ES2135514T3 - Benzoilguanidinas orto-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents
Benzoilguanidinas orto-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.Info
- Publication number
- ES2135514T3 ES2135514T3 ES94113047T ES94113047T ES2135514T3 ES 2135514 T3 ES2135514 T3 ES 2135514T3 ES 94113047 T ES94113047 T ES 94113047T ES 94113047 T ES94113047 T ES 94113047T ES 2135514 T3 ES2135514 T3 ES 2135514T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- cyclo
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE DESCRIBE BENZOIL GUANIDINA ORTO SUSTITUIDA DE LA FORMULA I DONDE SIGNIFICAN: R(1) ES H, HAL, CN, NO2, (CICLO)ALQUIL, (O)(S)[NR(5)](CH2)B (CF2)C L, R(1) ES 2F 11), R(12) PUEDE SER DEFINIDO COMO R(10) O SER HIDROGENO, (C1 ALQUIL, O (R1) ES NAFTIL, (B)FENIL(IL), (C1 3)R(15), 8), 14) ES HIDROGENO, METIL, R(16) ES HIDROGENO, ALQUIL O CONJUNTAMENTE CON CICLOALQUIL PORTAN ATOMO DE CARBONO, R(18) ES FENIL, HETEROARIL, (CICLO)ALQUIL, R(19), R(20), R(21), R(22), R(23) SON HIDROGENO, METIL, R(24) ES H, (CICLO)ALQUIL, COMO R(1), R(4) ES ALQUIL, HAL, CN, ASI COMO SUS SALES TOLERABLES FARMACEUTICAMENTE. LOS COMPUESTOS I NO TIENEN NINGUNA PROPIEDAD SALIDIURETICA NO DESEADA, INCLUSO MUY BUENAS PROPIEDADES ANTIARRITMICAS. SON APROPIADOS COMO MEDICAMENTO ANTIARRITMICO CON COMPONENTE CARDIOPROTECTOR PARA LA PROFILAXIS DEL INFARTO Y EL TRATAMIENTO DEL INFARTO ASI COMO PARA EL TRATAMIENTO DE LA ANGINA DE PECHO DE FORMA SOBRESALIENTE. INHIBEN O EVITAN FUERTEMENTE TAMBIEN DE MODO PREVENTIVO LOS PROCESOS PATOFISIOLOGICOS EN EL APARECIMIENTO DE DAÑOS INDUCIDOS ISQUEMICOS. COMO CONSECUENCIA DE SUS EFECTOS PROTECTORES CONTRA SITUACIONES PATOLOGICAS HIPOXICAS E ISQUEMICAS LOS COMPUESTOS DE LA FORMULA I DE ACUERDO CON LA INVENCION COMO CONSECUENCIA DE LA INHIBICION DEL MECANISMO DE INTERCAMBIO NA+/H+ CELULAR PUEDEN SER UTILIZADOS COMO MEDICAMENTO PARA EL TRATAMIENTO DE TODAS LAS ENFERMEDADES AGUDAS O CRONICAS DEBIDO A DAÑOS DESENCADENADOS ISQUEMICOS O ENFERMEDADES INDUCIDAS DE FORMA PRIMARIA O SECUNDARIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4328869A DE4328869A1 (de) | 1993-08-27 | 1993-08-27 | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2135514T3 true ES2135514T3 (es) | 1999-11-01 |
Family
ID=6496184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94113047T Expired - Lifetime ES2135514T3 (es) | 1993-08-27 | 1994-08-22 | Benzoilguanidinas orto-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5965744A (es) |
EP (1) | EP0640588B1 (es) |
JP (1) | JP3655650B2 (es) |
CN (1) | CN1064954C (es) |
AT (1) | ATE184273T1 (es) |
AU (1) | AU685137B2 (es) |
CA (1) | CA2130944C (es) |
DE (2) | DE4328869A1 (es) |
DK (1) | DK0640588T3 (es) |
ES (1) | ES2135514T3 (es) |
FI (1) | FI120341B (es) |
GR (1) | GR3031851T3 (es) |
HU (1) | HU217635B (es) |
IL (1) | IL110772A (es) |
NO (1) | NO301975B1 (es) |
NZ (1) | NZ264307A (es) |
TW (1) | TW400318B (es) |
ZA (1) | ZA946507B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
IL114670A0 (en) * | 1994-08-05 | 1995-11-27 | Fujisawa Pharmaceutical Co | Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4430916A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Alkyl-benzoylguanidin-Derivate |
DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
DE19502644A1 (de) * | 1995-01-28 | 1996-08-01 | Merck Patent Gmbh | 4-Amino-benzoylguanidin-Derivate |
DE19502895A1 (de) * | 1995-01-31 | 1996-08-01 | Merck Patent Gmbh | 4-Mercapto-benzoylguanidin-Derivate |
DE19517848A1 (de) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorhaltige Benzoylguanidine |
DE19518073A1 (de) * | 1995-05-17 | 1996-11-21 | Hoechst Ag | Substituierte Benzyloxycarbonylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19518796A1 (de) * | 1995-05-22 | 1996-11-28 | Hoechst Ag | Fluorphenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19526381A1 (de) * | 1995-07-19 | 1997-01-23 | Hoechst Ag | 4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19531138A1 (de) * | 1995-08-24 | 1997-02-27 | Merck Patent Gmbh | Alkenyl-benzoylguanidin-Derivate |
DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19542306A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
CA2195697A1 (en) | 1996-02-02 | 1997-08-03 | Masahumi Kitano | Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof |
DE19606509A1 (de) * | 1996-02-22 | 1997-08-28 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
WO1997031900A1 (fr) * | 1996-02-29 | 1997-09-04 | Kissei Pharmaceutical Co., Ltd. | Derives d'imidazole et inhibiteur d'epaississement de la paroi vasculaire |
DE19608161A1 (de) | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19608162A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19621319A1 (de) * | 1996-05-28 | 1997-12-04 | Hoechst Ag | Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19624178A1 (de) * | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US6262229B1 (en) | 1996-12-04 | 2001-07-17 | Biomeasure Incorporated | Somatostatin antagonists |
DE19713427A1 (de) * | 1997-04-01 | 1998-10-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19737224A1 (de) | 1997-08-27 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen |
DE19950898A1 (de) * | 1999-10-22 | 2001-04-26 | Aventis Pharma Gmbh | Heterocyclisch substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10001879A1 (de) * | 2000-01-19 | 2001-07-19 | Aventis Pharma Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10060292A1 (de) | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament |
DE10163239A1 (de) * | 2001-12-21 | 2003-07-10 | Aventis Pharma Gmbh | Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament |
US6953465B2 (en) * | 2002-03-25 | 2005-10-11 | Concentric Medical, Inc. | Containers and methods for delivering vaso-occluding filaments and particles |
NZ596107A (en) | 2005-06-24 | 2013-09-27 | Biotron Ltd | Antiviral compounds and methods |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
DE59307360D1 (de) * | 1992-02-15 | 1997-10-23 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
EP0556674B1 (de) * | 1992-02-15 | 1996-06-19 | Hoechst Aktiengesellschaft | 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen |
DE59306029D1 (de) * | 1992-12-16 | 1997-05-07 | Hoechst Ag | 3,5-Substituierte Aminobenzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1993
- 1993-08-27 DE DE4328869A patent/DE4328869A1/de not_active Withdrawn
- 1993-12-17 TW TW082110699A patent/TW400318B/zh not_active IP Right Cessation
-
1994
- 1994-08-22 DE DE59408722T patent/DE59408722D1/de not_active Expired - Lifetime
- 1994-08-22 EP EP94113047A patent/EP0640588B1/de not_active Expired - Lifetime
- 1994-08-22 AT AT94113047T patent/ATE184273T1/de active
- 1994-08-22 DK DK94113047T patent/DK0640588T3/da active
- 1994-08-22 ES ES94113047T patent/ES2135514T3/es not_active Expired - Lifetime
- 1994-08-25 IL IL11077294A patent/IL110772A/xx not_active IP Right Cessation
- 1994-08-25 CN CN941091902A patent/CN1064954C/zh not_active Expired - Fee Related
- 1994-08-25 FI FI943901A patent/FI120341B/fi not_active IP Right Cessation
- 1994-08-25 NZ NZ264307A patent/NZ264307A/en not_active IP Right Cessation
- 1994-08-25 HU HU9402454A patent/HU217635B/hu not_active IP Right Cessation
- 1994-08-26 CA CA002130944A patent/CA2130944C/en not_active Expired - Fee Related
- 1994-08-26 AU AU71507/94A patent/AU685137B2/en not_active Ceased
- 1994-08-26 ZA ZA946507A patent/ZA946507B/xx unknown
- 1994-08-26 NO NO943175A patent/NO301975B1/no not_active IP Right Cessation
- 1994-08-26 JP JP20158594A patent/JP3655650B2/ja not_active Expired - Fee Related
-
1997
- 1997-02-24 US US08/805,321 patent/US5965744A/en not_active Expired - Lifetime
-
1999
- 1999-11-17 GR GR990402945T patent/GR3031851T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
TW400318B (en) | 2000-08-01 |
JP3655650B2 (ja) | 2005-06-02 |
AU685137B2 (en) | 1998-01-15 |
EP0640588A1 (de) | 1995-03-01 |
NZ264307A (en) | 1995-04-27 |
ATE184273T1 (de) | 1999-09-15 |
US5965744A (en) | 1999-10-12 |
HU217635B (hu) | 2000-03-28 |
HUT70538A (en) | 1995-10-30 |
FI943901A (fi) | 1995-02-28 |
HU9402454D0 (en) | 1994-10-28 |
EP0640588B1 (de) | 1999-09-08 |
NO943175D0 (no) | 1994-08-26 |
DK0640588T3 (da) | 2000-03-27 |
FI943901A0 (fi) | 1994-08-25 |
CA2130944A1 (en) | 1995-02-28 |
CA2130944C (en) | 2005-11-15 |
CN1064954C (zh) | 2001-04-25 |
NO301975B1 (no) | 1998-01-05 |
NO943175L (no) | 1995-02-28 |
GR3031851T3 (en) | 2000-02-29 |
JPH07109251A (ja) | 1995-04-25 |
CN1106381A (zh) | 1995-08-09 |
FI120341B (fi) | 2009-09-30 |
DE59408722D1 (de) | 1999-10-14 |
DE4328869A1 (de) | 1995-03-02 |
AU7150794A (en) | 1995-03-09 |
ZA946507B (en) | 1995-03-28 |
IL110772A (en) | 2000-06-29 |
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Legal Events
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FG2A | Definitive protection |
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