FR2743065B1 - Reactif et procede utiles pour greffer un groupement difluoromethyle substitue sur un compose comportant au moins une fonction electrophile - Google Patents

Reactif et procede utiles pour greffer un groupement difluoromethyle substitue sur un compose comportant au moins une fonction electrophile

Info

Publication number
FR2743065B1
FR2743065B1 FR9515763A FR9515763A FR2743065B1 FR 2743065 B1 FR2743065 B1 FR 2743065B1 FR 9515763 A FR9515763 A FR 9515763A FR 9515763 A FR9515763 A FR 9515763A FR 2743065 B1 FR2743065 B1 FR 2743065B1
Authority
FR
France
Prior art keywords
grafting
reagent
compound
difluoromethyl group
method useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9515763A
Other languages
English (en)
Other versions
FR2743065A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhodia Chimie SAS
Original Assignee
Rhone Poulenc Chimie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Chimie SA filed Critical Rhone Poulenc Chimie SA
Priority to FR9515763A priority Critical patent/FR2743065B1/fr
Priority to IL11753496A priority patent/IL117534A0/xx
Priority to SK370-96A priority patent/SK37096A3/sk
Priority to AU48228/96A priority patent/AU4822896A/en
Priority to CZ96855A priority patent/CZ85596A3/cs
Priority to US08/620,348 priority patent/US5756849A/en
Priority to RO96-00640A priority patent/RO117911B1/ro
Priority to UA96031110A priority patent/UA45324C2/uk
Priority to BR9601109A priority patent/BR9601109A/pt
Priority to PL96313435A priority patent/PL313435A1/xx
Priority to DE69612899T priority patent/DE69612899T3/de
Priority to EP96400625A priority patent/EP0733614B2/fr
Priority to HU9600724A priority patent/HU217027B/hu
Priority to AT96400625T priority patent/ATE201393T1/de
Priority to MXPA/A/1996/001075A priority patent/MXPA96001075A/xx
Priority to TR96/00234A priority patent/TR199600234A1/xx
Priority to PT96400625T priority patent/PT733614E/pt
Priority to DK96400625T priority patent/DK0733614T3/da
Priority to CNB961057556A priority patent/CN1150148C/zh
Priority to ES96400625T priority patent/ES2157407T5/es
Priority to CA002172450A priority patent/CA2172450A1/fr
Priority to RU96105817/04A priority patent/RU2204545C2/ru
Priority to KR1019960008042A priority patent/KR100436787B1/ko
Priority to JP09296096A priority patent/JP4450875B2/ja
Publication of FR2743065A1 publication Critical patent/FR2743065A1/fr
Application granted granted Critical
Publication of FR2743065B1 publication Critical patent/FR2743065B1/fr
Priority to US09/201,854 priority patent/US6464895B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/48—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation involving decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR9515763A 1995-03-24 1995-12-29 Reactif et procede utiles pour greffer un groupement difluoromethyle substitue sur un compose comportant au moins une fonction electrophile Expired - Fee Related FR2743065B1 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
FR9515763A FR2743065B1 (fr) 1995-12-29 1995-12-29 Reactif et procede utiles pour greffer un groupement difluoromethyle substitue sur un compose comportant au moins une fonction electrophile
IL11753496A IL117534A0 (en) 1995-03-24 1996-03-18 Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function
SK370-96A SK37096A3 (en) 1995-03-24 1996-03-20 An reagent and its use for binding substituted difluoromethyl group on a compound having at least one electrophilic group
CZ96855A CZ85596A3 (en) 1995-03-24 1996-03-21 Reagent and method of attaching a substituted difluoromethyl group to a compound having at least one electrophilic group
AU48228/96A AU4822896A (en) 1995-03-24 1996-03-21 Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function
CNB961057556A CN1150148C (zh) 1995-03-24 1996-03-22 用于将取代的二氟甲基基团接枝到至少含有一个亲电子官能团化合物上的试剂及其方法
UA96031110A UA45324C2 (uk) 1995-03-24 1996-03-22 Нуклеофільний реагент для введення заміщеної дифторметильної групи та спосіб одержання похідних, що містять дифторметиленову групу
BR9601109A BR9601109A (pt) 1995-03-24 1996-03-22 Reativo nucleofílico útil para enxertar um grupamento difluorometila substituido sobre um composto que compreende pelo menos uma função eletrofílica e processo de sintese de um derivado que compreende um grupamento difluorometileno
PL96313435A PL313435A1 (en) 1995-03-24 1996-03-22 Reactant and method useful in transplanting the substituted difluoromethyl group to a compound containing at least one electrophylic functional group
DE69612899T DE69612899T3 (de) 1995-03-24 1996-03-22 Reagenz und Verfahren zum Anbringen einer substituierten Difluoromethylgruppe an einer Verbindung mit mindenstens einer elektrophilen Funktion
EP96400625A EP0733614B2 (fr) 1995-03-24 1996-03-22 Réactif et procédé utiles pour greffer un groupement difluorométhyle substitué sur un composé comportant au moins une fonction électrophile
HU9600724A HU217027B (hu) 1995-03-24 1996-03-22 Reagens és eljárás szubsztituált difluor-metil-csoport bevitelére egy vagy több elektrofil csoportot tartalmazó vegyületbe és a reagens alkalmazása
US08/620,348 US5756849A (en) 1995-03-24 1996-03-22 Process for grafting a substituted difluoromethyl group onto a compound containing an electrophilic functional group
MXPA/A/1996/001075A MXPA96001075A (en) 1995-03-24 1996-03-22 Reagent and procedure useful for grafting a trifluorometry group substituted on a compound that has at least one functional group electrofil
TR96/00234A TR199600234A1 (tr) 1995-03-24 1996-03-22 Ikameli bir diflorometil grubunu en azindan bir elektrofilik fonksiyon iceren bir bilesime eklemek icin yararli belirtec ve islem.
PT96400625T PT733614E (pt) 1995-03-24 1996-03-22 Reagente e processo uteis para enxertar um grupo difluorometilo substituido num composto comportando pelo menos uma funcao electrofila
DK96400625T DK0733614T3 (da) 1995-03-24 1996-03-22 Reagens og fremgangsmåde til at knytte en substitueret difluormethylgruppe til en forbindelse, der har mindst en elektrofil funktion
RO96-00640A RO117911B1 (ro) 1995-03-24 1996-03-22 Reactiv si procedeu pentru grefarea unei grupari difluormetilenice, substituite pe un compus care are cel putin o functie electrofila
ES96400625T ES2157407T5 (es) 1995-03-24 1996-03-22 Reactivo y procedimiento para injertar un grupo difluorometilo sustituido en un compuesto que tiene al menos una funcion electrofila.
CA002172450A CA2172450A1 (fr) 1995-03-24 1996-03-22 Reactif et procede utiles pour greffer un groupement difluoromethyle substitue sur un compose comportant au moins une fonction electrophile
RU96105817/04A RU2204545C2 (ru) 1995-03-24 1996-03-22 Реактив и способ для введения замещенной дифторметильной группы в соединения, имеющие по меньшей мере одну электрофильную функцию
AT96400625T ATE201393T1 (de) 1995-03-24 1996-03-22 Reagenz und verfahren zum anbringen einer substituierten difluoromethylgruppe an einer verbindung mit mindenstens einer elektrophilen funktion
KR1019960008042A KR100436787B1 (ko) 1995-03-24 1996-03-23 치환된디플루오로메틸기를하나이상의친전자성작용기를함유하는화합물상에그라프팅하기위한시약및방법
JP09296096A JP4450875B2 (ja) 1995-03-24 1996-03-25 求電子官能基少なくとも１個を含有する化合物上に置換ジフルオロメチル基をグラフトさせるのに有用な試薬及び方法
US09/201,854 US6464895B2 (en) 1995-03-24 1998-12-01 Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9515763A FR2743065B1 (fr) 1995-12-29 1995-12-29 Reactif et procede utiles pour greffer un groupement difluoromethyle substitue sur un compose comportant au moins une fonction electrophile

Publications (2)

Publication Number Publication Date
FR2743065A1 FR2743065A1 (fr) 1997-07-04
FR2743065B1 true FR2743065B1 (fr) 1998-03-20

Family

ID=9486170

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9515763A Expired - Fee Related FR2743065B1 (fr) 1995-03-24 1995-12-29 Reactif et procede utiles pour greffer un groupement difluoromethyle substitue sur un compose comportant au moins une fonction electrophile

Country Status (1)

Country Link
FR (1) FR2743065B1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808748A (en) * 1985-12-12 1989-02-28 Ethyl Corporation Trifluoromethylation process
US4822904A (en) * 1985-12-12 1989-04-18 Ethyl Corporation Perfluoroalkylation process
US4990699A (en) * 1988-10-17 1991-02-05 Ethyl Corporation Perfluoroalkylation process

Also Published As

Publication number Publication date
FR2743065A1 (fr) 1997-07-04

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