ES2156446T3 - Formulacion farmaceutica semisolida que contiene dexketoprofeno trometanol. - Google Patents

Formulacion farmaceutica semisolida que contiene dexketoprofeno trometanol.

Info

Publication number
ES2156446T3
ES2156446T3 ES98937444T ES98937444T ES2156446T3 ES 2156446 T3 ES2156446 T3 ES 2156446T3 ES 98937444 T ES98937444 T ES 98937444T ES 98937444 T ES98937444 T ES 98937444T ES 2156446 T3 ES2156446 T3 ES 2156446T3
Authority
ES
Spain
Prior art keywords
pharmaceutical formulation
dexketoprophene
tromethanol
formulation containing
semisolid pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98937444T
Other languages
English (en)
Inventor
Casellas David Mauleon
Benet Albert Palomer
Perez Luisa Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Application granted granted Critical
Publication of ES2156446T3 publication Critical patent/ES2156446T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere a un procedimiento para la preparación de una formulación farmacéutica semisólida (gel o crema) que contiene dexketoprofeno trometamol y diferentes aminas como agentes neutralizantes, para el tratamiento tópico de procesos inflamatorios en humanos. Las formulaciones farmacéuticas de esta invención presentan ventajas derivadas de su gran estabilidad al almacenamiento sin modificaciones importantes en la apariencia del producto con el tiempo, así como su débil actividad alérgica y fotoalérgica.
ES98937444T 1997-06-04 1998-06-04 Formulacion farmaceutica semisolida que contiene dexketoprofeno trometanol. Expired - Lifetime ES2156446T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701213A ES2124196B1 (es) 1997-06-04 1997-06-04 Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.

Publications (1)

Publication Number Publication Date
ES2156446T3 true ES2156446T3 (es) 2001-06-16

Family

ID=8299560

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009701213A Expired - Lifetime ES2124196B1 (es) 1997-06-04 1997-06-04 Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.
ES98937444T Expired - Lifetime ES2156446T3 (es) 1997-06-04 1998-06-04 Formulacion farmaceutica semisolida que contiene dexketoprofeno trometanol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES009701213A Expired - Lifetime ES2124196B1 (es) 1997-06-04 1997-06-04 Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.

Country Status (29)

Country Link
EP (1) EP0996437B1 (es)
JP (1) JP2002502407A (es)
KR (1) KR100543558B1 (es)
CN (1) CN1195510C (es)
AT (1) ATE201137T1 (es)
AU (1) AU728442B2 (es)
BG (1) BG64299B1 (es)
BR (1) BR9810072B1 (es)
CA (1) CA2293589C (es)
CU (1) CU22866A3 (es)
CZ (1) CZ290118B6 (es)
DE (1) DE69800804T2 (es)
DK (1) DK0996437T3 (es)
EA (1) EA002026B1 (es)
EC (1) ECSP014108A (es)
EE (1) EE03905B1 (es)
ES (2) ES2124196B1 (es)
GR (1) GR3036319T3 (es)
HK (1) HK1027753A1 (es)
HN (1) HN2001000137A (es)
HU (1) HU226686B1 (es)
ID (1) ID26240A (es)
NZ (1) NZ501487A (es)
PL (1) PL190779B1 (es)
PT (1) PT996437E (es)
SK (1) SK284317B6 (es)
TR (1) TR199903018T2 (es)
UA (1) UA57075C2 (es)
WO (1) WO1998055113A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19935159A1 (de) * 1999-07-27 2001-02-22 Schuster Wolfgang Mittel zur Muskelentspannung
FR2797766B1 (fr) * 1999-08-27 2003-04-04 Menarini France Nouvelles formes topiques a consistance pateuse sous forme d'un gel distribue en doses
WO2013022410A2 (en) 2011-08-08 2013-02-14 Mahmut Bilgic Production method for effervescent formulations comprising dexketoprofen
EP2764875A1 (en) * 2013-02-06 2014-08-13 Galenicum Health S.L. Process for preparing a stable pharmaceutical composition comprising dexketoprofen trometamol
FR3024360A1 (fr) * 2014-07-30 2016-02-05 Pf Medicament Emulsions aux stearates
RU2667465C2 (ru) * 2015-10-28 2018-09-19 Закрытое Акционерное Общество "Фармфирма "Сотекс" Фармацевтическая композиция для наружного применения, содержащая соль декскетопрофена, и способ ее получения
CN109303762A (zh) * 2017-07-28 2019-02-05 韩美药品株式会社 含有酮洛芬的半固体制剂及其制备方法
KR101935830B1 (ko) * 2018-02-13 2019-01-07 주식회사 오스테오시스 외부역박동시스템과 그 제어방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319340A1 (fr) * 1975-07-28 1977-02-25 Roussel Uclaf Nouveau sel de l'acide a-methyl benzoyl-5 thiophene-2 acetique, procede de preparation et application a titre de medicament
IT1124398B (it) * 1979-12-05 1986-05-07 Menarini Sas Utilizzazione della forma farmaceutica gel contenente acido 23 benzoilfenil propionico impiegabile in terapia per uso topico
IT1207994B (it) * 1986-01-03 1989-06-01 Therapicon Srl Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche.
US4960892A (en) * 1988-06-10 1990-10-02 American Home Products Corporation Naphthalenepropionic acid derivatives as anti-inflammatory/anti-allergic agents
US5091182A (en) * 1990-07-23 1992-02-25 Syntex (U.S.A.) Inc. Dispensing units for ketorolac topical gel formlations
ES2058024B1 (es) * 1992-11-10 1995-05-01 Menarini Lab Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.

Also Published As

Publication number Publication date
CA2293589A1 (en) 1998-12-10
SK284317B6 (sk) 2005-01-03
HK1027753A1 (en) 2001-01-23
DE69800804T2 (de) 2001-09-13
HUP0002734A2 (hu) 2001-01-29
ECSP014108A (es) 2002-02-25
EE9900556A (et) 2000-06-15
BG64299B1 (bg) 2004-09-30
KR20010013320A (ko) 2001-02-26
CZ290118B6 (cs) 2002-06-12
AU728442B2 (en) 2001-01-11
CN1195510C (zh) 2005-04-06
WO1998055113A1 (en) 1998-12-10
KR100543558B1 (ko) 2006-01-20
EP0996437B1 (en) 2001-05-16
BG103926A (en) 2000-09-29
ATE201137T1 (de) 2001-06-15
TR199903018T2 (xx) 2000-05-22
EE03905B1 (et) 2002-12-16
HUP0002734A3 (en) 2003-05-28
CN1259048A (zh) 2000-07-05
EP0996437A1 (en) 2000-05-03
CA2293589C (en) 2008-01-22
NZ501487A (en) 2001-06-29
CZ431399A3 (cs) 2000-05-17
PL337156A1 (en) 2000-07-31
GR3036319T3 (en) 2001-11-30
JP2002502407A (ja) 2002-01-22
CU22866A3 (es) 2003-08-13
HU226686B1 (en) 2009-06-29
AU8624498A (en) 1998-12-21
ID26240A (id) 2000-12-07
PL190779B1 (pl) 2006-01-31
DK0996437T3 (da) 2001-08-06
ES2124196A1 (es) 1999-01-16
EA199900998A1 (ru) 2000-06-26
EA002026B1 (ru) 2001-12-24
SK164999A3 (en) 2000-09-12
DE69800804D1 (de) 2001-06-21
HN2001000137A (es) 2001-10-29
BR9810072A (pt) 2000-09-19
ES2124196B1 (es) 1999-12-01
BR9810072B1 (pt) 2010-07-13
UA57075C2 (uk) 2003-06-16
PT996437E (pt) 2001-09-28

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