ES2121000T3 - Composicion utilizada como agente terapeutico contra enfermedades hepaticas virales cronicas. - Google Patents
Composicion utilizada como agente terapeutico contra enfermedades hepaticas virales cronicas.Info
- Publication number
- ES2121000T3 ES2121000T3 ES92900527T ES92900527T ES2121000T3 ES 2121000 T3 ES2121000 T3 ES 2121000T3 ES 92900527 T ES92900527 T ES 92900527T ES 92900527 T ES92900527 T ES 92900527T ES 2121000 T3 ES2121000 T3 ES 2121000T3
- Authority
- ES
- Spain
- Prior art keywords
- therapeutic agent
- chronic viral
- composition used
- agent against
- hepatic diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001684 chronic effect Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002440 hepatic effect Effects 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 206010019799 Hepatitis viral Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 201000001862 viral hepatitis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
SE DA A CONOCER UNA COMBINACION, QUE COMPRENDE POR LO MENOS UNA SECUENCIA POLIPEPTIDA, MEDIADORA DE LA ANTIGENICIDAD DE UNO O MAS EPITOPES Y UN PORTADOR, CAPAZ DE PRESENTAR ESTA/ESTAS SECUENCIA(S) POLIPEPTIDA, LA CUAL ES UTIL PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE HEPATITIS VIRAL CRONICA.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90124775 | 1990-12-19 | ||
EP90124775A EP0491077A1 (en) | 1990-12-19 | 1990-12-19 | A composition used as a therapeutic agent against chronic viral hepatic diseases |
EP92900527A EP0563093B2 (en) | 1990-12-19 | 1991-12-19 | A composition used as a therapeutic agent against chronic viral hepatic diseases |
PCT/EP1991/002460 WO1992011368A1 (en) | 1990-12-19 | 1991-12-19 | A composition used as a therapeutic agent against chronic viral hepatic diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2121000T3 true ES2121000T3 (es) | 1998-11-16 |
ES2121000T5 ES2121000T5 (es) | 2008-04-16 |
Family
ID=8204863
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92900527T Expired - Lifetime ES2121000T5 (es) | 1990-12-19 | 1991-12-19 | Composicion utilizada como agente terapeutico contra enfermedades hepaticas virales cronicas. |
Country Status (15)
Country | Link |
---|---|
US (2) | US6020167A (es) |
EP (2) | EP0491077A1 (es) |
JP (2) | JP3857305B2 (es) |
KR (1) | KR0156587B1 (es) |
AT (1) | ATE170220T1 (es) |
AU (1) | AU657935B2 (es) |
CA (1) | CA2098021C (es) |
CZ (1) | CZ290233B6 (es) |
DE (1) | DE69130071T3 (es) |
DK (1) | DK0563093T4 (es) |
ES (1) | ES2121000T5 (es) |
HK (1) | HK1002901A1 (es) |
HU (1) | HU216301B (es) |
SK (1) | SK280551B6 (es) |
WO (1) | WO1992011368A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10299017I2 (de) * | 1987-06-22 | 2005-05-25 | Medeva Holdings Bv | Hepatitis-B-Oberfl{chenantigen enthaltendes Peptid. |
EP0491077A1 (en) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | A composition used as a therapeutic agent against chronic viral hepatic diseases |
DE4107612A1 (de) | 1991-03-09 | 1992-09-10 | Behringwerke Ag | Rekombinante proteine mit der immunreaktivitaet des hepatitis b virus e antigens (hbeag), verfahren zu ihrer herstellung und ihre verwendung in immunoassays und impfstoffen |
US7611713B2 (en) | 1993-03-05 | 2009-11-03 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide compositions |
US6689363B1 (en) | 1992-01-29 | 2004-02-10 | Epimmune Inc. | Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions |
US6509149B2 (en) | 1995-06-06 | 2003-01-21 | Hybridon, Inc. | HPV-specific oligonucleotides |
CA2260761C (en) * | 1996-06-25 | 2011-05-03 | Nico Johannes Christiaan Maria Beekman | Vaccine comprising antigens bound to carriers through labile bonds |
US7091324B2 (en) | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
JP2003528138A (ja) * | 2000-03-29 | 2003-09-24 | ジョージタウン・ユニバーシティ | デルタ肝炎ウイルス感染症の治療法 |
IL142802A (en) * | 2000-04-27 | 2015-01-29 | Enzo Therapeutics Inc | Use of one or more HBV antigens for the preparation of oral pharmaceutical preparations for the treatment of a person with active HBV infection or hepatocellular carcinoma |
US6787526B1 (en) | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
RU2295536C2 (ru) * | 2001-02-05 | 2007-03-20 | Стрессджен Байотекнолоджиз Корп. | Композиции на основе белка вируса гепатита в и стрессового белка и их применение |
US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
WO2003080672A1 (en) * | 2002-03-22 | 2003-10-02 | Aprogen, Inc. | Humanized antibody and process for preparing same |
DE10339927A1 (de) * | 2003-08-29 | 2005-03-24 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | Zusammensetzung zur Prophylaxe/Therapie von HBV-Infektionen und HBV-vermittelten Erkrankungen |
GB0326416D0 (en) | 2003-11-12 | 2003-12-17 | Karolinska Innovations Ab | Methods and means relating to hepatitis B infection |
CA2549865A1 (en) * | 2003-11-12 | 2005-06-02 | Hbv Theranostica Ab | Methods and means relating to hepatitis b infection |
US9603921B2 (en) * | 2004-10-27 | 2017-03-28 | Janssen Vaccines Ag | Virosome particles comprising antigens from influenza virus and hepatitis b virus |
WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
WO2009092396A1 (en) | 2008-01-25 | 2009-07-30 | Universitätsklinikum Heidelberg | Hydrophobic modified pres-derived peptides of hepatitis b virus (hbv) and their use as hbv and hdv entry inhibitors |
CN101485672B (zh) * | 2008-12-05 | 2010-08-25 | 广东粤龙药业有限公司 | 异丙景糖酐在制备治疗人HBeAg阳性慢性乙型肝炎药物中的应用 |
US10076570B2 (en) | 2009-08-07 | 2018-09-18 | Transgene S.A. | Composition for treating HBV infection |
KR20120052352A (ko) | 2009-08-07 | 2012-05-23 | 트랜스진 에스.에이. | Hbv 감염을 치료하는 조성물 |
Family Cites Families (85)
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US34705A (en) * | 1862-03-18 | Improvement in tompions for fire-arms | ||
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FR2480779B2 (fr) * | 1979-08-30 | 1986-07-18 | Anvar | Vecteur contenant une sequence nucleotidique de l'antigene de surface du virus de l'hepatite b et procede de fabrication d'une molecule immunogene mettant en oeuvre ce vecteur |
EP0182442B2 (en) * | 1978-12-22 | 1996-04-03 | Biogen, Inc. | Recombinant DNA molecules and their method of production |
ES8105035A1 (es) * | 1978-12-22 | 1981-05-16 | Biogen Nv | Un metodo para producir al menos un polipeptido que muestra antigenicidad de hbv |
IE52036B1 (en) * | 1979-05-24 | 1987-05-27 | Univ California | Non-passageable viruses |
US4935235A (en) * | 1979-05-24 | 1990-06-19 | The Regents Of The University Of California | Non-passageable viruses |
US5196194A (en) * | 1979-05-24 | 1993-03-23 | The Regents Of The University Of California | Vaccines containing Hepatitis B S-protein |
USRE34705E (en) | 1979-08-30 | 1994-08-23 | Institut Pasteur | Nucleotidic sequence coding the surface antigen of the hepatitis B virus, vector containing said nucleotidic sequence, process allowing the obtention thereof and antigen obtained thereby |
US4415491A (en) * | 1980-01-14 | 1983-11-15 | The Regents Of The University Of California | Synthetic vaccine peptide epitomes of hepatitis B surface antigen |
EP0038765B1 (fr) * | 1980-04-22 | 1987-09-02 | Institut Pasteur | Vaccin contre l'hépatite virale B, procédé et cellules eucaryotes transformées pour la production de ce vaccin |
IL63224A (en) * | 1980-07-17 | 1985-05-31 | Scripps Clinic Res | Synthetic peptide specific antigenic determinant and method of manufacturing antigenic materials therefrom |
GR76274B (es) * | 1981-08-04 | 1984-08-04 | Univ California | |
AU8746582A (en) * | 1981-09-02 | 1983-03-10 | Biogen N.V. | Hepatitis b virus e type antigen |
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JPS58194897A (ja) * | 1982-05-07 | 1983-11-12 | Takeda Chem Ind Ltd | 新規dna,その製造方法およびそれで形質転換させた宿主 |
JPS5936698A (ja) * | 1982-08-20 | 1984-02-28 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えdnaおよび形質転換動物細胞 |
US4977092A (en) * | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
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FR2559159B1 (fr) * | 1984-02-02 | 1986-09-12 | Inst Nat Sante Rech Med | Vecteurs viraux de clonage et d'expression d'une proteine dans une cellule eucaryote, comportant au moins une partie du genome d'un retro-virus; cellules eucaryotes transfectees; procede utilisant de telles cellules et proteines obtenues |
FR2560890B1 (fr) * | 1984-03-07 | 1987-10-16 | Grp Genie Genetique | Composition utile pour la fabrication de vaccins contenant des particules portant l'antigene de surface du virus de l'hepatite b et le recepteur de l'albumine serique humaine polymerisee, cellules animales capables de produire de telles particules et procede pour leur obtention |
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US4777240A (en) * | 1984-03-08 | 1988-10-11 | Scripps Clinic And Research Foundation | SV40 expression vector containing HBxAg as an expression marker |
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GB8421282D0 (en) * | 1984-08-22 | 1984-09-26 | Connaught Lab | Multispecific antigenic proteins |
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EP0180012A1 (de) * | 1984-10-27 | 1986-05-07 | Wolfram H. Prof. Dr. Gerlich | Immunogene Polypeptidsequenz des Hepatitis B-Virus |
US4683136A (en) * | 1985-03-06 | 1987-07-28 | Scripps Clinic And Research Foundation | Proteinaceous antigens with conformation-independent and conformation-dependent determinants |
CA1324094C (en) * | 1985-04-03 | 1993-11-09 | Dino Dina | Hepatitis a virus vaccines |
FI861417A0 (fi) * | 1985-04-15 | 1986-04-01 | Endotronics Inc | Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav. |
US5837249A (en) * | 1985-04-19 | 1998-11-17 | The Wistar Institute | Method for generating an immunogenic T cell response protective against a virus |
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FR2581394B1 (fr) * | 1985-05-02 | 1988-08-05 | Grp Genie Genetique | Particules ayant les proprietes immunogenes de l'antigene hbs et portant un site antigenique etranger aux epitopes portes par l'antigene hbs, vecteurs et cellules animales pour la production de telles particules et compositions contenant de telles particules pour la production de vaccins mixtes |
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US4959323A (en) * | 1985-11-04 | 1990-09-25 | Mt. Sinai School Of Medicine Of The City University Of New York | Production and use of pre S polypeptides of hepatitis B virus |
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ATE159031T1 (de) * | 1989-07-25 | 1997-10-15 | Smithkline Biolog | Antigene sowie verfahren zu deren herstellung |
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EP0491077A1 (en) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | A composition used as a therapeutic agent against chronic viral hepatic diseases |
US5102989A (en) * | 1991-03-15 | 1992-04-07 | Merck & Co., Inc. | Method of stabilizing recombinant hepatitis B virus surface proteins from recombinant host cells |
IL101653A0 (en) * | 1991-04-29 | 1992-12-30 | Merck & Co Inc | Multiple hepatitis b virus surface proteins which form particles |
CA2067003A1 (en) * | 1991-04-29 | 1992-10-30 | Peter J. Kniskern | Hbsag escape mutant vaccine |
US5840303A (en) * | 1991-08-26 | 1998-11-24 | The Scripps Research Foundation | Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus |
JP2501186Y2 (ja) * | 1992-03-31 | 1996-06-12 | 株式会社栗本鐵工所 | ハンマ―ミル |
CN1094311A (zh) * | 1993-04-27 | 1994-11-02 | 中国科学院上海生物化学研究所 | 氨端带前表面抗原决定簇的乙型肝炎表面抗原蛋白 |
CN1063343C (zh) * | 1993-04-27 | 2001-03-21 | 中国科学院上海生物化学研究所 | 氨端带前表面抗原决定簇的乙型肝炎表面抗原蛋白 |
CN1059927C (zh) * | 1994-03-10 | 2000-12-27 | 中国科学院上海生物化学研究所 | 羧端带有前表面抗原1抗原决定簇的乙肝表面抗原融合基因及其编码蛋白 |
US5792163A (en) * | 1996-01-03 | 1998-08-11 | Hitzig; Gary | Linear punch |
-
1990
- 1990-12-19 EP EP90124775A patent/EP0491077A1/en not_active Withdrawn
-
1991
- 1991-12-19 DE DE69130071T patent/DE69130071T3/de not_active Expired - Lifetime
- 1991-12-19 DK DK92900527T patent/DK0563093T4/da active
- 1991-12-19 SK SK636-93A patent/SK280551B6/sk unknown
- 1991-12-19 AT AT92900527T patent/ATE170220T1/de not_active IP Right Cessation
- 1991-12-19 US US08/075,520 patent/US6020167A/en not_active Expired - Lifetime
- 1991-12-19 CA CA002098021A patent/CA2098021C/en not_active Expired - Lifetime
- 1991-12-19 ES ES92900527T patent/ES2121000T5/es not_active Expired - Lifetime
- 1991-12-19 HU HU9301794A patent/HU216301B/hu unknown
- 1991-12-19 CZ CZ19931186A patent/CZ290233B6/cs not_active IP Right Cessation
- 1991-12-19 JP JP50100592A patent/JP3857305B2/ja not_active Expired - Lifetime
- 1991-12-19 EP EP92900527A patent/EP0563093B2/en not_active Expired - Lifetime
- 1991-12-19 WO PCT/EP1991/002460 patent/WO1992011368A1/en active IP Right Grant
- 1991-12-19 AU AU90817/91A patent/AU657935B2/en not_active Ceased
-
1993
- 1993-06-18 KR KR1019930701862A patent/KR0156587B1/ko not_active IP Right Cessation
-
1998
- 1998-03-10 HK HK98101997A patent/HK1002901A1/xx not_active IP Right Cessation
-
2000
- 2000-06-07 JP JP2000175584A patent/JP2001019643A/ja active Pending
-
2003
- 2003-03-21 US US10/394,896 patent/US20030235591A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0563093B1 (en) | 1998-08-26 |
HUT66437A (en) | 1994-11-28 |
HU9301794D0 (en) | 1993-10-28 |
DK0563093T3 (da) | 1999-02-08 |
US6020167A (en) | 2000-02-01 |
CZ118693A3 (en) | 1994-02-16 |
CA2098021A1 (en) | 1992-06-20 |
WO1992011368A1 (en) | 1992-07-09 |
EP0563093A1 (en) | 1993-10-06 |
US20030235591A1 (en) | 2003-12-25 |
SK280551B6 (sk) | 2000-03-13 |
DE69130071T2 (de) | 1999-01-07 |
EP0563093B2 (en) | 2007-10-03 |
HK1002901A1 (en) | 1998-09-25 |
ES2121000T5 (es) | 2008-04-16 |
KR0156587B1 (en) | 1998-10-15 |
SK63693A3 (en) | 1993-10-06 |
DE69130071T3 (de) | 2008-02-21 |
HU216301B (hu) | 1999-06-28 |
CZ290233B6 (cs) | 2002-06-12 |
JP3857305B2 (ja) | 2006-12-13 |
ATE170220T1 (de) | 1998-09-15 |
AU657935B2 (en) | 1995-03-30 |
DE69130071D1 (de) | 1998-10-01 |
DK0563093T4 (da) | 2008-01-21 |
JPH06507303A (ja) | 1994-08-25 |
AU9081791A (en) | 1992-07-22 |
JP2001019643A (ja) | 2001-01-23 |
EP0491077A1 (en) | 1992-06-24 |
CA2098021C (en) | 2000-04-25 |
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