ES2132395T3 - Especificidad lisosomica de inmunogenos. - Google Patents

Especificidad lisosomica de inmunogenos.

Info

Publication number
ES2132395T3
ES2132395T3 ES94910648T ES94910648T ES2132395T3 ES 2132395 T3 ES2132395 T3 ES 2132395T3 ES 94910648 T ES94910648 T ES 94910648T ES 94910648 T ES94910648 T ES 94910648T ES 2132395 T3 ES2132395 T3 ES 2132395T3
Authority
ES
Spain
Prior art keywords
chemical
lysosomal
mhc
class
altigenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94910648T
Other languages
English (en)
Inventor
J Thomas August
Drew M Pardoll
Frank G Guarnieri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of ES2132395T3 publication Critical patent/ES2132395T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

LOS INVENTORES HAN DESCUBIERTO UNA SEÑAL DIRECTORA, QUE DIRIGIRA LAS PROTEINAS AL COMPARTIMENTO ENDOSOMAL/LISOSOMAL, Y HAN DEMOSTRADO QUE PROTEINAS QUIMERICAS QUE CONTIENEN UN DOMINIO ANTIGENICO LUMINAL Y UNA SEÑAL DIRECTORA CITOPLASMICA ENDOSOMAL/LISOSOMAL GUIARA EFECTIVAMENTE LOS ANTIGENOS AL COMPARTIMENTO, DONDE EL DOMINIO ANTIGENICO ES PROCESADO Y LOS PEPTIDOS DEL MISMO ESTAN PRESENTADOS EN LA SUPERFICIE DE LA CELULA EN ASOCIACION CON MOLECULAS DE CLASE II HISTOCOMPATIBLEMENTE MAYORES (MHC). EL DNA QUIMERICO QUE CODIFICA EL ANTIGENO, UNIDO A UNA SECUENCIA DIRECTORA ENDOSOMAL/LISOSOMAL, INSERTADA EN UN VECTOR DE INMUNIZACION, PUEDE INTRODUCIR LOS GENES QUIMERICOS DENTRO DE LAS CELULAS, DONDE LOS ANTIGENOS RECOMBINANTES ESTAN MANIFESTADOS Y DIRIGIDOS AL COMPARTIMENTO ENDOSOMAL/LISOSOMAL. COMO RESULTADO, LOS ANTIGENOS SE ASOCIAN MAS EFICIENTEMENTE CON MOLECULAS DE CLASE II MHC, OBTENIENDOSE REFORZADA IN VIVO UNA ESTIMULACION DE CELULAS T CD4{SUP,+} ESPECIFICA PARA EL ANTIGENO RECOMBINANTE.LOS ANTIGENOS SE DISTRIBUYEN EN EL COMPARTIMENTO ENDOSOMAL/LISOSOMAL POR MEDIO DE CONSTRUCCIONES QUIMERICAS QUE CONTIENEN DICHAS SEÑALES DIRECTORAS LISOSOMALES QUE SERAN VALIOSAS EN CUALQUIER ESTRATEGIA DE VACUNACION O INMUNIZACION QUE BUSQUE ESTIMULAR RESPUESTAS INMUNES RESTRINGIDAS CD4{SUP,+} MHC DE CLASE II.
ES94910648T 1993-01-22 1994-01-21 Especificidad lisosomica de inmunogenos. Expired - Lifetime ES2132395T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/006,845 US5633234A (en) 1993-01-22 1993-01-22 Lysosomal targeting of immunogens

Publications (1)

Publication Number Publication Date
ES2132395T3 true ES2132395T3 (es) 1999-08-16

Family

ID=21722901

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94910648T Expired - Lifetime ES2132395T3 (es) 1993-01-22 1994-01-21 Especificidad lisosomica de inmunogenos.

Country Status (10)

Country Link
US (1) US5633234A (es)
EP (1) EP0680513B1 (es)
JP (1) JP3581366B2 (es)
AT (1) ATE180835T1 (es)
CA (1) CA2154445C (es)
DE (1) DE69418856T2 (es)
DK (1) DK0680513T3 (es)
ES (1) ES2132395T3 (es)
GR (1) GR3031026T3 (es)
WO (1) WO1994017192A2 (es)

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EP0680513A1 (en) 1995-11-08
CA2154445A1 (en) 1994-08-04
DK0680513T3 (da) 1999-12-27
CA2154445C (en) 2007-06-26
GR3031026T3 (en) 1999-12-31
EP0680513B1 (en) 1999-06-02
DE69418856T2 (de) 2000-01-20
JP3581366B2 (ja) 2004-10-27
WO1994017192A2 (en) 1994-08-04
US5633234A (en) 1997-05-27
WO1994017192A3 (en) 1994-09-15
DE69418856D1 (de) 1999-07-08
JPH08505878A (ja) 1996-06-25
ATE180835T1 (de) 1999-06-15

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