ES2196078T3 - Nuevo intermediario para la produccion de un derivado de piridina y procedimiento para producir este derivado. - Google Patents
Nuevo intermediario para la produccion de un derivado de piridina y procedimiento para producir este derivado.Info
- Publication number
- ES2196078T3 ES2196078T3 ES95932208T ES95932208T ES2196078T3 ES 2196078 T3 ES2196078 T3 ES 2196078T3 ES 95932208 T ES95932208 T ES 95932208T ES 95932208 T ES95932208 T ES 95932208T ES 2196078 T3 ES2196078 T3 ES 2196078T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- represented
- produce
- procedure
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
ESTA INVENCION SE REFIERE A: (1) UN COMPUESTO REPRESENTADO POR LA FORMULA (V), SU TAUTOMERO Y UNA MEZCLA DE LOS MISMOS; (2) UN PROCEDIMIENTO PARA PRODUCIR EL COMPUESTO REPRESENTADO POR LA FORMULA ARRIBA MENCIONADA (V), SU TAUTOMERO O UNA MEZCLA DE LOS MISMOS, QUE COMPRENDE LA REACCION DE N-VINILPIPERIDONA REPRESENTADA POR LA FORMULA (I) CON UN NICOTINATO REPRESENTADO POR LA FORMULA (II), EN DONDE R REPRESENTA UN GRUPO DE ALQUILO BAJO, EN PRESENCIA DE UN ALCOXIDO DE SODIO; (3) UN PROCEDIMIENTO PARA PRODUCIR UN DERIVADO DE PIRIDINA REPRESENTADO POR LA FORMULA (III), QUE COMPRENDE LA PRODUCCION DEL COMPUESTO REPRESENTADO POR LA FORMULA (V), SU TAUTOMERO O UNA MEZCLA DE LOS MISMOS MEDIANTE EL PROCEDIMIENTO DESCRITO EN EL PUNTO ANTERIOR (2), Y A CONTINUACION TRATAR EL COMPUESTO OBTENIDO CON UN ACIDO; Y (4) UN PROCEDIMIENTO PARA PRODUCIR UN DERIVADO DE PIRIDINA REPRESENTADO POR LA FORMULA (IV), EN EL CUAL EL TRATAMIENTO CON UN ACIDO COMO SE DESCRIBE EN EL PUNTO ANTERIOR (3) ES SEGUIDO DE OTRO TRATAMIENTO CON UNA BASE. ASI, LA PRESENTE INVENCION PROPORCIONA PROCEDIMIENTOS INDUSTRIALES PARA PRODUCIR DERIVADOS DE PIRIDINA REPRESENTADOS POR LAS FORMULA (III) Y (IV) DE FORMA SEGURA, ECONOMICA, FACIL Y EFICAZ SIN UTILIZAR NINGUN REACTIVO PELIGROSO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25272694A JP3219946B2 (ja) | 1994-09-22 | 1994-09-22 | 新規製造中間体及びピリジン誘導体の製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196078T3 true ES2196078T3 (es) | 2003-12-16 |
Family
ID=17241414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95932208T Expired - Lifetime ES2196078T3 (es) | 1994-09-22 | 1995-09-21 | Nuevo intermediario para la produccion de un derivado de piridina y procedimiento para producir este derivado. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5734059A (es) |
EP (1) | EP0787724B1 (es) |
JP (1) | JP3219946B2 (es) |
CA (1) | CA2200604C (es) |
DE (1) | DE69530408T2 (es) |
ES (1) | ES2196078T3 (es) |
WO (1) | WO1996009300A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1531820A1 (en) * | 2002-08-30 | 2005-05-25 | Memory Pharmaceuticals Corporation | Anabaseine derivatives useful in the treatment of neurodegenerative diseases |
WO2005123075A2 (en) * | 2004-06-08 | 2005-12-29 | University Of Florida Research Foundation, Inc. | Controlling angiogenesis with anabaseine analogs |
WO2018064529A1 (en) | 2016-09-29 | 2018-04-05 | The Uab Research Foundation | Methods and compositions for increasing mucus clearance |
ES2898315T3 (es) * | 2017-12-22 | 2022-03-07 | Siegfried Ag | Preparación de nicotina racémica mediante reacción de nicotinato de etilo con n-vinilpirrolidona en presencia de una base de alcoholato y etapas de proceso posteriores |
WO2020099491A1 (en) | 2018-11-14 | 2020-05-22 | Novozymes A/S | Oral care composition comprising a polypeptide having dnase activity |
US20230332124A1 (en) | 2020-08-24 | 2023-10-19 | Novozymes A/S | Oral care composition comprising a fructanase |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0573568T3 (da) * | 1991-03-01 | 2001-04-23 | Univ Florida | Anvendelse af nicotinære analoger til behandling af degenerative sygdomme i nervesystemet |
-
1994
- 1994-09-22 JP JP25272694A patent/JP3219946B2/ja not_active Expired - Fee Related
-
1995
- 1995-09-21 CA CA002200604A patent/CA2200604C/en not_active Expired - Fee Related
- 1995-09-21 WO PCT/JP1995/001911 patent/WO1996009300A1/ja active IP Right Grant
- 1995-09-21 DE DE69530408T patent/DE69530408T2/de not_active Expired - Lifetime
- 1995-09-21 EP EP95932208A patent/EP0787724B1/en not_active Expired - Lifetime
- 1995-09-21 ES ES95932208T patent/ES2196078T3/es not_active Expired - Lifetime
- 1995-09-21 US US08/809,467 patent/US5734059A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0787724A4 (en) | 1998-01-07 |
DE69530408T2 (de) | 2003-10-30 |
JPH0892242A (ja) | 1996-04-09 |
CA2200604A1 (en) | 1996-03-28 |
EP0787724A1 (en) | 1997-08-06 |
WO1996009300A1 (fr) | 1996-03-28 |
US5734059A (en) | 1998-03-31 |
CA2200604C (en) | 2001-04-10 |
JP3219946B2 (ja) | 2001-10-15 |
EP0787724B1 (en) | 2003-04-16 |
DE69530408D1 (de) | 2003-05-22 |
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