ES2142350T3 - Amidas del acido 4-oxo-acetidin-2-sulfonico y sus sales, procedimiento para su preparacion y su utilizacion. - Google Patents

Amidas del acido 4-oxo-acetidin-2-sulfonico y sus sales, procedimiento para su preparacion y su utilizacion.

Info

Publication number
ES2142350T3
ES2142350T3 ES93919299T ES93919299T ES2142350T3 ES 2142350 T3 ES2142350 T3 ES 2142350T3 ES 93919299 T ES93919299 T ES 93919299T ES 93919299 T ES93919299 T ES 93919299T ES 2142350 T3 ES2142350 T3 ES 2142350T3
Authority
ES
Spain
Prior art keywords
me2c
hydrogen
oxo
salts
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93919299T
Other languages
English (en)
Inventor
Mice Kovacevic
Jure J Herak
Zora Mandic
Irena Lukic
Mirjana Tomic
Zinka Brkic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Handels GmbH
Pliva Farmaceutika dd
Original Assignee
Pliva Handels GmbH
Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Handels GmbH, Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd filed Critical Pliva Handels GmbH
Application granted granted Critical
Publication of ES2142350T3 publication Critical patent/ES2142350T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

4 - OXO - AZETIDINA - 2 - AMIDA ACIDO SULFONICO Y SUS SALES DE LA FORMULA GENERAL (I), DONDE LOS RESTOS TIENEN EL SIGUIENTE SIGNIFICADO: R1 ES HIDROGENO, HALOGENO; R2 ES HIDROGENO, HALOGENO, NH2, FENIL - CH2CONH, FENIL OCH2CONH, EFTALIMIDO, O MENHCOC6H4CONH, ISOXAZOLIL CARBONILAMINO; R3 ES HIDROGENO, ME2C = C - COOME, H2C = C(ME) - CH - COOME, ME2C = C - COOCH2 FENIL, H2C = C(ME) - CH - COOCH2C6H4NO2 - P, ME2C = C - COOCH2C6H4NO2 P, ME2C = C - COOH2C6H4NO2 - M, H2C = C(ME) - CHCO - OCH2C6H4ME - M, ME2C = C - COOH; R4 ES HIDROGENO O SODIO Y R5 ES HIDROGENO, ALQUIL, BENZIL O UN HETEROCICLO, POR EJEMPLO ISOXAZOL, PIRAZOL ETC., PROCEDIMIENTO PARA SU ELABORACION Y SU UTILIZACION COMO COMPUESTOS INTERMEDIOS PARA LA SINTESIS DE ANALOGOS BETA-LACTAMO O COMO SUSTANCIA ACTIVA PARA LA ELABORACION DE PREPARADOS EN TERAPIA ANTIMICROBIAL.
ES93919299T 1992-09-08 1993-09-08 Amidas del acido 4-oxo-acetidin-2-sulfonico y sus sales, procedimiento para su preparacion y su utilizacion. Expired - Lifetime ES2142350T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4230053A DE4230053A1 (de) 1992-09-08 1992-09-08 4-Oxo-azetidin-2-sulfonsäureamide und ihre Salze, Verfahren zu deren Herstellung und ihre Verwendung

Publications (1)

Publication Number Publication Date
ES2142350T3 true ES2142350T3 (es) 2000-04-16

Family

ID=6467533

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93919299T Expired - Lifetime ES2142350T3 (es) 1992-09-08 1993-09-08 Amidas del acido 4-oxo-acetidin-2-sulfonico y sus sales, procedimiento para su preparacion y su utilizacion.

Country Status (19)

Country Link
US (1) US5466686A (es)
EP (1) EP0659177B1 (es)
JP (1) JPH08501093A (es)
CN (1) CN1042130C (es)
AT (1) ATE187441T1 (es)
BG (1) BG62135B1 (es)
CA (1) CA2142275A1 (es)
CZ (1) CZ54595A3 (es)
DE (2) DE4230053A1 (es)
ES (1) ES2142350T3 (es)
GR (1) GR3032702T3 (es)
HR (1) HRP930613A2 (es)
HU (1) HU217979B (es)
PL (1) PL173895B1 (es)
PT (1) PT659177E (es)
RO (1) RO115256B1 (es)
RU (1) RU2124003C1 (es)
SK (1) SK29295A3 (es)
WO (1) WO1994005632A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP921292A2 (en) * 1992-11-17 1994-08-31 Pliva Pharm & Chem Works 5-thia-1,4-diazabicyclo (4.2.0.)octane -3,8-dioxo analogs of beta-lactams, the process for the preparation and use thereof
HRP970146A2 (en) * 1997-03-13 1998-10-31 Mice Kovacevic Epoxi-azetidines, preparation and use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1056372A (en) * 1974-12-24 1979-06-12 Eli Lilly And Company Method of preparation of 3-methylenecephams
JPS58210060A (ja) * 1982-05-31 1983-12-07 Takeda Chem Ind Ltd ２−オキソアゼチジン誘導体、その製造法および用途
US4436596A (en) * 1982-11-16 1984-03-13 Eli Lilly And Company N-Substituted-2-(R)-(sulfinic acid)-3-(S)-(acylamido)-4-oxo-azetidines and process
RU2043988C1 (ru) * 1991-02-12 1995-09-20 Плива Хандельс ГмбХ 4-оксоазетидин-2-сульфоновые кислоты или их соли в качестве промежуточных продуктов в синтезе бета-лактамовых антибиотиков и способ их получения

Also Published As

Publication number Publication date
EP0659177A1 (de) 1995-06-28
SK29295A3 (en) 1995-09-13
DE59309898D1 (de) 2000-01-13
RU2124003C1 (ru) 1998-12-27
PL307851A1 (en) 1995-06-26
RU95111375A (ru) 1997-03-20
PL173895B1 (pl) 1998-05-29
GR3032702T3 (en) 2000-06-30
JPH08501093A (ja) 1996-02-06
HRP930613A2 (en) 1998-06-30
HU217979B (hu) 2000-05-28
EP0659177B1 (de) 1999-12-08
BG99296A (bg) 1995-12-29
DE4230053A1 (de) 1994-03-10
CN1042130C (zh) 1999-02-17
WO1994005632A1 (de) 1994-03-17
HUT73528A (en) 1996-08-28
ATE187441T1 (de) 1999-12-15
CA2142275A1 (en) 1994-03-17
US5466686A (en) 1995-11-14
BG62135B1 (bg) 1999-03-31
CZ54595A3 (en) 1995-12-13
CN1099750A (zh) 1995-03-08
PT659177E (pt) 2000-04-28
HU9500694D0 (en) 1995-04-28
RO115256B1 (ro) 1999-12-30

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