ES2129387T3 - Parche de nicotina de accion prolongada. - Google Patents

Parche de nicotina de accion prolongada.

Info

Publication number
ES2129387T3
ES2129387T3 ES89308978T ES89308978T ES2129387T3 ES 2129387 T3 ES2129387 T3 ES 2129387T3 ES 89308978 T ES89308978 T ES 89308978T ES 89308978 T ES89308978 T ES 89308978T ES 2129387 T3 ES2129387 T3 ES 2129387T3
Authority
ES
Spain
Prior art keywords
nicotine
patch
prolonged action
nicotine patch
monolith
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89308978T
Other languages
English (en)
Inventor
Richard W Baker
Frank Kochinke
Carl Huang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia and Upjohn AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn AB filed Critical Pharmacia and Upjohn AB
Application granted granted Critical
Publication of ES2129387T3 publication Critical patent/ES2129387T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

UN PREPARADO TRANSDERMICO PARA REMISION DE LA NICOTINA DURANTE PERIODOS PROLONGADOS DE 12-24 HORAS. EL PREPARADO INCLUYE UNA MEMBRANA DE CONTROL DE INDICE O MONOLITO PARA RETENER EL FLUJO DE NICOTINA DENTRO DE LIMITES UTILES Y SEGUROS. EL PREPARADO SE REEMPLAZA UNA VEZ AL DIA Y SE PUEDE UTILIZAR PARA TERAPIA DE CESASION DEL HABITO DE FUMAR O EN OTRAS SITUACIONS EN LAS SE INDICA LA REMISION DE NICOTINICA QUE AFECTA AL CUERPO.
ES89308978T 1988-10-28 1989-09-05 Parche de nicotina de accion prolongada. Expired - Lifetime ES2129387T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/264,397 US4943435A (en) 1987-10-05 1988-10-28 Prolonged activity nicotine patch

Publications (1)

Publication Number Publication Date
ES2129387T3 true ES2129387T3 (es) 1999-06-16

Family

ID=23005890

Family Applications (2)

Application Number Title Priority Date Filing Date
ES89308978T Expired - Lifetime ES2129387T3 (es) 1988-10-28 1989-09-05 Parche de nicotina de accion prolongada.
ES98116736T Expired - Lifetime ES2241083T3 (es) 1988-10-28 1989-09-05 Parche de nicotina de actividad prolongada.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98116736T Expired - Lifetime ES2241083T3 (es) 1988-10-28 1989-09-05 Parche de nicotina de actividad prolongada.

Country Status (13)

Country Link
US (1) US4943435A (es)
EP (2) EP0916339B1 (es)
JP (1) JP3359630B2 (es)
AT (2) ATE177651T1 (es)
AU (1) AU635714B2 (es)
CA (1) CA1338009C (es)
DE (2) DE68928952T2 (es)
DK (1) DK175328B1 (es)
ES (2) ES2129387T3 (es)
GR (1) GR3030041T3 (es)
MX (1) MX165947B (es)
NO (1) NO301216B1 (es)
NZ (1) NZ230554A (es)

Families Citing this family (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
AU622162B2 (en) * 1988-04-22 1992-04-02 Ciba-Geigy Ag Transdermal monolith systems
AU682813B2 (en) * 1988-06-14 1997-10-23 Alza Corporation Subsaturated transdermal delivery device
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5077104A (en) * 1989-12-21 1991-12-31 Alza Corporation Nicotine packaging materials
US5455043A (en) * 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
US5071704A (en) * 1990-06-13 1991-12-10 Fischel Ghodsian Fariba Device for controlled release of vapors and scents
US5512292A (en) * 1990-10-29 1996-04-30 Alza Corporation Transdermal contraceptive formulations methods and devices
US5403595A (en) * 1991-05-07 1995-04-04 Dynagen, Inc. Controlled, sustained release delivery system for smoking cessation
US5402777A (en) * 1991-06-28 1995-04-04 Alza Corporation Methods and devices for facilitated non-invasive oxygen monitoring
AU660336B2 (en) * 1991-10-18 1995-06-22 Alza Corporation Device for the transdermal administration of melatonin
US5533995A (en) * 1991-11-13 1996-07-09 Elan Corporation, Plc Passive transdermal device with controlled drug delivery
US6010715A (en) * 1992-04-01 2000-01-04 Bertek, Inc. Transdermal patch incorporating a polymer film incorporated with an active agent
CA2075517C (en) 1992-04-01 1997-03-11 John Wick Transdermal patch incorporating a polymer film incorporated with an active agent
US5780051A (en) * 1992-04-02 1998-07-14 Dynagen, Inc. Methods and articles of manufacture for nicotine cessation and monitoring nicotine use
WO1993023025A1 (en) * 1992-05-13 1993-11-25 Alza Corporation Transdermal administration of oxybutynin
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
US5883115A (en) * 1992-11-09 1999-03-16 Pharmetrix Division Technical Chemicals & Products, Inc. Transdermal delivery of the eutomer of a chiral drug
US5762952A (en) * 1993-04-27 1998-06-09 Hercon Laboratories Corporation Transdermal delivery of active drugs
US6602892B1 (en) * 1993-06-10 2003-08-05 David P. L. Sachs Methods for nicotine replacement dosage determination
US5451407A (en) * 1993-06-21 1995-09-19 Alza Corporation Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug
US5919478A (en) * 1993-06-25 1999-07-06 Alza Corporation Incorporating poly-N-vinyl amide in a transdermal system
EP0708627B1 (en) * 1993-07-09 2000-02-02 Cygnus, Inc. Method and device for providing nicotine replacement therapy transdermally/transbuccally
US5362496A (en) * 1993-08-04 1994-11-08 Pharmetrix Corporation Method and therapeutic system for smoking cessation
DE4332094C2 (de) * 1993-09-22 1995-09-07 Lohmann Therapie Syst Lts Lösemittelfrei herstellbares Wirkstoffpflaster und Verfahren zu seiner Herstellung
EP0721348B1 (en) * 1993-09-29 1999-09-01 Alza Corporation Monoglyceride/lactate ester permeation enhancer
ATE246909T1 (de) * 1994-03-07 2003-08-15 Theratech Inc Medikament enthaltende, adhesive, zusammenbaubare,transdermale abgabevorrichtung
US5547681A (en) * 1994-07-14 1996-08-20 Union Carbide Chemicals & Plastics Technology Corporation Dermal patch
US5785991A (en) * 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US6093419A (en) * 1995-06-07 2000-07-25 Lectec Corporation Compliance verification method and device in compulsory drug administration
US6572879B1 (en) 1995-06-07 2003-06-03 Alza Corporation Formulations for transdermal delivery of pergolide
US5716635A (en) * 1995-07-19 1998-02-10 M. E. Cody Products, Inc. Plantago major transdermal patch for use in treating a tobacco or nicotine habit
US5840327A (en) * 1995-08-21 1998-11-24 Alza Corporation Transdermal drug delivery device having enhanced adhesion
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
AUPO108596A0 (en) * 1996-07-18 1996-08-08 Collier, Gregory Treatment of obesity
EP0934078B1 (en) * 1996-10-24 2002-12-18 Alza Corporation Permeation enhancers for transdermal drug delivery compositions, devices, and methods
DE19650329A1 (de) * 1996-12-04 1998-06-10 Hexal Ag Flächiges selbsthaftendes Wirkstoffpflaster
DE19705138A1 (de) 1997-02-11 1998-08-13 Lohmann Therapie Syst Lts Dehnbares transdermales therapeutisches System
US6203817B1 (en) 1997-02-19 2001-03-20 Alza Corporation Reduction of skin reactions caused by transdermal drug delivery
US6113940A (en) * 1997-03-03 2000-09-05 Brooke; Lawrence L. Cannabinoid patch and method for cannabis transdermal delivery
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
US6267984B1 (en) 1997-12-22 2001-07-31 Alza Corporation Skin permeation enhancer compositions comprising a monoglyceride and ethyl palmitate
US6063401A (en) 1998-05-06 2000-05-16 M.E. Cody Products, Inc. Plantago major and hypericum perforatum compound for use in treating a tobacco or nicotine habit
MY122454A (en) * 1998-06-05 2006-04-29 Upjohn Co Use of oxazolidinones for the preparation of a medicament for transdermal delivery
US6045825A (en) 1998-06-17 2000-04-04 M. E. Cody Products, Inc. Plantago major and Piper methysticum compound for use in treating a tobacco or nicotine habit
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
NZ512432A (en) * 1998-12-18 2003-10-31 Alza Corp Transparent transdermal nicotine delivery devices
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US6270781B1 (en) 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
PT1163019E (pt) * 1999-03-25 2007-12-06 Metabolix Inc Dispositivos médicos e aplicações de polímeros de poli-hidroxialcanoato
KR100622332B1 (ko) * 1999-04-01 2006-09-13 알자 코포레이션 폴리우레탄 약물 리저버를 함유하는 경피 약물 수송 장치
US6248760B1 (en) * 1999-04-14 2001-06-19 Paul C Wilhelmsen Tablet giving rapid release of nicotine for transmucosal administration
DE60042828D1 (de) 1999-07-28 2009-10-08 Univ R Nicotinrezeptoragonisten in stammzellen und vorlaüferzellinduktion
US7838539B2 (en) 1999-07-28 2010-11-23 The Board Of Trustees Of The Leland Stanford Junior University Nicotine receptor agonists in stem cell and progenitor cell recruitment
CA2382599C (en) 1999-08-30 2005-11-08 Tepha, Inc. Flushable disposable polymeric products
US6905016B2 (en) * 2000-03-14 2005-06-14 Noven Pharmaceuticals, Inc. Packaging system for transdermal drug delivery systems
KR100337161B1 (ko) * 2000-04-10 2002-05-18 서경배 폴리우레탄 및 폴리에테르를 함유하는 약물 전달용 필름형성제 및 이를 함유하는 경피 투여형 제제
US7658942B2 (en) * 2000-04-12 2010-02-09 The Procter & Gamble Company Cosmetic devices
US7179483B2 (en) * 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
DE10053376A1 (de) * 2000-10-27 2002-05-23 Lohmann Therapie Syst Lts Haltevorrichtung für flächenförmige wirkstoffhaltige Systeme und ihre Verwendung zur Bestimmung der Wirkstofffreisetzung
DE10056014A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Mehrschichtige Trägerkonstruktion für wirkstofhaltige Pflastersyteme
US6682757B1 (en) 2000-11-16 2004-01-27 Euro-Celtique, S.A. Titratable dosage transdermal delivery system
DE10110391A1 (de) 2001-03-03 2002-09-26 Lohmann Therapie Syst Lts Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff
SE521512C2 (sv) 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
CA2461661A1 (en) * 2001-10-19 2003-05-01 Maxim Pharmaceuticals, Inc. Use of histamine to treat liver disease
NZ532074A (en) * 2001-11-06 2006-02-24 Maxim Pharm Inc Compositions for the treatment of infectious diseases
IL161857A0 (en) * 2001-11-30 2005-11-20 Pfizer Prod Inc Pharmaceutical compositions of 5,7,14-triazatetracycloÄ10.3.1.0(2,11).0(4,9)Ü-hexadeca-2(11)3,5,7,9-pentaene
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
US20040097467A1 (en) * 2002-08-22 2004-05-20 Vijaya Juturu Arginine silicate inositol complex and use thereof
US20040086551A1 (en) * 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
ATE359075T1 (de) 2002-12-20 2007-05-15 Niconovum Ab Chemisch und physikalisch stabiles teilchenförmiges material enthaltend nikotin und microcrystalline cellulose
WO2004060387A1 (en) * 2002-12-27 2004-07-22 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US7655618B2 (en) * 2002-12-27 2010-02-02 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
CA2523489A1 (en) 2003-04-24 2004-11-25 Vanderbilt University Compositions and methods for controlling insects
US7622269B2 (en) 2004-03-19 2009-11-24 Tyratech, Inc. Methods of screening tyramine- and octopamine-expressing cells for compounds and compositions having potential insect control activity
PT1638615E (pt) * 2003-05-08 2015-02-04 Tepha Inc Fibras e tecidos médicos de polihidroxialcanoato
CA2531833C (en) * 2003-07-08 2009-10-20 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US8524272B2 (en) 2003-08-15 2013-09-03 Mylan Technologies, Inc. Transdermal patch incorporating active agent migration barrier layer
WO2005020825A1 (en) * 2003-08-22 2005-03-10 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
WO2005053641A1 (en) * 2003-12-05 2005-06-16 Namibia Medical Investments (Pty) Limited Patch
US20050171192A1 (en) * 2003-12-11 2005-08-04 Gehlsen Kurt R. Use of histamine to treat bone disease
US7105263B2 (en) * 2003-12-30 2006-09-12 Samsung Electronics Company Dry toner comprising encapsulated pigment, methods and uses
DK1729746T3 (da) * 2004-03-19 2010-03-08 Mcneil Ab Anordning til transdermal administration af nikotin
US20060002913A1 (en) * 2004-06-22 2006-01-05 Gehlsen Kurt R Use of histamine and related compounds to treat disorders affecting muscle function
US20060008432A1 (en) * 2004-07-07 2006-01-12 Sebastiano Scarampi Gilsonite derived pharmaceutical delivery compositions and methods: nail applications
PT1778305E (pt) * 2004-08-03 2010-07-27 Tepha Inc Suturas de poli-hidroxialcanoato que n†o se enrolam
EP1824470B1 (en) 2004-12-17 2014-08-06 Alan B. Cash Method for extending lifespan and delaying the onset of age-related disease
JP2008528204A (ja) * 2005-01-28 2008-07-31 テファ， インコーポレイテッド ポリ−４−ヒドロキシブチレート粒子を使用した塞栓形成
US20060264455A1 (en) 2005-05-23 2006-11-23 Schachter Steven C Use of huperzine for disorders
WO2007035939A2 (en) 2005-09-23 2007-03-29 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications
WO2007035940A2 (en) * 2005-09-23 2007-03-29 Alza Corporation Transdermal norelgestromin delivery system
US7888422B2 (en) * 2005-11-09 2011-02-15 Mylan Technologies Inc. Long-wearing removable pressure sensitive adhesive
JP2009519246A (ja) * 2005-12-08 2009-05-14 フェルティン ファルマ 経皮タバコアルカロイドパッチ
JP2009518319A (ja) * 2005-12-08 2009-05-07 フェルティン ファルマ 低曲げ強度経皮タバコアルカロイドパッチ
JP5694645B2 (ja) 2006-03-16 2015-04-01 ニコノヴァム エービーＮｉｃｏｎｏｖｕｍ Ａｂ 改善された嗅ぎたばこ組成物
JP5000910B2 (ja) * 2006-03-29 2012-08-15 リンテック株式会社 貼付剤及びその製造方法
WO2007121188A2 (en) * 2006-04-10 2007-10-25 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
PL2026803T3 (pl) * 2006-05-16 2012-05-31 Knopp Neurosciences Inc Kompozycje R(+) i S(-) pramipeksolu i sposoby ich zastosowania
CN101478984B (zh) 2006-06-27 2013-02-20 蒂拉德克公司 治疗寄生虫感染的组合物和方法
US20110150766A1 (en) * 2006-07-07 2011-06-23 Royds Robert B Transdermal patch with fatal overdose protection
US20080008747A1 (en) * 2006-07-07 2008-01-10 Royds Robert B Transdermal patch
BRPI0714350B1 (pt) 2006-07-17 2017-03-07 Tyratech Inc composições e métodos para controle de insentos
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US8524695B2 (en) * 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
WO2008080064A1 (en) 2006-12-21 2008-07-03 Trustees Of Tufts College Synthetic lipophilic inositol glycans for treatment of cancer and glucose-metabolism disorders
EP2137171A4 (en) 2007-03-14 2010-05-19 Knopp Neurosciences Inc SYNTHESIS OF BENZOTHIAZOLE DIAMINES SUBSTITUTED AND PURIFIED FROM THE CHIRAL PERSPECTIVE
BRPI0721705A2 (pt) * 2007-05-31 2013-02-13 Fertin Pharma As adesivo reservatàrio transdÉrmico de alcaloide de tabaco
EP2158908B1 (en) * 2007-06-21 2013-04-24 Fujimoto Co., Ltd. Composition for transdermal administration
PL2173330T3 (pl) 2007-07-04 2012-08-31 Luye Pharma Ag Układ zasobnika z zamkniętą membraną
US9017301B2 (en) * 2007-09-04 2015-04-28 Mylan Technologies, Inc. Transdermal drug delivery systems comprising a coated release liner
ATE551977T1 (de) * 2008-02-28 2012-04-15 Steffen Barth Pflaster
DE102008015101A1 (de) 2008-03-19 2009-09-24 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Kauzusammensetzung und deren Verwendung
US8691256B2 (en) * 2008-03-19 2014-04-08 Tyratech, Inc. Pest control compositions and methods
US20110172293A1 (en) 2008-07-08 2011-07-14 Fish Jason E Methods and Compositions for Modulating Angiogenesis
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
WO2010028134A2 (en) * 2008-09-04 2010-03-11 President And Fellows Of Harvard College Treatment of neurological disorders using huperzine
GB0817486D0 (en) * 2008-09-24 2008-10-29 Smith & Nephew Delivery system
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
AU2010262970A1 (en) * 2009-06-19 2012-01-12 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
WO2012096866A2 (en) 2011-01-10 2012-07-19 Inverseon, Inc. Use of beta-adrenergic inverse agonists for smoking cessation
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US20140271923A1 (en) 2013-03-14 2014-09-18 Christopher Brian Reid Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
WO2014188329A2 (en) 2013-05-20 2014-11-27 Mylan, Inc. Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
HRP20251187T1 (hr) 2013-07-12 2025-11-21 Areteia Therapeutics, Inc. Liječenje povišenih razina eozinofila i/ili bazofila
US9642840B2 (en) 2013-08-13 2017-05-09 Knopp Biosciences, Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
US9763918B2 (en) 2013-08-13 2017-09-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
DE102014000200A1 (de) * 2014-01-03 2015-07-09 Michael Horstmann Transdermales Therapeutisches System
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US11191735B2 (en) 2015-03-13 2021-12-07 Nutrition 21, Llc Arginine silicate for periodontal disease
US20170135969A1 (en) 2015-11-12 2017-05-18 Jds Therapeutics, Llc Topical arginine-silicate-inositol for wound healing
AU2016381372B2 (en) * 2015-12-30 2021-07-22 Next Generation Labs, LLC Nicotine replacement therapy products comprising synthetic nicotine
AU2017318672B2 (en) 2016-09-01 2022-03-10 Nutrition 21, Llc Magnesium biotinate compositions and methods of use
WO2018057737A1 (en) 2016-09-22 2018-03-29 Cash Alan B Method to alleviate the symptoms of pms
WO2020092431A1 (en) 2018-11-02 2020-05-07 Nutrition 21, Llc Compositions containing inositol-stabilized arginine silicate complexes and inositol for improving cognitive function in video gamers
WO2021127048A1 (en) 2019-12-16 2021-06-24 Nutrition 21, Llc Methods of production of arginine-silicate complexes
DE102020112143B4 (de) 2020-05-05 2022-03-17 Lts Lohmann Therapie-Systeme Ag Nicotin - Corona
BR112023014144A2 (pt) 2021-01-14 2023-10-31 B Cash Alan Tratamento de fadiga patológica com oxaloacetato

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3731683A (en) * 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3742951A (en) * 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
US4624665A (en) * 1984-10-01 1986-11-25 Biotek, Inc. Method of transdermal drug delivery
US4687481A (en) * 1984-10-01 1987-08-18 Biotek, Inc. Transdermal drug delivery system
DE3438284A1 (de) * 1984-10-16 1985-03-07 Hans-Harald von 2400 Lübeck Tilly Nikotinhaltiges depotpflaster
US4638043A (en) * 1984-11-13 1987-01-20 Thermedics, Inc. Drug release system
US4597961A (en) * 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US4706676A (en) * 1985-02-11 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Dermal substance collection device
JPS61251619A (ja) * 1985-04-30 1986-11-08 Nitto Electric Ind Co Ltd ニコチン含有テ−プ製剤
US4715387A (en) * 1985-08-23 1987-12-29 The Regents Of The Univ. Of California Aerosol for use in the reduction of tobacco smoking
US4627429A (en) * 1986-02-28 1986-12-09 American Home Products Corporation Storage-stable transdermal adhesive patch
DE3629304A1 (de) * 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
DE3786998D1 (de) * 1986-11-20 1993-09-16 Ciba Geigy Ag Benutzer-aktivierte therapeutische systeme.
US4839174A (en) * 1987-10-05 1989-06-13 Pharmetrix Corporation Novel transdermal nicotine patch
PT90820B (pt) * 1988-06-14 1995-05-31 Alza Corp Dispositivo de libertacao transdermica sub-saturado

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DK434189A (da) 1990-04-29
AU4105789A (en) 1990-05-03
NO893570D0 (no) 1989-09-05
EP0916339B1 (en) 2005-04-13
DE68929533D1 (de) 2005-05-19
MX165947B (es) 1992-12-09
JPH02174714A (ja) 1990-07-06
ES2241083T3 (es) 2005-10-16
EP0366240A1 (en) 1990-05-02
ATE292968T1 (de) 2005-04-15
NO893570L (no) 1990-04-30
DE68929533T2 (de) 2006-03-09
DE68928952T2 (de) 1999-08-26
EP0366240B1 (en) 1999-03-17
DE68928952D1 (de) 1999-04-22
EP0916339A1 (en) 1999-05-19
CA1338009C (en) 1996-01-30
DK434189D0 (da) 1989-09-01
NZ230554A (en) 1991-02-26
NO301216B1 (no) 1997-09-29
AU635714B2 (en) 1993-04-01
US4943435A (en) 1990-07-24
JP3359630B2 (ja) 2002-12-24
DK175328B1 (da) 2004-08-23
GR3030041T3 (en) 1999-07-30
ATE177651T1 (de) 1999-04-15

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