ES2109545T3 - Benzoilguanidina sustituida, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico asi como el medicamento que la contiene. - Google Patents
Benzoilguanidina sustituida, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico asi como el medicamento que la contiene.Info
- Publication number
- ES2109545T3 ES2109545T3 ES94108281T ES94108281T ES2109545T3 ES 2109545 T3 ES2109545 T3 ES 2109545T3 ES 94108281 T ES94108281 T ES 94108281T ES 94108281 T ES94108281 T ES 94108281T ES 2109545 T3 ES2109545 T3 ES 2109545T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- medicinal product
- image
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
Abstract
SE DESCRIBE GUANIDINA BENZONIL DE LA FORMULA I CON R(1) ES IGUAL A H, HAL, M IGUAL A 0 UAL 0 MISMO SIGNIFICADO DE H, R(2) CON Y IGUAL A O, S R(11), R(12) = H, ALQUIL Y H ES CERO O 1 Y I, Y K IGUAL 0 DONDE INCLUSO H, I Y K SON AL MISMO TIEMPO IGUALES A CERO, R(3) SE DEFINE COMO R(1), O ALQUIL, OR(16) O SALES TOLERABLES FARMACEUTICAMENTE. SE OBTIENEN A PARTIR DE UN COMPUESTO II BAJO TRANSFORMACION CON GUANIDINA, DONDE R(1) HASTA R(4) POSEEN EL SIGNIFICADO DADO Y L ES UN NUCLEOFILO LIGERO SUSTITUIBLE. LOS COMPUESTOS SON APROPIADOS COMO MEDICAMENTOS ANTIARRITMICOS CON COMPONENTES CARDIOPROTECTORES PARA PROFILAXIS DEL INFARTO Y TRATAMIENTO DEL INFARTO, ASI COMO PARA EL TRATAMIENTO DE LA ANGINA DE PECHO DE FORMA SOBRESALIENTE, CON LO CUAL SON TAMBIEN PREVENTIVOS EN PROCESOS PATOFISIOLOGICOS EN LA GENERACION DE DAÑOS INDUCIDOS ISQUEMICOS, EN PARTICULAR EN LA SOLUCION ISQUIMICA INDUCIDA DE LA ARRITMIA CARDIACA, QUE LA INHIBEN O LA DISMINUYEN DE FORMA CONSIDERABLE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4318658A DE4318658A1 (de) | 1993-06-04 | 1993-06-04 | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2109545T3 true ES2109545T3 (es) | 1998-01-16 |
Family
ID=6489681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94108281T Expired - Lifetime ES2109545T3 (es) | 1993-06-04 | 1994-05-30 | Benzoilguanidina sustituida, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico asi como el medicamento que la contiene. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5880156A (es) |
EP (1) | EP0627413B1 (es) |
JP (1) | JP3718240B2 (es) |
AT (1) | ATE158572T1 (es) |
AU (1) | AU668304B2 (es) |
CA (1) | CA2125105C (es) |
DE (2) | DE4318658A1 (es) |
DK (1) | DK0627413T3 (es) |
ES (1) | ES2109545T3 (es) |
FI (1) | FI942598A (es) |
GR (1) | GR3024927T3 (es) |
HU (1) | HU215972B (es) |
NO (1) | NO300679B1 (es) |
NZ (1) | NZ260660A (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4318756A1 (de) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
TW415937B (en) * | 1994-01-25 | 2000-12-21 | Hoechst Ag | Phenyl-substituted alkylcarboxylic acid guanidides bearing perfluoroalkyl groups, process for their preparation, their use as a medicament or diagnostic, and medicament containing them |
DE4417004A1 (de) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4422685A1 (de) * | 1994-06-29 | 1996-01-04 | Hoechst Ag | Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
IL114670A0 (en) * | 1994-08-05 | 1995-11-27 | Fujisawa Pharmaceutical Co | Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4432101A1 (de) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Aminosäure-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19502895A1 (de) * | 1995-01-31 | 1996-08-01 | Merck Patent Gmbh | 4-Mercapto-benzoylguanidin-Derivate |
EP0765867A1 (de) * | 1995-09-27 | 1997-04-02 | Hoechst Aktiengesellschaft | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament |
DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19542306A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
WO1997027183A1 (en) * | 1996-01-26 | 1997-07-31 | Fujisawa Pharmaceutical Co., Ltd. | Guanidine derivatives |
DE19608162A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19622222A1 (de) * | 1996-06-03 | 1997-12-04 | Hoechst Ag | Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikament zur Normalisierung der Serumlipide |
DE19737463A1 (de) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden |
DE60036540T2 (de) * | 1999-03-25 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp. | Rho-kinase-inhibitoren für die vorbeugung oder behandlung von interstitieller pneumonie und pulmonaler fibrose |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
DE3502629A1 (de) * | 1985-01-26 | 1986-07-31 | Hoechst Ag, 6230 Frankfurt | Phenoxybenzoesaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz |
DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
DE59302959D1 (de) * | 1992-02-15 | 1996-07-25 | Hoechst Ag | 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen |
CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
DE4318756A1 (de) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1993
- 1993-06-04 DE DE4318658A patent/DE4318658A1/de not_active Withdrawn
-
1994
- 1994-05-06 HU HU9401430A patent/HU215972B/hu not_active IP Right Cessation
- 1994-05-30 DE DE59404128T patent/DE59404128D1/de not_active Expired - Lifetime
- 1994-05-30 EP EP94108281A patent/EP0627413B1/de not_active Expired - Lifetime
- 1994-05-30 DK DK94108281.0T patent/DK0627413T3/da active
- 1994-05-30 ES ES94108281T patent/ES2109545T3/es not_active Expired - Lifetime
- 1994-05-30 AT AT94108281T patent/ATE158572T1/de not_active IP Right Cessation
- 1994-06-02 NZ NZ260660A patent/NZ260660A/en unknown
- 1994-06-02 FI FI942598A patent/FI942598A/fi unknown
- 1994-06-03 AU AU64543/94A patent/AU668304B2/en not_active Ceased
- 1994-06-03 JP JP12161594A patent/JP3718240B2/ja not_active Expired - Fee Related
- 1994-06-03 NO NO942062A patent/NO300679B1/no not_active IP Right Cessation
- 1994-06-03 CA CA002125105A patent/CA2125105C/en not_active Expired - Fee Related
-
1996
- 1996-01-30 US US08/898,889 patent/US5880156A/en not_active Expired - Lifetime
-
1997
- 1997-10-03 GR GR970402568T patent/GR3024927T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0627413T3 (da) | 1998-04-14 |
EP0627413B1 (de) | 1997-09-24 |
NZ260660A (en) | 1995-09-26 |
HU215972B (hu) | 1999-03-29 |
JPH06345643A (ja) | 1994-12-20 |
US5880156A (en) | 1999-03-09 |
HU9401430D0 (en) | 1994-08-29 |
FI942598A0 (fi) | 1994-06-02 |
DE59404128D1 (de) | 1997-10-30 |
NO942062D0 (no) | 1994-06-03 |
AU6454394A (en) | 1994-12-08 |
JP3718240B2 (ja) | 2005-11-24 |
CA2125105C (en) | 2006-05-09 |
CA2125105A1 (en) | 1994-12-05 |
GR3024927T3 (en) | 1998-01-30 |
NO942062L (no) | 1994-12-05 |
FI942598A (fi) | 1994-12-05 |
NO300679B1 (no) | 1997-07-07 |
EP0627413A1 (de) | 1994-12-07 |
DE4318658A1 (de) | 1994-12-08 |
HUT70941A (en) | 1995-11-28 |
AU668304B2 (en) | 1996-04-26 |
ATE158572T1 (de) | 1997-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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