物研发有限公司 一种咪唑吡嗪化合物及其制备方法
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
SG11201708047UA (en) 2015-04-03 2017-10-30 Incyte Corp Heterocyclic compounds as lsd1 inhibitors
WO2017027678A1 (en) 2015-08-12 2017-02-16 Incyte Corporation Salts of an lsd1 inhibitor
TWI833686B (zh) 2016-04-22 2024-03-01 美商英塞特公司 Lsd1 抑制劑之調配物
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1600969A (en) * 1977-01-07 1981-10-21 Acf Chemiefarma Nv Heterocyclic compounds
US4352804A (en) * 1978-07-25 1982-10-05 Acf Chemiefarma Nv Oxime ethers, their preparation and pharmaceutical compositions containing them
US4925849A (en) * 1987-06-15 1990-05-15 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutically useful pyrazolopyridines

Also Published As

Publication number Publication date
IL105693A0 (en) 1993-09-22
JPH07507796A (ja) 1995-08-31
MX9303594A (es) 1994-01-31
US5597816A (en) 1997-01-28
GR3029946T3 (en) 1999-07-30
DE69323883T2 (de) 1999-07-22
CN1081678A (zh) 1994-02-09
WO1993025553A1 (en) 1993-12-23
US5523318A (en) 1996-06-04
US5565468A (en) 1996-10-15
AU4293393A (en) 1994-01-04
ATE177426T1 (de) 1999-03-15
ES2130269T3 (es) 1999-07-01
EP0649425B1 (en) 1999-03-10
DE69323883D1 (de) 1999-04-15
EP0649425A1 (en) 1995-04-26

Similar Documents

Publication Publication Date Title
DK0649425T3 (da) Pyridino-, pyrrolidino- og azepino-substituerede oximer, som er anvendelige som anti-atherosklerose- og anti-hypercholester
MX9302214A (es) Derivados de taxol y proceso para su preparacion
IL126038A0 (en) Novel benzothiepines and derivatives thereof and pharmaceutical compositions comprising them
IS4185A (is) Hliðstæð aðferð til framleiðslu fenýlsúlfonylamino-pýrimidines afleiða
ATE167476T1 (de) Substituierte 2-phenyl-3-methocypropensäurenester als fungizide mittel.
AU9125191A (en) Retroviral protease inhibitors
PT688789E (pt) Processo de lipopeptideos processo para a sua preparacao e sua utilizacao
GB9003939D0 (en) Sulphatase inhibitors
DK0425650T3 (da) Antiinflammatoriske 4-aminophenolderivater
BG104117A (en) Universally applicable blood plasma
ES2072784T3 (es) Benzo- y piridopiridonas substituidas con sulfonilbencilo.
MX9606300A (es) Arilalquiltioalquiltiopiridinas substituidas para combatir bacterias helicobactas.
ES2090177T3 (es) Derivados de pirrol.
BG100248A (en) Squalene synthetase inhibitors
TR199701298T1 (xx) Tetralinler.
KR950700988A (ko) 미생물, 이들의 제조방법 및 이들의 사용(Micro-organisms, preparation method therefor and uses thereof)
SE9402241D0 (sv) Inhibitor
AU5994696A (en) Modified alpha-d-glcp-(1-2)-alpha-d-glcp-(1-3)-alpha-d-glcp- analogues
MX9606295A (es) Tiopiridinas para el combate de bacterias heliobacter.
PL312966A1 (en) Derivatives of thiocarbamoil
MX9800053A (es) Herbicidas de cis-2,3-expoxicicloalcanol bencilado.
RU1809521C (ru) Генератор плазмы
FI963783A0 (fi) Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä aminoasetyylimerkaptojohdannaisia
IT1255470B (it) Composti attivi come inibitori dell'enzima hmg-coa reduttasi
MX9207565A (es) Hidroxilacion.