ES2144792T3 - Uso de inhibidores de la nadph oxidasa para la preparacion de un medicamento para la prevencion de la aterosclerosis. - Google Patents

Uso de inhibidores de la nadph oxidasa para la preparacion de un medicamento para la prevencion de la aterosclerosis.

Info

Publication number
ES2144792T3
ES2144792T3 ES96940912T ES96940912T ES2144792T3 ES 2144792 T3 ES2144792 T3 ES 2144792T3 ES 96940912 T ES96940912 T ES 96940912T ES 96940912 T ES96940912 T ES 96940912T ES 2144792 T3 ES2144792 T3 ES 2144792T3
Authority
ES
Spain
Prior art keywords
nadph oxidase
prevention
atherosclerosis
medication
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96940912T
Other languages
English (en)
Inventor
James A Holland
David K Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Application granted granted Critical
Publication of ES2144792T3 publication Critical patent/ES2144792T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

SE PROPORCIONA UN METODO PARA LA PREVENCION Y EL TRATAMIENTO DE LA ATEROSCLEROSIS Y ENFERMEDADES RELACIONADAS EN MAMIFEROS, EN EL QUE SE ADMINISTRA UN INHIBIDOR DE LA NADPH OXIDASA. EL INHIBIDOR DE LA NADPH OXIDASA PREVIENE LA PRODUCCION DE ESPECIES DE OXIGENO REACTIVO ANTE LA EXPOSICION DE LAS CELULAS ENDOTELIALES A NIVELES ATEROGENICOS DE LDL, DANDO LUGAR ASI A UNA DISMINUCION DE LA ENDOCITOSIS Y LA HIPERPERMEABILIDAD VASCULAR. LOS INHIBIDORES PREFERIDOS DE LA NADPH OXIDASA SON LOS CORRESPONDIENTES A LA FORMULA (I). ADEMAS, SE PROPORCIONA UN METODO DIAGNOSTICO PARA PREDECIR EL RIESGO DE ENFERMEDADES ATEROSCLEROTICAS PARA UN PACIENTE HUMANO.
ES96940912T 1995-11-27 1996-11-27 Uso de inhibidores de la nadph oxidasa para la preparacion de un medicamento para la prevencion de la aterosclerosis. Expired - Lifetime ES2144792T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/562,767 US5763496A (en) 1995-11-27 1995-11-27 Prevention of atherosclerosis using NADPH oxidase inhibitors

Publications (1)

Publication Number Publication Date
ES2144792T3 true ES2144792T3 (es) 2000-06-16

Family

ID=24247689

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96940912T Expired - Lifetime ES2144792T3 (es) 1995-11-27 1996-11-27 Uso de inhibidores de la nadph oxidasa para la preparacion de un medicamento para la prevencion de la aterosclerosis.

Country Status (10)

Country Link
US (2) US5763496A (es)
EP (2) EP0861070B1 (es)
JP (2) JPH11507946A (es)
AT (1) ATE189957T1 (es)
AU (1) AU1085997A (es)
CA (1) CA2238098C (es)
DE (1) DE69606882T2 (es)
ES (1) ES2144792T3 (es)
GR (1) GR3033067T3 (es)
WO (1) WO1997019679A2 (es)

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Also Published As

Publication number Publication date
EP0861070A2 (en) 1998-09-02
JP2003176224A (ja) 2003-06-24
DE69606882D1 (de) 2000-04-06
WO1997019679A3 (en) 1997-08-28
DE69606882T2 (de) 2000-08-17
CA2238098A1 (en) 1997-06-05
GR3033067T3 (en) 2000-08-31
US5763496A (en) 1998-06-09
ATE189957T1 (de) 2000-03-15
EP0914821A3 (en) 2000-04-26
CA2238098C (en) 2001-01-30
EP0861070B1 (en) 2000-03-01
US5902831A (en) 1999-05-11
WO1997019679A2 (en) 1997-06-05
AU1085997A (en) 1997-06-19
EP0914821A2 (en) 1999-05-12
JPH11507946A (ja) 1999-07-13

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