ES2176675T3 - Inhibidor de bomba de protones. - Google Patents
Inhibidor de bomba de protones.Info
- Publication number
- ES2176675T3 ES2176675T3 ES97903172T ES97903172T ES2176675T3 ES 2176675 T3 ES2176675 T3 ES 2176675T3 ES 97903172 T ES97903172 T ES 97903172T ES 97903172 T ES97903172 T ES 97903172T ES 2176675 T3 ES2176675 T3 ES 2176675T3
- Authority
- ES
- Spain
- Prior art keywords
- aupo
- tiadiazol
- aup
- atio
- protons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical group C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- UTCSSFWDNNEEBH-UHFFFAOYSA-N imidazo[1,2-a]pyridine Chemical compound C1=CC=CC2=NC=CN21 UTCSSFWDNNEEBH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE TIADIAZOL QUE SON EFECTIVOS COMO INHIBIDORES DE LA BOMBA DE PROTONES, UTILES PARA EL TRATAMIENTO DE ULCERAS PEPTICAS, MEDIANTE INHIBICION DE LA ENZIMA DE LA BOMBA DE PROTONES H + /K + - A TPASA. DICHOS COMPUESTOS SON 1, 2, 4 - TIADIAZOL [4, 5 - A]BENZIMIDAZOL SUSTITUIDO EN POSICION 3 E IMIDAZO[1, 2 - D] - 1, 2, 4 TIADIAZOLES SUSTITUIDOS EN POSICION 3, CORRESPONDIENTES A LA SIGUIENTE FORMULA GENERAL (I), DONDE X Y Z REPRESENTAN CADA UNO UN CICLO DE BENCENO OPCIONALMENTE SUSTITUIDO, CONDENSADO CON EL NUCLEO DE DIAZOL, O BIEN REPRESENTAN DIVERSAS AGRUPACIONES QUIMICAS INDEPENDIENTES (HIDROGENO, ALQUILO INFERIOR, HALO, ETC.) E Y SE SELECCIONA A PARTIR DE UN AMPLIO GRUPO DE SUSTANCIAS P.EJ. GRUPOS CARBONILO Y HETEROCICLICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/606,987 US5677302A (en) | 1996-02-26 | 1996-02-26 | Thiadiazole compounds useful as proton pump inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2176675T3 true ES2176675T3 (es) | 2002-12-01 |
Family
ID=24430335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97903172T Expired - Lifetime ES2176675T3 (es) | 1996-02-26 | 1997-02-26 | Inhibidor de bomba de protones. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5677302A (es) |
| EP (1) | EP0883622B1 (es) |
| JP (1) | JPH11513993A (es) |
| KR (1) | KR19990087397A (es) |
| CN (1) | CN1216547A (es) |
| AT (1) | ATE217627T1 (es) |
| AU (1) | AU1762297A (es) |
| BR (1) | BR9707757A (es) |
| CA (1) | CA2247901A1 (es) |
| CZ (1) | CZ271298A3 (es) |
| DE (1) | DE69712608T2 (es) |
| DK (1) | DK0883622T3 (es) |
| ES (1) | ES2176675T3 (es) |
| HU (1) | HUP9901565A2 (es) |
| IL (1) | IL125944A0 (es) |
| NO (1) | NO983914L (es) |
| PL (1) | PL328863A1 (es) |
| PT (1) | PT883622E (es) |
| TR (1) | TR199801670T2 (es) |
| WO (1) | WO1997031923A1 (es) |
| YU (1) | YU42598A (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| US7365047B1 (en) * | 1999-09-28 | 2008-04-29 | The Regents Of The University Of California | Use of pentagastrin to inhibit gastric acid secretion or as a diuretic |
| UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| CA2379375A1 (en) * | 2002-03-28 | 2003-09-28 | Apotex Inc. | Sulfonamide derivatives of 3-substituted imidazol[1,2-d]-1,2,4-thiadiazoles and 3-substituted-[1,2,4] thiadiazolo[4,5-a] benzimidazole as inhibitors of fibrin cross-linking and transglutaminases |
| AU2003254282A1 (en) * | 2002-08-01 | 2004-02-23 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
| KR101179012B1 (ko) | 2003-03-10 | 2012-09-03 | 니코메드 게엠베하 | 로플루미라스트 신규한 제조 방법 |
| EP1861074B1 (en) | 2005-03-16 | 2013-04-24 | Takeda GmbH | Taste masked dosage form containing roflumilast |
| US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| US7981908B2 (en) * | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| WO2008012621A2 (en) | 2006-07-25 | 2008-01-31 | Vecta, Ltd. | Compositions and meth0ds for inhibiting gastric acide secretion using derivatives of small dicarboxylic acids in combination with ppi |
| EP2401283B1 (en) * | 2009-02-25 | 2014-08-13 | Urifer Ltd. | 6-phenyl-2-[((piperidin-4-ylmethyl)-piperazin-1yl) or piperazin 1-ylmethyl)-piperidin-1-yl)]-imidazo[2,1-b][1,3,4]thiadiazole derivatives and their use |
| CN110082487A (zh) * | 2019-05-13 | 2019-08-02 | 丽珠医药集团股份有限公司 | 检测试剂、检测系统及拉唑类药物肠吸收的试验方法 |
| CN113880864A (zh) * | 2021-11-22 | 2022-01-04 | 吉首大学 | 含苯并咪唑骈杂硒咪唑亚胺的化合物及其制法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3864353A (en) * | 1973-12-17 | 1975-02-04 | Squibb & Sons Inc | 1-(1-Imidazolyl) (1,2,4) thiadiazolo (4,5-alpha) benzimidazoles |
| US5106863A (en) * | 1990-03-26 | 1992-04-21 | Ortho Pharmaceutical Corporation | Substituted imidazole and pyridine derivatives |
| DE4023215A1 (de) * | 1990-07-21 | 1992-01-23 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung |
-
1996
- 1996-02-26 US US08/606,987 patent/US5677302A/en not_active Expired - Fee Related
-
1997
- 1997-02-21 US US08/803,650 patent/US6093738A/en not_active Expired - Fee Related
- 1997-02-26 PL PL97328863A patent/PL328863A1/xx unknown
- 1997-02-26 CA CA002247901A patent/CA2247901A1/en not_active Abandoned
- 1997-02-26 AT AT97903172T patent/ATE217627T1/de not_active IP Right Cessation
- 1997-02-26 BR BR9707757-7A patent/BR9707757A/pt unknown
- 1997-02-26 KR KR1019980706813A patent/KR19990087397A/ko not_active Application Discontinuation
- 1997-02-26 DE DE69712608T patent/DE69712608T2/de not_active Expired - Fee Related
- 1997-02-26 TR TR1998/01670T patent/TR199801670T2/xx unknown
- 1997-02-26 IL IL12594497A patent/IL125944A0/xx unknown
- 1997-02-26 ES ES97903172T patent/ES2176675T3/es not_active Expired - Lifetime
- 1997-02-26 EP EP97903172A patent/EP0883622B1/en not_active Expired - Lifetime
- 1997-02-26 CN CN97193847A patent/CN1216547A/zh active Pending
- 1997-02-26 JP JP9530480A patent/JPH11513993A/ja not_active Ceased
- 1997-02-26 CZ CZ982712A patent/CZ271298A3/cs unknown
- 1997-02-26 YU YU42598A patent/YU42598A/sh unknown
- 1997-02-26 AU AU17622/97A patent/AU1762297A/en not_active Abandoned
- 1997-02-26 DK DK97903172T patent/DK0883622T3/da active
- 1997-02-26 HU HU9901565A patent/HUP9901565A2/hu unknown
- 1997-02-26 WO PCT/CA1997/000125 patent/WO1997031923A1/en not_active Application Discontinuation
- 1997-02-26 PT PT97903172T patent/PT883622E/pt unknown
-
1998
- 1998-08-26 NO NO983914A patent/NO983914L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0883622B1 (en) | 2002-05-15 |
| DE69712608T2 (de) | 2002-08-29 |
| NO983914L (no) | 1998-10-23 |
| CZ271298A3 (cs) | 1999-02-17 |
| WO1997031923A1 (en) | 1997-09-04 |
| CA2247901A1 (en) | 1997-09-04 |
| BR9707757A (pt) | 2000-10-24 |
| IL125944A0 (en) | 1999-04-11 |
| US6093738A (en) | 2000-07-25 |
| CN1216547A (zh) | 1999-05-12 |
| AU1762297A (en) | 1997-09-16 |
| EP0883622A1 (en) | 1998-12-16 |
| NO983914D0 (no) | 1998-08-26 |
| KR19990087397A (ko) | 1999-12-27 |
| ATE217627T1 (de) | 2002-06-15 |
| DE69712608D1 (de) | 2002-06-20 |
| JPH11513993A (ja) | 1999-11-30 |
| TR199801670T2 (xx) | 1998-11-23 |
| PT883622E (pt) | 2002-09-30 |
| PL328863A1 (en) | 1999-03-01 |
| DK0883622T3 (da) | 2002-09-09 |
| YU42598A (sh) | 2000-12-28 |
| US5677302A (en) | 1997-10-14 |
| HUP9901565A2 (hu) | 1999-08-30 |
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