CN112931812A - 高稳定性口服美白制剂及其制备方法 - Google Patents
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- CN112931812A CN112931812A CN202110198271.2A CN202110198271A CN112931812A CN 112931812 A CN112931812 A CN 112931812A CN 202110198271 A CN202110198271 A CN 202110198271A CN 112931812 A CN112931812 A CN 112931812A
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Abstract
本发明公开了一种高稳定性口服美白制剂,其特征在于,按质量份数计,包括有以下组分:酵母颗粒20~60份,复合果粉20~50份,充气糖浆颗粒5~30份。本发明还公开了一种上述高稳定性口服美白制剂的制备方法。与现有技术相比,本发明的高稳定性口服美白制剂能够降低氧化分解风险,克服发酵气与酒糟味给消费者带来的不适影响。
Description
技术领域
本发明涉及食品及其加工方法技术领域,具体指一种高稳定性口服美白制剂及其制备方法。
背景技术
因为“一白遮三丑”的传统美观念,女性,尤其为亚洲女性对于美白的追求就像人类对于光明的追求一样从未停止。美白必然要与黑色素做斗争,黑色素是一种氨基酸衍生物,正是黑色素的存在,皮肤才有了颜色。在紫外线的影响之下,皮肤为保护身体,机体激活酪氨酸酶的活性,合成并释放黑色素,黑色素吸收紫外线,防止紫外线对人体造成伤害。随着时间推移,黑色素经皮肤细胞代谢至表面形成雀斑等形状。
随着人们生活质量的提高,将最天然来源的物质用于美白产品已然成为一种趋势,谷胱甘肽广泛存在于动植物和微生物体内,通过其发酵所得提取物的形式且已大量应用于美白产品,谷胱甘肽(GSH)是由谷氨酸、半胱氨酸和甘氨酸结合,含有巯基的三肽,是重要生理功能的结构基础:
①GSH能参与细胞内的氧化还原反应,对巯基酶有激活作用;
②GSH结构上的巯基是含巯基酶和蛋白巯基稳定,是氧化剂;
③通过胞内代谢循环参与跨膜氨基酸转运;
④GSH在细胞外界异物的解毒和羟基过氧化物、自由基的清除重要作用。
在美白方面,GSH的具体作用机理包括:
①通过与酶的含铜活性位点结合直接抑制酪氨酸酶的活性;
②调节从真黑素到褐黑素产生的转换机制;
③清除有助于酪氨酸酶活化和黑素形成的自由基和过氧化物;
④调节黑素细胞毒性剂(苯醌、邻醌等物质)的脱色能力。
但大量美白产品中仅仅使用了GSH或其发酵产物形式,但对其使用比例和量效比的研究非常浅薄。谷胱甘肽具有还原型谷胱甘肽(GSH)和氧化型谷胱甘肽(GSSG)两种形态,GSSG由2分子GSH脱氢后以二硫键相连缩合形成的,其抗氧化性大大衰减,同时GSH在空气中具有很强的引湿性,其在水溶液中非常不稳定,制剂研究过程中往往加入维生素C以防止氧化分解,刘婷等在《还原型谷胱甘肽与维生素C联用对黄褐斑的治疗作用》中介绍到维生素C不仅仅类似GSH能抑制酪氨酸酶的活性,又能可逆地加氢或脱氢,使已氧化的GSSG再度还原为GSH。
中国专利“CN102366397”、“CN104042559”、“CN105434323”等使用含谷胱甘肽的发酵提取物制备美白产品,均使用了防腐剂,对皮肤具有一定的刺激或致敏可能性。随着科技进步,普通化妆品中常见的成分也越来越多地在美容口服产品中出现了,美容化妆品逐渐进入了“口服”时代。口服美白产品除了功效之外,其安全性显得格外重要。同时作为食品的美白产品,其口感的舒适性、质量稳定性也非常重要。
中国专利“CN105816414”使用酵母水应用于美白产品,其不良特殊发酵气味或酒糟味道在经过多级过滤分离后依旧难以去除,且工艺涉及多级培养、白陶土、活性炭吸附、超低温粉碎、工艺复杂,生产成本高,且易产生废水。中国专利“CN107485597”能降低90%黑色素的口服美白针,其液体制剂经过高温灭菌后灌装,工艺中的高温将对谷胱甘肽的含量及稳定性有影响。
中国专利“CN111053233”采用固体饮料,克服了液体制剂中谷胱甘肽不稳定性的风险,但是工艺涉及红外灭菌,灭菌的瞬时高温对谷胱甘肽的含量和稳定性影响依旧存在风险。邓张双等在《酵母产还原型谷胱甘肽制备过程中的稳定性研究》一文中研究有氧条件、pH,温度的影响,其中溶氧影响最大,温度次之,如100℃灭菌高温对GSH的含量影响将呈指数下降。
中国专利“CN1634554”也考虑到了谷胱甘肽本身强烈的引湿性带来的不稳定性,发明使用软胶囊外囊隔离的办法使谷胱甘肽提高稳定性,其中使用聚乙二醇4000或聚乙二醇6000做为稳定剂,但具有致泄的风险,对其最终制剂关于美白等功效的影响无法证明。
中国专利“CN106692097”提及谷胱甘肽的片剂,使用硬脂富马酸钠解决因谷胱甘肽摩擦具强静电和较强引湿性的性质,导致在制备过程中易出现粘冲、流动性差、片重差异等问题,同时稀释剂以及硬脂富马酸钠能解决还原型谷胱甘肽稳定性差的问题,使制得的还原型谷胱甘肽药物制剂能够同时满足制备工艺顺畅和具有较好稳定性。
综上所述,使用GSH作为主原料的膏霜液体化妆品几乎都含有防腐剂,有一定的刺激或致敏风险,大量的化学试剂添加,其副作用始终存在。在安全性更高的口服美白时代,市场现有产品往往首先因工艺或配方问题难以克服GSH氧化降解的风险,即无法保证GSH的功效稳定性,通过足量增加GSH的操作,又无法保证在货架期的稳定性,且产生更高的成本。其次作为食品方向,并未克服其发酵气与酒糟味给消费者带来的不适影响。
发明内容
本发明所要解决的第一个技术问题是针对现有技术的现状,提供一种具有降低氧化分解风险的高稳定性口服美白制剂。
本发明所要解决的第二个技术问题是针对现有技术的现状,提供一种能够克服发酵气与酒糟味给消费者带来的不适影响的高稳定性口服美白制剂。
本发明所要解决的第三个技术问题是提供一种上述高稳定性口服美白制剂的制备方法。
本发明解决第一个和第二个技术问题所采用的技术方案为:一种高稳定性口服美白制剂,其特征在于,按质量份数计,包括有以下组分:
酵母颗粒 20~60份
复合果粉 20~50份
充气糖浆颗粒 5~30份。
优选地,所述的酵母颗粒由酵母抽提物经环糊精包合得到。
其中,酵母提取物(富含谷胱甘肽)已在背景描述其美白功效,其美白产品应用及原理以为公知;环糊精包合技术是指利用环糊精分子的空腔结构特性,将有效成分包裹,改善体系状态,使酵母颗粒在实际储存、加工、转运的过程中较酵母提取物本身,具有更高稳定性(主要克服了原料本身的引湿性),同时克服了酵母提取物在设备及器具使用过程中因发酵气味或酒糟味带来的清洁困难,及食用影响。
进一步,所述酵母颗粒的制备方法包括有以下步骤:将酵母提取物加入环糊精浆液中,经搅拌、超声、冷冻干燥、破碎过筛得到所需的酵母颗粒。
进一步,所述酵母抽提物和环糊精的质量比为10:1~10。
优选地,按质量份数计,所述的复合果粉包括有以下组分:
其中,葡萄籽提取物:富含多酚类物质,含量高达5~8%,包括原花青素,儿茶素,表儿茶素,没食子酸,表儿茶素没食子酸酯等多酚类物质组成,是一种极具潜力的天然抗氧化剂,是迄今发现的植物来源的最高效的抗氧化剂之一,体内和体外试验表明,葡萄籽提取物的抗氧化效果,是维生素E50倍,是维生素C20倍,它能有效清除人体内多余的自由基,具有超强的延缓衰老和增强免疫力的作用。在欧洲,葡萄籽被誉为“口服的皮肤化妆品”。葡萄籽提取物作为东方女性美白的功能成分,通过抑制酪氨酸酶活性,清除自由基减少黑色素沉积。
石榴提取物:主要以石榴皮、石榴籽或石榴汁为原料,提取含有多酚、黄酮、有机酸等成分。从石榴皮提取分离可得安石榴苷、安石榴林、木麻黄宁、石榴皮亭A、石榴皮亭B、鞣云实精、鞣花酸、没食子酸等多酚;从石榴汁中提取可分离得没食子酸、槲皮苷、绿原酸、根皮苷、咖啡酸原儿茶酸、儿茶素及香豆酸等,其中没食子酸和儿茶素的含量较高。石榴提取物多酚在抗氧化、抗皮肤癌、抗菌方面有着优异特性,用于食品添加剂可起到抗紫外线、美白和保湿等作用。
橄榄果粉:羟基酪醇(HT)是一种天然多酚类化合物,具有很强的抗氧化活性,主要以酯类的形式存在于橄榄的果实和枝叶中,被视为最强大的抗氧化剂之一应用于美容产品保健品,能有效增强皮肤弹性和润泽,具除皱抗衰老之功效。
酸樱桃提取物:樱桃果含有蛋白质、糖、果酸及维生素A、B1、B2、维生素C,尼克酸、钙、磷、铁等多种维生素,其中维生素C的质量分数高达1215~3024mg/hg,是番石榴、木瓜及草莓等水果的10~50倍,为极佳的天然维生素C来源,是名副其实的“天然维生素C之王”。
利用复合果粉中的原花青素、多酚、维生素C等抗氧化、去除自由基的作用,使之与谷胱甘肽(GSH)联用具有增效美白和保湿的目的之外,同时以抗氧化剂的形式可有效缓解谷胱甘肽本身易氧化的特性。
优选地,所述充气糖浆颗粒的制备方法包括有以下步骤:以还原糖为原料,经加热制浆、二氧化碳膨化、冷却、破碎、过筛得到的所需的充气糖果颗粒。
进一步,所述的还原糖为具还原性的单糖、二糖中的至少一种。
其中,由于充气糖浆颗粒以还原糖为原料,经制浆、充气膨化、冷却、破碎、过筛得到。这样,经机械擦搅使糖体充入无数细密的二氧化碳气泡,食用时给消费者带来独特的体验感。同时因其疏松的结构及包含二氧化碳微小气泡的特点,使制剂成品获得更好的阻氧效果,进一步地缓解了谷胱甘肽在制剂加工、储存运输过程中的氧化问题。
本发明解决第三个技术问题所采用的技术方案为:一种上述高稳定性口服美白制剂的制备方法,其特征在于包括以下步骤:按质量份数配比,20~60份酵母颗粒、20~50份复合果粉、5~30份充气糖浆颗粒经混合、干法制粒、压片、包衣制成所需的高稳定性口服美白制剂。
与现有技术相比,本发明的优点在于:
(1)本发明的高稳定性口服美白制剂由酵母颗粒(富含谷胱甘肽)、复合果粉以及充气糖浆颗粒制备得到,适用美白需求人群,无添加防腐剂及香精;
(2)本发明的产品配方中谷胱甘肽(GSH)、维生素C、花青素等抗氧化剂具有美白协同增效的作用基础上,用天然果粉给消费者以更高的食品安全性及充气糖浆颗粒带来的高体验感,使食用产品过程更加愉悦;
(3)酵母颗粒克服了酵母提取物强引湿性带来的工艺影响,同时掩盖了物料本身不适的发酵气味,与含气糖浆阻断技术与包衣隔离技术,实现了三重工艺防护,使产品在货架期具有高稳定性,降低GSH易氧化分解的风险,保证产品功效的稳定性。
附图说明
图1为本发明稳定性试验对比例GSH含量变化曲线。
具体实施方式
以下结合附图实施例对本发明作进一步详细描述。
实施例1:
(1)原料准备:按质量份数计,酵母颗粒60份(酵母颗粒中由酵母提取物:环糊精=10:2包合得到,具体的环糊精包合技术为公知常规技术,此处不再赘述)、复合果粉20份、充气糖浆颗粒20份,微晶纤维素适量、硬脂酸镁适量;
其中复合果粉中的葡萄籽提取物含量为5份、石榴提取物含量为5份、橄榄果粉含量为5份、酸樱桃提取物含量为5份;
充气糖浆颗粒还原糖为原料,经制浆、充气膨化、冷却、破碎、过筛得到,此为跳跳糖的生产工艺,此处不再赘述。
(2)制备方法:将上述原料称量后经混合、干法制粒、压片、包衣制成。
实施例2:
(1)原料准备:按质量份数计,酵母颗粒20份、复合果粉50份、充气糖浆颗粒30份,微晶纤维素适量、硬脂酸镁适量;
其中复合果粉中葡萄籽提取物含量为15份、石榴提取物含量为10份、橄榄果粉含量为10份、酸樱桃提取物含量为15份;
(2)制备方法:同实施例1。
实施例3:
(1)原料准备:按质量份数计,酵母颗粒25份、复合果粉45份、充气糖浆颗粒30份,微晶纤维素适量、硬脂酸镁适量;
其中复合果粉中葡萄籽提取物含量为15份、石榴提取物含量为10份、橄榄果粉含量为10份、酸樱桃提取物含量为10份;
(2)制备方法:同实施例1。
实施例4:
(1)原料准备:按质量份数计,酵母颗粒30份、复合果粉50份、充气糖浆颗粒20份,微晶纤维素适量、硬脂酸镁适量;
其中复合果粉中葡萄籽提取物含量为15份、石榴提取物含量为10份、橄榄果粉含量为10份、酸樱桃提取物含量为15份;
(2)制备方法:同实施例1。
实施例5:
(1)原料准备:按质量份数计,酵母颗粒40份、复合果粉30份、充气糖浆颗粒30份,微晶纤维素适量、硬脂酸镁适量;
其中复合果粉中葡萄籽提取物含量为5份、石榴提取物含量为10份、橄榄果粉含量为5份、酸樱桃提取物含量为10份;
(2)制备方法:同实施例1。
实施例6:
(1)原料准备:按质量份数计,酵母颗粒50份、复合果粉45份、充气糖浆颗粒5份,微晶纤维素适量、硬脂酸镁适量;
其中复合果粉中葡萄籽提取物含量为15份、石榴提取物含量为5份、橄榄果粉含量为10份、酸樱桃提取物含量为15份;
(2)制备方法:同实施例1。
实施例7:
(1)原料准备:按质量份数计,酵母颗粒55份、复合果粉35份、充气糖浆颗粒10份,微晶纤维素适量、硬脂酸镁适量;
其中复合果粉中葡萄籽提取物含量为5份、石榴提取物含量为15份、橄榄果粉含量为10份、酸樱桃提取物含量为5份;
(2)制备方法:同实施例1。
对比例1:酵母提取物50份(与60份酵母颗粒的GSH含量近似),微晶纤维素适量、硬脂酸镁适量,经混合、干法制粒、压片、包衣制成。
对比例2:本对比例与实施例1的区别在于:缺少复合果粉,充气糖浆颗粒。
对比例3:本对比例与实施例1的区别在于:缺少充气糖浆颗粒。
对比例4:本对比例与实施例1的区别在于:充气糖浆颗粒被替换成普通糖浆颗粒,并未充入二氧化碳。
对比例5:市售美白丸产品(配方:GSH、甜瓜SOD、多元酚)。
GSH样品稳定性测试:将实施例1~7和对比例1~5的样品进行稳定性加速试验,对比分析样品气味、外观的变化,并检测GSH的含量变化。
材料:TG-1000加速稳定箱、Agilent 1260高效液相色谱仪、电子天平以及其他玻璃仪器。
实验方法:实施例1~7(S1,S2,S3,S4,S5,S6,S7)、对比例1~5(D1,D2,D3,D4,D5),共12个样品片剂,储存于透明塑料无菌袋中,密封,放入加速箱,箱内条件设定为:温度40℃,相对湿度75%,开启箱内照明,实验周期为3个月,记录每个案例的各项指标初始变化。本实验目的在于模拟高温高湿条件下,检测分析各样品GSH含量的变化,反映GSH在不同配方及制备工艺下的稳定性差异。
检测方法:色谱条件与系统适用性试验参考《中国药典》第二部“谷胱甘肽片”【含量测定】相关项下;
标准样品制备:精密称取谷胱甘肽对照品适量,加流动相溶解并定量稀释制成每lmL中含0.2mg的溶液,作为对照品溶液(检测临时配用)。
试验样品制备:取样品20片,精密称定,研细,精密称取适量(根据配方量计算起始值相当于谷胱甘肽100mg),置100mL容量瓶中,加流动相适量,超声溶解,用流动相稀释至刻度,摇匀,滤过,精密量取续滤液适量,用流动相定量稀释成每1mL中含0.2mg的溶液。
计算方法:按外标法峰面积计算试验样品浓度。根据试验样品首测GSH浓度的计算值,将0.2mg/mL的对照品储备溶液,用流动相稀释制成相近浓度标准液,再次测定,所得浓度计算值作为结果值。
检测结果:稳定性试验样品GSH含量变化如表1所示,稳定性试验对比例GSH含量变化曲线如图1所示,稳定性试验后样品气味、色泽对比效果如表2所示。
表1:稳定性试验样品GSH含量变化
表2:稳定性试验后样品气味、色泽对比效果
注:色泽主要观察其片面色泽均匀度;
由表1~2和图1可以看出:实施例1~7在掩味和抗氧化剂稳定性方面明显优于对比例1~5。
酪氨酸酶抑制试验:
实验材料:紫外分光光度计、台式离心机、L-多巴、磷酸二氢钠、酪氨酸酶。
前处理准备:将经过3个月稳定性试验的实施例1~7、对比例1~5的片剂样品加水溶解,超声,并稀释定容至10mg/mL的样品液,L-多巴配制成0.2mg/mL的L-多巴溶液,酪氨酸酶溶液=100U/mL。
实验步骤:
含酶空白样品吸光度检测值M:取L-多巴溶液、纯化水、磷酸缓冲液:酪氨酸酶溶液=1:1:1:1,在30℃恒温水浴中反应40min,在475nm条件下测定吸光值;
无酶空白样品吸光度检测值N:取L-多巴溶液、纯化水、磷酸缓冲液=1:2:1,在30℃恒温水浴中反应40min,在475nm条件下测定吸光值;
纠正基础吸光值=M-N;
样品吸光度检测值Q:取L-多巴溶液、样品液、磷酸缓冲液:酪氨酸酶溶液=1:1:1:1,在30℃恒温水浴中反应40min,在475nm条件下测定吸光值;
无酶样品吸光度检测值P:取L-多巴溶液、样品液、磷酸缓冲液:纯化水=1:1:1:1,在30℃恒温水浴中反应40min,在475nm条件下测定吸光值;
纠正样品吸光度值=P-Q;
酪氨酸酶抑制率%=[(M-N)-(P-Q)]/(M-N)×100%。
检测结果:上述的酪氨酸酶抑制试验的稳定性试验样品酪氨酸酶抑制率对比情况如表3所示。
表3:稳定性试验样品酪氨酸酶抑制率对比情况
注:下降率(%)=酪氨酸抑制率(第3月)-酪氨酸抑制率(第0月)。
氨酸酶的活性与和黑色素的形成相关,在一定条件下,L-多巴能在酪氨酸酶的作用下生成多巴醌,该物质在475nm处附近有最大吸收。酪氨酸酶的抑制率可以直接的反映口服美白制剂的美白功效。
由表3可以看出:酪氨酸酶的抑制率与GSH含量成一定相关性,但通过抑制下降率可知,高稳定性口服美白制剂及制备方法可使GSH在高温高湿条件下维持较高的酪氨酸酶抑制率,稳定性极强。
人群验证试验:
实验方法:
挑选120名志愿者,男女不限,年龄18-60,一共分为12组,每组10人。实施例1~7和对比例1~5制备的口服美白制剂(第一组服用实施例1的美白组合物,第二组服用实施例2的口服美白制剂,以此类推,第12组服用对比例5的口服美白制剂),按照各配方产品的食用方法以及用量,同区域同时试用12周。受试者需在此期间保证作息规律,不熬夜;试验期间面部勿更换护肤品或化妆品;饮食中减少辛辣油腻食物的摄入,正常活动。每周需定时进行一次脸部皮肤状态测试,剔除季节变化或其他原因导致皮肤敏感人群,试验数据分析4周、8周、12周皮肤评价指标改善率。
评价指标:
(1)皮肤亮度L*、b*值
L*、a*、b*分别表征亮度、红绿色相、黄蓝色相,对应可评价皮肤发黑、发红、发黄的情况,此三种情况是影响肤色美观的主要方面,其中L*(亮度)即指从纯黑(L=0)到纯白(L=100)的亮度范围,即值越大颜色越偏向白色,反之偏向黑色,b*值越低,表示皮肤的黄度越低。a*值越小,皮肤红斑越少。
(2)ITA°数值
ITA°值是对个人皮肤颜色的测量分级指标,建立在皮肤美容常用的CIE L*a*b*颜色空间的基础上,通过皮肤色度仪进行测量。
计算公式:ITA=arctangent[(L*-50)/b*]×180/π
简而言之,上述四个指标分别代表了皮肤颜色发黑、发红、发黄的程度及其综合情况。也就是ITA数值越大,皮肤亮度越亮。
检测结果:上述实验的人群使用L*值改善率统计结果如表4所示,人群试用ITA°值改善率统计结果如表5所示。
表4:人群使用L*值改善率统计结果
注:S1组无效人数1人、S4组无效人数1人、D1组无效人数1人、D3组无效人数1人、D5组无效人数1人。
由表4可以看出:在测试周期12周内,受试者服用实施例1~7较对比例1~5的皮肤亮度L*值呈明显上升趋势,皮肤白度增加。
表5:人群试用ITA°值改善率统计结果
由表5可以看出:在测试12周内,受试者使用本发明的高稳定性口服美白制剂后,ITA°值呈升高趋势,因此,说明本发明的高稳定性口服美白制剂具有提高皮肤明亮度的效果。
本发明的高稳定性口服美白制剂以由环糊精包合的酵母提取物(富含谷胱甘肽)、富含维生素C、花青素、羟基酪醇等多酚的复合果粉、以及充气糖浆颗粒经过混合、干法制粒、压片、包衣制成的口服片剂或压片糖果,适用美白需求人群:
(1)制备工艺操作简单可执行,过程无添加防腐剂及香精。
(2)本发明的产品配方中谷胱甘肽(GSH)、维生素C、花青素等抗氧化剂具有美白协同增效的作用基础上,用天然果粉给消费者以更高的食品安全性及充气糖浆颗粒带来的高体验感,使食用产品过程更加愉悦;
(3)环糊精包合技术不仅克服了酵母提取物强引湿性带来的工艺影响,同时掩盖了物料本身不适的发酵气味,与含气糖浆阻断技术与包衣隔离技术,实现了三重工艺防护,使产品在货架期具有高稳定性,降低GSH易氧化分解的风险,保证产品功效的稳定性。
Claims (8)
1.一种高稳定性口服美白制剂,其特征在于,按质量份数计,包括有以下组分:
酵母颗粒 20~60份
复合果粉 20~50份
充气糖浆颗粒 5~30份。
2.根据权利要求1所述的高稳定性口服美白制剂,其特征在于:所述的酵母颗粒由酵母抽提物经环糊精包合得到。
3.根据权利要求2所述的高稳定性口服美白制剂,其特征在于:所述酵母颗粒的制备方法包括有以下步骤:将酵母提取物加入环糊精浆液中,经搅拌、超声、冷冻干燥、破碎过筛得到所需的酵母颗粒。
4.根据权利要求2所述的高稳定性口服美白制剂,其特征在于:所述酵母抽提物和环糊精的质量比为10:1~10。
6.根据权利要求1所述的高稳定性口服美白制剂,其特征在于:所述充气糖浆颗粒的制备方法包括有以下步骤:以还原糖为原料,经加热制浆、二氧化碳膨化、冷却、破碎、过筛得到的所需的充气糖果颗粒。
7.根据权利要求6所述的高稳定性口服美白制剂,其特征在于:所述的还原糖为具还原性的单糖、二糖中的至少一种。
8.一种权利要求1至7中任一权利要求所述的高稳定性口服美白制剂的制备方法,其特征在于包括以下步骤:按质量份数配比,20~60份酵母颗粒、20~50份复合果粉、5~30份充气糖浆颗粒经混合、干法制粒、压片、包衣制成所需的高稳定性口服美白制剂。
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0678713A (ja) * | 1991-02-27 | 1994-03-22 | Oriental Yeast Co Ltd | グルタチオンの安定化法及びそれを含有する飲料 |
JP2000060482A (ja) * | 1998-06-11 | 2000-02-29 | Fancl Corp | 食品組成物 |
CN104686660A (zh) * | 2013-12-06 | 2015-06-10 | 内蒙古伊利实业集团股份有限公司 | 一种含有跳跳糖的奶片及其制备方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
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JPH0678713A (ja) * | 1991-02-27 | 1994-03-22 | Oriental Yeast Co Ltd | グルタチオンの安定化法及びそれを含有する飲料 |
JP2000060482A (ja) * | 1998-06-11 | 2000-02-29 | Fancl Corp | 食品組成物 |
CN104686660A (zh) * | 2013-12-06 | 2015-06-10 | 内蒙古伊利实业集团股份有限公司 | 一种含有跳跳糖的奶片及其制备方法 |
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