ES2180751T3 - Inhibidor de metastasis de cancer. - Google Patents

Inhibidor de metastasis de cancer.

Info

Publication number
ES2180751T3
ES2180751T3 ES96909329T ES96909329T ES2180751T3 ES 2180751 T3 ES2180751 T3 ES 2180751T3 ES 96909329 T ES96909329 T ES 96909329T ES 96909329 T ES96909329 T ES 96909329T ES 2180751 T3 ES2180751 T3 ES 2180751T3
Authority
ES
Spain
Prior art keywords
sub
cancerose
represent
metastasis
benzoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96909329T
Other languages
English (en)
Inventor
Jiro Shibata
Konstanty Wierzba
Koji Murakami
Yuji Yamada
Koichi Shudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2180751T3 publication Critical patent/ES2180751T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

INHIBIDOR DE LA METASTASIS CANCEROSA QUE INCLUYE UN DERIVADO DE ACIDO BENZOICO QUE SE REPRESENTA POR LA FORMULA GENERAL (I) Y TIENE UN EFECTO INHIBITORIO DE LA METASTASIS CANCEROSA EXCELENTE Y SUBRAYABLE COMO INGREDIENTE ACTIVO; EL USO DE DERIVADOS DE ACIDO BENZOICO PARA PRODUCIR EL INHIBIDOR DE LA METASTASIS CANCEROSA; Y UN METODO PARA INHIBIR LA METASTASIS CANCEROSA MEDIANTE LA ADMINISTRACION DE UNA CANTIDAD EFECTIVA DEL DERIVADO DE ACIDO BENZOICO A MAMIFEROS. EN DICHA FORMULA (I), R{SUB,1},R{SUB,2},R{SUB,3} Y R{SUB,4) PUEDEN SER LO MISMO O DIFERENTES Y REPRESENTAR CADA UNO HIDROGENO, HIDROXI O TRIMETILSILIL, O ALTERNATIVAMENTE R{SUB,3}, R{SUB,4} SE UNEN MUTUAMENTE PARA REPRESENTAR TETRAMETILENO SUSTITUTIVO DE ALQUIL INFERIOR; Y X REPRESENTA -COCH=C(OH)-, -NHCO-O-CONH-, QUE SE PROPORCIONA CUANDO R{SUB,3} Y R{SUB,4} SE UNEN MUTUAMENTE PARA REPRESENTAR TETRAMETILENO DE SUSTITUTIVO DE ALQUIL INFERIOR, X REPRESENTA -COCH=C(OH)-O- CONH-.
ES96909329T 1995-04-10 1996-04-10 Inhibidor de metastasis de cancer. Expired - Lifetime ES2180751T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8380395 1995-04-10

Publications (1)

Publication Number Publication Date
ES2180751T3 true ES2180751T3 (es) 2003-02-16

Family

ID=13812829

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96909329T Expired - Lifetime ES2180751T3 (es) 1995-04-10 1996-04-10 Inhibidor de metastasis de cancer.

Country Status (12)

Country Link
US (1) US5750515A (es)
EP (1) EP0768084B1 (es)
JP (1) JP3208437B2 (es)
KR (1) KR100207356B1 (es)
AT (1) ATE223713T1 (es)
AU (1) AU693682B2 (es)
CA (1) CA2191850C (es)
DE (1) DE69623555T2 (es)
DK (1) DK0768084T3 (es)
ES (1) ES2180751T3 (es)
PT (1) PT768084E (es)
WO (1) WO1996032101A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008204A (en) 1995-09-01 1999-12-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5965606A (en) * 1995-12-29 1999-10-12 Allergan Sales, Inc. Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity
KR20010063274A (ko) * 1999-12-22 2001-07-09 성재갑 〔1-｛〔1-（1,3-벤조디옥솔-5-일메틸-1ｈ-이미다졸-5-일〕메틸｝-4-(1-나프틸)-1ｈ-피롤-3-일〕（4-메틸-1-피페라지닐）메타논의 약학적 조성물
NO20003591L (no) * 2000-07-13 2002-01-14 Thia Medica As Fettsyreanaloger for behandling av kreft
DE60136477D1 (de) 2000-10-02 2008-12-18 Hoffmann La Roche Retinoide zur behandlung von emphysem
US8198328B2 (en) * 2004-01-21 2012-06-12 New York University Treatment of cancer using benzoic acid derivatives
US20050202055A1 (en) * 2004-03-11 2005-09-15 Koichi Shudo, Tokyo, Japan Anti-wrinkle agent
US8415315B2 (en) 2004-05-06 2013-04-09 University Of Central Florida Research Foundation, Inc. Methods and compositions for inhibiting the proliferation of cancer cells
EP1862168A4 (en) * 2005-03-08 2008-04-30 Taiho Pharmaceutical Co Ltd METHOD FOR THE TREATMENT OF LIVER CANCER
RU2405447C2 (ru) * 2005-10-24 2010-12-10 Тайхо Фармасьютикал Ко., Лтд. СПОСОБ ПРОГНОЗИРОВАНИЯ ЭФФЕКТИВНОСТИ АГОНИСТА RAR-α
TW200922554A (en) * 2007-10-11 2009-06-01 Taiho Pharmaceutical Co Ltd Bis(trimethylsilyl)phenyl compound or salt thereof, and use thereof
GB0915196D0 (en) 2009-09-01 2009-10-07 King S College London Therapeutic compounds and their use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5513238A (en) * 1978-07-17 1980-01-30 Banyu Pharmaceut Co Ltd Novel compound having immunoactivating action, its preparation and application
JP2752630B2 (ja) * 1988-03-29 1998-05-18 大鵬薬品工業株式会社 新規安息香酸誘導体及びその製造方法
JP2761023B2 (ja) * 1989-03-20 1998-06-04 大鵬薬品工業株式会社 新規安息香酸誘導体及びその製造方法
JPH0366647A (ja) * 1989-08-03 1991-03-22 Koichi Shudo フェニルベンゾエート誘導体
JPH03115289A (ja) * 1989-09-28 1991-05-16 Koichi Shudo 新規安息香酸誘導体、その製造方法及びその用途
JP3650144B2 (ja) * 1994-06-08 2005-05-18 花王株式会社 細胞接着抑制剤

Also Published As

Publication number Publication date
EP0768084A4 (en) 1999-05-06
DE69623555D1 (de) 2002-10-17
DK0768084T3 (da) 2002-10-14
WO1996032101A1 (en) 1996-10-17
CA2191850C (en) 2002-06-18
AU5287596A (en) 1996-10-30
CA2191850A1 (en) 1996-10-17
DE69623555T2 (de) 2003-05-15
AU693682B2 (en) 1998-07-02
US5750515A (en) 1998-05-12
KR970703761A (ko) 1997-08-09
KR100207356B1 (ko) 1999-07-15
JP3208437B2 (ja) 2001-09-10
ATE223713T1 (de) 2002-09-15
EP0768084B1 (en) 2002-09-11
EP0768084A1 (en) 1997-04-16
PT768084E (pt) 2002-12-31

Similar Documents

Publication Publication Date Title
ES2180751T3 (es) Inhibidor de metastasis de cancer.
MX9202328A (es) Composicion farmaceutica local que contiene un compuesto alilamina como el agente activo.
ES2118160T3 (es) Compuestos de azol, su produccion y su uso.
ECSP941111A (es) Nuevas sulfonilaminopirimidinas,
ES2171416T3 (es) Remedio contra la trombocitopenia.
PA8486001A1 (es) Composiciones de celecoxib
DK0696280T3 (da) Substituerede pyrrolidin-3-yl-alkyl-piperidiner anvendelige som tachykinin-antagonister
ES2121988T3 (es) Derivado de morfinano y uso medicinal.
UY26285A1 (es) Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas
ES2164920T3 (es) Nuevos derivados heterociclicos y uso medicinal de los mismos.
NO950757L (no) Antitussiv
ES2101449T3 (es) Inhibicion de la seborrea y el acne.
ATE287267T1 (de) Kombinationstherapien mit gefässschädigender aktivität
BR0315662A (pt) Derivados de 1-(4-benzil-piperazin-1-il)-3-fenil-propenona
NO950243D0 (no) Nye nimesulidsalt-cyklodekstrin-inklusjonskomplekser
CO5690566A2 (es) Metodo para inhibir la produccion de lipoproteina remanente
AR004474A1 (es) Compuestos de 10-aminoalifatil-dibenz [b,f]oxepinas antineurodegenerativamente activas, utiles para el tratamiento de estados neurodegenerativos y composiciones farmaceuticas que los contienen
NO985679D0 (no) Dihydrobenzopyran og beslektede forbindelser nyttige som anti-inflammasjonsmidler
ES2161439T3 (es) Derivados triterpenicos medicamentos para enfermedades hepaticas.
ES2136581A1 (es) Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb.
TR200102514T2 (tr) COPD tedavisi için metod
MX9301723A (es) Derivados de carbinol di-arilo puenteados, composiciones y metodos de uso.
UA41350C2 (uk) Похідна морфоліну або її фармацевтично прийнятна сіль та фармацевтична композиція на її основі
AR047880A1 (es) COMBINACIoN DE UN INHIBIDOR DE RENINA Y DIURÉTICOS
SE9302203L (sv) Komposition för topisk administration av bispilokarpinsyradiestrar till ögat i form av en vattenlösning