ES2094919T3 - Proceso para purificar pentostatina. - Google Patents

Proceso para purificar pentostatina.

Info

Publication number
ES2094919T3
ES2094919T3 ES92916090T ES92916090T ES2094919T3 ES 2094919 T3 ES2094919 T3 ES 2094919T3 ES 92916090 T ES92916090 T ES 92916090T ES 92916090 T ES92916090 T ES 92916090T ES 2094919 T3 ES2094919 T3 ES 2094919T3
Authority
ES
Spain
Prior art keywords
pentostatin
purify
application
concentrate
stronally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92916090T
Other languages
English (en)
Inventor
James Clark French
Peter Mcdonnell
Howard Daniel Hollis Showalter
Colin Rath Edmunds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2094919T3 publication Critical patent/ES2094919T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PRESENTA UN PROCESO PARA AISLAR CROMATOGRAFICAMENTE PENTOSTATINA DE UN CONCENTRADO CRUDO QUE COMPRENDE LA APLICACION DEL CONCENTRADO A UNA RESINA DE INTERCAMBIO DE ANIONES DE BORATO FUERTEMENTE BASICO SEGUIDA POR LA APLICACION A UN LECHO ACTIVADO DE SEPABEADS SP207, O UN EQUIVALENTE DEL MISMO, Y LA RECOLECCION DE LAS FRACCIONES QUE CONTENGAN PENTOSTATINA.
ES92916090T 1991-07-31 1992-07-16 Proceso para purificar pentostatina. Expired - Lifetime ES2094919T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73871591A 1991-07-31 1991-07-31

Publications (1)

Publication Number Publication Date
ES2094919T3 true ES2094919T3 (es) 1997-02-01

Family

ID=24969187

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92916090T Expired - Lifetime ES2094919T3 (es) 1991-07-31 1992-07-16 Proceso para purificar pentostatina.

Country Status (15)

Country Link
US (1) US5463035A (es)
EP (1) EP0596943B1 (es)
JP (1) JP3141029B2 (es)
AT (1) ATE145404T1 (es)
AU (1) AU2381792A (es)
DE (1) DE69215375T2 (es)
DK (1) DK0596943T3 (es)
ES (1) ES2094919T3 (es)
GR (1) GR3022387T3 (es)
HU (1) HU215126B (es)
IE (1) IE80618B1 (es)
MX (1) MX9204460A (es)
PT (1) PT100755B (es)
WO (1) WO1993003048A1 (es)
ZA (1) ZA925732B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE371021T1 (de) * 2003-01-16 2007-09-15 Adorkem Technology Spa Immobilisierte biokatalysatoren für die herstellung von natürlichen nukleosiden und modifizierten analogen durch enzymatische transglykosylierungsreaktionen
ITMI20052516A1 (it) * 2005-12-29 2007-06-30 Evultis Sa PROCESSO PER L'ISOLAMENTO DI PèRINCIPI FARMACOLOGICAMENTE ATTIVI DI ORIGINE VEGETALE ED ANIMALE
CN101792722B (zh) * 2009-02-04 2013-04-10 杭州华东医药集团生物工程研究所有限公司 一种链霉菌及其应用
CN101798330A (zh) * 2009-02-06 2010-08-11 杭州华东医药集团生物工程研究所有限公司 一种喷司他丁的提取纯化方法
US20100261666A1 (en) * 2009-04-14 2010-10-14 The Board Of Trustees Of The University Of Illinois Compositions and methods for the treatment of myocardial dysfunction associated with sirs or sepsis
CN102453065B (zh) * 2010-10-29 2014-12-17 上海医药工业研究院 一种去除喷司他丁发酵液中杂质的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923785A (en) * 1974-04-22 1975-12-02 Parke Davis & Co (R)-3-(2-deoxy-{62 -D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo{8 4,5-d{9 {8 1,3{9 diazepin-8-ol
US4713372A (en) * 1984-03-16 1987-12-15 Warner-Lambert Company 2-chloropentostatin compound having adenosine diaminase inhibitory activity
IT1182764B (it) * 1985-06-26 1987-10-05 Pietro Crocoli Water closet, particolarmente adatto per veicoli
US4935342A (en) * 1986-12-01 1990-06-19 Syngene, Inc. Method of isolating and purifying nucleic acids from biological samples
US4908441A (en) * 1988-07-19 1990-03-13 Warner-Lambert Company Deoxyadenosine compounds and methods of making and using the same

Also Published As

Publication number Publication date
IE80618B1 (en) 1998-10-21
AU2381792A (en) 1993-03-02
MX9204460A (es) 1993-04-01
HUT65981A (en) 1994-08-29
GR3022387T3 (en) 1997-04-30
DE69215375D1 (de) 1997-01-02
DE69215375T2 (de) 1997-03-13
PT100755B (pt) 1999-07-30
IE922507A1 (en) 1993-02-10
JPH06509355A (ja) 1994-10-20
DK0596943T3 (da) 1997-04-21
JP3141029B2 (ja) 2001-03-05
EP0596943A1 (en) 1994-05-18
HU215126B (hu) 1998-09-28
EP0596943B1 (en) 1996-11-20
HU9400257D0 (en) 1994-05-30
US5463035A (en) 1995-10-31
ZA925732B (en) 1994-01-31
ATE145404T1 (de) 1996-12-15
WO1993003048A1 (en) 1993-02-18
PT100755A (pt) 1993-10-29

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