ES2114189T3 - Procedimiento para la preparacion de fluor-6-halogeno-2-quinoleina. - Google Patents

Procedimiento para la preparacion de fluor-6-halogeno-2-quinoleina.

Info

Publication number
ES2114189T3
ES2114189T3 ES94913146T ES94913146T ES2114189T3 ES 2114189 T3 ES2114189 T3 ES 2114189T3 ES 94913146 T ES94913146 T ES 94913146T ES 94913146 T ES94913146 T ES 94913146T ES 2114189 T3 ES2114189 T3 ES 2114189T3
Authority
ES
Spain
Prior art keywords
pct
halogen
hal
preparation
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94913146T
Other languages
English (en)
Inventor
Herve Garcia
Roland Jacquot
Patrick Leon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2114189T3 publication Critical patent/ES2114189T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

UN PROCESO DE PREPARACION DE FLUORO-6 HALOGENO-2 QUINOLEINA DE FORMULA GENERAL (I) EN LA QUE R ES UN ATOMO DE HIDROGENO O UN RADICAL ALCOILO, HAL Y HAL'' SON ATOMOS DE HALOGENO IDENTICOS O DIFERENTES, CARACTERIZADO EN QUE SE HACE REACCIONAR UN AGENTE DE HALOGENACION SOBRE EL HIDROXI-1 QUINOLONA DE FORMULA GENERAL (II) EN LA QUE HAL ESTA DEFINIDO COMO ANTERIORMENTE Y R{SUB,1} SE DEFINE COMO R CON LA EXCEPCION DE REPRESENTAR UN ATOMO DE HIDROGENO, Y A CONTINUACION LIBERA EVENTUALMENTE LA FUNCION ACIDA SI SE QUIERE OBTENER UNA FLUORO-6 HALOGENO-2 QUINOLEINA PARA LA QUE R ES UN ATOMO DE HIDROGENO.
ES94913146T 1993-04-08 1994-04-07 Procedimiento para la preparacion de fluor-6-halogeno-2-quinoleina. Expired - Lifetime ES2114189T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9304163A FR2703681B1 (fr) 1993-04-08 1993-04-08 Procede de preparation de fluoro-6-halogeno-2 quinoleine

Publications (1)

Publication Number Publication Date
ES2114189T3 true ES2114189T3 (es) 1998-05-16

Family

ID=9445879

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94913146T Expired - Lifetime ES2114189T3 (es) 1993-04-08 1994-04-07 Procedimiento para la preparacion de fluor-6-halogeno-2-quinoleina.

Country Status (21)

Country Link
US (1) US5624933A (es)
EP (1) EP0693060B1 (es)
JP (1) JP3666753B2 (es)
KR (1) KR100330141B1 (es)
AT (1) ATE164155T1 (es)
AU (1) AU680493B2 (es)
CA (1) CA2158746C (es)
CZ (1) CZ283705B6 (es)
DE (1) DE69409101T2 (es)
DK (1) DK0693060T3 (es)
ES (1) ES2114189T3 (es)
FI (1) FI113263B (es)
FR (1) FR2703681B1 (es)
GR (1) GR3026401T3 (es)
HU (1) HU221861B1 (es)
IL (1) IL109255A (es)
NO (1) NO305752B1 (es)
NZ (1) NZ265072A (es)
SK (1) SK281139B6 (es)
TW (1) TW261612B (es)
WO (1) WO1994024113A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7510170B2 (en) 2006-11-09 2009-03-31 Guan Hong Enterprise Co., Ltd. Humidifying fan

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1458205A (en) * 1973-04-13 1976-12-08 Pfizer Fused pyrimidin-4- 3h-ones as antiallergy agents
US4190659A (en) * 1973-08-27 1980-02-26 Sandoz, Inc. Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
US4710507A (en) * 1983-12-22 1987-12-01 Pfizer Inc. Quinolone inotropic agents
DK111387A (da) * 1986-03-05 1987-09-06 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
DE3713672A1 (de) * 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
AU623473B2 (en) * 1989-01-16 1992-05-14 Laboratoire Roger Bellon New benzo(1,8)naphthyridine derivatives and their preparation
NZ232090A (en) * 1989-01-16 1990-12-21 Bellon Labor Sa Roger Halogen-containing 1-substituted-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof
NZ232091A (en) * 1989-01-16 1990-12-21 Bellon Labor Sa Roger 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof
US4948894A (en) * 1989-02-21 1990-08-14 American Cyanamid Company 8-fluoro and 7, 8, 10-trifluoro-9-(substituted)-6-oxo-6H-benzo-(C)quinolizine-5-carboxylic acids
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
FR2682384B1 (fr) * 1991-10-10 1995-04-07 Bellon Laboratoires Procede de preparation de benzo (b) naphtyridines.
FR2682378B1 (fr) * 1991-10-10 1995-04-07 Bellon Laboratoires Nouveaux derives de l'acide fluoroquinoleine carboxylique-3 et leur preparation.

Also Published As

Publication number Publication date
IL109255A (en) 2000-01-31
HUT73560A (en) 1996-08-28
SK281139B6 (sk) 2000-12-11
DK0693060T3 (da) 1998-10-19
NO953914D0 (no) 1995-10-02
NZ265072A (en) 1997-08-22
DE69409101D1 (de) 1998-04-23
KR960701854A (ko) 1996-03-28
JPH08508747A (ja) 1996-09-17
NO953914L (no) 1995-10-02
EP0693060B1 (fr) 1998-03-18
EP0693060A1 (fr) 1996-01-24
ATE164155T1 (de) 1998-04-15
DE69409101T2 (de) 1998-07-23
IL109255A0 (en) 1994-07-31
GR3026401T3 (en) 1998-06-30
US5624933A (en) 1997-04-29
WO1994024113A1 (fr) 1994-10-27
HU9502934D0 (en) 1995-12-28
CA2158746A1 (fr) 1994-10-27
HU221861B1 (hu) 2003-02-28
FI113263B (fi) 2004-03-31
FI954750A (fi) 1995-10-05
NO305752B1 (no) 1999-07-19
CZ260095A3 (en) 1996-01-17
SK125695A3 (en) 1996-06-05
KR100330141B1 (ko) 2002-09-27
JP3666753B2 (ja) 2005-06-29
AU6540894A (en) 1994-11-08
AU680493B2 (en) 1997-07-31
CA2158746C (fr) 2006-08-29
TW261612B (es) 1995-11-01
FR2703681B1 (fr) 1995-05-12
CZ283705B6 (cs) 1998-06-17
FR2703681A1 (fr) 1994-10-14
FI954750A0 (fi) 1995-10-05

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