IL116387A - 5-acyl-1,4-dihydropyridines for control of disorders of CNS with modulating action on potassium channels certain such novel compounds and their preparation - Google Patents

5-acyl-1,4-dihydropyridines for control of disorders of CNS with modulating action on potassium channels certain such novel compounds and their preparation

Info

Publication number
IL116387A
IL116387A IL11638795A IL11638795A IL116387A IL 116387 A IL116387 A IL 116387A IL 11638795 A IL11638795 A IL 11638795A IL 11638795 A IL11638795 A IL 11638795A IL 116387 A IL116387 A IL 116387A
Authority
IL
Israel
Prior art keywords
dihydropyridines
preparation
alkyl
disorders
cns
Prior art date
Application number
IL11638795A
Other languages
English (en)
Other versions
IL116387A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL116387A0 publication Critical patent/IL116387A0/xx
Publication of IL116387A publication Critical patent/IL116387A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11638795A 1994-12-16 1995-12-14 5-acyl-1,4-dihydropyridines for control of disorders of CNS with modulating action on potassium channels certain such novel compounds and their preparation IL116387A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4444864A DE4444864A1 (de) 1994-12-16 1994-12-16 Verwendung von 5-Acyl-1,4-dihydropyridinen

Publications (2)

Publication Number Publication Date
IL116387A0 IL116387A0 (en) 1996-03-31
IL116387A true IL116387A (en) 2000-11-21

Family

ID=6535989

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11638795A IL116387A (en) 1994-12-16 1995-12-14 5-acyl-1,4-dihydropyridines for control of disorders of CNS with modulating action on potassium channels certain such novel compounds and their preparation

Country Status (25)

Country Link
US (2) US5646166A (es)
EP (1) EP0717036B1 (es)
JP (1) JPH08239364A (es)
KR (1) KR960022464A (es)
CN (1) CN1130505A (es)
AT (1) ATE177735T1 (es)
AU (1) AU704466B2 (es)
CA (1) CA2165130A1 (es)
CZ (1) CZ332995A3 (es)
DE (2) DE4444864A1 (es)
DK (1) DK0717036T3 (es)
EE (1) EE9500075A (es)
ES (1) ES2130506T3 (es)
FI (1) FI956015A (es)
GR (1) GR3030319T3 (es)
HU (1) HUT74185A (es)
IL (1) IL116387A (es)
NO (1) NO309125B1 (es)
NZ (1) NZ280662A (es)
PL (1) PL311845A1 (es)
RU (1) RU2158259C2 (es)
SI (1) SI0717036T1 (es)
SK (1) SK158195A3 (es)
TW (1) TW381023B (es)
ZA (1) ZA9510693B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1131322A2 (en) * 1998-10-28 2001-09-12 Abbott Laboratories Dihydropyridine compounds and methods of use
BR0206595A (pt) * 2001-01-30 2004-07-13 Lilly Co Eli Composto, composição farmacêutica, e uso de um composto
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US20050075359A1 (en) * 2003-03-14 2005-04-07 Rikako Kono Large conductance calcium-activated K channel opener
AU2006203819A1 (en) * 2005-01-07 2006-07-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
CN110606822A (zh) * 2011-11-24 2019-12-24 里克特吉迪翁公司 具有hsp调节活性的1,4-二氢吡啶衍生物
CN103420901B (zh) * 2012-05-22 2015-06-17 中国科学院大连化学物理研究所 一种制备1,2-二氢吡啶衍生物的方法
CN103420900B (zh) * 2012-05-22 2015-06-03 中国科学院大连化学物理研究所 一种制备卤代-1,2-二氢吡啶的方法
CN103804283B (zh) * 2012-11-06 2016-04-20 中国科学院大连化学物理研究所 一种制备1,2-二氢吡啶衍生物的方法
CN103804286B (zh) * 2012-11-06 2016-07-06 中国科学院大连化学物理研究所 一种由3-氮杂-1,5-烯炔制备吡啶衍生物的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966948A (en) 1970-01-24 1976-06-29 Bayer Aktiengesellschaft Spasmolytic, vaso-dilating and anti-hypertensive compositions and methods
DE2018738A1 (en) 1970-04-18 1971-10-28 Farbenfabriken Bayer Ag, 5090 Leverkusen Hydrogenated pyridines, quinolines andacridi
DE2018739A1 (en) 1970-04-18 1971-10-28 Farbenfabriken Bayer Ag, 5090 Leverkusen 1,4-dihydro-3,5-diacyl-4-arylpyridines,coronary active
GB1430961A (en) * 1972-01-22 1976-04-07 Yamanouchi Pharma Co Ltd 1-substituted-1,4-dihyddrypyridine derivatives
FR2649395B1 (fr) * 1989-07-04 1992-11-06 Adir Nouveau derive de la dihydro-1,4 pyridine denomme (-) Ÿi1Ÿ(((amino-2 ethoxy)-2 ethoxy) methylŸi1Ÿ) -2 (dichloro-2,3 phenyl)-4 ethoxycarbonyl-3 methoxycarbonyl-5 methyl-6 dihydro-1,4 pyridine, son procede de preparation et les compositions qui le contiennent
US5446057A (en) * 1993-09-24 1995-08-29 Warner-Lambert Company Substituted tetrahydropyridine and piperidine carboxylic acids as muscarinic antagonists
JP3709997B2 (ja) * 1994-03-29 2005-10-26 日東電工株式会社 耐熱性ネガ型フォトレジスト組成物および感光性基材、ならびにネガ型パターン形成方法

Also Published As

Publication number Publication date
FI956015A (fi) 1996-06-17
GR3030319T3 (en) 1999-09-30
DE59505373D1 (de) 1999-04-22
HUT74185A (en) 1996-11-28
SK158195A3 (en) 1996-09-04
EE9500075A (et) 1996-06-17
HU9503592D0 (en) 1996-02-28
CZ332995A3 (en) 1996-07-17
KR960022464A (ko) 1996-07-18
SI0717036T1 (en) 1999-06-30
ZA9510693B (en) 1996-07-03
FI956015A0 (fi) 1995-12-14
NO955104D0 (no) 1995-12-15
AU4029395A (en) 1996-06-27
CA2165130A1 (en) 1996-06-17
JPH08239364A (ja) 1996-09-17
DK0717036T3 (da) 1999-10-11
AU704466B2 (en) 1999-04-22
TW381023B (en) 2000-02-01
IL116387A0 (en) 1996-03-31
DE4444864A1 (de) 1996-06-20
US5646166A (en) 1997-07-08
EP0717036B1 (de) 1999-03-17
NO955104L (no) 1996-06-17
CN1130505A (zh) 1996-09-11
ES2130506T3 (es) 1999-07-01
NZ280662A (en) 1997-02-24
RU2158259C2 (ru) 2000-10-27
US5942526A (en) 1999-08-24
PL311845A1 (en) 1996-06-24
NO309125B1 (no) 2000-12-18
ATE177735T1 (de) 1999-04-15
EP0717036A1 (de) 1996-06-19

Similar Documents

Publication Publication Date Title
DE3783415D1 (de) Aryloxycarbonsaeurederivate, ihre herstellung und verwendung.
IL116387A (en) 5-acyl-1,4-dihydropyridines for control of disorders of CNS with modulating action on potassium channels certain such novel compounds and their preparation
ATE323080T1 (de) Chinolyl-propylpiperidinderivate und deren verwendung als antimikrobielles mittel
DE3682032D1 (de) Propylamine, verfahren zu ihrer herstellung und ihre verwendung als fungizide.
DK0688771T3 (da) Anvendelse af lactamforbindelser som farmaceutiske aktivstoffer
HK1011207A1 (en) New imidazoline compounds, process for preparing them and pharmaceutical compositions containing them
NO954139L (no) Kinoksaliner, deres fremstilling og anvendelse
IL117150A (en) Substituted benzenesulfonylureas and - thioureas processes for their preparation their use in the preparation of medicaments and pharmaceutical compositions containing them
DE3867563D1 (en) 2-amino-5-hydroxy-4-pyrimidone.
ATE281452T1 (de) 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
AU4029495A (en) Use of 1,2-bridged 1,4-dihydropyridines as medicaments
ATE192155T1 (de) Tetracyclische 1,4-oxazin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE59700841D1 (de) 2-Cyano-3,5-dihydroxy-hex-2-en-carbonsäure-amidderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE59712054D1 (de) 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees