ES2130506T3 - Uso de 5-acil-1,4-dihidropiridinas para tratamiento de enfermedades del snc. - Google Patents

Uso de 5-acil-1,4-dihidropiridinas para tratamiento de enfermedades del snc.

Info

Publication number
ES2130506T3
ES2130506T3 ES95119053T ES95119053T ES2130506T3 ES 2130506 T3 ES2130506 T3 ES 2130506T3 ES 95119053 T ES95119053 T ES 95119053T ES 95119053 T ES95119053 T ES 95119053T ES 2130506 T3 ES2130506 T3 ES 2130506T3
Authority
ES
Spain
Prior art keywords
alkyl
dihydropyridides
acil
treatment
prepn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95119053T
Other languages
English (en)
Inventor
Klaus Dr Urbahns
Hans-Georg Dr Heine
Thomas Dr Glaser
Reilinde Dr Wittka
Vry Jean-Marie-Viktor Dr De
Henning Dr Sommermeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2130506T3 publication Critical patent/ES2130506T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

LA PRESENTE INVENCION TRATA DE UNA NUEVA UTILIZACION DE LAS EN PARTE CONOCIDAS 1-ALQUIL-3,5-DIACIL-1,4-DIHIDROPIRIDINAS DE FORMULA GENERAL (I) EN LA CUAL R{SUP,1} A R{SUP,4} TIENEN EL SIGNIFICADO DADO EN LA DESCRIPCION, EL PROCEDIMIENTO PARA SU OBTENCION Y SU USO COMO MEDICAMENTO COMO MODULADORES SELECTIVOS DEL CANAL DE POTASIO, ESPECIALMENTE EN EL TRATAMIENTO DEL SISTEMA NERVIOSO CENTRAL.
ES95119053T 1994-12-16 1995-12-04 Uso de 5-acil-1,4-dihidropiridinas para tratamiento de enfermedades del snc. Expired - Lifetime ES2130506T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4444864A DE4444864A1 (de) 1994-12-16 1994-12-16 Verwendung von 5-Acyl-1,4-dihydropyridinen

Publications (1)

Publication Number Publication Date
ES2130506T3 true ES2130506T3 (es) 1999-07-01

Family

ID=6535989

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95119053T Expired - Lifetime ES2130506T3 (es) 1994-12-16 1995-12-04 Uso de 5-acil-1,4-dihidropiridinas para tratamiento de enfermedades del snc.

Country Status (25)

Country Link
US (2) US5646166A (es)
EP (1) EP0717036B1 (es)
JP (1) JPH08239364A (es)
KR (1) KR960022464A (es)
CN (1) CN1130505A (es)
AT (1) ATE177735T1 (es)
AU (1) AU704466B2 (es)
CA (1) CA2165130A1 (es)
CZ (1) CZ332995A3 (es)
DE (2) DE4444864A1 (es)
DK (1) DK0717036T3 (es)
EE (1) EE9500075A (es)
ES (1) ES2130506T3 (es)
FI (1) FI956015A (es)
GR (1) GR3030319T3 (es)
HU (1) HUT74185A (es)
IL (1) IL116387A (es)
NO (1) NO309125B1 (es)
NZ (1) NZ280662A (es)
PL (1) PL311845A1 (es)
RU (1) RU2158259C2 (es)
SI (1) SI0717036T1 (es)
SK (1) SK158195A3 (es)
TW (1) TW381023B (es)
ZA (1) ZA9510693B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002528452A (ja) * 1998-10-28 2002-09-03 アボット・ラボラトリーズ ジヒドロピリジン化合物および使用方法
CN1275967C (zh) * 2001-01-30 2006-09-20 伊莱利利公司 用作5－ht6受体拮抗剂的苯磺酸吲哚－5－基酯
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US20050075359A1 (en) * 2003-03-14 2005-04-07 Rikako Kono Large conductance calcium-activated K channel opener
AU2006203819A1 (en) * 2005-01-07 2006-07-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
CN103998038A (zh) * 2011-11-24 2014-08-20 里皮达特发展研究及咨询公司 具有hsp调节活性的1,4-二氢吡啶衍生物
CN103420901B (zh) * 2012-05-22 2015-06-17 中国科学院大连化学物理研究所 一种制备1,2-二氢吡啶衍生物的方法
CN103420900B (zh) * 2012-05-22 2015-06-03 中国科学院大连化学物理研究所 一种制备卤代-1,2-二氢吡啶的方法
CN103804283B (zh) * 2012-11-06 2016-04-20 中国科学院大连化学物理研究所 一种制备1,2-二氢吡啶衍生物的方法
CN103804286B (zh) * 2012-11-06 2016-07-06 中国科学院大连化学物理研究所 一种由3-氮杂-1,5-烯炔制备吡啶衍生物的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966948A (en) 1970-01-24 1976-06-29 Bayer Aktiengesellschaft Spasmolytic, vaso-dilating and anti-hypertensive compositions and methods
DE2018739A1 (en) 1970-04-18 1971-10-28 Farbenfabriken Bayer Ag, 5090 Leverkusen 1,4-dihydro-3,5-diacyl-4-arylpyridines,coronary active
DE2018738A1 (en) 1970-04-18 1971-10-28 Farbenfabriken Bayer Ag, 5090 Leverkusen Hydrogenated pyridines, quinolines andacridi
GB1430961A (en) * 1972-01-22 1976-04-07 Yamanouchi Pharma Co Ltd 1-substituted-1,4-dihyddrypyridine derivatives
FR2649395B1 (fr) * 1989-07-04 1992-11-06 Adir Nouveau derive de la dihydro-1,4 pyridine denomme (-) Ÿi1Ÿ(((amino-2 ethoxy)-2 ethoxy) methylŸi1Ÿ) -2 (dichloro-2,3 phenyl)-4 ethoxycarbonyl-3 methoxycarbonyl-5 methyl-6 dihydro-1,4 pyridine, son procede de preparation et les compositions qui le contiennent
US5446057A (en) * 1993-09-24 1995-08-29 Warner-Lambert Company Substituted tetrahydropyridine and piperidine carboxylic acids as muscarinic antagonists
JP3709997B2 (ja) * 1994-03-29 2005-10-26 日東電工株式会社 耐熱性ネガ型フォトレジスト組成物および感光性基材、ならびにネガ型パターン形成方法

Also Published As

Publication number Publication date
FI956015A0 (fi) 1995-12-14
DE59505373D1 (de) 1999-04-22
NO309125B1 (no) 2000-12-18
TW381023B (en) 2000-02-01
US5646166A (en) 1997-07-08
SK158195A3 (en) 1996-09-04
NO955104D0 (no) 1995-12-15
KR960022464A (ko) 1996-07-18
HUT74185A (en) 1996-11-28
IL116387A0 (en) 1996-03-31
DE4444864A1 (de) 1996-06-20
ATE177735T1 (de) 1999-04-15
AU4029395A (en) 1996-06-27
EP0717036B1 (de) 1999-03-17
GR3030319T3 (en) 1999-09-30
SI0717036T1 (en) 1999-06-30
FI956015A (fi) 1996-06-17
ZA9510693B (en) 1996-07-03
NZ280662A (en) 1997-02-24
HU9503592D0 (en) 1996-02-28
IL116387A (en) 2000-11-21
NO955104L (no) 1996-06-17
RU2158259C2 (ru) 2000-10-27
DK0717036T3 (da) 1999-10-11
PL311845A1 (en) 1996-06-24
AU704466B2 (en) 1999-04-22
EE9500075A (et) 1996-06-17
CZ332995A3 (en) 1996-07-17
JPH08239364A (ja) 1996-09-17
CN1130505A (zh) 1996-09-11
CA2165130A1 (en) 1996-06-17
EP0717036A1 (de) 1996-06-19
US5942526A (en) 1999-08-24

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