DK0649425T3 - Pyridino-, pyrrolidino- og azepino-substituerede oximer, som er anvendelige som anti-atherosklerose- og anti-hypercholester - Google Patents
Pyridino-, pyrrolidino- og azepino-substituerede oximer, som er anvendelige som anti-atherosklerose- og anti-hypercholesterInfo
- Publication number
- DK0649425T3 DK0649425T3 DK93912362T DK93912362T DK0649425T3 DK 0649425 T3 DK0649425 T3 DK 0649425T3 DK 93912362 T DK93912362 T DK 93912362T DK 93912362 T DK93912362 T DK 93912362T DK 0649425 T3 DK0649425 T3 DK 0649425T3
- Authority
- DK
- Denmark
- Prior art keywords
- atherosclerosis
- substituted
- oxymers
- hypercholester
- azepino
- Prior art date
Links
- 230000000879 anti-atherosclerotic effect Effects 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90022992A | 1992-06-17 | 1992-06-17 | |
PCT/US1993/004059 WO1993025553A1 (en) | 1992-06-17 | 1993-05-05 | Pyridino-, pyrrolidino- and azepino-substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0649425T3 true DK0649425T3 (da) | 1999-09-27 |
Family
ID=25412199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93912362T DK0649425T3 (da) | 1992-06-17 | 1993-05-05 | Pyridino-, pyrrolidino- og azepino-substituerede oximer, som er anvendelige som anti-atherosklerose- og anti-hypercholester |
Country Status (13)
Country | Link |
---|---|
US (3) | US5565468A (da) |
EP (1) | EP0649425B1 (da) |
JP (1) | JPH07507796A (da) |
CN (1) | CN1081678A (da) |
AT (1) | ATE177426T1 (da) |
AU (1) | AU4293393A (da) |
DE (1) | DE69323883T2 (da) |
DK (1) | DK0649425T3 (da) |
ES (1) | ES2130269T3 (da) |
GR (1) | GR3029946T3 (da) |
IL (1) | IL105693A0 (da) |
MX (1) | MX9303594A (da) |
WO (1) | WO1993025553A1 (da) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
CZ301491B6 (cs) * | 2001-04-27 | 2010-03-24 | Eisai R&D Management Co., Ltd. | Pyrazolo[1,5-a]pyridiny a léciva s jejich obsahem |
SI1397364T1 (sl) * | 2001-05-24 | 2007-12-31 | Lilly Co Eli | Novi pirolni derivati kot farmacevtske uäśinkovine |
NZ538860A (en) * | 2002-10-22 | 2006-07-28 | Eisai Co Ltd | 7-Phenyl pyrazolopyridine compounds |
US7176216B2 (en) * | 2002-10-22 | 2007-02-13 | Eisai Co., Ltd. | 7-phenylpyrazolopyridine compounds |
WO2007008529A2 (en) * | 2005-07-08 | 2007-01-18 | Kalypsys, Inc | Celullar cholesterol absorption modifiers |
US7501438B2 (en) | 2006-07-07 | 2009-03-10 | Forest Laboratories Holdings Limited | Pyridoimidazole derivatives |
AU2008273050A1 (en) * | 2007-07-11 | 2009-01-15 | Auckland Uniservices Limited | Pyrazolo[1,5-a]pyridines and their use in cancer therapy |
SI2266990T1 (sl) * | 2008-04-15 | 2013-01-31 | Eisai R&D Management Co. Ltd. | Spojina 3-fenilpirazolo(5,1-b)tiazola |
AR078521A1 (es) * | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
EP2487177A1 (en) * | 2009-10-08 | 2012-08-15 | Eisai R&D Management Co., Ltd. | Pyrazoloxazole compound |
WO2015123408A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
WO2015123437A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
TWI720451B (zh) | 2014-02-13 | 2021-03-01 | 美商英塞特控股公司 | 作為lsd1抑制劑之環丙胺 |
ES2760261T3 (es) | 2014-02-13 | 2020-05-13 | Incyte Corp | Ciclopropilaminas como inhibidores de LSD1 |
CN103980281B (zh) * | 2014-05-27 | 2016-06-08 | 天津市斯芬克司药物研发有限公司 | 一种咪唑吡嗪化合物及其制备方法 |
WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
TWI687419B (zh) | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為lsd1抑制劑之咪唑并吡啶及咪唑并吡嗪 |
US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
SG11201708047UA (en) | 2015-04-03 | 2017-10-30 | Incyte Corp | Heterocyclic compounds as lsd1 inhibitors |
WO2017027678A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Salts of an lsd1 inhibitor |
TWI833686B (zh) | 2016-04-22 | 2024-03-01 | 美商英塞特公司 | Lsd1 抑制劑之調配物 |
WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1600969A (en) * | 1977-01-07 | 1981-10-21 | Acf Chemiefarma Nv | Heterocyclic compounds |
US4352804A (en) * | 1978-07-25 | 1982-10-05 | Acf Chemiefarma Nv | Oxime ethers, their preparation and pharmaceutical compositions containing them |
US4925849A (en) * | 1987-06-15 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutically useful pyrazolopyridines |
-
1993
- 1993-05-05 ES ES93912362T patent/ES2130269T3/es not_active Expired - Lifetime
- 1993-05-05 JP JP6501458A patent/JPH07507796A/ja active Pending
- 1993-05-05 AT AT93912362T patent/ATE177426T1/de not_active IP Right Cessation
- 1993-05-05 DE DE69323883T patent/DE69323883T2/de not_active Expired - Fee Related
- 1993-05-05 WO PCT/US1993/004059 patent/WO1993025553A1/en active IP Right Grant
- 1993-05-05 AU AU42933/93A patent/AU4293393A/en not_active Abandoned
- 1993-05-05 DK DK93912362T patent/DK0649425T3/da active
- 1993-05-05 EP EP93912362A patent/EP0649425B1/en not_active Expired - Lifetime
- 1993-05-13 IL IL105693A patent/IL105693A0/xx unknown
- 1993-06-16 MX MX9303594A patent/MX9303594A/es unknown
- 1993-06-17 CN CN93107183A patent/CN1081678A/zh active Pending
-
1994
- 1994-09-27 US US08/313,684 patent/US5565468A/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/468,158 patent/US5597816A/en not_active Expired - Fee Related
- 1995-06-06 US US08/466,181 patent/US5523318A/en not_active Expired - Fee Related
-
1999
- 1999-04-13 GR GR990401036T patent/GR3029946T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL105693A0 (en) | 1993-09-22 |
JPH07507796A (ja) | 1995-08-31 |
MX9303594A (es) | 1994-01-31 |
US5597816A (en) | 1997-01-28 |
GR3029946T3 (en) | 1999-07-30 |
DE69323883T2 (de) | 1999-07-22 |
CN1081678A (zh) | 1994-02-09 |
WO1993025553A1 (en) | 1993-12-23 |
US5523318A (en) | 1996-06-04 |
US5565468A (en) | 1996-10-15 |
AU4293393A (en) | 1994-01-04 |
ATE177426T1 (de) | 1999-03-15 |
ES2130269T3 (es) | 1999-07-01 |
EP0649425B1 (en) | 1999-03-10 |
DE69323883D1 (de) | 1999-04-15 |
EP0649425A1 (en) | 1995-04-26 |
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