ES2104802T3 - Composiciones reactivas y su uso en la esferificacion de los globulos rojos. - Google Patents
Composiciones reactivas y su uso en la esferificacion de los globulos rojos.Info
- Publication number
- ES2104802T3 ES2104802T3 ES92120307T ES92120307T ES2104802T3 ES 2104802 T3 ES2104802 T3 ES 2104802T3 ES 92120307 T ES92120307 T ES 92120307T ES 92120307 T ES92120307 T ES 92120307T ES 2104802 T3 ES2104802 T3 ES 2104802T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- cell
- hemoglobin
- volume
- hemoglobin concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 8
- 102000001554 Hemoglobins Human genes 0.000 abstract 5
- 108010054147 Hemoglobins Proteins 0.000 abstract 5
- 210000003743 erythrocyte Anatomy 0.000 abstract 3
- 210000001995 reticulocyte Anatomy 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000010186 staining Methods 0.000 abstract 1
- 239000002888 zwitterionic surfactant Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5002—Partitioning blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1402—Data analysis by thresholding or gating operations performed on the acquired signals or stored data
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1477—Multiparameters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/102499—Blood gas standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
METODOS PARA LA PREPARACION DE MUESTRAS SANGUINEAS UTILIZANDO COMPOSICIONES REACTIVAS QUE INCLUYEN UN SUPERFICIACTIVO ANFOTERICO ZWITERONICO PARA CELULAS PARA ELIMINAR EL RUIDO ORIENTACIONAL. CUANDO LA COMPOSICION REACTIVA QUE INCLUYE UN TINTE PARA TEÑIR UN SUBGRUPO DE CELULAS REACCIONA CON UNA MUESTRA DE SANGRE, Y LA MEZCLA DE REACCION SE PASA POR LA REGION SENSIBLE DE UN CITOMETRO DE FLUJO, SE MIDE LA LUZ ESPARCIDA Y ABSORBIDA POR CADA CELULA; LAS CELULAS TEÑIDAS PUEDEN DISTINGUIRSE DE LAS NO TEÑIDAS, Y CUANDO LAS CELULAS SON RETICULOCITOS Y ERITROCITOS MADUROS, RESPECTIVAMENTE, EL VOLUMEN Y CONCENTRACION DE HEMOGLOBINA DE CADA RETICULOCITO Y ERITROCITO, Y EL CONTENIDO DE HEMOGLOBINA, VOLUMEN CELULAR MEDIO, CONCENTRACION DE HEMOGLOBINA CORPUSCULAR MEDIA Y HEMOGLOBINA CELULAR MEDIA DE LOS RETICULOCITOS Y ERITROCITOS SE CALCULA DEL VOLUMEN CELULA POR CELULA MEDIDO Y CONCENTRACION DE HEMOGLOBINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/802,674 US5284771A (en) | 1991-12-05 | 1991-12-05 | Reagent compositions and their use in sphering cells |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2104802T3 true ES2104802T3 (es) | 1997-10-16 |
Family
ID=25184391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92120307T Expired - Lifetime ES2104802T3 (es) | 1991-12-05 | 1992-11-27 | Composiciones reactivas y su uso en la esferificacion de los globulos rojos. |
Country Status (12)
Country | Link |
---|---|
US (2) | US5284771A (es) |
EP (1) | EP0545313B1 (es) |
JP (1) | JP2711786B2 (es) |
KR (1) | KR100276145B1 (es) |
AT (1) | ATE155887T1 (es) |
AU (1) | AU661728B2 (es) |
CA (1) | CA2077790C (es) |
DE (1) | DE69221086T2 (es) |
DK (1) | DK0545313T3 (es) |
ES (1) | ES2104802T3 (es) |
IL (1) | IL103056A (es) |
TW (1) | TW265412B (es) |
Families Citing this family (61)
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DE69432410T2 (de) * | 1993-05-14 | 2004-03-04 | Coulter International Corp., Miami | Retikulozyt bestimmungsverfahren und geraet, das lichtstreuungstechniken verwendet |
US5691204A (en) * | 1995-04-21 | 1997-11-25 | Abbott Laboratories | Compositions and methods for the rapid analysis of reticulocytes |
JP3425830B2 (ja) * | 1995-10-06 | 2003-07-14 | シスメックス株式会社 | 新規化合物とその用途 |
US5733784A (en) * | 1995-11-20 | 1998-03-31 | Abbott Laboratories | Reagent system and method for the differentiation and identification of reticulocytes |
US5817519A (en) * | 1995-12-28 | 1998-10-06 | Bayer Corporation | Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
US6025201A (en) * | 1995-12-28 | 2000-02-15 | Bayer Corporation | Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
TW379284B (en) * | 1996-04-12 | 2000-01-11 | Toa Medical Electronics | Agent for detecting reticulocyte |
US5830764A (en) * | 1996-11-12 | 1998-11-03 | Bayer Corporation | Methods and reagent compositions for the determination of membrane surface area and sphericity of erythrocytes and reticulocytes for the diagnosis of red blood cell disorders |
FR2759166B1 (fr) * | 1997-01-31 | 1999-04-23 | Abx Sa | Reactif de coloration pour la determination de cellules sanguines |
US6114173A (en) * | 1997-04-03 | 2000-09-05 | Bayer Corporation | Fully automated method and reagent composition therefor for rapid identification and characterization of reticulocytes erythrocytes and platelets in whole blood |
JPH10307135A (ja) * | 1997-05-02 | 1998-11-17 | Toa Medical Electronics Co Ltd | 赤血球形態異常の検出方法 |
US6271035B1 (en) * | 1998-10-20 | 2001-08-07 | Coulter International Corp. | Methods and compositions for rapid staining of nucleic acids in whole cells |
US6060322A (en) * | 1998-10-20 | 2000-05-09 | Coulter International Corp. | Method for identification of reticulated cells |
US6582574B1 (en) * | 1999-03-31 | 2003-06-24 | City Of Hope | pK-matched running buffers for gel electrophoresis |
EP1166110A1 (en) * | 1999-03-31 | 2002-01-02 | Bayer Corporation | Single channel, single dilution detection method |
US6190919B1 (en) * | 1999-04-21 | 2001-02-20 | The United States Of America As Represented By The Secretary Of The Navy | System for controlling deglycerolization of red blood cells |
US6468732B1 (en) * | 2000-04-04 | 2002-10-22 | Bayer Corporation | Method and long-term stable bicarbonate-containing diluent composition, and storage means therefor, for reducing or reversing aeration induced cell shrinkage and storage induced cell swelling of a whole blood sample |
US6368864B1 (en) | 2000-05-05 | 2002-04-09 | Coulter International Corp. | Dyes and methods of reticulocyte enumeration |
US6784981B1 (en) * | 2000-06-02 | 2004-08-31 | Idexx Laboratories, Inc. | Flow cytometry-based hematology system |
DE60234821D1 (de) * | 2001-03-09 | 2010-02-04 | Mitsubishi Chem Medience Corp | Messverfahren für vollblut |
US6630990B2 (en) | 2001-06-05 | 2003-10-07 | Abbott Laboratories | Optical method and apparatus for red blood cell differentiation on a cell-by-cell basis, and simultaneous analysis of white blood cell differentiation |
CA2428740A1 (en) | 2002-05-20 | 2003-11-20 | Bayer Corporation | Automated method and reagent therefor for assaying body fluid samples such as cerebrospinal fluid (csf) |
DE102004006182B4 (de) * | 2003-08-19 | 2007-08-16 | Biotronix Gmbh | Verfahren zur elektrooptischen Analyse von Zellsuspensionen |
US7625712B2 (en) | 2004-05-21 | 2009-12-01 | Beckman Coulter, Inc. | Method for a fully automated monoclonal antibody-based extended differential |
US7674598B2 (en) * | 2004-05-21 | 2010-03-09 | Beckman Coulter, Inc. | Method for a fully automated monoclonal antibody-based extended differential |
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JP2007147476A (ja) * | 2005-11-29 | 2007-06-14 | Nidec Sankyo Corp | 光散乱式粒子計数装置 |
CN101349644B (zh) * | 2007-07-20 | 2012-06-27 | 深圳迈瑞生物医疗电子股份有限公司 | 一种白细胞分类试剂和其使用方法 |
US8102161B2 (en) * | 2007-09-25 | 2012-01-24 | Tdk Corporation | Stable output in a switching power supply by smoothing the output of the secondary coil |
JP2011502264A (ja) * | 2007-10-29 | 2011-01-20 | ベックマン コールター, インコーポレイテッド | 血小板集団の迅速な抗体ベースの分析のための方法 |
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CN103823051B (zh) * | 2008-03-21 | 2015-11-18 | 艾博特健康公司 | 利用红细胞内含有的血红蛋白的本征色素沉着来确定血样的红细胞指数的方法及设备 |
CN109239321A (zh) | 2008-03-21 | 2019-01-18 | 艾博特健康公司 | 单独和在聚合凝块中检测和计数血小板的方法及设备 |
JP5082010B2 (ja) | 2008-03-21 | 2012-11-28 | アボット ポイント オブ ケア インコーポレイテッド | 赤血球中に含まれるヘモグロビンの固有色素を利用して血液試料のヘマトクリットを測定する方法及び装置 |
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CN101602762B (zh) * | 2008-06-10 | 2013-10-16 | 深圳迈瑞生物医疗电子股份有限公司 | 不对称菁类化合物、其制备方法及应用 |
CN101726579B (zh) * | 2008-10-17 | 2014-06-18 | 深圳迈瑞生物医疗电子股份有限公司 | 血液检测试剂和方法 |
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CN101988082B (zh) * | 2009-07-31 | 2015-04-08 | 深圳迈瑞生物医疗电子股份有限公司 | 白细胞分类计数试剂、试剂盒及其制备方法和白细胞分类计数的方法 |
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DE102011003101B4 (de) | 2010-12-23 | 2016-04-07 | Siemens Healthcare Diagnostics Products Gmbh | Verfahren zum Nachweis einer Plasmodieninfektion |
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CN105334191B (zh) * | 2014-07-25 | 2020-09-08 | 深圳迈瑞生物医疗电子股份有限公司 | 单个红细胞的血红蛋白浓度、体积修正方法及装置 |
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FR3073047B1 (fr) | 2017-11-02 | 2021-01-29 | Commissariat Energie Atomique | Procede optique d'estimation d'un volume representatif de particules presentes dans un echantillon |
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-
1991
- 1991-12-05 US US07/802,674 patent/US5284771A/en not_active Expired - Lifetime
-
1992
- 1992-09-04 IL IL103056A patent/IL103056A/xx not_active IP Right Cessation
- 1992-09-09 CA CA002077790A patent/CA2077790C/en not_active Expired - Fee Related
- 1992-11-05 AU AU28166/92A patent/AU661728B2/en not_active Ceased
- 1992-11-27 DE DE69221086T patent/DE69221086T2/de not_active Expired - Lifetime
- 1992-11-27 DK DK92120307.1T patent/DK0545313T3/da active
- 1992-11-27 ES ES92120307T patent/ES2104802T3/es not_active Expired - Lifetime
- 1992-11-27 EP EP92120307A patent/EP0545313B1/en not_active Expired - Lifetime
- 1992-11-27 AT AT92120307T patent/ATE155887T1/de not_active IP Right Cessation
- 1992-12-03 KR KR1019920023172A patent/KR100276145B1/ko not_active IP Right Cessation
- 1992-12-04 JP JP4350138A patent/JP2711786B2/ja not_active Expired - Lifetime
-
1993
- 1993-04-20 TW TW082103031A patent/TW265412B/zh active
-
1994
- 1994-12-22 US US08/362,744 patent/US5633167A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69221086D1 (de) | 1997-09-04 |
DK0545313T3 (da) | 1998-02-16 |
US5284771A (en) | 1994-02-08 |
DE69221086T2 (de) | 1997-11-13 |
US5633167A (en) | 1997-05-27 |
TW265412B (es) | 1995-12-11 |
AU661728B2 (en) | 1995-08-03 |
JP2711786B2 (ja) | 1998-02-10 |
EP0545313A1 (en) | 1993-06-09 |
JPH06180316A (ja) | 1994-06-28 |
KR100276145B1 (ko) | 2000-12-15 |
ATE155887T1 (de) | 1997-08-15 |
IL103056A0 (en) | 1993-02-21 |
AU2816692A (en) | 1993-06-10 |
CA2077790C (en) | 2002-07-02 |
EP0545313B1 (en) | 1997-07-23 |
CA2077790A1 (en) | 1993-06-06 |
IL103056A (en) | 1997-04-15 |
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