ES2110720T3 - Inhibidores biarilicos de la fosfolipasa a2. - Google Patents
Inhibidores biarilicos de la fosfolipasa a2.Info
- Publication number
- ES2110720T3 ES2110720T3 ES94402773T ES94402773T ES2110720T3 ES 2110720 T3 ES2110720 T3 ES 2110720T3 ES 94402773 T ES94402773 T ES 94402773T ES 94402773 T ES94402773 T ES 94402773T ES 2110720 T3 ES2110720 T3 ES 2110720T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- alkenyl
- inhibitors
- phospholipase
- so2h
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
- C07C47/57—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/33—Polycyclic acids
- C07C63/49—Polycyclic acids containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
- C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Rheumatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
COMPUESTOS DE BIARILO, INHIBIDORES EFECTIVOS DE LA FOSFOLIPASA A2 (PLA2) DE LAS FORMULAS I Y II: EN LAS QUE: Y = COOH, CH2CO2H, H, F, CL, BR, I, COOR'', CH2COR'', CONH2, COR", CHO, CH2OH, CH2OR", OH, OR", CF3, ALQUILO C1-6, ALQUENILO C1-6, HALOALQUILO C1-6, NO2, P(O) (OH)2, SO2H O SO3H; Z = H, F, CL, BR, I, CONH2, COR", CHO, CH2OH, CH2OR", OH, OR", CF3, ALQUILO C1-6, ALQUENILO C1-6, HALOALQUILO C1-6, NO2, P(O)(OH)2, SO2H O SO3H; X = (CH2)N, N = 0, 1 O 2; O UN CIS O TRAS CH=CH; R = GRUPOS ALQUILO, ARILO, ARILALQUILO, ALQUILOXI, ARILALQUILOXI, ALQUENILO O ARILALQUENILO SUSTITUIDOS O NO SUSTITUIDOS CON LA CONDICION DE QUE R DEBE TENER 8 O MAS CARBONOS; R'' = H, ALQUILO C1-6, C(R1)2OC(O)R2, CH2CH2NR3R4, CH2CH2CH2NR3R4 U OTROS GRUPOS CON LOS QUE SE OBTIENEN ESTERES FISIOLOGICAMENTE HIDROLIZABLES; R" = ALQUILO C1-6; R1 = H, CH3, C2H5, CH2CH2CH3; R2 = ARILO C6-12, ALQUILO C1-7 LINEAL, RAMIFICADO O CICLICO O ALCOXI C17 LINEAL, RAMIFICADO O CICLICO; R3 = R4 O PUEDE ESTAR ENLAZADO A R4 PARA FORMAR UN GRUPO CICLOALQUILO C3-C6 O UN GRUPO -CH2CH2OCH2CH2-; Y R4 = ALQUILO C1-3; O SALES DE LOS MISMOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/171,038 US5391817A (en) | 1993-12-21 | 1993-12-21 | Biaryl phospholipase A2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2110720T3 true ES2110720T3 (es) | 1998-02-16 |
Family
ID=22622237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94402773T Expired - Lifetime ES2110720T3 (es) | 1993-12-21 | 1994-12-02 | Inhibidores biarilicos de la fosfolipasa a2. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5391817A (es) |
EP (1) | EP0664282B1 (es) |
JP (1) | JPH07223997A (es) |
AT (1) | ATE159509T1 (es) |
AU (1) | AU689511B2 (es) |
CA (1) | CA2135979A1 (es) |
DE (1) | DE69406415T2 (es) |
DK (1) | DK0664282T3 (es) |
ES (1) | ES2110720T3 (es) |
GR (1) | GR3025983T3 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL114950A0 (en) * | 1994-08-22 | 1995-12-08 | Hoechst Schering Agrevo Gmbh | Biphenyl derivatives and herbicidal agentd containing the same |
KR100340273B1 (ko) * | 1997-10-14 | 2002-06-14 | 야마모토 카즈모토 | 비페닐-5-알칸산 유도체 및 이의 용도 |
US6867320B2 (en) * | 2002-02-21 | 2005-03-15 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivatives and use thereof |
JP2005520829A (ja) * | 2002-03-19 | 2005-07-14 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | ベンジルアルコール誘導体 |
US20040018533A1 (en) * | 2002-06-04 | 2004-01-29 | Adam Gail Isabel Reid | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
WO2004002296A2 (en) * | 2002-06-27 | 2004-01-08 | Sequenom, Inc. | Therapeutic methods for reducing fat deposition and treating associated conditions |
AU2003248793A1 (en) * | 2002-06-27 | 2004-01-19 | Sequenom, Inc | Diagnosing predisposition to fat deposition and associated condition |
WO2005016862A1 (en) * | 2003-08-14 | 2005-02-24 | Asahi Kasei Pharma Corporation | Substituted arylalkanoic acid derivative and use thereof |
EP2006271A4 (en) | 2006-03-30 | 2011-08-10 | Asahi Kasei Pharma Corp | SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF |
ATE543799T1 (de) * | 2007-10-19 | 2012-02-15 | Janssen Pharmaceutica Nv | Piperidinyl- und piperazinylmodulatoren von g- sekretase |
WO2009052350A1 (en) * | 2007-10-19 | 2009-04-23 | Janssen Pharmaceutica, N.V. | Amine linked modulators of y-secretase |
CA2702959C (en) * | 2007-10-19 | 2016-07-26 | Janssen Pharmaceutica Nv | Carbon linked modulators of .gamma.-secretase |
MX2010011221A (es) | 2008-04-28 | 2010-11-01 | Asahi Kasei Pharma Corp | Derivado del acido fenilpropionico y uso del mismo. |
WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2341506A1 (de) * | 1973-08-16 | 1975-02-27 | Thomae Gmbh Dr K | Neue biphenylderivate und verfahren zu ihrer herstellung |
DE2341505A1 (de) * | 1973-08-16 | 1975-02-27 | Thomae Gmbh Dr K | Neue beta-ketocarbonsaeureester |
GB1592161A (en) * | 1976-08-13 | 1981-07-01 | Secr Defence | Biphenyl carboxylic esters and their use as liquid crystal materials |
US4537906A (en) * | 1982-12-06 | 1985-08-27 | Merck Frosst Canada, Inc. | Substituted phenylalkenoic acids and esters |
EP0188222B1 (en) * | 1985-01-09 | 1992-04-29 | Dainippon Ink And Chemicals, Inc. | Novel liquid cristalline compounds having substituents |
DE3914227A1 (de) * | 1989-04-29 | 1991-01-10 | Hoechst Ag | Verfahren zur herstellung von 2,7-difluor-9-fluorenon und neue zwischenprodukte |
JPH03258749A (ja) * | 1990-03-07 | 1991-11-19 | Ono Pharmaceut Co Ltd | ベンゾフェノン誘導体、それらの製造方法、およびそれらを含有する薬剤 |
US5235100A (en) * | 1992-01-24 | 1993-08-10 | Ethyl Corporation | Preparation of optically active aliphatic carboxylic acids |
-
1993
- 1993-12-21 US US08/171,038 patent/US5391817A/en not_active Expired - Lifetime
-
1994
- 1994-11-16 CA CA002135979A patent/CA2135979A1/en not_active Abandoned
- 1994-12-02 DK DK94402773.9T patent/DK0664282T3/da active
- 1994-12-02 EP EP94402773A patent/EP0664282B1/en not_active Expired - Lifetime
- 1994-12-02 ES ES94402773T patent/ES2110720T3/es not_active Expired - Lifetime
- 1994-12-02 DE DE69406415T patent/DE69406415T2/de not_active Expired - Fee Related
- 1994-12-02 AT AT94402773T patent/ATE159509T1/de not_active IP Right Cessation
- 1994-12-19 JP JP6339381A patent/JPH07223997A/ja active Pending
- 1994-12-20 AU AU81577/94A patent/AU689511B2/en not_active Ceased
-
1998
- 1998-01-21 GR GR980400155T patent/GR3025983T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0664282A1 (en) | 1995-07-26 |
DE69406415T2 (de) | 1998-06-04 |
GR3025983T3 (en) | 1998-04-30 |
EP0664282B1 (en) | 1997-10-22 |
DE69406415D1 (de) | 1997-11-27 |
AU689511B2 (en) | 1998-04-02 |
ATE159509T1 (de) | 1997-11-15 |
CA2135979A1 (en) | 1995-06-22 |
AU8157794A (en) | 1995-06-29 |
JPH07223997A (ja) | 1995-08-22 |
US5391817A (en) | 1995-02-21 |
DK0664282T3 (da) | 1998-05-25 |
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