ES2169716T3 - Nuevos derivados de 2,3-metano-aminoacidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents
Nuevos derivados de 2,3-metano-aminoacidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2169716T3 ES2169716T3 ES00401197T ES00401197T ES2169716T3 ES 2169716 T3 ES2169716 T3 ES 2169716T3 ES 00401197 T ES00401197 T ES 00401197T ES 00401197 T ES00401197 T ES 00401197T ES 2169716 T3 ES2169716 T3 ES 2169716T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- linear
- branched
- alkyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 isothioureido group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Compuesto De fórmula (I): I en la cual : n representa2ó 3, R1 representa un grupo cicloalquilo-(C3-C8), un grupo fenilo eventualmente sustituido o un grupo alquilo-(C1-C6) lineal o ramificado eventualmente sustituido por uno o varios grupos, idénticos o diferentes, halógeno, cicloalquilo-(C3-C8) y fenilo eventualmente sustituido, R2 representa: un grupo amino, un grupo amidino sustituido eventualmente por uno o varios grupos idénticos o diferentes, alquilo-(C1-C6) lineal o ramificado, o hidroxilo, un grupo guanidino sustituido eventualmente por un grupo alquilo-(C1-C6) lineal o ramificado, o un grupo isotioureido sustituido eventualmente por un grupo alquilo-(C1-C6) lineal o ramificado, Ar representa un grupo arilo o un grupo heteroarilo nitrogenado monocíclico, X1 representa un grupo hidroxilo, un grupo amino o un grupo -NHR3, R3 representa un grupo propargilo, un grupo imino-metilo, un grupo alquil-sulfonilo-(C1-C6) lineal o ramificado, un grupo aril-alquil-sulfonilo-(C1-C6) lineal o ramicado, un grupo -CONR''3R"3 o un grupo alquilo-(C1-C6) lineal o ramificado eventualmente sustituido por ún grupo -CO2R''3, un grupo-CONR''3R"3, ún grupo heterocíclico ún grupo heterocíclico, ún grupo amino-sulfonilo, ún grupo arilo, ún grupo heteroarilo, R''3 y R"3, idénticos o diferentes, representan cada uno un átomo de hidrógeno, o un grupo alquilsulfonilo-(C1-C6) lineal o ramificado, un grupo arilo, un grupo alquilo-(C1-C6) lineal o ramificado (eventualmente sustituido por un grupo carboxilo, alcoxi-carbonilo-(C1-C6) lineal o ramificado o carbamoilo), o forman con el átomo de nitrógeno que los lleva un grupo heterocíclico, sus isómeros así como sus sales de adición de un ácido o de una base farmacéuticamente aceptable, entendiéndose que: por grupo fenilo eventualmente sustituido, se entiende sustituido por uno o varios grupos, idénticos o diferentes, seleccionados entre halógeno, alquilo-(C1-C6) lineal o ramificado, alcoxilo-(C1-C6) lineal o ramificado, hidroxilo, trihalo-alquilo-(C1-C6) lineal o ramificado y amino (sustituido eventualmente por uno o varios grupos alquilo-(C1-C6) lineal o ramificado), 5 10 15 20 por grupo heterocíclico, se entiende un grupo monoo bicíclico, saturado o insaturado, de 5 a 12 eslabones que contiene uno, dos o tres heteroátomos seleccionados entre oxígeno, nitrógeno o azufre, entendiéndose que el heterociclo puede ser eventualmente sustituido por uno o varios grupos, idénticos o diferentes, seleccionados entre halógeno, alquilo-(C1-C6) lineal o ramicado, alcoxilo-(C1-C6) lineal o ramificado, oxo, hidroxilo, trihalo-alquilo-(C1-C6) lineal o ramificado y amino (sustituido eventualmente por uno o varios alquilo-(C1-C6) lineal o ramificado), por grupo arilo, se entiende fenilo, bifenilo, naftilo, estando cada uno de estos grupos eventualmente sustituido por uno o varios grupos, idénticos o diferentes, seleccionados entre halógeno, alquilo-(C1-C6) lineal o ramificado, alcoxilo-(C1-C6) lineal o ramificado, hidroxilo, trihalo-alquilo-(C1-C6) lineal o ramificado, amino (sustituido eventualmente por uno o varios grupos alquilo-(C1-C6) lineal o ramificado) y carboxilo, y por grupo heteroarilo, se entiende un grupo aromático monoo bicíclico de 5 a 12 eslabones que contienen uno, dos o tres heteroátomos seleccionados entre oxígeno, nitrógeno o azufre, entendiéndose que el heteroarilo puede ser eventualmente sustituido por uno o varios grupos, idénticos o diferentes, seleccionados entre halógeno, alquilo-(C1-C6) lineal o ramificado, hidroxilo, alcoxilo-(C1-C6) lineal o ramificado, trihalo-metilo, y amino (sustituido eventualmente por uno o varios grupos alquilo-(C1-C6) lineal o ramificado).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9905601A FR2793248B1 (fr) | 1999-05-03 | 1999-05-03 | Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2169716T3 true ES2169716T3 (es) | 2002-07-16 |
Family
ID=9545154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00401197T Expired - Lifetime ES2169716T3 (es) | 1999-05-03 | 2000-05-02 | Nuevos derivados de 2,3-metano-aminoacidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6288077B1 (es) |
| EP (1) | EP1050534B1 (es) |
| JP (1) | JP3200053B2 (es) |
| KR (1) | KR100439599B1 (es) |
| CN (1) | CN1130347C (es) |
| AT (1) | ATE210131T1 (es) |
| AU (1) | AU763670B2 (es) |
| BR (1) | BR0002075A (es) |
| CA (1) | CA2308780C (es) |
| DE (1) | DE60000036T2 (es) |
| DK (1) | DK1050534T3 (es) |
| EA (1) | EA002645B1 (es) |
| ES (1) | ES2169716T3 (es) |
| FR (1) | FR2793248B1 (es) |
| HK (1) | HK1032237A1 (es) |
| HU (1) | HUP0001712A3 (es) |
| MX (1) | MXPA00004241A (es) |
| NO (1) | NO20002314L (es) |
| NZ (1) | NZ504298A (es) |
| PL (1) | PL198571B1 (es) |
| PT (1) | PT1050534E (es) |
| SI (1) | SI1050534T1 (es) |
| ZA (1) | ZA200002152B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774110B2 (en) * | 2001-03-19 | 2004-08-10 | Lg Life Sciences Ltd. | Orally available peptidic thrombin inhibitors |
| JP2003072059A (ja) * | 2001-06-21 | 2003-03-12 | Ricoh Co Ltd | インクジェット記録装置及び複写機 |
| TW200911787A (en) * | 2007-07-03 | 2009-03-16 | Astrazeneca Ab | New aza-bicyclohexane compounds useful as inhibitors of thrombin |
| TW201002689A (en) * | 2008-06-23 | 2010-01-16 | Astrazeneca Ab | Novel compounds |
| WO2020092139A1 (en) * | 2018-10-29 | 2020-05-07 | Huahai Us Inc. | Novel dipeptide compounds and uses thereof |
| WO2024015574A1 (en) * | 2022-07-14 | 2024-01-18 | Jnana Therapeutics Inc. | Small molecule inhibitors of mammalian slc6a19 function |
| WO2024118721A1 (en) * | 2022-11-30 | 2024-06-06 | Jnana Therapeutics Inc. | Crystalline forms of a piperidine inhibitor of slc6a19 function |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954158A (en) * | 1983-08-16 | 1990-09-04 | University Of Georgia Research Foundation, Inc. | 2,3-methanoproline |
| FR2701951B1 (fr) * | 1993-02-24 | 1995-06-09 | Adir | Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| US5688826A (en) * | 1995-11-16 | 1997-11-18 | Eli Lilly And Company | Excitatory amino acid derivatives |
| NO310618B1 (no) * | 1997-04-10 | 2001-07-30 | Ono Pharmaceutical Co | Kondenserte piperidinforbindelser, fremstilling og anvendelse derav, samt preparater omfattende slike forbindelser |
-
1999
- 1999-05-03 FR FR9905601A patent/FR2793248B1/fr not_active Expired - Fee Related
-
2000
- 2000-04-27 EA EA200000374A patent/EA002645B1/ru not_active IP Right Cessation
- 2000-04-28 PL PL339967A patent/PL198571B1/pl unknown
- 2000-04-30 CN CN00119227A patent/CN1130347C/zh not_active Expired - Fee Related
- 2000-05-02 MX MXPA00004241A patent/MXPA00004241A/es active IP Right Grant
- 2000-05-02 NZ NZ504298A patent/NZ504298A/xx unknown
- 2000-05-02 PT PT00401197T patent/PT1050534E/pt unknown
- 2000-05-02 US US09/561,618 patent/US6288077B1/en not_active Expired - Fee Related
- 2000-05-02 DE DE60000036T patent/DE60000036T2/de not_active Expired - Fee Related
- 2000-05-02 HU HU0001712A patent/HUP0001712A3/hu unknown
- 2000-05-02 ES ES00401197T patent/ES2169716T3/es not_active Expired - Lifetime
- 2000-05-02 EP EP00401197A patent/EP1050534B1/fr not_active Expired - Lifetime
- 2000-05-02 AT AT00401197T patent/ATE210131T1/de not_active IP Right Cessation
- 2000-05-02 DK DK00401197T patent/DK1050534T3/da active
- 2000-05-02 NO NO20002314A patent/NO20002314L/no not_active Application Discontinuation
- 2000-05-02 SI SI200030004T patent/SI1050534T1/xx unknown
- 2000-05-03 ZA ZA200002152A patent/ZA200002152B/xx unknown
- 2000-05-03 AU AU31325/00A patent/AU763670B2/en not_active Ceased
- 2000-05-03 CA CA002308780A patent/CA2308780C/fr not_active Expired - Fee Related
- 2000-05-03 KR KR10-2000-0023669A patent/KR100439599B1/ko not_active IP Right Cessation
- 2000-05-03 BR BR0002075-3A patent/BR0002075A/pt not_active Application Discontinuation
- 2000-05-08 JP JP2000134144A patent/JP3200053B2/ja not_active Expired - Fee Related
-
2001
- 2001-04-23 HK HK01102869A patent/HK1032237A1/xx not_active IP Right Cessation
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