ES2149991T3 - Tetrahidroindeno(1,2-d)(1,3,2)oxazaboroles y su utilizacion como catalizadores enantioselectivos. - Google Patents

Tetrahidroindeno(1,2-d)(1,3,2)oxazaboroles y su utilizacion como catalizadores enantioselectivos.

Info

Publication number
ES2149991T3
ES2149991T3 ES95921397T ES95921397T ES2149991T3 ES 2149991 T3 ES2149991 T3 ES 2149991T3 ES 95921397 T ES95921397 T ES 95921397T ES 95921397 T ES95921397 T ES 95921397T ES 2149991 T3 ES2149991 T3 ES 2149991T3
Authority
ES
Spain
Prior art keywords
tetrahydroindeno
oxazaborols
enantial
catalyzers
effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95921397T
Other languages
English (en)
Inventor
Yun Gao
Yaping Hong
Charles M Zepp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of ES2149991T3 publication Critical patent/ES2149991T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02Boron compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Abstract

SE DESCRIBE UN METODO PARA LA REDUCCION ENANTIOSELECTIVA DE QUETONAS PROQUIRALES MEDIANTE CANTIDADES CATALITICAS DE TETRAHIDROINDENO[[]1,2-D[]][[]1,3,2[]]OXAZABOROLES DE FORMULA (II). LOS OXAZABOROLES PUEDEN GENERARSE IN SITU A PARTIR DE LOS CIS-1-AMINO-2-INDANOLES O IMINO INDANOLES CORRESPONDIENTES (III). TAMBIEN SE DESCRIBEN NUEVOS COMPUESTOS DE FORMULAS (II) Y (III).
ES95921397T 1994-05-31 1995-05-24 Tetrahidroindeno(1,2-d)(1,3,2)oxazaboroles y su utilizacion como catalizadores enantioselectivos. Expired - Lifetime ES2149991T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/250,821 US5495054A (en) 1994-05-31 1994-05-31 Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts

Publications (1)

Publication Number Publication Date
ES2149991T3 true ES2149991T3 (es) 2000-11-16

Family

ID=22949300

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95921397T Expired - Lifetime ES2149991T3 (es) 1994-05-31 1995-05-24 Tetrahidroindeno(1,2-d)(1,3,2)oxazaboroles y su utilizacion como catalizadores enantioselectivos.

Country Status (12)

Country Link
US (1) US5495054A (es)
EP (1) EP0763005B1 (es)
JP (1) JP3867250B2 (es)
AT (1) ATE195711T1 (es)
AU (1) AU689595B2 (es)
CA (1) CA2191073C (es)
DE (1) DE69518516T2 (es)
DK (1) DK0763005T3 (es)
ES (1) ES2149991T3 (es)
GR (1) GR3034809T3 (es)
PT (1) PT763005E (es)
WO (1) WO1995032937A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0713848B1 (en) * 1994-10-28 1999-09-08 SUMIKA FINE CHEMICALS Company, Limited Process for producing optically active carbinols
US5929284A (en) * 1995-02-03 1999-07-27 Kaneka Corporation Processes for producing α-halo ketones, α-halohydrins and epoxides
WO2002051781A1 (fr) * 2000-12-25 2002-07-04 Ajinomoto Co., Inc. Procede permettant de preparer un compose d'halohydrine optiquement actif
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
KR20070000508A (ko) * 2004-04-02 2007-01-02 글락소 그룹 리미티드 화학적 방법 및 결정형
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
UY30550A1 (es) 2006-08-22 2008-03-31 Boehringer Ingelheim Int Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
CN101747211A (zh) * 2009-07-03 2010-06-23 凯莱英生命科学技术(天津)有限公司 一种手性β-氨基醇衍生物的合成方法及其部分最终产物
EP2560939A2 (en) 2010-04-20 2013-02-27 Actavis Group Ptc Ehf Novel process for preparing phenylcyclopropylamine derivatives using novel intermediates
CN110627673B (zh) * 2018-06-22 2023-04-07 上海天慈中商药业有限公司 一种福莫特罗关键中间体的制备方法
CN109748788B (zh) * 2019-01-17 2021-05-14 南方科技大学 ɑ-羟基酸制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
US5039802A (en) * 1990-04-18 1991-08-13 Merck & Co., Inc. Arylation process for preparation of chiral catalysts for ketone reduction
US5157129A (en) * 1990-04-18 1992-10-20 Merck & Co., Inc. Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide
US5189177A (en) * 1990-04-18 1993-02-23 Merck & Co., Inc. Chiral boron catalysts for reduction of ketones and process for their preparation
US5264585A (en) * 1990-04-18 1993-11-23 Merck & Co., Inc. Chiral catalysts for reduction of ketones and process for their preparation
AU659929B2 (en) * 1992-05-14 1995-06-01 Pfizer Inc. Enantioselective oxazaborolidine catalysts
TW416958B (en) * 1993-05-14 2001-01-01 Pfizer Enantioselective oxazaborolidine catalysts

Also Published As

Publication number Publication date
PT763005E (pt) 2001-01-31
DE69518516T2 (de) 2001-04-19
AU689595B2 (en) 1998-04-02
JPH10501530A (ja) 1998-02-10
EP0763005B1 (en) 2000-08-23
CA2191073A1 (en) 1995-12-07
AU2648795A (en) 1995-12-21
GR3034809T3 (en) 2001-02-28
ATE195711T1 (de) 2000-09-15
US5495054A (en) 1996-02-27
DK0763005T3 (da) 2000-12-27
JP3867250B2 (ja) 2007-01-10
DE69518516D1 (de) 2000-09-28
WO1995032937A1 (en) 1995-12-07
CA2191073C (en) 2007-07-17
EP0763005A4 (en) 1997-10-22
EP0763005A1 (en) 1997-03-19

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