ES2126573T3 - Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado. - Google Patents

Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.

Info

Publication number
ES2126573T3
ES2126573T3 ES91913666T ES91913666T ES2126573T3 ES 2126573 T3 ES2126573 T3 ES 2126573T3 ES 91913666 T ES91913666 T ES 91913666T ES 91913666 T ES91913666 T ES 91913666T ES 2126573 T3 ES2126573 T3 ES 2126573T3
Authority
ES
Spain
Prior art keywords
lower alkyl
substituted
hydroxy
phenyl
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913666T
Other languages
English (en)
Spanish (es)
Inventor
Makoto Inoue
Kinji Hashimoto
Toshiko Kuwahara
Yukio Sugimoto
Takuji Uesako
Toshiaki Funato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2126573T3 publication Critical patent/ES2126573T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES91913666T 1991-04-22 1991-08-06 Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado. Expired - Lifetime ES2126573T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9070791 1991-04-22

Publications (1)

Publication Number Publication Date
ES2126573T3 true ES2126573T3 (es) 1999-04-01

Family

ID=14006001

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913666T Expired - Lifetime ES2126573T3 (es) 1991-04-22 1991-08-06 Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.

Country Status (12)

Country Link
US (1) US5688949A (show.php)
EP (1) EP0591528B1 (show.php)
JP (1) JPH0570353A (show.php)
KR (1) KR100191774B1 (show.php)
AT (1) ATE174917T1 (show.php)
AU (1) AU651986B2 (show.php)
CA (1) CA2107479C (show.php)
DE (1) DE69130683T2 (show.php)
DK (1) DK0591528T3 (show.php)
ES (1) ES2126573T3 (show.php)
TW (1) TW221434B (show.php)
WO (1) WO1992018504A1 (show.php)

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US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
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US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
EE04316B1 (et) * 1996-07-24 2004-06-15 Dupont Pharmaceuticals Company Asolotriasiinid ja -pürimidiinid, neid sisaldavadfarmatseutilised kompositsioonid ning nende kasutamine ravimite valmistamiseks
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
AU4331500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
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EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
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US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
AR041135A1 (es) * 2002-09-04 2005-05-04 Schering Corp Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclinas
KR20050033659A (ko) 2002-09-04 2005-04-12 쉐링 코포레이션 사이클린 의존성 키나제 억제제로서의 피라졸로[1,5-ａ]피리미딘 화합물
US7205308B2 (en) * 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
CN1310918C (zh) 2002-09-04 2007-04-18 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶
WO2004022560A1 (en) * 2002-09-04 2004-03-18 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
EP2194058B1 (en) 2002-09-04 2013-11-27 Merck Sharp & Dohme Corp. Pyrazolopyrimidines suitable for the treatment of cancer diseases
US7557110B2 (en) 2003-02-28 2009-07-07 Teijin Pharma Limited Pyrazolo[1,5-A] pyrimidine derivatives
US20070179161A1 (en) * 2003-03-31 2007-08-02 Vernalis (Cambridge) Limited. Pyrazolopyrimidine compounds and their use in medicine
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
ATE478852T1 (de) * 2005-09-09 2010-09-15 Schering Corp Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase
JP5052518B2 (ja) 2005-10-06 2012-10-17 シェーリング コーポレイション プロテインキナーゼインヒビターとしてのピラゾロピリミジン
CN101321759A (zh) * 2005-10-06 2008-12-10 先灵公司 作为蛋白激酶抑制剂的吡唑并嘧啶化合物
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
KR20090091315A (ko) 2006-11-29 2009-08-27 아보트 러보러터리즈 디아실글리세롤 ｏ-아실트랜스퍼라제 1형 효소의 억제제
PL2222675T3 (pl) 2007-12-19 2014-02-28 Genentech Inc 5-anilinoimidazopirydyny i sposoby zastosowania
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
CA2760945A1 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
SG181423A1 (en) * 2009-12-23 2012-07-30 Univ Leuven Kath Novel antiviral compounds
US8927562B2 (en) * 2010-09-28 2015-01-06 Merck Sharp & Dohme Corp. Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
NZ610315A (en) 2010-11-15 2015-08-28 Univ Leuven Kath Antiviral condensed heterocyclic compounds
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
CN106232119B (zh) * 2013-12-11 2021-02-19 河谷控股Ip有限责任公司 A型流感rna-依赖性rna聚合酶的小分子抑制剂
CA2935658C (en) * 2014-01-22 2023-02-21 Apodemus Ab Pyrazolo[1,5-a]pyrimidin-7-amine derivatives useful in therapy
GB201410817D0 (en) 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
JOP20200055A1 (ar) * 2017-09-15 2020-03-10 Aduro Biotech Inc مركبات بيرازولو بيريميدينون واستخداماتها
DE102018201598A1 (de) 2018-02-02 2019-08-08 Beiersdorf Ag Stabile Wundheilsalbe
CN116348468A (zh) 2020-10-23 2023-06-27 日东制药株式会社 Cftr调节剂化合物、组合物及其用途

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BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US4026893A (en) * 1975-11-07 1977-05-31 Squibb & Sons Inc Pyrazolo{8 1,5-a{9 pyrido{8 3,2-e{9 pyrimidine-7-carboxylic acid derivatives
DE3338292A1 (de) * 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
JPS60100381A (ja) * 1983-11-04 1985-06-04 Yuasa Battery Co Ltd 密閉形鉛蓄電池
JPS60100581A (ja) * 1983-11-07 1985-06-04 S D S Baiotetsuku:Kk ピラゾロ〔１，５−ａ〕ピリミジン誘導体，それらを含有する農園芸用殺菌剤及びそれらの製造方法
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids

Also Published As

Publication number Publication date
DE69130683T2 (de) 1999-05-06
KR100191774B1 (ko) 1999-06-15
CA2107479A1 (en) 1992-10-23
AU651986B2 (en) 1994-08-11
WO1992018504A1 (en) 1992-10-29
AU8295891A (en) 1992-11-17
EP0591528A4 (en) 1995-02-15
EP0591528B1 (en) 1998-12-23
ATE174917T1 (de) 1999-01-15
CA2107479C (en) 1997-12-16
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13
TW221434B (show.php) 1994-03-01
JPH0570353A (ja) 1993-03-23
US5688949A (en) 1997-11-18
DE69130683D1 (de) 1999-02-04

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