CN107669731A - 一种护肤组合物及其应用、保健品 - Google Patents
一种护肤组合物及其应用、保健品 Download PDFInfo
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Abstract
本发明涉及保健品领域，特别涉及一种具有美白、抗衰老功效的护肤组合物及其保健品、用途。本发明提供的护肤组合物包括：浓缩香瓜粉、针叶樱桃粉和浓缩橄榄汁冻干粉。实验结果表明，本发明选用包括浓缩香瓜粉、针叶樱桃粉和浓缩橄榄汁冻干粉这三种天然药食同源的药材组成的组合物在美白、延缓衰老方面具有协同增效作用，能够有效地抑制酪氨酸形成、清除自由基、改善皮肤光损伤。以上结果表明，本发明提供的护肤组合物具有显著地美白、延缓衰老的作用。
Description
技术领域
本发明涉及保健品技术领域，具体涉及一种护肤组合物及其应用、保健品。
背景技术
现代医学对肤色暗黄生化本质的认识：关于皮肤衰老的机理研究得非常多，先后出现过很多学说，但能够较为合理地揭示肤色暗黄问题的主要有自由基衰老学说、非酶糖基化衰老学说。
肤色暗黄与自由基衰老学说：自由基(Free Radicals)衰老学说最早是由DenhamHarman于1955年提出来的。该学说认为：自由基具有极强的氧化能力，当机体内的自由基代谢处于不平衡状态时，过量的自由基就会引起机体损伤，将不饱和脂肪酸氧化成过氧化脂质(lipid peroxidase，LPO)，其终产物丙二醛(malonic dialdehyde，MDA)是很强的交联剂，与蛋白质、核酸等生物大分子交联，形成难溶性物质-脂褐素。人进入中老年之后，随着年龄的增大，皮肤内脂褐素类物质的量逐渐增多，从而使肤色暗黄现象愈发严重。
肤色暗黄与非酶糖基化衰老学说：非酶糖基化衰老学说(又称美拉德反应衰老学说)，作为分子水平的又一个重要的衰老学说，是近年来衰老机制研究的重点。生物体内非酶糖基化反应是指在无酶催化的条件下，还原性糖的醛基或酮基与蛋白质等大分子中的游离氨基反应生成可逆或不可逆结合物-高级糖基化终末产物(Advanced glycation end-products,AGEs)的过程。Dyer等发现皮肤衰老与非酶糖基化有关，皮肤的真皮层中富含胶原蛋白和弹性蛋白，蛋白质分子中的氨基酸容易与细胞外液中葡萄糖的醛基或酮基发生非酶糖基化反应，且随着年龄的增长，AGEs进行性增加，AGEs发生褐变后形成棕黄色的生物垃圾，堆积在皮肤的真皮层，令肌肤失去剔透感而泛黄、暗沉。此外，皮肤中AGEs增加，使胶原蛋白形成分子间交联，不但降低了皮肤的弹性和通透性，使养料及废物的扩散性能减弱，而且降低了胶原的可溶性使其难以被胶原酶水解，造成皮肤弹性下降，皱纹不易平复且不断加深，从而加快皮肤的衰老过程。
现代医学解决肤色暗黄、延缓衰老问题主要从以上两方面入手：①抑制非酶糖基化反应，消除羰基化合物对肌肤的危害；②清除自由基、避免脂质过氧化，减少羰基化合物的产生和肤色暗黄的形成。
目前市场上具有美白、抗衰老功效的保健品种类繁多、品质参差不齐，能够有效解决肤色暗黄、延缓衰老问题，且效果显著的保健品并不多见。
发明内容
本发明的目的在于提供一种具有美白、延缓衰老功效的护肤组合物及其应用、保健品。
为实现上述发明目的，本发明提供如下技术方案：
本发明提供的护肤组合物，包括浓缩香瓜粉、针叶樱桃粉和浓缩橄榄汁冻干粉。
作为优选，以重量份计，所述护肤组合物包括如下组分：
浓缩香瓜粉10-50份、针叶樱桃粉10-40份和浓缩橄榄汁冻干粉1-15份。
作为优选，所述组合物还包括库拉索芦荟凝胶、葡萄籽提取物和番茄红素。
作为优选，以重量份计，所述护肤组合物包括如下组分：
浓缩香瓜粉10-50份、针叶樱桃粉10-40份、浓缩橄榄汁冻干粉1-15份、库拉索芦荟凝胶1-10份、葡萄籽提取物1-5份和番茄红素0.1-1份。
本发明选用浓缩香瓜粉、针叶樱桃粉和浓缩橄榄汁冻干粉这三种天然药食两用植物提取物组成的组合物在美白、延缓衰老方面表现出协同增效作用，能够有效地抑制酪氨酸形成、清除自由基、改善皮肤光损伤，表明本发明所述组合物美白、延缓衰老的效果显著。在上述几味药材的基础上，添加库拉索芦荟凝胶、葡萄籽提取物和番茄红素，能够更显著的增强美白、延缓衰老的作用。
香瓜又称甘瓜或甜瓜，葫芦科植物的果实肉质，具多室及多种子，和浆果很像。香瓜中抗氧化性物质含量极高，以SOD和维生素C为主，能起到清除体内自由基，缓解衰老，也有一定的抗紫外线的功效，降低色素的形成和沉淀，能起到很好的美容养颜功效。尤其是在阳光充足的季节,能够避免色素沉着,起到防晒、增白、抗皱之保护皮肤的作用。
橄榄(Canarium album(Lour.)Raeusch.)又名山榄，又称谏果，橄榄科橄榄属乔木植物。南京人称它为青果，岭南人称作橄榄，不论生啖或是煮汁，它都能生津止渴、治咽喉瘸、解鱼熬之毒和喉闻骨鲠。橄榄营养丰富，果肉内含蛋白质、碳水化合物、脂肪、维生素C以及钙、磷、铁等矿物质。用现代生物技术分析，橄榄中主要活性物质为多酚类化学成，研究证明橄榄多酚具有较强的自由基清除能力及较高的抗氧化活性，橄榄多酚的自由基清除能力高于人工合成抗氧化剂BHA和抗坏血酸。羟基酪醇(hydroxytyrosol)，又名3，4-二羟基苯乙醇，是一种天然抗氧化剂，广泛存在于橄榄(olive)科橄榄属植物的枝叶及果实中，特别是地中海地区的橄榄树中含量较高，是橄榄油的有效成分。大量的研究表明羟基酪醇具有很强的抗氧化作用(Aeschbach et al.1994；Visioli et al.1998)，可阻止多不饱和脂肪酸的自氧化(Tsinidou et al.1995)。羟基酪醇对自由基的清除能力比其他一些合成的和天然的抗氧剂的抗氧化能力都高，例如，它是维生素E抗氧化性的10倍、二丁基羟基甲苯(BHT)的1000多倍。Goya等研究发现羟基酪醇能够降低由叔丁基过氧化氢所引起HepG2细胞内的ROS水平和脂质过氧化水平增高，阻止了叔丁基过氧化氢所导致的谷胱甘肽下降。谷胱甘肽为细胞所分泌的内生性主要抗氧化物质，能直接中和自由基和活性氧分子。
针叶樱桃，金虎尾科(Malpighiaceae)金虎尾属(Malpighia)凹缘金虎尾(M.emarginata)的果实。主产于巴西，其维生素C、维生素P(芦丁)、超氧化歧化酶(SOD)含量均雄冠世界所有水果，有“三王之果”之称。特别是维生素C，100克鲜果维生素C含量3500毫克，相当于苹果的500倍，柑橘的100倍，葡萄的600倍，梨的200倍，猕猴桃的12倍，被誉为维C之王。
库拉索芦荟凝胶，以库拉索芦荟叶片为原料，经沥醌清洗、去皮、漂烫、杀菌等步骤制成，芦荟凝胶冻干粉在滋润干燥肌肤、祛斑除痘、削除皱纹、恢复皮肤弹性，提高人体免疫力，清除自由基，缓解发炎和受损皮肤的疼痛等方面有着独特神奇的功效。
葡萄籽，葡萄籽是葡萄的种子，是葡萄酒和其他产品的下脚料，经晒干后分离葡萄皮、葡萄梗后所得产物，占整粒葡萄质量的4％～6％。葡萄籽含有丰富的氨基酸、维生素、矿物质和膳食纤维等多种营养物物质以及多种活性成分，如儿茶素类和原花青素类等多酚类物质，具有保健、美容之功效。
番茄红素，是类胡萝卜素的一种,主要存在于番茄、西瓜、葡萄柚和木瓜等食品中。番茄红素是从番茄中提取的天然生物抗氧化剂,有较独特的长链分子结构。研究表明番茄红素的抗氧化能力是维生素E的1 0 0倍。一个番茄红素分子可以清除数千个单线态氧。番茄红素是淬灭单线态氧和清除过氧化氢、自由基最强的类胡萝卜素,抑制、破坏单线态氧能力是胡萝卜素的2倍。因此番茄红素可以通过淬灭单线态氧预防脂类氧化,保护生物膜免受自由基的伤害,达到保护容颜,延缓衰老的作用。
在本发明提供的一些具体实施例中，以重量份计，所述护肤组合物包括如下组分：
浓缩香瓜粉30份、针叶樱桃粉20份、浓缩橄榄汁冻干粉15份、库拉索芦荟凝胶4份、葡萄籽提取物1份和番茄红素0.1份。
在本发明提供的一些具体实施例中，以重量份计，所述护肤组合物包括如下组分：
浓缩香瓜粉50份、针叶樱桃粉10份、浓缩橄榄汁冻干粉1份、库拉索芦荟凝胶4份、葡萄籽提取物1份和番茄红素0.1份。
在本发明提供的一些具体实施例中，以重量份计，所述护肤组合物包括如下组分：
浓缩香瓜粉10份、针叶樱桃粉40份、浓缩橄榄汁冻干粉12份、库拉索芦荟凝胶4份、葡萄籽提取物1份和番茄红素0.1份。
在本发明提供的一些具体实施例中，以重量份计，所述护肤组合物包括如下组分：
在本发明提供的一些具体实施例中，以重量份计，所述护肤组合物包括如下组分：
浓缩香瓜粉50份、针叶樱桃粉10份、浓缩橄榄汁冻干粉1份。
本发明提供的护肤组合物中，浓缩香瓜粉、针叶樱桃粉、浓缩橄榄汁冻干粉、库拉索芦荟凝胶和葡萄籽提取物可以是冻干粉，也可以是浓缩物，所述浓缩物和所述冻干粉的功效量应与所述原提取物成分份量相等。
本发明还提供了所述护肤组合物在制备具有美白、抗衰老功效的药物或保健品中的应用。
本发明还提供了一种具有美白抗衰老作用的药物，包括所述护肤组合物和药学上可接受的辅料。
本发明还提供了一种具有美白、抗衰老作用的保健品，包括所述护肤组合物和保健品中可接受的辅料。
作为优选，所述保健品中可接受的辅料选自异麦芽酮糖醇、微晶纤维素、硬脂酸镁、麦芽糖醇、抗性糊精、甜菊糖苷、预胶化淀粉、二氧化硅中的一种或两种以上。
在本发明提供的一些具体实施例中，以重量份计，所述保健品中可接受的辅料为异麦芽酮糖醇20-40份、微晶纤维素20-40份、硬脂酸镁1-5份。
在本发明提供的一些具体实施例中，以重量份计，所述保健品中可接受的辅料为麦芽糖醇20-40份、抗性糊精20-40份、甜菊糖苷1-5份。
在本发明提供的一些具体实施例中，以重量份计，所述保健品中可接受的辅料为预胶化淀粉20-40份、硬脂酸镁0.5-2份、二氧化硅0.5-2份。
本发明中，保健食品的剂型为片剂、胶囊剂、丸剂、颗粒剂、粉剂剂、口服液剂。
作为优选，所述保健品为压片糖果。压片糖果是粉末、颗粒经制粒或干粉混合(无需制粒)直接压片而成的产品，主要类型有普通压片糖、包衣压片糖、多层压片糖、泡腾压片糖以及咀嚼型压片糖。包装时尚、方便的压片糖果以其产品口味丰富、具清新口气或保健功能等特点，成为近年来糖果市场发展最快的糖果品类之一。
实验结果表明，本发明选用浓缩香瓜粉、针叶樱桃粉和浓缩橄榄汁冻干粉这三种天然药食两用植物提取物组成的组合物在美白、延缓衰老方面表现出协同增效作用，能够有效地抑制酪氨酸形成、清除自由基、改善皮肤光损伤。在上述几味药材的基础上，添加库拉索芦荟凝胶、葡萄籽提取物和番茄红素后能够明显的增强美白、延缓衰老的作用。
具体实施方式
本发明公开了一种护肤组合物及其应用、保健品，本领域技术人员可以借鉴本文内容，适当改进工艺参数实现。特别需要指出的是，所有类似的替换和改动对本领域技术人员来说是显而易见的，它们都被视为包括在本发明。本发明的方法及应用已经通过较佳实施例进行了描述，相关人员明显能在不脱离本发明内容、精神和范围内对本文所述的方法和应用进行改动或适当变更与组合，来实现和应用本发明技术。
对所公开的实施例的说明，使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下，在其它实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
下面结合实施例，进一步阐述本发明：
实施例1本发明护肤组合物
浓缩香瓜粉10份、针叶樱桃粉40份、浓缩橄榄汁冻干粉12份，混合，即得。
实施例2本发明护肤组合物
浓缩香瓜粉50份、针叶樱桃粉10份、浓缩橄榄汁冻干粉1份，混合即得。
实施例3本发明护肤组合物
浓缩香瓜粉30份、针叶樱桃粉20份、浓缩橄榄汁冻干粉15份，混合即得。
实施例4本发明护肤组合物
浓缩香瓜粉30份、针叶樱桃粉20份、浓缩橄榄汁冻干粉15份、库拉索芦荟凝胶4份、葡萄籽提取物1份、番茄红素0.1份，混合即得。
实施例5本发明护肤组合物
浓缩香瓜粉50份、针叶樱桃粉10份、浓缩橄榄汁冻干粉1份、库拉索芦荟凝胶4份、葡萄籽提取物1份和番茄红素0.1份，混合即得。
实施例6本发明护肤组合物
浓缩香瓜粉10份、针叶樱桃粉40份、浓缩橄榄汁冻干粉12份、库拉索芦荟凝胶4份、葡萄籽提取物1份和番茄红素0.1份，混合即得。
比较例1～6的护肤组合物
比较例1～6的护肤组合物，如表1所示。
表1比较例1～6的护肤组合物
实施例7体外试验
将实施例1～6和比较例1～6的组合物，加水稀释，得到终浓度为10mg/mL的样品液。
(1)抑制酪氨酸酶活性的测定：在各试管中分别加入磷酸盐缓冲液(PBS)和样品液、酪氨酸酶溶液，混合均匀，于恒温水浴(37℃)反应10min，分别迅速移入多巴溶液1mL，混匀，放回水浴中反应5min，当反应至5min时马上测各收拾样品在475nm处的吸光度，计算供试药液对酪氨酸酶的抑制率。
(2)DPPH自由基清除率的测定：精密移取DPPH自由基溶液、样品液和无水乙醇各2mL于同一试管中，混匀后避光静置20min，分别测定517nm处的吸光度，计算供试药液对DPPH的清除率。
结果如表2所示。
表2不同配方酪氨酸酶抑制率、DPPH清除率结果
注：综合评分＝酪氨酸酶抑制率×50％+DPPH清除率×50％。
根据表2数据可知，实施例1～6组对酪氨酸酶抑制率及DPPH清除率均明显优于单药各组和比较例1～6组，具有显著的美白作用。
实施例8本发明组合物对大鼠皮肤光损伤的防护作用
动物分组：取Wistar大鼠120只，5周龄，体重122.5±5.5g，雌雄各半，按清洁动物标准条件雌雄分笼喂养。随机分为15组，包括正常对照组、模型对照组、单药组和试验组，每组8只，按照表3所示的给药方式灌胃给药(0.83g/kg)，连续给药4周，试验期间大鼠正常饮水，正常饲喂普通基础颗粒饲料。
表3分组与给药方式
实验方法：
动物脱毛+UVA照射：将大鼠用乙醚吸入法适度麻醉，以眼科剪刀剪短背部鼠毛至1mm，然后用电动剃须刀将剩余鼠毛剃净，脱毛区约5.0×4.5cm。照射前6h脱毛。
标本取材：照射后24h乙醚吸入法麻醉大鼠，以皮肤活检术取下背部脱毛区中央处皮肤，尽量去除皮下组织，生理盐水洗净后分别置入10％中性福尔马林和液氮中保存备用。标本取材后，常规10％福尔马林固定，石蜡包埋4μm连续切片，常规HE染色。
皮肤MDA含量、超氧化物歧化酶(SOD)活性、谷胱甘肽过氧化物酶(GSH-Px)活性的检测：末次UVA十UVB照射实验结束后，处死大鼠，取大鼠背部照射区部分皮肤，去除皮下脂肪称重，制成10％组织匀浆，以3000转/分钟的速度离心10分钟，取上清液进行各指标测定。
结果如表4所示。
表4丙二醛(MDA)含量及抗氧化酶活性测定(n＝8，x±s)
| 组别 | MDA(nmol/mg prot) | SOD(U/mg port) | GSH-Px(U/mg port) |
| 对照组 | 13.76±1.11 | 14.28±1.48 | 12.13±1.83 |
| UVA+UVB照射组 | 25.05±1.64▲▲ | 8.75±1.29▲▲ | 7.88±1.10▲▲ |
| UVA+UVB照射+单药组 | |||
| 浓缩香瓜粉 | 24.21±1.11 | 8.30±1.49 | 8.50±1.08 |
| 针叶樱桃粉 | 24.50±1.18 | 8.71±0.78 | 8.88±1.10 |
| 浓缩橄榄汁冻干粉 | 24.98±1.15 | 8.82±1.08 | 8.90±1.29 |
| UVA+UVB照射+试验组 | |||
| 实施例1组 | 23.41±0.78* | 10.38±1.45* | 9.20±1.49* |
| 实施例2组 | 18.10±1.10** | 10.04±1.12* | 9.77±1.83* |
| 实施例3组 | 22.77±1.95* | 9.94±1.09* | 9.70±1.95* |
| 实施例4组 | 14.30±1.25** | 15.76±1.28** | 14.98±1.25** |
| 实施例5组 | 15.10±0.88** | 14.24±1.08** | 13.51±1.87** |
| 实施例6组 | 15.91±1.06** | 13.44±1.56** | 12.08±1.37** |
| 比较例1组 | 24.01±0.83 | 9.77±1.86 | 9.02±1.45 |
| 比较例2组 | 24.15±1.45 | 8.97±1.46 | 8.96±1.41 |
| 比较例3组 | 23.98±1.00 | 9.43±1.44 | 9.03±1.76 |
| 比较例4组 | 23.85±1.04 | 9.61±1.11 | 8.99±1.38 |
| 比较例5组 | 23.99±1.08 | 9.66±0.83 | 9.09±1.47 |
| 比较例6组 | 24.15±1.19 | 9.56±1.02 | 9.01±1.44 |
注：与正常对照组比较：▲P＜0.05，▲▲P＜0.01；与模型对照组比较：*P＜0.05，**P＜0.01
结果显示，与对照组比较，UVA+UVB照射可使大鼠皮肤组织匀浆中MDA含量显著增高，SOD活性和谷胱甘肽过氧化物酶(GSH-Px)活性均显著降低。与UVA+UVB照射组比较，UVA+UVB照射+实施例1～6组能够显著降低皮肤组织匀浆中MDA的含量(P＜0.05)，显著提高SOD活性和GSH-Px活性(P＜0.05)。其中，实施例4的组合物对对紫外线防护效果最好。比较例1～6组的皮肤组织匀浆中MDA的含量、SOD活性和GSH-Px活性与模型组对比，未达显著差异，这表明，比较例组的组合物对对紫外线防护效果不明显。
实施例9美白抗衰功效测试试验
本实验使用荷兰DiagnOptics的AGE Reader(皮肤AGEs荧光光谱仪)，通过无创法测定受试者皮肤自体荧光(skin autofluorescence，AF)参考值判断实施例1是否可以降低皮肤组织中AGEs含量。入选受试者20人，女性，平均年龄28岁。受试期间口服实施例1的组合物，连续服用1个月。检测服用前后皮肤AGEs含量，结果如表5所示：
表5受试者服用前后肝功能变化比较(n＝20，x±s)
| 受试人数 | AF值 | |
| 服用前 | 20 | 1.8±0.3 |
| 服用后 | 20 | 1.5±0.2** |
注：服用前后对比，**P＜0.01
由表5结果可知，与服用前相比，受试者服用本发明实施例1的组合物后皮肤自体荧光值显著下降(P＜0.01)，表明本发明提供的组合物能够显著延缓皮肤衰老。
取实施例2～6所述的组合物进行美白抗衰功效测试试验，结果与实施例1相同或相近，无显著性差异(P>0.05)。
实施例10本发明护肤组合物片剂的制备
(1)称量、备料：称取实施例4所述组合物、异麦芽酮糖醇30份、微晶纤维素30份、硬脂酸镁3份，备用。
(2)混合：将上述除硬脂酸镁外的原料混合25min，然后加入硬脂酸镁再混合5min。
(3)压片：用压片机将上述混合料进行压片，0.5g/片，得到素片。
(4)包衣：称取配方量包衣剂，配置成适宜的固形物含量，在配桨锅中搅拌30～45分钟；搅拌完成后，对素片进行包衣，至片面基本成膜、颜色一致。
实施例11本发明护肤组合物粉剂的制备
(1)称量、称取实施例5所述组合物、麦芽糖醇30份、抗性糊精30份、甜菊糖苷3份，备用。
(2)混合：先将甜菊糖苷与抗性糊精混合10分钟，至颜色均匀后，再加入实施例5所述的组合物和麦芽糖醇，混合30分钟至完全均匀后出料。
(3)分装：按要求调整好设备，再将60mm空白铝箔膜准确安装于颗粒包装机上，待空机调试完毕后下料进行包装，至装量、外型符合要求才正式分装，净重量控制在每袋4克，每袋装量差异±4.5％，每10分钟检查一次装量差异，随时抽检外观和密封性。密封性用密封试验仪进行检测，真空度应小于或等于-60kpa，测试时间应该大于或等于3分钟。外袋上不得有粉粘结，不得有泄漏。
实施例12本发明护肤组合物硬胶囊的制备
(1)备料、混合：称取实施例6所述组合物、预胶化淀粉30份、硬脂酸镁1.5份、二氧化硅1.5份，备用。
(2)填充：混合好的物料在全自动填充剂上填充，装量0.5g/粒。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。
Claims (10)
1.一种护肤组合物，其特征在于，包括浓缩香瓜粉、针叶樱桃粉和浓缩橄榄汁冻干粉。
2.根据权利要求1所述的护肤组合物，其特征在于，以重量份计，包括如下组分：
浓缩香瓜粉10-50份、针叶樱桃粉10-40份和浓缩橄榄汁冻干粉1-15份。
3.根据权利要求1或2所述的护肤组合物，其特征在于，还包括库拉索芦荟凝胶、葡萄籽提取物和番茄红素。
4.根据权利要求3所述的护肤组合物，以重量份计，包括如下组分：
浓缩香瓜粉10-50份、针叶樱桃粉10-40份、浓缩橄榄汁冻干粉1-15份、库拉索芦荟凝胶1-10份、葡萄籽提取物1-5份和番茄红素0.1-1份。
5.根据权利要求3或4所述的护肤组合物，其特征在于，所述浓缩香瓜粉、所述针叶樱桃粉、所述浓缩橄榄汁冻干粉、所述库拉索芦荟凝胶、所述葡萄籽提取物为冻干粉或浓缩物。
6.权利要求1～5任一项所述的护肤组合物在制备具有美白、抗衰老功效的药物或保健品中的应用。
7.一种具有美白抗衰老作用的药物，其特征在于，包括如权利要求1至5任一项所述的组合物和药学上可接受的辅料。
8.一种具有美白、抗衰老作用的保健品，其特征在于，包括如权利要求1至5任一项所述的组合物和保健品中可接受的辅料。
9.据权利要求8所述的保健品，其特征在于，所述保健品中可接受的辅料选自异麦芽酮糖醇、微晶纤维素、硬脂酸镁、麦芽糖醇、抗性糊精、甜菊糖苷、预胶化淀粉、二氧化硅中的一种或两种以上。
10.根据权利要求8所述的保健品，其特征在于，其剂型为片剂、胶囊剂、丸剂、颗粒剂、粉剂剂、口服液剂。
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| WO2019100923A1 (zh) * | 2017-11-21 | 2019-05-31 | 汤臣倍健股份有限公司 | 一种护肤组合物及其应用、保健品 |
| CN113521136A (zh) * | 2021-08-04 | 2021-10-22 | 上海楷达生物科技有限公司 | 一种有助于皮肤美白和除皱的组合物 |
| CN114259515A (zh) * | 2021-12-31 | 2022-04-01 | 安琪纽特股份有限公司 | 一种具有抗糖化作用的组合物及应用 |
| CN114601006A (zh) * | 2022-01-28 | 2022-06-10 | 广州市诺品健康科技有限公司 | 一种美白压片糖果及其制备方法 |
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| CN106954813A (zh) * | 2017-03-16 | 2017-07-18 | 广州瓷肌化妆品有限公司 | 一种美白保健食品及其制备方法 |
| CN107669731B (zh) * | 2017-11-21 | 2020-07-28 | 汤臣倍健股份有限公司 | 一种护肤组合物及其应用、保健品 |
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| CN113521136A (zh) * | 2021-08-04 | 2021-10-22 | 上海楷达生物科技有限公司 | 一种有助于皮肤美白和除皱的组合物 |
| CN114259515A (zh) * | 2021-12-31 | 2022-04-01 | 安琪纽特股份有限公司 | 一种具有抗糖化作用的组合物及应用 |
| CN114601006A (zh) * | 2022-01-28 | 2022-06-10 | 广州市诺品健康科技有限公司 | 一种美白压片糖果及其制备方法 |
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