ES2164270T3 - Preparado farmaceutico adhesivo a la piel, en especial tts, para la cesion de 17-beta-estradiol al organismo humano. - Google Patents
Preparado farmaceutico adhesivo a la piel, en especial tts, para la cesion de 17-beta-estradiol al organismo humano.Info
- Publication number
- ES2164270T3 ES2164270T3 ES96944648T ES96944648T ES2164270T3 ES 2164270 T3 ES2164270 T3 ES 2164270T3 ES 96944648 T ES96944648 T ES 96944648T ES 96944648 T ES96944648 T ES 96944648T ES 2164270 T3 ES2164270 T3 ES 2164270T3
- Authority
- ES
- Spain
- Prior art keywords
- estradiol
- human organism
- assignment
- beta
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title abstract 5
- 229960005309 estradiol Drugs 0.000 title abstract 4
- 239000000853 adhesive Substances 0.000 title 1
- 230000001070 adhesive effect Effects 0.000 title 1
- 229930182833 estradiol Natural products 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000007792 gaseous phase Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000005022 packaging material Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
LA INVENCION TRATA DE UNA PREPARACION FARMACEUTICA QUE SE ADHIERE A LA PIEL, EN ESPECIAL TTS, PARA LA LIBERACION DE LA SUSTANCIA ACTIVA 17 BE ESTRADIOL EN EL ORGANISMO HUMANO, A CU YO EFECTO LA CONCENTRACION DE ESTRADIOL, QUE SE ENCUENTRA ALLI EN FORMA DISUELTA, ESTA EN TODAS LAS CAPAS MATRICES Y, SI EXISTE UNA CAPA ADHERENTE, TAMBIEN EN ESTA, ENTRE SU CONCENTRACION DE SATURACION EN EQUILIBRIO CON UNA FASE GASEOSA CON MENOS DEL 10 % DE HUMEDAD RELATIVA DEL AIRE Y SU CONCENTRACION DE SATURACION EN EQUILIBRIO CON UNA FASE GASEOSA CON MAS DEL 90 % DE HUMEDAD RELATIVA DEL AIRE. ESTA PREPARACION ESTA CARACTERIZADA PORQUE LA CANTIDAD DE ESTRADIOL CONTENIDA EN LA PREPARACION SUPONE AL MENOS EL TRIPLE DE LA SOLUBILIDAD DE SATURACION MEDIDA AL 95 % DE HUMEDAD RELATIVA DEL AIRE Y EL AIRE ENCERRADO EN EL MATERIAL DE EMPAQUETADO SE REGULA A UNA HUMEDAD RELATIVA DEL AIRE DE ENTRE EL 5 % Y POR DEBAJO DEL 0,5 %.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19600347A DE19600347A1 (de) | 1996-01-08 | 1996-01-08 | Hauthaftende pharmazeutische Zubereitung, insbesondere TTS zur Abgabe von 17-beta-Estradiol an den menschlichen Organismus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2164270T3 true ES2164270T3 (es) | 2002-02-16 |
Family
ID=7782261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96944648T Expired - Lifetime ES2164270T3 (es) | 1996-01-08 | 1996-12-23 | Preparado farmaceutico adhesivo a la piel, en especial tts, para la cesion de 17-beta-estradiol al organismo humano. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6267982B1 (es) |
| EP (1) | EP0880366B1 (es) |
| JP (1) | JP2000505071A (es) |
| KR (1) | KR100476579B1 (es) |
| CN (1) | CN1107525C (es) |
| AT (1) | ATE205406T1 (es) |
| AU (1) | AU721677B2 (es) |
| CA (1) | CA2242577C (es) |
| CZ (1) | CZ289291B6 (es) |
| DE (2) | DE19600347A1 (es) |
| DK (1) | DK0880366T3 (es) |
| ES (1) | ES2164270T3 (es) |
| HU (1) | HUP9901102A3 (es) |
| IL (1) | IL125160A (es) |
| MY (1) | MY129733A (es) |
| NO (1) | NO312878B1 (es) |
| NZ (1) | NZ325817A (es) |
| PL (1) | PL187275B1 (es) |
| SK (1) | SK282984B6 (es) |
| WO (1) | WO1997025077A1 (es) |
| ZA (1) | ZA97111B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6623763B2 (en) * | 1996-01-08 | 2003-09-23 | Lts Lohmann Therape-System Ag | Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism |
| US20020039597A1 (en) * | 1998-04-20 | 2002-04-04 | Koji Ukai | Stabilized compositions containing benzimidazole-type compounds |
| DE19827732A1 (de) * | 1998-06-22 | 1999-12-23 | Rottapharm Bv | Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie |
| AU2001237164A1 (en) * | 2000-03-02 | 2001-09-12 | Mcgill University | Caspase-inhibitory-factor (cif) and uses thereof |
| US20070158227A1 (en) * | 2004-01-30 | 2007-07-12 | Satoshi Amano | Plaster enclosing packaging bag |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863738A (en) * | 1987-11-23 | 1989-09-05 | Alza Corporation | Skin permeation enhancer compositions using glycerol monooleate |
| AU633887B2 (en) * | 1989-02-28 | 1993-02-11 | Teijin Limited | Poultice and preparation thereof |
| IT1253265B (it) * | 1991-11-25 | 1995-07-14 | Rotta Research Lab | Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo. |
| DE4223360C1 (es) * | 1992-07-16 | 1993-04-08 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
| DE4237453C1 (es) * | 1992-11-06 | 1993-08-19 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
| DE4405899A1 (de) * | 1994-02-18 | 1995-08-24 | Schering Ag | Mittel zur transdermalen Applikation enthaltend Desogestrel |
| DE4429667C2 (de) * | 1994-08-20 | 1996-07-11 | Lohmann Therapie Syst Lts | Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung |
| DE4429664C2 (de) * | 1994-08-20 | 1997-09-11 | Lohmann Therapie Syst Lts | Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung |
-
1996
- 1996-01-08 DE DE19600347A patent/DE19600347A1/de not_active Withdrawn
- 1996-12-23 AT AT96944648T patent/ATE205406T1/de active
- 1996-12-23 KR KR10-1998-0705246A patent/KR100476579B1/ko not_active IP Right Cessation
- 1996-12-23 WO PCT/EP1996/005822 patent/WO1997025077A1/de active IP Right Grant
- 1996-12-23 AU AU13057/97A patent/AU721677B2/en not_active Ceased
- 1996-12-23 US US09/101,720 patent/US6267982B1/en not_active Expired - Lifetime
- 1996-12-23 ES ES96944648T patent/ES2164270T3/es not_active Expired - Lifetime
- 1996-12-23 HU HU9901102A patent/HUP9901102A3/hu unknown
- 1996-12-23 CN CN96199544A patent/CN1107525C/zh not_active Expired - Fee Related
- 1996-12-23 IL IL12516096A patent/IL125160A/xx not_active IP Right Cessation
- 1996-12-23 CZ CZ19982140A patent/CZ289291B6/cs not_active IP Right Cessation
- 1996-12-23 SK SK908-98A patent/SK282984B6/sk unknown
- 1996-12-23 NZ NZ325817A patent/NZ325817A/xx not_active IP Right Cessation
- 1996-12-23 EP EP96944648A patent/EP0880366B1/de not_active Expired - Lifetime
- 1996-12-23 PL PL96327940A patent/PL187275B1/pl not_active IP Right Cessation
- 1996-12-23 CA CA002242577A patent/CA2242577C/en not_active Expired - Fee Related
- 1996-12-23 DK DK96944648T patent/DK0880366T3/da active
- 1996-12-23 JP JP9524813A patent/JP2000505071A/ja active Pending
- 1996-12-23 DE DE59607696T patent/DE59607696D1/de not_active Expired - Lifetime
-
1997
- 1997-01-06 MY MYPI97000032A patent/MY129733A/en unknown
- 1997-01-07 ZA ZA9700111A patent/ZA97111B/xx unknown
-
1998
- 1998-07-03 NO NO19983098A patent/NO312878B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MY129733A (en) | 2007-04-30 |
| PL327940A1 (en) | 1999-01-04 |
| NO983098L (no) | 1998-07-03 |
| SK90898A3 (en) | 1999-01-11 |
| HUP9901102A3 (en) | 1999-11-29 |
| EP0880366B1 (de) | 2001-09-12 |
| CN1207049A (zh) | 1999-02-03 |
| KR100476579B1 (ko) | 2005-09-26 |
| IL125160A (en) | 2003-01-12 |
| CZ289291B6 (cs) | 2001-12-12 |
| CA2242577A1 (en) | 1997-07-17 |
| WO1997025077A1 (de) | 1997-07-17 |
| ATE205406T1 (de) | 2001-09-15 |
| NZ325817A (en) | 1999-01-28 |
| PL187275B1 (pl) | 2004-06-30 |
| EP0880366A1 (de) | 1998-12-02 |
| CN1107525C (zh) | 2003-05-07 |
| AU1305797A (en) | 1997-08-01 |
| HUP9901102A2 (hu) | 1999-08-30 |
| CA2242577C (en) | 2006-06-06 |
| AU721677B2 (en) | 2000-07-13 |
| ZA97111B (en) | 1997-08-18 |
| SK282984B6 (sk) | 2003-01-09 |
| DE59607696D1 (de) | 2001-10-18 |
| CZ214098A3 (cs) | 1998-11-11 |
| DK0880366T3 (da) | 2001-12-27 |
| KR19990077110A (ko) | 1999-10-25 |
| NO312878B1 (no) | 2002-07-15 |
| NO983098D0 (no) | 1998-07-03 |
| DE19600347A1 (de) | 1997-07-10 |
| US6267982B1 (en) | 2001-07-31 |
| JP2000505071A (ja) | 2000-04-25 |
| IL125160A0 (en) | 1999-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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