ES2166741A1 - Procedimiento de potenciacion de la actividad antitumoral de una sustancia que contiene amigdalina, composicion que contiene la sustancia que contiene amigdalina potenciada, procedimiento para evaluar la eficacia antitumoral del tratamiento de la sustancia que contiene amigdalina - Google Patents
Procedimiento de potenciacion de la actividad antitumoral de una sustancia que contiene amigdalina, composicion que contiene la sustancia que contiene amigdalina potenciada, procedimiento para evaluar la eficacia antitumoral del tratamiento de la sustancia que contiene amigdalinaInfo
- Publication number
- ES2166741A1 ES2166741A1 ES200100097A ES200100097A ES2166741A1 ES 2166741 A1 ES2166741 A1 ES 2166741A1 ES 200100097 A ES200100097 A ES 200100097A ES 200100097 A ES200100097 A ES 200100097A ES 2166741 A1 ES2166741 A1 ES 2166741A1
- Authority
- ES
- Spain
- Prior art keywords
- amygdalin
- substance
- antitumor
- assessing
- efficacy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 title abstract 6
- 229940089837 amygdalin Drugs 0.000 title abstract 6
- YZLOSXFCSIDECK-UHFFFAOYSA-N amygdalin Natural products OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC(C#N)c3ccccc3 YZLOSXFCSIDECK-UHFFFAOYSA-N 0.000 title abstract 6
- YGHHWSRCTPQFFC-UHFFFAOYSA-N eucalyptosin A Natural products OC1C(O)C(O)C(CO)OC1OC1C(OC(C#N)C=2C=CC=CC=2)OC(CO)C(O)C1O YGHHWSRCTPQFFC-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000126 substance Substances 0.000 title abstract 5
- 230000003190 augmentative effect Effects 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 3
- 230000003416 augmentation Effects 0.000 title 1
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- -1 peroxide lipid Chemical class 0.000 abstract 2
- 241001092070 Eriobotrya Species 0.000 abstract 1
- 235000009008 Eriobotrya japonica Nutrition 0.000 abstract 1
- 229940090949 docosahexaenoic acid Drugs 0.000 abstract 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimiento de potenciación de la actividad antitumoral de una sustancia que contiene amigdalina, composición que contiene la sustancia que contiene amigdalina potenciada, procedimiento para evaluar la eficacia antitumoral del tratamiento de la sustancia que contiene amigdalina y procedimiento para evaluar la sustancia antitumoral que contiene amigdalina. La presente invención consiste en aumentar la eficacia anticancerígena de la semilla de níspero que contiene amigdalina, etc., mediante el tostado con radiación infrarroja, la fermentación con Koji y el recubrimiento con aceite. La invención se refiere a la mayor formación de lípido peróxido en el sistema de irradiación de ácido docosahexanoico con rayos ultravioletas, añadiendo concentraciones crecientes del producto que contiene amigdalina tratado con los procedimientos. Se evalúa y predice que cuanto más lípido peróxido se forme, mayor es la eficacia anticancerígena por vía oral. La invención aplica el procedimiento de esta invencióna la evaluación de la eficacia de sustancias que contienen amigdalina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000008337A JP2001199892A (ja) | 2000-01-17 | 2000-01-17 | アミグダリン含有物の抗腫瘍活性強化方法、抗腫瘍活性強化アミグダリン含有物を含む組成物、アミグダリン含有物処理の抗腫瘍有効性評価方法、およびアミグダリン含有物の抗腫瘍有効性評価方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2166741A1 true ES2166741A1 (es) | 2002-04-16 |
ES2166741B1 ES2166741B1 (es) | 2003-11-16 |
Family
ID=18536624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200100097A Expired - Lifetime ES2166741B1 (es) | 2000-01-17 | 2001-01-16 | Procedimiento de potenciacion de la actividad antitumoral de una sustancia que contiene amigdalina, composicion que contiene la sustancia que contiene amigdalina potenciada, procedimiento para evaluar la eficacia antitumoral del tratamiento de la sustancia que contiene amigdalina |
Country Status (19)
Country | Link |
---|---|
US (2) | US20010009903A1 (es) |
JP (1) | JP2001199892A (es) |
KR (1) | KR20010076279A (es) |
CN (1) | CN1319431A (es) |
AU (1) | AU1502101A (es) |
CA (1) | CA2331167A1 (es) |
DE (1) | DE10101543A1 (es) |
DK (1) | DK200100086A (es) |
ES (1) | ES2166741B1 (es) |
FR (1) | FR2805746A1 (es) |
GB (1) | GB2360211A (es) |
ID (1) | ID29765A (es) |
IL (1) | IL140900A0 (es) |
IS (1) | IS5804A (es) |
IT (1) | ITTO20010028A1 (es) |
NL (1) | NL1017117C2 (es) |
NO (1) | NO20010049L (es) |
SE (1) | SE0100083L (es) |
ZA (1) | ZA200100377B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3256746B2 (ja) * | 2000-03-02 | 2002-02-12 | 高知医科大学長 | 細胞線維化を抑制する組成物及び枇杷核エキスの調製方法 |
KR100470294B1 (ko) * | 2002-08-20 | 2005-02-05 | (주) 한약마을 | 도인 또는 행인으로부터 아미그달린을 효과적으로 얻는추출방법 |
GB0402728D0 (en) * | 2004-02-07 | 2004-03-10 | Pharming Ltd | Pesticides |
JP2006197928A (ja) * | 2004-12-22 | 2006-08-03 | Yamaguchi Prefecture | タケノコ麹及びその製造方法並びにタケノコ醗酵食品及びその製造方法 |
WO2007001080A1 (ja) * | 2005-06-27 | 2007-01-04 | Kagoshima University | ビワ葉抽出物を含有する飲食品及び医薬品 |
CN101190019B (zh) * | 2006-11-21 | 2011-03-09 | 马玉林 | 杏仁酱及其制备方法 |
CN107400150A (zh) * | 2017-08-16 | 2017-11-28 | 黄山市歙县绿色三潭枇杷生物科技有限公司 | 一种从枇杷核中提取苦杏仁苷的方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2007414A6 (es) * | 1986-09-25 | 1989-06-16 | Kozo Niwa | Procedimiento de produccion de productos naturales antioxidantes para fines mediocos. |
ES2036496A1 (es) * | 1991-08-14 | 1993-05-16 | Kozo Niwa | Composicion vegetal de bajo peso molecular compuesta por semilla de cardo mariano. |
ES2049189A1 (es) * | 1992-06-22 | 1994-04-01 | Niwa | Metodo para la produccion de un preparado oleoso. |
JPH06227998A (ja) * | 1993-01-28 | 1994-08-16 | Sanji Kumai | ニトリル配糖体を含有する生薬エキスの制癌活性 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2314800A (en) * | 1996-12-05 | 1998-01-14 | Henry Berry & Co Ltd | Component assembly machine |
-
2000
- 2000-01-17 JP JP2000008337A patent/JP2001199892A/ja active Pending
-
2001
- 2001-01-04 NO NO20010049A patent/NO20010049L/no not_active Application Discontinuation
- 2001-01-05 IS IS5804A patent/IS5804A/is unknown
- 2001-01-12 ZA ZA200100377A patent/ZA200100377B/xx unknown
- 2001-01-12 SE SE0100083A patent/SE0100083L/xx not_active Application Discontinuation
- 2001-01-15 IL IL14090001A patent/IL140900A0/xx unknown
- 2001-01-15 DE DE10101543A patent/DE10101543A1/de not_active Withdrawn
- 2001-01-16 NL NL1017117A patent/NL1017117C2/nl not_active IP Right Cessation
- 2001-01-16 CA CA002331167A patent/CA2331167A1/en not_active Abandoned
- 2001-01-16 ES ES200100097A patent/ES2166741B1/es not_active Expired - Lifetime
- 2001-01-16 IT IT2001TO000028A patent/ITTO20010028A1/it unknown
- 2001-01-16 KR KR1020010002334A patent/KR20010076279A/ko not_active Application Discontinuation
- 2001-01-16 AU AU15021/01A patent/AU1502101A/en not_active Abandoned
- 2001-01-16 US US09/760,992 patent/US20010009903A1/en not_active Abandoned
- 2001-01-17 ID IDP20010032D patent/ID29765A/id unknown
- 2001-01-17 GB GB0101181A patent/GB2360211A/en not_active Withdrawn
- 2001-01-17 CN CN01111914A patent/CN1319431A/zh active Pending
- 2001-01-17 DK DK200100086A patent/DK200100086A/da not_active Application Discontinuation
- 2001-01-17 FR FR0100612A patent/FR2805746A1/fr not_active Withdrawn
- 2001-10-24 US US10/038,428 patent/US20020098252A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2007414A6 (es) * | 1986-09-25 | 1989-06-16 | Kozo Niwa | Procedimiento de produccion de productos naturales antioxidantes para fines mediocos. |
ES2036496A1 (es) * | 1991-08-14 | 1993-05-16 | Kozo Niwa | Composicion vegetal de bajo peso molecular compuesta por semilla de cardo mariano. |
ES2049189A1 (es) * | 1992-06-22 | 1994-04-01 | Niwa | Metodo para la produccion de un preparado oleoso. |
JPH06227998A (ja) * | 1993-01-28 | 1994-08-16 | Sanji Kumai | ニトリル配糖体を含有する生薬エキスの制癌活性 |
Non-Patent Citations (1)
Title |
---|
NIWA K. et al.: "Anti-cancer effect in vitro and clinical efficacy of a cancer therapeutic containing natural herbs (BG-104), exposed to far infrared-ray heating and fermentation process using Aspergillus oryzae", Oyo Yakuri, Vol. 47, no 5, paginas 465-77, (1994), ISSN: 0300-8533, (resumen), HCAPLUS [en linea]. Columbus, OH (EE.UU.): Chemical Abstracts Service [recuperado el 10.04.2001]. Recuperado de: STN International, Columbus, OH (EE.UU.). No de acceso 1994:49737 * |
Also Published As
Publication number | Publication date |
---|---|
ITTO20010028A0 (it) | 2001-01-16 |
NL1017117A1 (nl) | 2001-07-19 |
FR2805746A1 (fr) | 2001-09-07 |
IS5804A (is) | 2001-07-17 |
DE10101543A1 (de) | 2001-07-19 |
ZA200100377B (en) | 2001-07-18 |
ID29765A (id) | 2001-10-11 |
NL1017117C2 (nl) | 2003-09-30 |
NO20010049L (no) | 2001-07-18 |
US20010009903A1 (en) | 2001-07-26 |
DK200100086A (da) | 2001-07-18 |
IL140900A0 (en) | 2002-02-10 |
CA2331167A1 (en) | 2001-07-17 |
GB0101181D0 (en) | 2001-02-28 |
KR20010076279A (ko) | 2001-08-11 |
CN1319431A (zh) | 2001-10-31 |
AU1502101A (en) | 2001-07-19 |
SE0100083L (sv) | 2001-07-18 |
GB2360211A (en) | 2001-09-19 |
NO20010049D0 (no) | 2001-01-04 |
JP2001199892A (ja) | 2001-07-24 |
ITTO20010028A1 (it) | 2002-07-16 |
US20020098252A1 (en) | 2002-07-25 |
ES2166741B1 (es) | 2003-11-16 |
SE0100083D0 (sv) | 2001-01-12 |
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