ES2115115T3 - Benzoilguanidinas sustituidas con urea, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents

Benzoilguanidinas sustituidas con urea, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Info

Publication number
ES2115115T3
ES2115115T3 ES94112383T ES94112383T ES2115115T3 ES 2115115 T3 ES2115115 T3 ES 2115115T3 ES 94112383 T ES94112383 T ES 94112383T ES 94112383 T ES94112383 T ES 94112383T ES 2115115 T3 ES2115115 T3 ES 2115115T3
Authority
ES
Spain
Prior art keywords
medicinal product
benzoilguanidines
urea
substituted
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94112383T
Other languages
English (en)
Inventor
Jan-Robert Dr Schwark
Hans-Jochen Dr Lang
Heinz-Werner Dr Kleemann
Andreas Dr Weichert
Wolfgang Dr Scholz
Udo Dr Albus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2115115T3 publication Critical patent/ES2115115T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBEN NUEVAS BENZOIL GUANIDINAS DE LA FORMULA I CON R(1), R(3) O R(4) IGUAL A OXIGENO, AZUFRE, R(6), R(7) Y R(8) IGUAL A H, (PERFLUOR)ALQU(EN)IL, DONDE R(7) Y R(8) PUEDEN SER TAMBIEN CONJUNTAMENTE 4 O 5 GRUPOS METILENO, QUE SON RESPECTIVAMENTE SUSTITUYENTES PERMANECIENTES R(1) HASTA R(5) H, HAL, (FLUOR)ALQU(EN)IL, CN, NO2, NR(16)R(17). LOS COMPUESTOS COMO CONSECUENCIA DE SUS PROPIEDADES FARMACOLOGICAS SON APROPIADOS COMO MEDICAMENTOS ANTIARRITMICOS CON COMPONENTES CARDIOPROTECTIVOS PARA PROFILAXIS DEL INFARTO Y EL TRATAMIENTO DE INFARTO, ASI COMO TRATAMIENTO DE LA ANGINA DE PECHO DE FORMA SOBRESALIENTE, CON LO CUAL TIENEN EFECTO TAMBIEN PREVENTIVO EN LOS PROCESOS PATOPSICOLOGICOS MEDIANTE LA GENERACION DE DAÑOS INDUCIDOS ISQUEMICOS, INHIBIENDO O EVITANDO FUERTEMENTE LAS ARRITMIAS CARDIACAS INDUCIDAS ISQUEMICAS. SE OBTIENEN MEDIANTE TRANSFORMACION DE UN COMPUESTO DE LA FORMULA II DONDE L ES UN GRUPO SUSTITUIBLE FACILMENTE NUCLEOFILO, CON GUANIDINA.
ES94112383T 1993-08-13 1994-08-08 Benzoilguanidinas sustituidas con urea, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. Expired - Lifetime ES2115115T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4327244A DE4327244A1 (de) 1993-08-13 1993-08-13 Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
ES2115115T3 true ES2115115T3 (es) 1998-06-16

Family

ID=6495131

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94112383T Expired - Lifetime ES2115115T3 (es) 1993-08-13 1994-08-08 Benzoilguanidinas sustituidas con urea, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Country Status (16)

Country Link
US (1) US5559153A (es)
EP (1) EP0638548B1 (es)
JP (1) JP3647901B2 (es)
CN (1) CN1060763C (es)
AT (1) ATE165342T1 (es)
AU (1) AU683273B2 (es)
CA (1) CA2130031C (es)
DE (2) DE4327244A1 (es)
DK (1) DK0638548T3 (es)
ES (1) ES2115115T3 (es)
FI (1) FI943716A7 (es)
HU (1) HU217628B (es)
IL (1) IL110625A (es)
NO (1) NO300680B1 (es)
NZ (1) NZ264216A (es)
ZA (1) ZA946074B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
IL114670A0 (en) * 1994-08-05 1995-11-27 Fujisawa Pharmaceutical Co Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
DE69603771T2 (de) * 1995-04-18 2000-09-07 Hoechst Ag Substituierte Indenoylguanidines mit antiarrhythmischer und cardioprotektiver Wirkung
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
DE19527305A1 (de) * 1995-07-26 1997-01-30 Hoechst Ag Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
WO1997027183A1 (en) * 1996-01-26 1997-07-31 Fujisawa Pharmaceutical Co., Ltd. Guanidine derivatives
DE19603425A1 (de) * 1996-01-31 1997-08-07 Hoechst Ag Substituierte Diaryldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19622370A1 (de) * 1996-06-04 1997-12-11 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6820824B1 (en) 1998-01-14 2004-11-23 3M Innovative Properties Company Apparatus for spraying liquids, disposable containers and liners suitable for use therewith
DE19713427A1 (de) * 1997-04-01 1998-10-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780027A (en) * 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
GB1311432A (en) * 1971-01-07 1973-03-28 Ici Ltd Guanidine derivatives their preparation and antiviral compositions containing them
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
US5276907A (en) * 1991-01-07 1994-01-04 Motorola Inc. Method and apparatus for dynamic distribution of a communication channel load in a cellular radio communication system
ES2089600T3 (es) * 1992-02-15 1996-10-01 Hoechst Ag Benzoilguanidina sustituida en 3,5, con efecto antiarritmico y efecto inhibidor de la proliferacion de celulas.

Also Published As

Publication number Publication date
IL110625A (en) 1999-03-12
HU9402346D0 (en) 1994-10-28
NO942985D0 (no) 1994-08-12
AU7022394A (en) 1995-02-23
NO300680B1 (no) 1997-07-07
ZA946074B (en) 1995-03-20
CN1111618A (zh) 1995-11-15
HUT71816A (en) 1996-02-28
DE4327244A1 (de) 1995-02-16
CN1060763C (zh) 2001-01-17
JP3647901B2 (ja) 2005-05-18
DE59405764D1 (de) 1998-05-28
JPH0776566A (ja) 1995-03-20
CA2130031C (en) 2005-11-15
FI943716L (fi) 1995-02-14
DK0638548T3 (da) 1998-11-23
AU683273B2 (en) 1997-11-06
IL110625A0 (en) 1994-11-11
US5559153A (en) 1996-09-24
EP0638548A1 (de) 1995-02-15
EP0638548B1 (de) 1998-04-22
HU217628B (hu) 2000-03-28
CA2130031A1 (en) 1995-02-14
FI943716A7 (fi) 1995-02-14
ATE165342T1 (de) 1998-05-15
NO942985L (no) 1995-02-14
NZ264216A (en) 1995-10-26
FI943716A0 (fi) 1994-08-11

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