ES2157407T3 - Reactivo y procedimiento para injertar un grupo difluorometilo sustituido en un compuesto que tiene al menos una funcion electrofila. - Google Patents

Reactivo y procedimiento para injertar un grupo difluorometilo sustituido en un compuesto que tiene al menos una funcion electrofila.

Info

Publication number
ES2157407T3
ES2157407T3 ES96400625T ES96400625T ES2157407T3 ES 2157407 T3 ES2157407 T3 ES 2157407T3 ES 96400625 T ES96400625 T ES 96400625T ES 96400625 T ES96400625 T ES 96400625T ES 2157407 T3 ES2157407 T3 ES 2157407T3
Authority
ES
Spain
Prior art keywords
difluorometilo
integrate
reagent
group replaced
electrophile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96400625T
Other languages
English (en)
Other versions
ES2157407T5 (es
Inventor
Gerard Forat
Jean-Manuel Mas
Laurent Saint-Jalmes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhodia Chimie SAS
Original Assignee
Rhodia Chimie SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26231834&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2157407(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR9503512A external-priority patent/FR2732010B1/fr
Priority claimed from FR9515763A external-priority patent/FR2743065B1/fr
Application filed by Rhodia Chimie SAS filed Critical Rhodia Chimie SAS
Application granted granted Critical
Publication of ES2157407T3 publication Critical patent/ES2157407T3/es
Publication of ES2157407T5 publication Critical patent/ES2157407T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C19/00—Acyclic saturated compounds containing halogen atoms
    • C07C19/08—Acyclic saturated compounds containing halogen atoms containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/48—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation involving decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN REACTIVO NUCLEOFILO UTIL PARA INJERTAR UN GRUPO DIFLUOROMETILO SUSTITUIDO SOBRE UN COMPUESTO QUE LLEVA AL MENOS UNA FUNCION ELECTROFILA, CARACTERIZADO POR EL HECHO DE QUE COMPRENDE: A) UN ACIDO FLUOROCARBOXILICO DE FORMULA EA-CF{SUB,2}-COOH DONDE EA REPRESENTA UN ATOMO O UN GRUPO ELECTROATRAYENTE, AL MENOS PARCIALMENTE SALIFICADO POR UN CATION ORGANICO O MINERAL, Y B) UN SOLVENTE APROTICO POLAR; Y POR EL HECHO DE QUE EL CONTENIDO EN PROTONES LIBERABLES LLEVADOS POR SUS DIVERSOS COMPONENTES, INCLUIDO SUS IMPUREZAS ES A LO SUMO IGUAL A LA MITAD DE LA CONCENTRACION MOLAR INICIAL DE DICHO ACIDO FLUOROCARBOXILICO. UN PROCEDIMIENTO DE SINTESIS UTILIZA ESTE REACTIVO POR CALENTAMIENTO PARA INJERTAR UN GRUPO DIFLUOROMETILO SUSTITUIDO SOBRE DIVERSOS COMPUESTOS.
ES96400625T 1995-03-24 1996-03-22 Reactivo y procedimiento para injertar un grupo difluorometilo sustituido en un compuesto que tiene al menos una funcion electrofila. Expired - Lifetime ES2157407T5 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9503512 1995-03-24
FR9503512A FR2732010B1 (fr) 1995-03-24 1995-03-24 Reactif et procede utiles pour greffer un groupement difluoromethyle substitue sur un compose comportant au moins une fonction electrophile
FR9515763A FR2743065B1 (fr) 1995-12-29 1995-12-29 Reactif et procede utiles pour greffer un groupement difluoromethyle substitue sur un compose comportant au moins une fonction electrophile
FR9515763 1995-12-29

Publications (2)

Publication Number Publication Date
ES2157407T3 true ES2157407T3 (es) 2001-08-16
ES2157407T5 ES2157407T5 (es) 2010-04-20

Family

ID=26231834

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96400625T Expired - Lifetime ES2157407T5 (es) 1995-03-24 1996-03-22 Reactivo y procedimiento para injertar un grupo difluorometilo sustituido en un compuesto que tiene al menos una funcion electrofila.

Country Status (22)

Country Link
US (1) US5756849A (es)
EP (1) EP0733614B2 (es)
JP (1) JP4450875B2 (es)
KR (1) KR100436787B1 (es)
CN (1) CN1150148C (es)
AT (1) ATE201393T1 (es)
AU (1) AU4822896A (es)
BR (1) BR9601109A (es)
CA (1) CA2172450A1 (es)
CZ (1) CZ85596A3 (es)
DE (1) DE69612899T3 (es)
DK (1) DK0733614T3 (es)
ES (1) ES2157407T5 (es)
HU (1) HU217027B (es)
IL (1) IL117534A0 (es)
PL (1) PL313435A1 (es)
PT (1) PT733614E (es)
RO (1) RO117911B1 (es)
RU (1) RU2204545C2 (es)
SK (1) SK37096A3 (es)
TR (1) TR199600234A1 (es)
UA (1) UA45324C2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19824488A1 (de) * 1998-06-02 1999-12-09 Bayer Ag Verfahren zur Herstellung von Perfluoralkyl-aryl-sulfiden und neue Perfluoralkyl-aryl-sulfide
US7385063B2 (en) 2001-01-26 2008-06-10 Chugai Seiyaku Kabushiki Kaisha Method for preparing imidazole derivatives
WO2002064136A2 (en) 2001-01-26 2002-08-22 Chugai Seiyaku Kabushiki Kaisha Malonyl-coa decarboxylase inhibitors useful as metabolic modulators
US7524969B2 (en) 2001-01-26 2009-04-28 Chugai Seiyaku Kabushiki Kaisha Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
PL204456B1 (pl) 2001-02-20 2010-01-29 Chugai Pharmaceutical Co Ltd Związki azolowe, ich zastosowanie i środek farmaceutyczny
FR2827285B1 (fr) * 2001-07-10 2003-12-05 Rhodia Chimie Sa Reactif et procede pour la perfluoroalcoylation
WO2003048033A2 (en) 2001-11-29 2003-06-12 University Of Southern California Magnesium mediated preparation of fluorinated alkylsilanes
FR2841551B1 (fr) * 2002-06-28 2006-01-13 Rhodia Chimie Sa Procede de synthese de derives a radical hydrogenofluoromethylene-sulfonyle
WO2005037258A2 (en) 2003-08-01 2005-04-28 Chugai Seiyaku Kabushiki Kaisha Cyanoguanidine-based azole compounds useful as malonyl-coa decarboxylase inhibitors
US7285562B2 (en) 2003-08-01 2007-10-23 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors
US7696365B2 (en) 2003-08-01 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors
CA2533749C (en) 2003-08-01 2012-07-10 Chugai Seiyaku Kabushiki Kaisha Piperidine compounds useful as malonyl-coa decarboxylase inhibitors
US7710197B2 (en) * 2007-07-11 2010-05-04 Axiom Microdevices, Inc. Low offset envelope detector and method of use
US11028105B2 (en) 2018-06-29 2021-06-08 The Regents Of The University Of Michigan Difluoromethyl and difluoromethylene transfer reagents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808748A (en) * 1985-12-12 1989-02-28 Ethyl Corporation Trifluoromethylation process
US4822904A (en) * 1985-12-12 1989-04-18 Ethyl Corporation Perfluoroalkylation process
US4990699A (en) * 1988-10-17 1991-02-05 Ethyl Corporation Perfluoroalkylation process

Also Published As

Publication number Publication date
UA45324C2 (uk) 2002-04-15
ES2157407T5 (es) 2010-04-20
PT733614E (pt) 2001-08-30
EP0733614B2 (fr) 2010-01-13
RO117911B1 (ro) 2002-09-30
AU4822896A (en) 1996-10-03
HU217027B (hu) 1999-11-29
EP0733614A1 (fr) 1996-09-25
SK37096A3 (en) 1997-07-09
CN1137508A (zh) 1996-12-11
ATE201393T1 (de) 2001-06-15
TR199600234A1 (tr) 1997-03-21
HUP9600724A1 (en) 1997-04-28
JPH08319251A (ja) 1996-12-03
KR100436787B1 (ko) 2004-09-18
HU9600724D0 (en) 1996-05-28
CN1150148C (zh) 2004-05-19
DE69612899T3 (de) 2010-06-10
DK0733614T3 (da) 2001-09-10
BR9601109A (pt) 1998-01-06
CZ85596A3 (en) 1996-10-16
KR960034146A (ko) 1996-10-22
RU2204545C2 (ru) 2003-05-20
MX9601075A (es) 1997-07-31
DE69612899D1 (de) 2001-06-28
PL313435A1 (en) 1996-09-30
DE69612899T2 (de) 2001-10-11
CA2172450A1 (fr) 1996-09-25
JP4450875B2 (ja) 2010-04-14
IL117534A0 (en) 1996-07-23
US5756849A (en) 1998-05-26
EP0733614B1 (fr) 2001-05-23

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